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ES2038166T3 - Procedimiento para preparar un derivado de indenotiazol. - Google Patents

Procedimiento para preparar un derivado de indenotiazol.

Info

Publication number
ES2038166T3
ES2038166T3 ES198787200041T ES87200041T ES2038166T3 ES 2038166 T3 ES2038166 T3 ES 2038166T3 ES 198787200041 T ES198787200041 T ES 198787200041T ES 87200041 T ES87200041 T ES 87200041T ES 2038166 T3 ES2038166 T3 ES 2038166T3
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
low alkyl
unsubstituted
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787200041T
Other languages
English (en)
Inventor
Masayoshi Tsuji
Akira Nakagawa
Hisataka Inoue
Terumi Hachiya
Yoshihiro Tanoue
Kouichi Ikesue
Masaru Saita
Takenobu Misoguchi
Tetuo Aoki
Hironobu Satoh
Kanji Noda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Application granted granted Critical
Publication of ES2038166T3 publication Critical patent/ES2038166T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO DERIVADO DE INDENOTIAZOL, REPRESENTADO POR LA FORMULA (IA) EN LA QUE X E Y SON IGUALES O DIFERENTES Y PUEDEN SER UN ATOMO DE H O DE HALOGENO, UN ALQUILO O ALCOXI DE CADENA CORTA; N ES UN ENTERO ENTRE 0 Y 4; R1 ES H, UN ALQUILO DE CADENA CORTA O UN GRUPO FENILO QUE PUEDE ESTAR SUSTITUIDO; R2 ES UN GRUPO ALQUILO O ALCOXI DE CADENA CORTA, CICLOALQUILO, FENOXI O FENILO QUE PUEDEN ESTAR SUSTITUIDOS, ALQUENILO, HETEROCICLICO O CICLOAMINO; R3 ES H, UN GRUPO ALQUILO SUSTITUIDO DE CADENA CORTA O ACIDO, Y R2 Y R3 PUEDEN RECOMBINARSE PARA FORMAR UN GRUPO CICLOAMINO. TAMBIEN SE REFIERE LA INVENCION A UN TAUTOMERO DEL COMPUESTO DE FORMULA IA EN LA QUE TODOS LOS SIMBOLOS SON LOS INDICADOS, EXCEPTO R3 QUE SE LIMITA A UN ATOMO DE H.
ES198787200041T 1986-01-16 1987-01-14 Procedimiento para preparar un derivado de indenotiazol. Expired - Lifetime ES2038166T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP764086 1986-01-16

Publications (1)

Publication Number Publication Date
ES2038166T3 true ES2038166T3 (es) 1993-07-16

Family

ID=11671425

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787200041T Expired - Lifetime ES2038166T3 (es) 1986-01-16 1987-01-14 Procedimiento para preparar un derivado de indenotiazol.

Country Status (12)

Country Link
US (1) US4877876A (es)
EP (1) EP0230334B1 (es)
JP (1) JPH0667919B2 (es)
KR (1) KR900003368B1 (es)
CN (1) CN87100171A (es)
AT (1) ATE75737T1 (es)
AU (1) AU598229B2 (es)
CA (1) CA1292226C (es)
DE (1) DE3778714D1 (es)
ES (1) ES2038166T3 (es)
SU (1) SU1609449A3 (es)
WO (1) WO1987004434A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2245660T3 (es) * 1990-11-30 2006-01-16 Otsuka Pharmaceutical Co., Ltd. Derivados de azol y su utilizacion como inhibidores de los radicales superoxidos.
EP0749966A4 (en) * 1994-03-11 1997-07-02 Yamanouchi Pharma Co Ltd 5-HT 3 RECEPTOR AGONIST, NEW THIAZOLE DERIVATIVE AND INTERMEDIATE FOR OBTAINING IT
TW416953B (en) 1996-09-25 2001-01-01 Takeda Chemical Industries Ltd Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908538A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen
DE19908537A1 (de) 1999-02-26 2000-08-31 Aventis Pharma Gmbh Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
KR20010111594A (ko) 1999-05-10 2001-12-19 로즈 암스트롱, 크리스틴 에이. 트러트웨인 방향족 아미드
RU2252219C2 (ru) * 1999-11-05 2005-05-20 Авентис Фарма Дойчланд Гмбх Производные индено-, нафто- и бензоциклогептадигидротиазола, их получение и их применение в качестве анорексических лекарственных средств
DE10008274A1 (de) * 2000-02-23 2001-08-30 Aventis Pharma Gmbh Substituierte 8,8a-Dihydro-3aH-indeno[1,2-d]thiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JP4898052B2 (ja) * 2000-02-23 2012-03-14 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ８ａ位で置換された８，８ａ−ジヒドロ−インデノ［１，２−ｄ］チアゾール誘導体、その製造方法及び医薬、例えば食欲抑制薬としてのその使用
NZ520981A (en) * 2000-02-26 2004-08-27 Aventis Pharma Gmbh 8,8a-dihydro-indeno[1,2-d]thiazole derivatives with a sulphonamido or sulphono substituent in the 2 position, a method for production thereof and use thereof as a medicament
AU2001280946A1 (en) * 2000-08-01 2002-02-13 University Of Virginia Patent Foundation Use of selective adenosine a1 receptor agonists, antagonists and allosteric enhancers to manipulate angiogenesis
WO2003061655A1 (en) * 2002-01-16 2003-07-31 University Of Virginia Patent Foundation 2-aminothiazole allosteric enhancers of a1 adenosine receptors
KR100874315B1 (ko) * 2004-08-05 2008-12-18 에프. 호프만-라 로슈 아게 치환된 ｎ-아실-2-아미노티아졸
AR061478A1 (es) * 2006-06-19 2008-08-27 Takeda Pharmaceutical Compuesto triciclico y composicion farmaceutica

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082773A (en) * 1972-07-03 1978-04-04 E. R. Squibb & Sons, Inc. Tricyclic tetrahydro naphthaleneols and related compounds
US4321372A (en) * 1980-06-16 1982-03-23 Pfizer Inc. Antiulcer thiazol-2-ylcarbamoyl-carboxylic acids, esters and amides
DE3027528A1 (de) * 1980-07-19 1982-02-18 Basf Ag, 6700 Ludwigshafen Ueberbrueckte thiazolyloxamidsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
DE3135250A1 (de) * 1981-09-05 1983-03-17 Basf Ag, 6700 Ludwigshafen Tricyclische thiazolyloxamate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel

Also Published As

Publication number Publication date
AU598229B2 (en) 1990-06-21
CN87100171A (zh) 1988-01-20
CA1292226C (en) 1991-11-19
KR880700798A (ko) 1988-04-12
US4877876A (en) 1989-10-31
ATE75737T1 (de) 1992-05-15
JPS62252780A (ja) 1987-11-04
KR900003368B1 (ko) 1990-05-16
AU6842087A (en) 1987-08-14
WO1987004434A1 (fr) 1987-07-30
DE3778714D1 (de) 1992-06-11
EP0230334B1 (en) 1992-05-06
JPH0667919B2 (ja) 1994-08-31
EP0230334A1 (en) 1987-07-29
SU1609449A3 (ru) 1990-11-23

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