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ES2183340T3 - Procedimiento para la preparcion de compuestos de 4-bromometil-bifenilo. - Google Patents

Procedimiento para la preparcion de compuestos de 4-bromometil-bifenilo.

Info

Publication number
ES2183340T3
ES2183340T3 ES98913755T ES98913755T ES2183340T3 ES 2183340 T3 ES2183340 T3 ES 2183340T3 ES 98913755 T ES98913755 T ES 98913755T ES 98913755 T ES98913755 T ES 98913755T ES 2183340 T3 ES2183340 T3 ES 2183340T3
Authority
ES
Spain
Prior art keywords
compounds
bromometil
bifenilo
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98913755T
Other languages
English (en)
Inventor
Aldo Salimbeni
Renato Canevotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Luso Farmaco dItalia SpA
Original Assignee
Istituto Luso Farmaco dItalia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Luso Farmaco dItalia SpA filed Critical Istituto Luso Farmaco dItalia SpA
Application granted granted Critical
Publication of ES2183340T3 publication Critical patent/ES2183340T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención se refiere a compuestos de fórmula (I) en la que R es tal y como se define en la descripción, que se preparan por bromación de compuestos de fórmula (II) por medio de Br{sub,2} o HBr en presencia de H{sub,2}O{sub,2}.
ES98913755T 1997-04-11 1998-04-06 Procedimiento para la preparcion de compuestos de 4-bromometil-bifenilo. Expired - Lifetime ES2183340T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000846A IT1291551B1 (it) 1997-04-11 1997-04-11 Processo per la preparazione di composti 4-bromometil bifenilici

Publications (1)

Publication Number Publication Date
ES2183340T3 true ES2183340T3 (es) 2003-03-16

Family

ID=11376859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98913755T Expired - Lifetime ES2183340T3 (es) 1997-04-11 1998-04-06 Procedimiento para la preparcion de compuestos de 4-bromometil-bifenilo.

Country Status (8)

Country Link
US (1) US6111114A (es)
EP (1) EP0973729B1 (es)
JP (1) JP2001518904A (es)
AU (1) AU6832898A (es)
DE (1) DE69807859T2 (es)
ES (1) ES2183340T3 (es)
IT (1) IT1291551B1 (es)
WO (1) WO1998046562A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2771090B1 (fr) * 1997-11-17 2000-02-04 Sanofi Sa Procede de preparation de derives de bromomethyl-biphenyle
DE19757995A1 (de) * 1997-12-29 1999-07-08 Great Lakes Chem Konstanz Gmbh Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen
DK1535901T3 (da) 2002-06-12 2008-04-07 Sumitomo Chemical Co Fremgangsmåde til fremstilling af 4' -brommethyl-2-cyanobiphenyl
JP4537678B2 (ja) * 2003-09-04 2010-09-01 住友化学株式会社 ２’−（１ｈ−テトラゾール−５−イル）ビフェニル−４−カルボアルデヒド結晶およびその製造方法
JP4437141B2 (ja) * 2004-09-02 2010-03-24 テバ ファーマシューティカル インダストリーズ リミティド オルメサルタンメドキソミルの精製法
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
CN1993355A (zh) * 2004-09-02 2007-07-04 特瓦制药工业有限公司 奥美沙坦酯的纯化方法
CN101039917A (zh) * 2004-10-15 2007-09-19 特瓦制药工业有限公司 制备替米沙坦的方法
CN101094849A (zh) * 2004-12-30 2007-12-26 特瓦制药工业有限公司 在ph高于2.5的情况下制备奥美沙坦酯的方法
KR20090108739A (ko) * 2005-01-03 2009-10-16 테바 파마슈티컬 인더스트리즈 리미티드 불순물의 양이 감소된 올메사탄 메독소밀
US20060258727A1 (en) * 2005-01-03 2006-11-16 Lilach Hedvati Olmesartan medoxomil with reduced levels of impurities
US7968727B2 (en) 2005-04-01 2011-06-28 Lek Pharmaceuticals, D.D. Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists
WO2008078340A1 (en) * 2006-12-27 2008-07-03 Calyx Chemicals And Pharmaceuticals Ltd. Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls
HUP0900788A2 (en) * 2009-12-16 2011-11-28 Sanofi Aventis Process for producing 4-bromomethyl-biphenyl derivatives
CN108947870B (zh) * 2018-07-23 2021-03-19 湖北宇阳药业有限公司 一种溴代沙坦联苯的制备方法
CN112010831A (zh) * 2020-09-08 2020-12-01 上海生农生化制品股份有限公司 一种绿色高效的苯醚缩酮溴化合成方法
CN112851549A (zh) * 2021-03-11 2021-05-28 安徽云帆药业有限公司 一种溴化钠套用实验方法
CN112898182A (zh) * 2021-03-11 2021-06-04 安徽云帆药业有限公司 一种制备4`-溴甲基-2-氰基联苯的合成方法
CN114426501A (zh) * 2021-12-23 2022-05-03 山东艾孚特科技有限公司 基于水相反应的溴代沙坦联苯的制备方法
CN114436833B (zh) * 2021-12-27 2024-12-24 南京红太阳医药研究院有限公司 一种替米沙坦关键中间体4′-溴甲基联苯-2-羧酸酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2688657B2 (ja) * 1989-02-23 1997-12-10 三光化学工業株式会社 芳香核に結合するメチル基の臭素化方法
US5312958A (en) * 1992-01-31 1994-05-17 Takeda Chemical Industries, Ltd. Process for producing 4-bromomethylbiphenyl compounds
EP0595150B1 (de) * 1992-10-29 1996-07-31 Hoechst Aktiengesellschaft Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen

Also Published As

Publication number Publication date
EP0973729A1 (en) 2000-01-26
ITMI970846A1 (it) 1998-10-11
DE69807859D1 (de) 2002-10-17
US6111114A (en) 2000-08-29
AU6832898A (en) 1998-11-11
WO1998046562A1 (en) 1998-10-22
DE69807859T2 (de) 2003-05-22
IT1291551B1 (it) 1999-01-11
EP0973729B1 (en) 2002-09-11
JP2001518904A (ja) 2001-10-16

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