DK0929565T3 - Nitratestere af corticoidforbindelser og farmaceutiske anvendelser deraf - Google Patents

Nitratestere af corticoidforbindelser og farmaceutiske anvendelser deraf

Info

Publication number: DK0929565T3
Authority: DK; Denmark
Prior art keywords: pharmaceutical applications; nitrate esters; compounds; corticoid compounds; corticoid
Prior art date: 1996-10-04

Application number

DK97910409T

Other languages

English (en)

Inventor

Soldato Piero Del

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-04

Filing date

1997-10-02

Publication date

2002-09-09

1997-10-02 Application filed by Nicox Sa filed Critical Nicox Sa

2002-09-09 Application granted granted Critical

2002-09-09 Publication of DK0929565T3 publication Critical patent/DK0929565T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK97910409T 1996-10-04 1997-10-02 Nitratestere af corticoidforbindelser og farmaceutiske anvendelser deraf DK0929565T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT96MI002048A IT1285770B1 (it)	1996-10-04	1996-10-04	Composti corticoidei
PCT/EP1997/005426 WO1998015568A2 (en)	1996-10-04	1997-10-02	Nitrate esters of corticoid compounds and pharmaceutical applications thereof

Publications (1)

Publication Number	Publication Date
DK0929565T3 true DK0929565T3 (da)	2002-09-09

Family

ID=11374972

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97910409T DK0929565T3 (da)	1996-10-04	1997-10-02	Nitratestere af corticoidforbindelser og farmaceutiske anvendelser deraf

Country Status (18)

Country	Link
US (8)	US6610676B1 (da)
EP (1)	EP0929565B1 (da)
JP (1)	JP4388600B2 (da)
KR (1)	KR100487898B1 (da)
CN (1)	CN1142939C (da)
AT (1)	ATE218142T1 (da)
AU (1)	AU719250B2 (da)
BR (1)	BR9711586A (da)
CA (1)	CA2267630C (da)
DE (1)	DE69712900T2 (da)
DK (1)	DK0929565T3 (da)
ES (1)	ES2177952T3 (da)
HU (1)	HUP9904149A3 (da)
IT (1)	IT1285770B1 (da)
PT (1)	PT929565E (da)
RU (1)	RU2186781C2 (da)
SI (1)	SI0929565T1 (da)
WO (1)	WO1998015568A2 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5824669A (en)	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) *	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei
IT1311922B1 (it) *	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1314184B1 (it)	1999-08-12	2002-12-06	Nicox Sa	Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
IT1320176B1 (it) *	2000-12-22	2003-11-26	Nicox Sa	Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en)	2000-12-29	2002-07-03	Nicox S.A.	Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en)	2001-05-22	2004-02-24	Nicox-S.A.	Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
JP4490689B2 (ja)	2001-10-03	2010-06-30	メルク・シャープ・エンド・ドーム・コーポレイション	アンドロゲン受容体調節剤としてのアンドロスタン１７β−カルボキサミド類
ITMI20020148A1 (it) *	2002-01-29	2003-07-29	Nicox Sa	Nuovi corticosteroidi
RU2261481C2 (ru) *	2003-03-26	2005-09-27	ФГУ Омская государственная медицинская академия	Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных
CN100513415C (zh) *	2005-08-03	2009-07-15	中国人民解放军军事医学科学院毒物药物研究所	胆汁酸衍生物及其医药用途
NZ566128A (en) *	2005-09-02	2011-03-31	Nicox Sa	Nitrooxy derivatives of glucocorticoids
US8802726B2 (en)	2006-02-03	2014-08-12	Nicox S.A.	Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7893058B2 (en) *	2006-05-15	2011-02-22	Janssen Pharmaceutica Nv	Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
CN101652380A (zh) *	2007-02-05	2010-02-17	尼科克斯公司	释放一氧化氮的类固醇
US20090087425A1 (en) *	2007-08-10	2009-04-02	Topigen Pharmaceuticals Inc.	Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US20090088411A1 (en) *	2007-08-31	2009-04-02	Topigen Pharmaceuticals Inc.	No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
CA2731513C (en) *	2008-07-31	2016-09-20	Nicox S.A.	Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
WO2010015528A1 (en)	2008-08-05	2010-02-11	Nicox S.A.	New no-releasing steroids for the treatment of retina and macula lutea diseases
CA2731477A1 (en) *	2008-08-05	2010-02-11	Nicox S.A.	New no releasing steroids derivatives
CA2796963A1 (en)	2010-04-23	2011-10-27	Piramal Enterprises Limited	Nitric oxide releasing prodrugs of therapeutic agents
CN102302501B (zh)	2010-06-07	2012-10-03	刘超	糖皮质激素硝基衍生物在制备利尿药物制剂中的应用
US9844599B2 (en)	2013-01-21	2017-12-19	Apparao Satyam	Nitric oxide releasing produgs of therapeutic agents
CN108191938B (zh) *	2018-01-11	2019-07-05	湖南新合新生物医药有限公司	9,11烯烃甾族化合物的制备方法
CN113069460B (zh) *	2021-03-24	2022-02-08	兰州大学	哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2990401A (en) *	1958-06-18	1961-06-27	American Cyanamid Co	11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
GB1054290A (da) *	1963-05-01
US3183252A (en) *	1963-09-05	1965-05-11	Syntex Corp	16-nitratoalkyl-pregnanes
US3494941A (en) *	1967-12-04	1970-02-10	American Home Prod	Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (da) *	1971-05-07	1973-12-28
GB1511820A (en) *	1974-03-27	1978-05-24	Plurichemie Anstalt	16-methyl-9alpha-halo steroid ethers and esters and their preparation
IE44534B1 (en) *	1975-09-08	1981-12-30	Squibb & Sons Inc	Ethers of 11 -hydroxy steroids and processes for the preparation thereof
IT1256345B (it)	1992-08-20	1995-12-01		Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it)	1992-11-26	1995-12-05	Soldato Piero Del	Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5457207A (en)	1993-10-05	1995-10-10	Regents Of The University Of Minnesota	Spirovesamicols
HU218923B (hu)	1993-10-06	2000-12-28	Nicox S.A.	Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
DK0759899T3 (da)	1994-05-10	1999-12-20	Nicox Sa	Nitroforbindelser og sammensætninger deraf med antiinflammatoriske, analgetiske og antitrombotiske aktiviteter
US5824669A (en) *	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5985862A (en) *	1996-05-02	1999-11-16	G.D. Searle & Co.	Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
US5837698A (en) *	1996-05-02	1998-11-17	G. D. Searle & Co.	Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) *	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei

1996
- 1996-10-04 IT IT96MI002048A patent/IT1285770B1/it active IP Right Grant
1997
- 1997-10-02 RU RU99108661/04A patent/RU2186781C2/ru not_active IP Right Cessation
- 1997-10-02 WO PCT/EP1997/005426 patent/WO1998015568A2/en not_active Ceased
- 1997-10-02 AT AT97910409T patent/ATE218142T1/de active
- 1997-10-02 EP EP97910409A patent/EP0929565B1/en not_active Expired - Lifetime
- 1997-10-02 KR KR10-1999-7002942A patent/KR100487898B1/ko not_active Expired - Fee Related
- 1997-10-02 SI SI9730333T patent/SI0929565T1/xx unknown
- 1997-10-02 JP JP51715498A patent/JP4388600B2/ja not_active Expired - Fee Related
- 1997-10-02 HU HU9904149A patent/HUP9904149A3/hu unknown
- 1997-10-02 CN CNB97180284XA patent/CN1142939C/zh not_active Expired - Fee Related
- 1997-10-02 DK DK97910409T patent/DK0929565T3/da active
- 1997-10-02 AU AU47803/97A patent/AU719250B2/en not_active Ceased
- 1997-10-02 DE DE69712900T patent/DE69712900T2/de not_active Expired - Lifetime
- 1997-10-02 BR BR9711586A patent/BR9711586A/pt not_active Application Discontinuation
- 1997-10-02 US US09/269,729 patent/US6610676B1/en not_active Expired - Fee Related
- 1997-10-02 ES ES97910409T patent/ES2177952T3/es not_active Expired - Lifetime
- 1997-10-02 CA CA002267630A patent/CA2267630C/en not_active Expired - Fee Related
- 1997-10-02 PT PT97910409T patent/PT929565E/pt unknown
2003
- 2003-06-17 US US10/462,637 patent/US7056905B2/en not_active Expired - Fee Related
2006
- 2006-03-14 US US11/374,315 patent/US7196075B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,220 patent/US7160871B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,219 patent/US7157450B2/en not_active Expired - Fee Related
- 2006-06-02 US US11/445,140 patent/US7205288B2/en not_active Expired - Fee Related
2007
- 2007-03-07 US US11/714,724 patent/US7368442B2/en not_active Expired - Fee Related
2008
- 2008-03-19 US US12/051,434 patent/US7605151B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20060160780A1 (en)	2006-07-20
US20080234242A1 (en)	2008-09-25
US7157450B2 (en)	2007-01-02
KR100487898B1 (ko)	2005-05-09
US20060160781A1 (en)	2006-07-20
JP4388600B2 (ja)	2009-12-24
ES2177952T3 (es)	2002-12-16
CN1253563A (zh)	2000-05-17
WO1998015568A3 (en)	1998-06-18
US20060270644A1 (en)	2006-11-30
US6610676B1 (en)	2003-08-26
HUP9904149A2 (hu)	2000-04-28
CN1142939C (zh)	2004-03-24
CA2267630A1 (en)	1998-04-16
HUP9904149A3 (en)	2001-03-28
ITMI962048A1 (it)	1998-04-04
US20070161612A1 (en)	2007-07-12
AU719250B2 (en)	2000-05-04
AU4780397A (en)	1998-05-05
EP0929565B1 (en)	2002-05-29
DE69712900T2 (de)	2002-12-12
RU2186781C2 (ru)	2002-08-10
US20060154905A1 (en)	2006-07-13
US7160871B2 (en)	2007-01-09
JP2001501637A (ja)	2001-02-06
US7368442B2 (en)	2008-05-06
IT1285770B1 (it)	1998-06-18
KR20000048911A (ko)	2000-07-25
WO1998015568A2 (en)	1998-04-16
BR9711586A (pt)	1999-08-24
US7056905B2 (en)	2006-06-06
US20050004089A1 (en)	2005-01-06
PT929565E (pt)	2002-10-31
CA2267630C (en)	2008-01-08
ATE218142T1 (de)	2002-06-15
US7196075B2 (en)	2007-03-27
DE69712900D1 (de)	2002-07-04
SI0929565T1 (en)	2002-08-31
US7605151B2 (en)	2009-10-20
US7205288B2 (en)	2007-04-17
EP0929565A2 (en)	1999-07-21

Publication	Publication Date	Title
DK0929565T3 (da)	2002-09-09	Nitratestere af corticoidforbindelser og farmaceutiske anvendelser deraf
PT1109812E (pt)	2005-09-30	Pirrolobenzodiazepinas
WO1996032003A3 (en)	1997-01-03	Tetrahydroimidazopyridoindolediones and their use as medicaments
ATE126215T1 (de)	1995-08-15	Anti-entzündende 4-aminophenol-derivate.
FR2705566B1 (fr)	1996-04-05	Nouvelles compositions pharmaceutiques.
FI965154L (fi)	1997-02-20	Lääkkeen paksusuoleen kuljettava koostumus
BR1100860A (pt)	1999-08-31	Composto, droga antiinflamatória, composição farmacêutica, epìmero r e epìmero s do composto
BR9611175B1 (pt)	2009-01-13	compostos e composiÇÕes farmacÊuticas.
DE59709414D1 (de)	2003-04-03	Oxyiminopregnancarbolactone
SE9504661D0 (sv)	1995-12-22	New compounds
PT695758E (pt)	2002-09-30	Amidas e esteres de pentapeptidos inibidores de cancro humano
ATE245977T1 (de)	2003-08-15	Therapeutische substituierte guanidine
DK0873351T3 (da)	2000-10-23	Steroidnitrit/nitratesterderivater anvendelige som antiinflammatoriske lægemidler
NO965516L (no)	1997-02-21	Sterolderivater anvendt til regulering av meiose
EE03771B1 (et)	2002-06-17	Tetrahüdropüridoühendid, neid sisaldav ravim ja nende kasutamine
SE9801494D0 (sv)	1998-04-28	Novel use
DK0714387T3 (da)	1998-10-12	Hidtil ukendte bis-naphthalimider til behandling af cancer
BG100248A (bg)	1996-07-31	Инхибитори на скваленсинтетаза
TR199701298T1 (xx)	1998-02-21	Tetralinler.
ES2118248T3 (es)	1998-09-16	Esteres y amidas de 9-cloro-prostaglandina y su empleo para preparar medicamentos.
PT1017681E (pt)	2004-06-30	Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios
ITMI950961A0 (it)	1995-05-12	Composizioni farmaceutiche contenenti gemfibrozil
ES2095431T3 (es)	1997-02-16	N-(isoquinolein-5-il)-sulfonil-azacicloalcanos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DK0779075T3 (da)	2002-02-18	Anvendelse af 3-alpha-hydroxy-5-alpha-androsta-16-en som lægemidler
SU1732642A1 (ru)	2001-06-10	4-хлоранилид n-ацетил-n-аллилантраниловой кислоты, проявляющий противовоспалительную и анальгетическую активность