DK0956033T3 - Totalsyntese af amino-Hip-analogen af didemnin A - Google Patents

Totalsyntese af amino-Hip-analogen af didemnin A

Info

Publication number: DK0956033T3
Authority: DK; Denmark
Prior art keywords: didemnin; amino; total synthesis; hip analog; hip
Prior art date: 1996-10-24

Application number

DK97946294T

Other languages

English (en)

Inventor

Kenneth L Rinehart

J Katauskas Alexandra

Alexandra J Sanborn

Original Assignee

Univ Illinois

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-24

Filing date

1997-10-24

Publication date

2003-10-06

1997-10-24 Application filed by Univ Illinois filed Critical Univ Illinois

2003-10-06 Application granted granted Critical

2003-10-06 Publication of DK0956033T3 publication Critical patent/DK0956033T3/da

Links

XQZOGOCTPKFYKC-VSZULPIASA-N (2r)-n-[(3s,6s,8s,12s,13r,16s,17r,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]-4-methyl-2-(m Chemical compound C([C@H]1C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)NC)C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N1C)C(C)C)O)[C@@H](C)CC)C1=CC=C(OC)C=C1 XQZOGOCTPKFYKC-VSZULPIASA-N 0.000 title abstract 3
108010061297 didemnins Proteins 0.000 title abstract 3
XQZOGOCTPKFYKC-UHFFFAOYSA-N epididemnin A1 Natural products CN1C(=O)C2CCCN2C(=O)C(CC(C)C)NC(=O)C(C)C(=O)C(C(C)C)OC(=O)CC(O)C(C(C)CC)NC(=O)C(NC(=O)C(CC(C)C)NC)C(C)OC(=O)C1CC1=CC=C(OC)C=C1 XQZOGOCTPKFYKC-UHFFFAOYSA-N 0.000 title abstract 3
238000006257 total synthesis reaction Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010189 synthetic method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Transplantation (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

DK97946294T 1996-10-24 1997-10-24 Totalsyntese af amino-Hip-analogen af didemnin A DK0956033T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2910996P	1996-10-24	1996-10-24
PCT/US1997/019211 WO1998017302A1 (en)	1996-10-24	1997-10-24	Total synthesis of the amino hip analogue of didemnin a

Publications (1)

Publication Number	Publication Date
DK0956033T3 true DK0956033T3 (da)	2003-10-06

Family

ID=21847275

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97946294T DK0956033T3 (da)	1996-10-24	1997-10-24	Totalsyntese af amino-Hip-analogen af didemnin A

Country Status (11)

Country	Link
US (1)	US6380156B1 (da)
EP (1)	EP0956033B1 (da)
JP (1)	JP2001504814A (da)
AT (1)	ATE245435T1 (da)
AU (1)	AU726146B2 (da)
CA (1)	CA2269878A1 (da)
DE (1)	DE69723728T2 (da)
DK (1)	DK0956033T3 (da)
ES (1)	ES2202644T3 (da)
PT (1)	PT956033E (da)
WO (1)	WO1998017302A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en)	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
CA2405779A1 (en)	2000-04-07	2001-10-18	The Trustees Of The University Of Pennsylvania	Tamandarin and didemnin analogs and methods of making and using them
US6509315B1 (en)	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
GB0103750D0 (en) *	2001-02-15	2001-04-04	Pharma Mar Sa	Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
UA76718C2 (uk) *	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
GB0016148D0 (en) *	2000-06-30	2000-08-23	Pharma Mar Sa	Synthetic methods for aplidine and new antitiumoral derivatives
HK1054191A1 (zh)	2000-10-12	2003-11-21	Pharma Mar, S.A.	施用aplidine時同時使用myoprotector的癌症治療
JP2006519848A (ja)	2003-03-12	2006-08-31	ファルマ・マール・ソシエダード・アノニマ	改良された抗腫瘍治療
JP4584245B2 (ja)	2003-03-12	2010-11-17	ダナ−ファーバーキャンサーインスティテュート，インコーポレイテッド	多発性骨髄腫治療用のアプリジン
MXPA05010064A (es)	2003-03-21	2006-05-17	Madeleine M Joullie	Analogos de tamandarin y fragmentos de los mismos y metodos para hacerlos y usarlos.
DE102004051023A1 (de) *	2004-10-20	2006-05-04	Bayer Healthcare Ag	Desoxo-Nonadepsipeptide
DE102004051024A1 (de) *	2004-10-20	2006-04-27	Bayer Healthcare Ag	Heterocyclyl-substituierte Nonadepsipeptide
DE102004051025A1 (de) *	2004-10-20	2006-04-27	Bayer Healthcare Ag	Substituierte Nonadepsipeptide
DE102004053410A1 (de) *	2004-11-05	2006-05-11	Bayer Healthcare Ag	Cyclische Nonadepsipeptidamide
DE102006003443A1 (de) *	2006-01-25	2007-07-26	Aicuris Gmbh & Co. Kg	Asparagin-10-substituierte Nonadepsipeptide
DK2029155T3 (da)	2006-02-28	2016-08-01	Pharma Mar Sa	Forbedret behandling af myelomatose
DE102006018250A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Verfahren zum Herstellen von cyclischen Depsipeptiden
DE102006018080A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Lysobactinamide
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
KR102744693B1 (ko)	2017-06-09	2024-12-18	추가이 세이야쿠 가부시키가이샤	N-치환 아미노산을 포함하는 펩타이드의 합성 방법
CN119143631A (zh) *	2018-11-30	2024-12-17	中外制药株式会社	用于肽化合物或酰胺化合物的脱保护方法和在固相反应中的树脂脱除方法以及用于生产肽化合物的方法

1997
- 1997-10-24 AU AU51495/98A patent/AU726146B2/en not_active Ceased
- 1997-10-24 PT PT97946294T patent/PT956033E/pt unknown
- 1997-10-24 JP JP51964998A patent/JP2001504814A/ja not_active Ceased
- 1997-10-24 US US09/284,905 patent/US6380156B1/en not_active Expired - Fee Related
- 1997-10-24 DE DE69723728T patent/DE69723728T2/de not_active Expired - Fee Related
- 1997-10-24 ES ES97946294T patent/ES2202644T3/es not_active Expired - Lifetime
- 1997-10-24 AT AT97946294T patent/ATE245435T1/de not_active IP Right Cessation
- 1997-10-24 DK DK97946294T patent/DK0956033T3/da active
- 1997-10-24 WO PCT/US1997/019211 patent/WO1998017302A1/en not_active Ceased
- 1997-10-24 CA CA002269878A patent/CA2269878A1/en not_active Abandoned
- 1997-10-24 EP EP97946294A patent/EP0956033B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69723728T2 (de)	2004-06-03
US6380156B1 (en)	2002-04-30
ES2202644T3 (es)	2004-04-01
EP0956033A1 (en)	1999-11-17
DE69723728D1 (de)	2003-08-28
EP0956033A4 (en)	2000-06-21
ATE245435T1 (de)	2003-08-15
AU5149598A (en)	1998-05-15
WO1998017302A1 (en)	1998-04-30
AU726146B2 (en)	2000-11-02
JP2001504814A (ja)	2001-04-10
CA2269878A1 (en)	1998-04-30
EP0956033B1 (en)	2003-07-23
PT956033E (pt)	2003-10-31

Similar Documents

Publication	Publication Date	Title
DK0956033T3 (da)	2003-10-06	Totalsyntese af amino-Hip-analogen af didemnin A
EA199700117A1 (ru)	1997-12-30	Трициклические бензазепиновые антагонисты вазопрессина, способ их получения, фармацевтическая композиция и способ лечения млекопитающих с использованием трициклических бензазепинов
TR200800474T2 (tr)	2008-04-21	Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
DK153943C (da)	1989-01-30	Fremgangsmaade til fremstilling af 1-hydroxyvitamin-d-forbindelser ud fra 1-hydroxy-3,5-cyclovitamin-d-forbindelser
MY121543A (en)	2006-02-28	Preparation of 3,4,4-trisubstituted-piperidinyl-n- alkylcarboxylates and intermediates
TR200001603T2 (tr)	2000-10-23	Yeni bileşikler
BG101893A (en)	1999-01-29	Nodulosporic acid derivatives
DK0982988T3 (da)	2004-01-19	I det væsentlige rent zonulin, en fysiologisk modulator af mammale tight junctions
DK251589A (da)	1989-11-26	Fremgangsmaade til fremstilling af 1,3-dioler
DE59409672D1 (de)	2001-04-12	Festphasensynthese von Oligoribonucleotiden
SV1999000060A (es)	1999-10-27	Procedimiento para la preparacion de (s,s)-bencil-2,8-diazabiciclo 4.3.0 nonano ref. 32965-sv
EP0973518A4 (en)	2004-05-26	SEMISYNTHETIC METHOD FOR PRODUCING DIDEMNINE ANALOGS
AR006058A1 (es)	1999-07-21	Procedimientos para preparar compuestos de dicianoacetato y de 1,2-pirazol-5-amino-3-substituido
DK0850231T3 (da)	2003-07-21	Fremgangsmåde til fremstilling af en 2-chlor-5-chlormethyl-thiazolforbindelse
DK0830349T3 (da)	2000-07-17	fremgangsmåde til fremstilling af N,N' -di-substituerede cycliske urinstoffer
ES2109103T3 (es)	1998-01-01	Procedimiento para la preparacion de trialquilsilil-7 bacatina iii.
ITMI913465A1 (it)	1993-06-23	Procedimento per la depurazione dell'1, 1, 1-trifluoro-2-fluoroetano
EP0749320A4 (en)	1997-06-18	FIBRIN-SPECIFIC ANTIBODIES FOR USE AS ANTITHROMBOSE AGENT
DE69805988D1 (de)	2002-07-18	Herstellung von 1,3-diaminopentan durch hydrierung von 3-aminopentanitril
DK0815092T3 (da)	1999-12-06	Fremgangsmåde til fremstilling af 1,2-benzisothiazolin-3-oner
IL128186A0 (en)	1999-11-30	Intermediates for the preparation of 2-imidazoline-5-ones
PT837677E (pt)	2006-08-31	Derivados hexa-hidroxibifenilo bromados
MY118946A (en)	2005-02-28	Novel intermediates and their use to prepare n, n''- bridged bisindolylmaleimides
KR970701687A (ko)	1997-04-12	레조르시놀로부터의 4, 6-디니트로레조르시놀의 일단계 제조방법 (One-step preparation of 4,6-dinitroresorcinol from resorcinol)
WO2000010992A3 (en)	2000-06-22	Water-dispersible or water-soluble d-tocotrienol compounds and methods for making therefor