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ES2177952T3 - Compuestos codrticoides de esteres de nitrato y su utilizacion farmaceutica. - Google Patents

Compuestos codrticoides de esteres de nitrato y su utilizacion farmaceutica.

Info

Publication number
ES2177952T3
ES2177952T3 ES97910409T ES97910409T ES2177952T3 ES 2177952 T3 ES2177952 T3 ES 2177952T3 ES 97910409 T ES97910409 T ES 97910409T ES 97910409 T ES97910409 T ES 97910409T ES 2177952 T3 ES2177952 T3 ES 2177952T3
Authority
ES
Spain
Prior art keywords
equal
compounds
codrticoid
group
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97910409T
Other languages
English (en)
Inventor
Soldato Piero Del
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Application granted granted Critical
Publication of ES2177952T3 publication Critical patent/ES2177952T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL B X 1 - NO 2 O A SUS ESTERES O SALES, DONDE B PRESENTA LA ESTRUCTURA (1), DONDE PUEDEN EXISTIR DIVERSOS SUSTITUYENTES EN LUGAR DE LOS HIDROGENOS H DEL GRUPO CH O DE LOS DOS HIDROGENOS H 2 DEL GRUPO CH 2 ; R Y R'' SON IGUALES O DISTINT OS ENTRE SI, Y PUEDEN SER HIROGENO O ALQUILOS LINEALES O RAMIFICADOS DE 1 A 4 ATOMOS DE CARBONO, PREFERIBLEMENTE R = R'' = CH3 ; SINEDO B UN RESIDUO CORTICOSTEROIDE; R'''' ES - (CO L) SUB,T - (X) T1 - DONDE T Y T1 SON ENTEROS IGUALES O DISTINTOS ENTRE SI, E IGUALES A 0 O 1; DONDE L ES UN GRUPO DE CONEXION BIVALENTE; X ES IGUAL A X 0 , DONDE X 0 = O, NH, NR 1C , DONDE R 1C ES UN ALQUILO LINEAL O RAMIFICADO DE 1 A 10 ATOMOS DE C; O IGUAL A X 2 , DONDE X 2 ES IGUAL A OH, CH 3 , CL, N(- CH 2 CH 3 ) 2 , SCH 2 F, SH; X 1 ES UN PUENTE DE CONEXION BIVALENTE YO, CUANDO Y ES UN ALQUILENO C 1 C 20 .
ES97910409T 1996-10-04 1997-10-02 Compuestos codrticoides de esteres de nitrato y su utilizacion farmaceutica. Expired - Lifetime ES2177952T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI002048A IT1285770B1 (it) 1996-10-04 1996-10-04 Composti corticoidei

Publications (1)

Publication Number Publication Date
ES2177952T3 true ES2177952T3 (es) 2002-12-16

Family

ID=11374972

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97910409T Expired - Lifetime ES2177952T3 (es) 1996-10-04 1997-10-02 Compuestos codrticoides de esteres de nitrato y su utilizacion farmaceutica.

Country Status (18)

Country Link
US (8) US6610676B1 (es)
EP (1) EP0929565B1 (es)
JP (1) JP4388600B2 (es)
KR (1) KR100487898B1 (es)
CN (1) CN1142939C (es)
AT (1) ATE218142T1 (es)
AU (1) AU719250B2 (es)
BR (1) BR9711586A (es)
CA (1) CA2267630C (es)
DE (1) DE69712900T2 (es)
DK (1) DK0929565T3 (es)
ES (1) ES2177952T3 (es)
HU (1) HUP9904149A3 (es)
IT (1) IT1285770B1 (es)
PT (1) PT929565E (es)
RU (1) RU2186781C2 (es)
SI (1) SI0929565T1 (es)
WO (1) WO1998015568A2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
AU2002331916B2 (en) 2001-10-03 2008-07-24 Merck Sharp & Dohme Corp. Androstane 17-beta-carboxamides as androgen receptor modulators
ITMI20020148A1 (it) 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
RU2261481C2 (ru) * 2003-03-26 2005-09-27 ФГУ Омская государственная медицинская академия Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途
WO2007025632A2 (en) * 2005-09-02 2007-03-08 Nicox S.A. Nitrooxy derivatives op glucocorticoids
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7893058B2 (en) * 2006-05-15 2011-02-22 Janssen Pharmaceutica Nv Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
US20100234334A1 (en) * 2007-02-05 2010-09-16 Nicox S.A. Nitric oxide releasing steroids
WO2009037584A2 (en) * 2007-08-10 2009-03-26 Topigen Pharmaceuticals Inc. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
WO2009071990A2 (en) * 2007-08-31 2009-06-11 Topigen Pharmaceuticals Inc. No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
AU2009277381B2 (en) * 2008-07-31 2014-04-24 Nicox S.A. Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
WO2010015528A1 (en) 2008-08-05 2010-02-11 Nicox S.A. New no-releasing steroids for the treatment of retina and macula lutea diseases
CN102186874A (zh) * 2008-08-05 2011-09-14 尼科克斯公司 新的释放no的类固醇衍生物
WO2011132171A1 (en) 2010-04-23 2011-10-27 Piramal Life Sciences Limited Nitric oxide releasing prodrugs of therapeutic agents
US8716268B2 (en) 2010-06-07 2014-05-06 Chao Liu Nitrate esters of corticoid compounds useful as diuretics
WO2014111957A1 (en) 2013-01-21 2014-07-24 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents
CN108191938B (zh) * 2018-01-11 2019-07-05 湖南新合新生物医药有限公司 9,11烯烃甾族化合物的制备方法
CN113069460B (zh) * 2021-03-24 2022-02-08 兰州大学 哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990401A (en) * 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
US3172896A (en) * 1963-05-01 1965-03-09 Aminoethers of s-androstenes
US3183252A (en) * 1963-09-05 1965-05-11 Syntex Corp 16-nitratoalkyl-pregnanes
US3494941A (en) * 1967-12-04 1970-02-10 American Home Prod Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (es) * 1971-05-07 1973-12-28
GB1510617A (en) * 1974-03-27 1978-05-10 Plurichemie Anstalt 16-methyl-9alpha-halo steroid esters and ethers and preparation thereof
CA1058161A (en) * 1975-09-08 1979-07-10 Ravi K. Varma 3,20-DIKETOPREGNENES HAVING AN 11.beta.-ACETAL GROUP AND DERIVATIVES THEREOF
IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5457207A (en) 1993-10-05 1995-10-10 Regents Of The University Of Minnesota Spirovesamicols
HU218923B (hu) 1993-10-06 2000-12-28 Nicox S.A. Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
RU2145595C1 (ru) 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei

Also Published As

Publication number Publication date
US20060154905A1 (en) 2006-07-13
SI0929565T1 (en) 2002-08-31
DE69712900T2 (de) 2002-12-12
DK0929565T3 (da) 2002-09-09
ITMI962048A1 (it) 1998-04-04
JP2001501637A (ja) 2001-02-06
US7160871B2 (en) 2007-01-09
US20070161612A1 (en) 2007-07-12
IT1285770B1 (it) 1998-06-18
EP0929565A2 (en) 1999-07-21
DE69712900D1 (de) 2002-07-04
JP4388600B2 (ja) 2009-12-24
BR9711586A (pt) 1999-08-24
CN1253563A (zh) 2000-05-17
CA2267630C (en) 2008-01-08
US20060270644A1 (en) 2006-11-30
KR100487898B1 (ko) 2005-05-09
US20080234242A1 (en) 2008-09-25
EP0929565B1 (en) 2002-05-29
US20060160781A1 (en) 2006-07-20
US7605151B2 (en) 2009-10-20
US7205288B2 (en) 2007-04-17
US20050004089A1 (en) 2005-01-06
US7056905B2 (en) 2006-06-06
WO1998015568A2 (en) 1998-04-16
CA2267630A1 (en) 1998-04-16
WO1998015568A3 (en) 1998-06-18
US6610676B1 (en) 2003-08-26
US7196075B2 (en) 2007-03-27
RU2186781C2 (ru) 2002-08-10
HUP9904149A3 (en) 2001-03-28
HUP9904149A2 (hu) 2000-04-28
US7157450B2 (en) 2007-01-02
ATE218142T1 (de) 2002-06-15
AU4780397A (en) 1998-05-05
PT929565E (pt) 2002-10-31
AU719250B2 (en) 2000-05-04
US20060160780A1 (en) 2006-07-20
CN1142939C (zh) 2004-03-24
US7368442B2 (en) 2008-05-06
KR20000048911A (ko) 2000-07-25

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