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ES2155893T3 - Procedimiento de preparacion de compuestos dopaminergicos tetraciclicos quirales. - Google Patents

Procedimiento de preparacion de compuestos dopaminergicos tetraciclicos quirales.

Info

Publication number
ES2155893T3
ES2155893T3 ES95927566T ES95927566T ES2155893T3 ES 2155893 T3 ES2155893 T3 ES 2155893T3 ES 95927566 T ES95927566 T ES 95927566T ES 95927566 T ES95927566 T ES 95927566T ES 2155893 T3 ES2155893 T3 ES 2155893T3
Authority
ES
Spain
Prior art keywords
procedure
tetraciclic
quiral
preparation
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95927566T
Other languages
English (en)
Inventor
Paul P Ehrlich
Michael R Michaelides
Maureen A Mclaughlin
Chi-Nung Hsaio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2155893T3 publication Critical patent/ES2155893T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR UN COMPUESTO TETRACICLICO QUIRAL DE FORMULA (I), EN DONDE R ES HIDROGENO O UN GRUPO ALQUILO C{SUB,1}-C{SUB,6} Y Z ES OXIGENO, AZUFRE O -CH=CH-, LOS COMPUESTOS TENIENDO USOS COMO AGONISTAS DE DOPAMINA. EL PROCEDIMIENTO ABARCA LA REACCION DE UN MATERIAL DE INICIO QUIRAL E INTERMEDIARIOS QUIRALES SUBSECUENTES EN UNA SERIE DE REACCIONES SINTETICAS DE PRESERVACION DE QUIRALIDAD.
ES95927566T 1994-08-18 1995-08-03 Procedimiento de preparacion de compuestos dopaminergicos tetraciclicos quirales. Expired - Lifetime ES2155893T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29267794A 1994-08-18 1994-08-18
US08/463,326 US5659037A (en) 1994-08-18 1995-06-05 Process for preparing chiral tetracyclic dopaminergic compounds

Publications (1)

Publication Number Publication Date
ES2155893T3 true ES2155893T3 (es) 2001-06-01

Family

ID=26967491

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95927566T Expired - Lifetime ES2155893T3 (es) 1994-08-18 1995-08-03 Procedimiento de preparacion de compuestos dopaminergicos tetraciclicos quirales.

Country Status (11)

Country Link
US (1) US5659037A (es)
EP (1) EP0777655B1 (es)
JP (1) JPH10504564A (es)
AT (1) ATE198592T1 (es)
CA (1) CA2195676A1 (es)
DE (1) DE69519864T2 (es)
DK (1) DK0777655T3 (es)
ES (1) ES2155893T3 (es)
GR (1) GR3035606T3 (es)
PT (1) PT777655E (es)
WO (1) WO1996006085A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5668141A (en) * 1996-04-02 1997-09-16 Abbott Laboratories Trans-2,6-,3,6-and 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzo[c]phenanthrene compounds as dopamine agonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3131191A (en) * 1962-08-08 1964-04-28 Smith Kline French Lab Process for the preparation of noraporphines
DE2625116C2 (de) * 1976-06-04 1984-01-26 Gödecke AG, 1000 Berlin Verfahren zur Herstellung von 4-Hydroxy-aporphin-Derivaten
US5047536A (en) * 1989-03-17 1991-09-10 Purdue Research Foundation Hexahydrobenzo(A)phenanthridine compounds
IE912999A1 (en) * 1990-09-07 1992-03-11 Abbott Lab Phenanthridine compounds
JP3476193B2 (ja) * 1992-05-26 2003-12-10 パーデュー・リサーチ・ファウンデーション 置換ヘキサヒドロベンゾ〔α〕フェナンスリジン類
DE69432217T2 (de) * 1993-04-06 2004-04-08 Abbott Laboratories, Abbott Park Tetracyclische verbindungen als dopamin-agonisten

Also Published As

Publication number Publication date
DE69519864D1 (de) 2001-02-15
EP0777655A1 (en) 1997-06-11
DE69519864T2 (de) 2001-08-02
GR3035606T3 (en) 2001-06-29
CA2195676A1 (en) 1996-02-29
WO1996006085A1 (en) 1996-02-29
EP0777655B1 (en) 2001-01-10
PT777655E (pt) 2001-06-29
DK0777655T3 (da) 2001-05-07
ATE198592T1 (de) 2001-01-15
JPH10504564A (ja) 1998-05-06
US5659037A (en) 1997-08-19

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