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ES2148320T3 - Administracion transmucosica de medicamentos macromoleculares. - Google Patents

Administracion transmucosica de medicamentos macromoleculares.

Info

Publication number
ES2148320T3
ES2148320T3 ES94908732T ES94908732T ES2148320T3 ES 2148320 T3 ES2148320 T3 ES 2148320T3 ES 94908732 T ES94908732 T ES 94908732T ES 94908732 T ES94908732 T ES 94908732T ES 2148320 T3 ES2148320 T3 ES 2148320T3
Authority
ES
Spain
Prior art keywords
macromolecular
polymer
drug
enhancer
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908732T
Other languages
English (en)
Inventor
Sonia J Heiber
Charles D Ebert
Sirish C Dave
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actavis Laboratories UT Inc
Original Assignee
Theratech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theratech Inc filed Critical Theratech Inc
Application granted granted Critical
Publication of ES2148320T3 publication Critical patent/ES2148320T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Landscapes

  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PRESENTAN UN METODO Y UN SISTEMA PARA LA ADMINISTRACION A TRAVES DE LAS MUCOSOS DE UN FARMACO MACROMOLECULAR A LA MUCOSA DE LA CAVIDAD BUCAL. EL SISTEMA CONSTA DE UNA CAPA INTERIOR QUE CONTIENE UN FARMACO, UN INTENSIFICADOR Y UN POLIMERO (11) QUE TIENE UNA SUPERFICIE ADAPTADA PARA ENTRAR EN CONTACTO Y ADHERIRSE AL TEJIDO MUCOSAL DE LA CAVIDAD BUCAL Y UNA SUPERFICIE OPUESTA EN CONTACTO CON Y QUE SE ADHIERE A UNA CAPA INERTE SUPERPUESTA (12). LA CAPA INTERIOR (11) CONTIENE DE UN DOS A UN SESENTA POR CIENTO EN PESO APROXIMADAMENTE DE UN INTENSIFICADOR DE SAL BILIAR, DE UN CINCO A UN SESENTA Y CINCO POR CIENTO EN PESO DE UN POLIMERO HIDROFILICO SOLUBLE EN AGUA O QUE PUEDE AUMENTAR DE VOLUMEN EN AGUA Y UNA CANTIDAD EFECTIVA DE UN FARMACO MACROMOLECULAR QUE TIENE UN PESO MOLECULAR DE AL MENOS 500 DALTONS. LAS FORMAS PREFERENTES DE FARMACOS MACROMOLECULARES SON POLISACARIDOS, POLIPEPTIDOS Y PROTEINAS. EL INTENSIFICADOR DE SAL BILIAR FACILITA LA ADMINISTRACION DE MACROMOLECULAS TALES COMO HEPARINA Y CALCITONINA DE BAJO PESO MOLECULAR. EL POLIMERO ACTUA A MODO DE PLASTIFICANTE PARA PREVENIR LA CRISTALIZACION Y/O AGLOMERACION DE TALES FARMACOS MACROMOLECULARES. LA CELULOSA DE HIDROXIPROPILO ES UN POLIMERO PARTICULARMENTE ADECUADO.
ES94908732T 1993-02-22 1994-02-03 Administracion transmucosica de medicamentos macromoleculares. Expired - Lifetime ES2148320T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/027,508 US5346701A (en) 1993-02-22 1993-02-22 Transmucosal delivery of macromolecular drugs

Publications (1)

Publication Number Publication Date
ES2148320T3 true ES2148320T3 (es) 2000-10-16

Family

ID=21838122

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94908732T Expired - Lifetime ES2148320T3 (es) 1993-02-22 1994-02-03 Administracion transmucosica de medicamentos macromoleculares.

Country Status (15)

Country Link
US (2) US5346701A (es)
EP (1) EP0684806B1 (es)
JP (1) JP2795749B2 (es)
KR (1) KR960700670A (es)
AT (1) ATE190216T1 (es)
AU (1) AU674571B2 (es)
CA (1) CA2156708C (es)
DE (1) DE69423342T2 (es)
DK (1) DK0684806T3 (es)
ES (1) ES2148320T3 (es)
GR (1) GR3033601T3 (es)
NO (1) NO953279L (es)
PT (1) PT684806E (es)
WO (1) WO1994018925A1 (es)
ZA (1) ZA941197B (es)

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EP0684806A1 (en) 1995-12-06
GR3033601T3 (en) 2000-10-31
JPH08507759A (ja) 1996-08-20
NO953279L (no) 1995-10-19
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US5516523A (en) 1996-05-14
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KR960700670A (ko) 1996-02-24
JP2795749B2 (ja) 1998-09-10
WO1994018925A1 (en) 1994-09-01
HK1010680A1 (en) 1999-06-25
US5346701A (en) 1994-09-13
DE69423342T2 (de) 2000-10-12
AU674571B2 (en) 1997-01-02
CA2156708C (en) 2005-05-03
EP0684806B1 (en) 2000-03-08
CA2156708A1 (en) 1994-09-01
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DE69423342D1 (de) 2000-04-13
EP0684806A4 (en) 1997-04-23

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