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ES2151168T3 - N-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas. - Google Patents

N-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas.

Info

Publication number
ES2151168T3
ES2151168T3 ES96916983T ES96916983T ES2151168T3 ES 2151168 T3 ES2151168 T3 ES 2151168T3 ES 96916983 T ES96916983 T ES 96916983T ES 96916983 T ES96916983 T ES 96916983T ES 2151168 T3 ES2151168 T3 ES 2151168T3
Authority
ES
Spain
Prior art keywords
amidas
benzodiazepin
dioxo
tetrahydro
arrhythmias
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96916983T
Other languages
English (en)
Inventor
David A Claremon
Roger M Freidinger
Nigel Liverton
Harold G Selnick
Garry R Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2151168T3 publication Critical patent/ES2151168T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS COMPUESTOS REPRESENTADOS POR LA FORMULA ESTRUCTURAL (I) QUE SON UTILES EN EL TRATAMIENTO DE LAS ARRITMIAS.
ES96916983T 1995-06-07 1996-06-03 N-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas. Expired - Lifetime ES2151168T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/474,801 US5691331A (en) 1995-06-07 1995-06-07 N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides

Publications (1)

Publication Number Publication Date
ES2151168T3 true ES2151168T3 (es) 2000-12-16

Family

ID=23884989

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96916983T Expired - Lifetime ES2151168T3 (es) 1995-06-07 1996-06-03 N-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas.

Country Status (12)

Country Link
US (1) US5691331A (es)
EP (1) EP0832075B1 (es)
JP (1) JPH11506758A (es)
AT (1) ATE196899T1 (es)
AU (1) AU704015B2 (es)
CA (1) CA2222492A1 (es)
DE (1) DE69610628T2 (es)
DK (1) DK0832075T3 (es)
ES (1) ES2151168T3 (es)
GR (1) GR3034602T3 (es)
PT (1) PT832075E (es)
WO (1) WO1996040655A1 (es)

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US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
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US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
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JP2004500419A (ja) * 2000-04-11 2004-01-08 デュポン　ファーマシューティカルズ　カンパニー Ａβタンパク質産生阻害剤としての置換ラクタム
US20100009966A1 (en) * 2001-04-11 2010-01-14 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of abeta protein production
MY156226A (en) * 2008-02-22 2016-01-29 Otsuka Pharma Co Ltd Benzodiazepine compound and pharmaceutical composition
JP5649577B2 (ja) 2009-08-21 2015-01-07 大塚製薬株式会社 ベンゾ［ｂ］［１，４］ジアゼピン−２，４−ジオン化合物の製造方法
TWI481601B (zh) * 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
JP2012184225A (ja) * 2011-02-18 2012-09-27 Otsuka Pharmaceut Co Ltd 医薬組成物
EA201891620A1 (ru) 2016-02-05 2019-02-28 Денали Терапьютикс Инк. Ингибиторы взаимодействующей с рецептором протеинкиназы 1
PL3552017T3 (pl) 2016-12-09 2022-08-08 Denali Therapeutics Inc. Związki użyteczne jako inhibitory RIPK1
MX2024008648A (es) 2022-01-12 2024-09-23 Denali Therapeutics Inc Formas cristalinas de (s)-5-bencil-n-(5-metil-4-oxo-2,3,4,5-tetrah idropirido [3,2- b][1,4]oxacepin-3-il)-4h-1,2,4-triazol-3-carboxam ida.

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DE3134672A1 (de) * 1981-09-02 1983-03-17 Boehringer Ingelheim KG, 6507 Ingelheim Heterocyclische verbindungen, ihre herstellung und verwendung
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
EP0107095B1 (en) * 1982-09-30 1987-09-09 Merck & Co. Inc. 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4470988A (en) * 1983-02-10 1984-09-11 Ciba-Geigy Corporation Benzazocinone and benzazoninone derivatives, and their pharmaceutical use
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
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US5324726A (en) * 1989-12-18 1994-06-28 Merck & Co., Inc. Benzodiazepine analogs
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CA2068355A1 (en) * 1991-05-14 1992-11-15 Mark S. Chambers Benzodiazephine derivatives, compositions containing them and their use in therapy
GB9116113D0 (en) * 1991-07-25 1991-09-11 Merck Sharp & Dohme Therapeutic agents
DE4125457A1 (de) * 1991-08-01 1993-02-04 Bayer Ag Verfahren zur herstellung von n-substituierten lactamen
KR970002640B1 (ko) * 1991-09-30 1997-03-07 요시또미세이야꾸 가부시끼가이샤 티에노디아제핀 화합물 및 그의 용도
WO1993007131A1 (en) * 1991-10-10 1993-04-15 Merck Sharp & Dohme Limited Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
AU2759692A (en) * 1991-10-24 1993-05-21 Glaxo Group Limited Benzodiazepine derivatives as antagonists of gastrin and/or cholecystokinin
EP0539170A1 (en) * 1991-10-24 1993-04-28 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
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US5428157A (en) * 1993-11-22 1995-06-27 Merck & Co., Inc. 3-acylaminobenzodiazepines
JP3621416B2 (ja) * 1993-12-28 2005-02-16 塩野義製薬株式会社 新規なベンゾジアゼピン誘導体
US5441950A (en) * 1994-06-09 1995-08-15 G. D. Searle & Co. Substituted dibenzoxazepine and dibenzthiazepine carbamate compounds, pharmaceutical compositions and methods of use

Also Published As

Publication number Publication date
DE69610628T2 (de) 2001-05-23
DE69610628D1 (de) 2000-11-16
GR3034602T3 (en) 2001-01-31
EP0832075A4 (en) 1998-10-07
WO1996040655A1 (en) 1996-12-19
JPH11506758A (ja) 1999-06-15
AU704015B2 (en) 1999-04-01
EP0832075A1 (en) 1998-04-01
ATE196899T1 (de) 2000-10-15
DK0832075T3 (da) 2000-11-20
US5691331A (en) 1997-11-25
PT832075E (pt) 2001-03-30
AU5968896A (en) 1996-12-30
CA2222492A1 (en) 1996-12-19
EP0832075B1 (en) 2000-10-11

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