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ES8604912A1 - Procedimiento de preparacion de nuevos derivados de (arilpi-peraziniletilaminoetoxi)-4 fenol - Google Patents

Procedimiento de preparacion de nuevos derivados de (arilpi-peraziniletilaminoetoxi)-4 fenol

Info

Publication number
ES8604912A1
ES8604912A1 ES545980A ES545980A ES8604912A1 ES 8604912 A1 ES8604912 A1 ES 8604912A1 ES 545980 A ES545980 A ES 545980A ES 545980 A ES545980 A ES 545980A ES 8604912 A1 ES8604912 A1 ES 8604912A1
Authority
ES
Spain
Prior art keywords
arylpiperazinylethylaminoethoxy
preparation
phenol derivatives
therapeutical application
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545980A
Other languages
English (en)
Other versions
ES545980A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cortial SA
Original Assignee
Cortial SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8412580A external-priority patent/FR2568878B1/fr
Priority claimed from FR8510388A external-priority patent/FR2584402B2/fr
Application filed by Cortial SA filed Critical Cortial SA
Publication of ES545980A0 publication Critical patent/ES545980A0/es
Publication of ES8604912A1 publication Critical patent/ES8604912A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS DE (ARILPIPERAZINILETILAMINOETOXI)-4-FENOL. COMPRENDE: HACER REACCIONAR UN (HALOGENO-2-ETOXIL)-4-ISOPROPIL-5-METIL-2-FENOL Y UNA ARILPIPERAZINA DE FORMULA (II) PARA OBTENER NUEVOS DERIVADOS DE (ARILPIPERAZINILETILAMINOETOXI)-4-FENOL DE FORMULA (I). SIENDO: N, 0 O 1; R1, H O GRUPO METILO; Y R2, CICLO FENILO SUSTITUIDO O NO POR UNO O VARIOS SUSTITUTIVOS SIMILARES O DIFERENTES SELECCIONADOS ENTRE EL GRUPO HIDROXILO, ALCOXILO, TRIFLUOROMETILO, CLORO, FLUORO O ALQUILO, O BIEN UN CICLO PIRIDILO-2,-3, O -4. SE UTILIZA EN TERAPEUTICA HUMANA Y VETERINARIA, ESPECIALMENTE EN TERAPEUTICA CARDIOVASCULAR, SICOTROPA, HIPOLIPIDEMIANTE Y ANTIALERGICA.
ES545980A 1984-08-07 1985-08-07 Procedimiento de preparacion de nuevos derivados de (arilpi-peraziniletilaminoetoxi)-4 fenol Expired ES8604912A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8412580A FR2568878B1 (fr) 1984-08-07 1984-08-07 Nouveaux derives de (phenylpiperazinylethylamine ethoxy)-4 phenol, leur methode de preparation et leur application therapeutique
FR8510388A FR2584402B2 (fr) 1985-07-04 1985-07-04 Nouveaux derives d'(arylpiperazinylethylaminoethoxy)-4 phenols, leur methode de preparation et leur application therapeutique

Publications (2)

Publication Number Publication Date
ES545980A0 ES545980A0 (es) 1986-02-16
ES8604912A1 true ES8604912A1 (es) 1986-02-16

Family

ID=26224104

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545980A Expired ES8604912A1 (es) 1984-08-07 1985-08-07 Procedimiento de preparacion de nuevos derivados de (arilpi-peraziniletilaminoetoxi)-4 fenol

Country Status (7)

Country Link
EP (1) EP0173634B1 (es)
CA (1) CA1253153A (es)
DE (1) DE3564683D1 (es)
ES (1) ES8604912A1 (es)
MA (1) MA20501A1 (es)
OA (1) OA08259A (es)
PT (1) PT80914B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0288647B1 (fr) * 1987-04-30 1992-04-08 INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) Société à responsabilité limitée dite: Dérivés du [(pyrrolidinyl-1)-2éthoxy]-5 p-cymène, le procédé de préparation desdits dérivés et les médicaments contenant lesdits dérivés
FR2632641B1 (fr) * 1988-06-13 1990-10-12 Irceba ((aryl-4-piperazinyl-1)-2 ethoxy)-3 p-cymene, les derives ortho, meta, para monosubstitues ou disubstitues sur le noyau phenyle dudit produit, le procede de preparation desdits derives, et les medicaments contenant lesdits composes comme principe actif
SI9520096A (sl) * 1994-09-30 1998-04-30 Pfizer Inc. Derivati 2,7-substituiranega oktahidro-1H-pirido /1,2-a/ pirazina
JPH10265386A (ja) * 1997-03-21 1998-10-06 Toshio Sato 抗酸化作用を有する抗アレルギー剤
FR2781797B1 (fr) * 1998-07-28 2000-11-03 Lipha Derives de piperazine antidiabetiques, leurs procedes de preparation et compositions pharmaceutiques les contenant

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3239520A (en) * 1961-11-20 1966-03-08 Nl Combinatie Chem Ind N-(monocarbocyclic aryloxy-lower alkyl)-n' (diloweralkyl, or heterocyclic)-lower alkylene diamines
FR2446M (fr) * 1962-02-26 1964-04-06 Soc Ind Fab Antibiotiques Sifa Nouveaux dérivés de la pipérazine.

Also Published As

Publication number Publication date
PT80914A (fr) 1985-09-01
EP0173634A1 (fr) 1986-03-05
ES545980A0 (es) 1986-02-16
DE3564683D1 (en) 1988-10-06
PT80914B (pt) 1987-09-30
EP0173634B1 (fr) 1988-08-31
MA20501A1 (fr) 1986-04-01
CA1253153A (fr) 1989-04-25
OA08259A (fr) 1987-10-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303