DE69712900D1 - Nitratester von corticoid verbindungen und die therapeutische verwendungen davon - Google Patents

Nitratester von corticoid verbindungen und die therapeutische verwendungen davon

Info

Publication number: DE69712900D1
Authority: DE; Germany
Prior art keywords: therapeutic uses; nitrate esters; compounds; corticoid compounds; corticoid
Prior art date: 1996-10-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69712900T

Other languages

English (en)

Other versions

DE69712900T2 (de

Inventor

Soldato Piero Del

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nicox SA

Original Assignee

Nicox SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-04

Filing date

1997-10-02

Publication date

2002-07-04

1997-10-02 Application filed by Nicox SA filed Critical Nicox SA

2002-07-04 Application granted granted Critical

2002-07-04 Publication of DE69712900D1 publication Critical patent/DE69712900D1/de

2002-12-12 Publication of DE69712900T2 publication Critical patent/DE69712900T2/de

2017-10-03 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE69712900T 1996-10-04 1997-10-02 Nitratester von corticoid verbindungen und die therapeutische verwendungen davon Expired - Lifetime DE69712900T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT96MI002048A IT1285770B1 (it)	1996-10-04	1996-10-04	Composti corticoidei
PCT/EP1997/005426 WO1998015568A2 (en)	1996-10-04	1997-10-02	Nitrate esters of corticoid compounds and pharmaceutical applications thereof

Publications (2)

Publication Number	Publication Date
DE69712900D1 true DE69712900D1 (de)	2002-07-04
DE69712900T2 DE69712900T2 (de)	2002-12-12

Family

ID=11374972

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69712900T Expired - Lifetime DE69712900T2 (de)	1996-10-04	1997-10-02	Nitratester von corticoid verbindungen und die therapeutische verwendungen davon

Country Status (18)

Country	Link
US (8)	US6610676B1 (de)
EP (1)	EP0929565B1 (de)
JP (1)	JP4388600B2 (de)
KR (1)	KR100487898B1 (de)
CN (1)	CN1142939C (de)
AT (1)	ATE218142T1 (de)
AU (1)	AU719250B2 (de)
BR (1)	BR9711586A (de)
CA (1)	CA2267630C (de)
DE (1)	DE69712900T2 (de)
DK (1)	DK0929565T3 (de)
ES (1)	ES2177952T3 (de)
HU (1)	HUP9904149A3 (de)
IT (1)	IT1285770B1 (de)
PT (1)	PT929565E (de)
RU (1)	RU2186781C2 (de)
SI (1)	SI0929565T1 (de)
WO (1)	WO1998015568A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5824669A (en)	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) *	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei
IT1311922B1 (it)	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1314184B1 (it)	1999-08-12	2002-12-06	Nicox Sa	Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
IT1320176B1 (it) *	2000-12-22	2003-11-26	Nicox Sa	Dispersioni solide di principi attivi nitrati.
EP1219306A1 (de)	2000-12-29	2002-07-03	Nicox S.A.	Zyklodextrin und NO-abgebende Arzneimittlen enthaltende Zusammensetzungen
US6696592B2 (en)	2001-05-22	2004-02-24	Nicox-S.A.	Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
CA2462456C (en)	2001-10-03	2010-05-04	Merck & Co., Inc.	Androstane 17-beta-carboxamides as androgen receptor modulators
ITMI20020148A1 (it)	2002-01-29	2003-07-29	Nicox Sa	Nuovi corticosteroidi
RU2261481C2 (ru) *	2003-03-26	2005-09-27	ФГУ Омская государственная медицинская академия	Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных
CN100513415C (zh) *	2005-08-03	2009-07-15	中国人民解放军军事医学科学院毒物药物研究所	胆汁酸衍生物及其医药用途
NZ566128A (en) *	2005-09-02	2011-03-31	Nicox Sa	Nitrooxy derivatives of glucocorticoids
US8802726B2 (en)	2006-02-03	2014-08-12	Nicox S.A.	Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7893058B2 (en) *	2006-05-15	2011-02-22	Janssen Pharmaceutica Nv	Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
EP2109618A1 (de) *	2007-02-05	2009-10-21	Nicox S.A.	Steroide zur freisetzung von stickoxid
US20090087425A1 (en) *	2007-08-10	2009-04-02	Topigen Pharmaceuticals Inc.	Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
WO2009071990A2 (en) *	2007-08-31	2009-06-11	Topigen Pharmaceuticals Inc.	No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
MX2011001119A (es) *	2008-07-31	2011-03-02	Nicox Sa	Glucocorticoides unidos a esteres de nitrato por medio de un enlazador aromatico en la posicion 21 y su uso en oftalmololgia.
CN102186873A (zh)	2008-08-05	2011-09-14	尼科克斯公司	用于治疗视网膜和黄斑疾病的新型释放no的甾类化合物
EP2321334A1 (de) *	2008-08-05	2011-05-18	Nicox S.A.	Neue no-freisetzende steroidderivate
AU2011243947A1 (en)	2010-04-23	2012-12-06	Piramal Enterprises Limited	Nitric oxide releasing prodrugs of therapeutic agents
US8716268B2 (en)	2010-06-07	2014-05-06	Chao Liu	Nitrate esters of corticoid compounds useful as diuretics
CA2897571C (en)	2013-01-21	2018-12-18	Apparao Satyam	Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
CN108191938B (zh) *	2018-01-11	2019-07-05	湖南新合新生物医药有限公司	9,11烯烃甾族化合物的制备方法
CN113069460B (zh) *	2021-03-24	2022-02-08	兰州大学	哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2990401A (en) *	1958-06-18	1961-06-27	American Cyanamid Co	11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
US3172896A (en) *	1963-05-01	1965-03-09		Aminoethers of s-androstenes
US3183252A (en) *	1963-09-05	1965-05-11	Syntex Corp	16-nitratoalkyl-pregnanes
US3494941A (en) *	1967-12-04	1970-02-10	American Home Prod	Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (de) *	1971-05-07	1973-12-28
NZ177056A (en) *	1974-03-27	1978-09-20	Plurichemie Anstalt	Certain 9 -(chloro or flruoro)-16( or )-methyl-11 ,17 -dihydroxypregna-1,4-diene-3,20-dione 17 -acylates or 11 ,17 -diacylates and certain preparature processes
IE44534B1 (en) *	1975-09-08	1981-12-30	Squibb & Sons Inc	Ethers of 11 -hydroxy steroids and processes for the preparation thereof
IT1256345B (it)	1992-08-20	1995-12-01		Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it)	1992-11-26	1995-12-05	Soldato Piero Del	Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5457207A (en)	1993-10-05	1995-10-10	Regents Of The University Of Minnesota	Spirovesamicols
SI0722434T1 (en)	1993-10-06	1998-12-31	Nicox S.A.	Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
CA2190087C (en)	1994-05-10	2005-08-02	Piero Del Soldato	Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities
US5824669A (en) *	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) *	1996-05-02	1998-11-17	G. D. Searle & Co.	Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US5985862A (en) *	1996-05-02	1999-11-16	G.D. Searle & Co.	Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) *	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei

1996
- 1996-10-04 IT IT96MI002048A patent/IT1285770B1/it active IP Right Grant
1997
- 1997-10-02 WO PCT/EP1997/005426 patent/WO1998015568A2/en not_active Ceased
- 1997-10-02 BR BR9711586A patent/BR9711586A/pt not_active Application Discontinuation
- 1997-10-02 CA CA002267630A patent/CA2267630C/en not_active Expired - Fee Related
- 1997-10-02 PT PT97910409T patent/PT929565E/pt unknown
- 1997-10-02 ES ES97910409T patent/ES2177952T3/es not_active Expired - Lifetime
- 1997-10-02 DK DK97910409T patent/DK0929565T3/da active
- 1997-10-02 CN CNB97180284XA patent/CN1142939C/zh not_active Expired - Fee Related
- 1997-10-02 US US09/269,729 patent/US6610676B1/en not_active Expired - Fee Related
- 1997-10-02 SI SI9730333T patent/SI0929565T1/xx unknown
- 1997-10-02 EP EP97910409A patent/EP0929565B1/de not_active Expired - Lifetime
- 1997-10-02 HU HU9904149A patent/HUP9904149A3/hu unknown
- 1997-10-02 DE DE69712900T patent/DE69712900T2/de not_active Expired - Lifetime
- 1997-10-02 AU AU47803/97A patent/AU719250B2/en not_active Ceased
- 1997-10-02 KR KR10-1999-7002942A patent/KR100487898B1/ko not_active Expired - Fee Related
- 1997-10-02 RU RU99108661/04A patent/RU2186781C2/ru not_active IP Right Cessation
- 1997-10-02 AT AT97910409T patent/ATE218142T1/de active
- 1997-10-02 JP JP51715498A patent/JP4388600B2/ja not_active Expired - Fee Related
2003
- 2003-06-17 US US10/462,637 patent/US7056905B2/en not_active Expired - Fee Related
2006
- 2006-03-14 US US11/374,315 patent/US7196075B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,219 patent/US7157450B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,220 patent/US7160871B2/en not_active Expired - Fee Related
- 2006-06-02 US US11/445,140 patent/US7205288B2/en not_active Expired - Fee Related
2007
- 2007-03-07 US US11/714,724 patent/US7368442B2/en not_active Expired - Fee Related
2008
- 2008-03-19 US US12/051,434 patent/US7605151B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US7157450B2 (en)	2007-01-02
BR9711586A (pt)	1999-08-24
EP0929565B1 (de)	2002-05-29
US7196075B2 (en)	2007-03-27
DE69712900T2 (de)	2002-12-12
US6610676B1 (en)	2003-08-26
KR20000048911A (ko)	2000-07-25
ES2177952T3 (es)	2002-12-16
US20060160781A1 (en)	2006-07-20
US7368442B2 (en)	2008-05-06
CA2267630C (en)	2008-01-08
JP4388600B2 (ja)	2009-12-24
CN1253563A (zh)	2000-05-17
WO1998015568A2 (en)	1998-04-16
CN1142939C (zh)	2004-03-24
US7160871B2 (en)	2007-01-09
ATE218142T1 (de)	2002-06-15
RU2186781C2 (ru)	2002-08-10
HUP9904149A2 (hu)	2000-04-28
KR100487898B1 (ko)	2005-05-09
SI0929565T1 (en)	2002-08-31
US20060270644A1 (en)	2006-11-30
US20080234242A1 (en)	2008-09-25
AU719250B2 (en)	2000-05-04
WO1998015568A3 (en)	1998-06-18
ITMI962048A1 (it)	1998-04-04
DK0929565T3 (da)	2002-09-09
IT1285770B1 (it)	1998-06-18
US20060160780A1 (en)	2006-07-20
US20050004089A1 (en)	2005-01-06
AU4780397A (en)	1998-05-05
US20060154905A1 (en)	2006-07-13
US20070161612A1 (en)	2007-07-12
JP2001501637A (ja)	2001-02-06
US7056905B2 (en)	2006-06-06
US7605151B2 (en)	2009-10-20
PT929565E (pt)	2002-10-31
EP0929565A2 (de)	1999-07-21
CA2267630A1 (en)	1998-04-16
US7205288B2 (en)	2007-04-17
HUP9904149A3 (en)	2001-03-28

Publication	Publication Date	Title
DE69712900D1 (de)	2002-07-04	Nitratester von corticoid verbindungen und die therapeutische verwendungen davon
DE69510940D1 (de)	1999-08-26	Pyrazolo und pyrrolopyridine
DK0944643T3 (da)	2003-05-05	Oxyiminopregnancarbolactoner.
FI935585A0 (fi)	1993-12-13	Pyrrolopyrimidiner
GB9514473D0 (en)	1995-09-13	Chemical compounds
CY1108610T1 (el)	2014-04-09	Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
ATE339406T1 (de)	2006-10-15	Chinazoline verbindungen als heilmittel
NO965516L (no)	1997-02-21	Sterolderivater anvendt til regulering av meiose
BG103399A (en)	2000-01-31	New heterocycle-substituted benzamides and their application for the treatment of diseases
HRP930239A2 (en)	1996-06-30	Anti-inflamatory 4-aminophenol derivatives
DE69735367D1 (de)	2006-04-27	THERAPEUTISCHE MULTISPEZIFISCHE VERBINDUNGEN, DIE ANTIKÖRPER GEGEN DEN FCalpha-REZEPTOR ENTHALTEN
DK1060163T3 (da)	2006-02-27	Nye piperazinyl-substituerede pyridylalkan-, -alken og -alkyncarboxamider
ATE82121T1 (de)	1992-11-15	Arzneimittel fuer die therapeutische behandlung von alopezie.
TR199901174T2 (xx)	1999-08-23	Yeni heterosiklilmetil-ikameli pirazol t�revleri.
DK1109812T3 (da)	2005-09-05	Pyrrolobenzodiazepiner
BG103219A (bg)	1999-10-29	Бензамидинови производни и използването им като лекарствени средства с ltb4-антагонистично действие
ATE223912T1 (de)	2002-09-15	Pyridylalkan-säureamide als cytostatika und immunosupressive arzneimittel
ATE243196T1 (de)	2003-07-15	Piperidine und pyrrolidine
DE60016460D1 (de)	2005-01-05	Verwendungen und zusammenstellungen von nitratestern als sedativa
IL131407A0 (en)	2001-01-28	Tetrahydropyrido compounds medicaments containing the same and the use thereof
TR199900662T2 (xx)	1999-06-21	1-Hidroksi-2-piridonlar�n seborik dermatit tedavisi amac�yla kullan�m�
TR199801485T2 (xx)	1998-10-21	Yeni 2,3 benzodiyazepin t�revleri, bu t�revlerin �retimi ve ila� olarak kullan�m�.
ES2118248T3 (es)	1998-09-16	Esteres y amidas de 9-cloro-prostaglandina y su empleo para preparar medicamentos.
GEP20002271B (en)	2000-10-25	Bicyclic Tachykinins Antagonists, Pharmaceutical Composition on Its Basis and Their Use
NO984651L (no)	1998-12-03	Anvendelse av benzonaftalenderivater for fremstilling av medikamenter for behandling av sykdommer i sentralnervesystemet

Legal Events

Date	Code	Title	Description
2003-06-26	8364	No opposition during term of opposition
2007-05-03	8327	Change in the person/name/address of the patent owner	Owner name: NICOX S.A., SOPHIA ANTIPOLIS, VALBONNE, FR