[go: up one dir, main page]

ES2004843T3 - Procedimiento de obtencion de un equivalente de piel y equivalente de piel correspondiente. - Google Patents

Procedimiento de obtencion de un equivalente de piel y equivalente de piel correspondiente.

Info

Publication number
ES2004843T3
ES2004843T3 ES198888400489T ES88400489T ES2004843T3 ES 2004843 T3 ES2004843 T3 ES 2004843T3 ES 198888400489 T ES198888400489 T ES 198888400489T ES 88400489 T ES88400489 T ES 88400489T ES 2004843 T3 ES2004843 T3 ES 2004843T3
Authority
ES
Spain
Prior art keywords
similar
equivalent
procedure
obtaining
corresponding skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888400489T
Other languages
English (en)
Other versions
ES2004843A4 (es
Inventor
Bruno Bernard
Marie-Cecile Lenoir
Braham Shroot
Yves-Michel Darmon
Daniel Asselineau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Centre International de Recherches Dermatologiques Galderma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre International de Recherches Dermatologiques Galderma filed Critical Centre International de Recherches Dermatologiques Galderma
Publication of ES2004843A4 publication Critical patent/ES2004843A4/es
Application granted granted Critical
Publication of ES2004843T3 publication Critical patent/ES2004843T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/10—Hair or skin implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/10—Hair or skin implants
    • A61F2/105—Skin implants, e.g. artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/40—Nucleotides, nucleosides or bases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/395—Thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/80—Neurotransmitters; Neurohormones
    • C12N2501/81—Adrenaline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/092—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells hair cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Inorganic Fibers (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA OBTENCION DE UN SIMILAR A PIEL Y EL SIMILAR A PIEL CORRESPONDIENTE (27). SEGUN ESTE PROCEDIMIENTO, SE PREPARA UN SIMILAR A DERMIS (24) MEZCLANDO CELULAS CONTRACTILES, UN MEDIO NUTRITIVO Y COLAGENO, PARA FORMAR UN GEL QUE SE CONTRAE; SE UTILIZA ESTE SIMILAR A DERMIS (24) COMO UN SUBSTRATO PARA UN SIMILAR A EPIDERMIS (26) OBTENIDO POR SIEMBRA CON LOS QUERATINOCITOS DE UNA EXPLANTACION ANIMAL O HUMANA. SEGUN LA INVENCION, SE SIEMBRA EL SUBSTRATO (24) EN MEDIO DE POR LO MENOS UN TROZO DE FOLICULO PILOSO (22), QUE TIENE POR LO MENOS PARCIALMENTE SU VAINA CELULAR, ESTANDO IMPLANTADO DICHO TROZO SENSIBLEMENTE PERPENDICULAR A LA SUPERFICIE LIBRE DEL SUBSTRATO.
ES198888400489T 1987-03-26 1988-03-02 Procedimiento de obtencion de un equivalente de piel y equivalente de piel correspondiente. Expired - Lifetime ES2004843T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR878704205A FR2612938B1 (fr) 1987-03-26 1987-03-26 Procede d'obtention d'un equivalent de peau et equivalent de peau correspondant

Publications (2)

Publication Number Publication Date
ES2004843A4 ES2004843A4 (es) 1989-02-16
ES2004843T3 true ES2004843T3 (es) 1992-05-01

Family

ID=9349449

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888400489T Expired - Lifetime ES2004843T3 (es) 1987-03-26 1988-03-02 Procedimiento de obtencion de un equivalente de piel y equivalente de piel correspondiente.

Country Status (16)

Country Link
US (1) US5639654A (es)
EP (1) EP0285471B1 (es)
JP (1) JP2733838B2 (es)
AT (1) ATE59971T1 (es)
AU (1) AU602394B2 (es)
CA (1) CA1296260C (es)
DE (2) DE285471T1 (es)
DK (1) DK164488A (es)
ES (1) ES2004843T3 (es)
FI (2) FI881363L (es)
FR (1) FR2612938B1 (es)
GR (2) GR880300158T1 (es)
NO (1) NO171222C (es)
NZ (1) NZ223828A (es)
PT (1) PT87084B (es)
ZA (2) ZA882033B (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8604360D0 (en) * 1986-02-21 1986-03-26 Univ Dundee Stimulation of hair growth
FR2612939B1 (fr) * 1987-03-26 1989-06-23 Cird Equivalent de peau
IL94611A (en) * 1989-06-05 1994-12-29 Organogenesis Inc Medium for cell cultures containing insulin or growth factor similar to insulin, transferrin or iron ion, triiodothyronine or thyroxine and method of use
US5106949A (en) * 1989-09-15 1992-04-21 Organogenesis, Inc. Collagen compositions and methods for preparation thereof
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5256418A (en) * 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
BR9106354A (pt) * 1990-04-24 1993-04-27 Mark Eisenberg Equivalente de pele viva composta,seu processo de preparacao; kit de teste,seu processo de preparacao,e processo de testar efeito de substancia sobre a pele
FR2667246A1 (fr) * 1990-10-02 1992-04-03 Imedex Biomateriau a base de collagene et des applications.
US5616500A (en) * 1993-04-30 1997-04-01 The United States Of America As Represented By The Department Of Health & Human Services Trichohyalin and transglutaminase-3 and methods of using same
JPH10136977A (ja) * 1996-11-11 1998-05-26 Toyobo Co Ltd 組織付属器官様構造体を含む人工組織およびその製造方法
US7419661B2 (en) 1997-04-30 2008-09-02 The Centre Of Excellence For Life Sciences Limited Dermal sheath tissue in wound healing
GB9708692D0 (en) * 1997-04-30 1997-06-18 Jahoda Colin A B Dermal sheath tissue and/or cells derived therefrom in wound healing
EP1005873B1 (en) * 1998-11-30 2003-04-09 IsoTis N.V. Artificial skin
US6454787B1 (en) 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
US6361551B1 (en) 1998-12-11 2002-03-26 C. R. Bard, Inc. Collagen hemostatic fibers
US7144729B2 (en) 2000-09-01 2006-12-05 Dfb Pharmaceuticals, Inc. Methods and compositions for tissue regeneration
DE10162814B4 (de) * 2001-12-19 2005-06-23 Henkel Kgaa Rekonstruiertes Haarfollikelmodell
US20050089512A1 (en) * 2001-12-19 2005-04-28 Kordula Schlotmann Skin/hair equivalent with reconstructed papillae
US20040101507A1 (en) * 2002-11-27 2004-05-27 Janco Predovan Skin cream
JP2004283371A (ja) * 2003-03-20 2004-10-14 Nagoya Industrial Science Research Inst 医用材料
JP2005305177A (ja) * 2005-05-11 2005-11-04 Toyobo Co Ltd 組織付属器官様構造体を含む人工組織およびその製造方法
FR2889808B1 (fr) 2005-08-17 2011-07-22 Oreal Utilisation de l'acide 8-hexadecene-1,16-dicarboxylique comme agent de soin destine a favoriser la cohesion de la couche cornee
FR2903702B1 (fr) 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation
FR2912916B1 (fr) 2007-02-26 2009-05-22 Oreal Composition cosmetique ou dermatologique comprenant un milieu de culture cellulaire
JP5340564B2 (ja) * 2007-07-05 2013-11-13 ライオン株式会社 人工皮膚およびその製造方法
CA2658074C (fr) 2008-03-17 2017-11-07 L'oreal Equivalent de peau pigmentee fonctionnelle
EP4520278A3 (en) 2008-04-01 2025-05-28 The General Hospital Corporation Apparatus for tissue grafting
KR101909645B1 (ko) 2010-05-07 2018-10-18 더 제너럴 하스피탈 코포레이션 조직이식과 조직복제 방법 및 장치
FR2967163A1 (fr) 2010-11-05 2012-05-11 Centre Nat Rech Scient Procede in vitro ou ex vivo pour la maintenance en survie et la generation ou reconstruction d'un epiderme
FR2976001B1 (fr) 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
FR2993282B1 (fr) 2012-07-13 2017-11-10 Expanscience Lab Procede d'identification de marqueurs moleculaires de la peau d'enfant
US10543127B2 (en) 2013-02-20 2020-01-28 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
JP2016529000A (ja) 2013-08-09 2016-09-23 サイトレリス バイオシステムズ，インコーポレーテッド 非熱組織切除を使用する皮膚治療のための方法及び機器
FR3011008B1 (fr) 2013-09-24 2017-12-29 Expanscience Lab Procedes d'evaluation des effets deleteres des uv sur la peau d'enfant
US9545302B2 (en) 2013-11-20 2017-01-17 Dermagenesis Llc Skin printing and auto-grafting
EP3082897A4 (en) 2013-12-19 2017-07-26 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
FR3016373B1 (fr) 2014-01-10 2018-01-19 Laboratoires Expanscience Modele de peau de mammelon reconstitue
FR3019186B1 (fr) 2014-03-31 2019-06-07 Laboratoires Expanscience Procedes d'evaluation des effets deleteres de l'urine sur la peau d'enfant
US11324534B2 (en) 2014-11-14 2022-05-10 Cytrellis Biosystems, Inc. Devices and methods for ablation of the skin
US10070886B2 (en) 2015-04-22 2018-09-11 Medline Industries, Inc. Method of harvesting tissue using sequential sections of a two dimensional array of needles
DE102015119877B4 (de) * 2015-11-17 2017-09-21 Technische Universität Berlin Verfahren zur Herstellung eines Hautäquivalents sowie dessen Verwendung für in vitro Tests und in vivo Transplantate
FR3045669B1 (fr) 2015-12-16 2019-04-05 Laboratoires Expanscience Procedes d'evaluation des effets de la deshydratation sur la peau d'enfant
US11166743B2 (en) 2016-03-29 2021-11-09 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
FR3053053B1 (fr) 2016-06-23 2018-07-13 Laboratoires Expanscience Modeles de la dermatite atopique juvenile
FR3054449B1 (fr) 2016-07-29 2018-08-31 L'oreal Equivalent de peau a compartiments dermiques juxtaposes distincts
BR112019005312A2 (pt) 2016-09-21 2019-07-16 Cytrellis Biosystems Inc dispositivos e métodos para a recomposição cosmética da pele
FR3068045B1 (fr) 2017-06-22 2021-06-04 Expanscience Lab Modeles de peau sensible reconstituee
CN107320781B (zh) * 2017-07-11 2020-03-10 广州润虹医药科技股份有限公司 含活细胞的组织工程皮肤及其制备方法
FR3071512B1 (fr) 2017-09-28 2022-02-25 Oreal Signatures moleculaires de trois sous-populations de fibroblastes dermiques et equivalent de derme comprenant une de ces sous-populations
CN109172868B (zh) * 2018-09-29 2021-05-28 山东大学苏州研究院 一种快速重建皮肤及毛囊的新方法
CN111330082B (zh) * 2020-01-16 2021-11-19 中国人民解放军总医院 构建含皮肤附属器的生物3d打印皮肤微单元模型的制备方法
FR3111904B1 (fr) 2020-06-30 2022-10-21 Oreal Bioencre pour bioimpression d’un modèle de jonction dermo-épidermique invaginée
FR3133198B1 (fr) 2022-03-04 2025-11-21 Pierre Fabre Dermo Cosmetique Modele de peau reconstituee
FR3138149A1 (fr) 2022-07-25 2024-01-26 Pierre Fabre Dermo-Cosmetique Méthode d’évaluation in vitro de l’activité photoprotectrice d’un actif

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539716A (en) * 1981-03-19 1985-09-10 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4458678A (en) * 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
US4485097A (en) * 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
US4604346A (en) * 1984-10-09 1986-08-05 Massachusetts Institute Of Technology Skin-equivalent prepared by the use of punch biopsy
JPS62246371A (ja) * 1986-04-19 1987-10-27 株式会社　高研 人工皮膚及びその製造方法
FR2612939B1 (fr) * 1987-03-26 1989-06-23 Cird Equivalent de peau

Also Published As

Publication number Publication date
ZA882033B (en) 1988-09-15
US5639654A (en) 1997-06-17
NO881349D0 (no) 1988-03-25
FR2612938B1 (fr) 1989-06-23
AU602394B2 (en) 1990-10-11
FI881363A7 (fi) 1988-09-27
NO171222C (no) 1993-02-10
ATE59971T1 (de) 1991-02-15
FR2612938A1 (fr) 1988-09-30
GR880300158T1 (en) 1988-12-16
EP0285471A1 (fr) 1988-10-05
FI881363A0 (fi) 1988-03-22
EP0285471B1 (fr) 1991-01-16
FI881362A0 (fi) 1988-03-22
FI881362L (fi) 1988-09-27
PT87084A (pt) 1988-04-01
CA1296260C (fr) 1992-02-25
NZ223828A (en) 1990-07-26
FI881362A7 (fi) 1988-09-27
PT87084B (pt) 1992-07-31
DK164488D0 (da) 1988-03-25
JP2733838B2 (ja) 1998-03-30
GR3001334T3 (en) 1992-08-31
ES2004843A4 (es) 1989-02-16
DK164488A (da) 1988-09-27
ZA882032B (en) 1988-09-15
NO881349L (no) 1988-09-27
DE285471T1 (de) 1990-03-01
FI881363L (fi) 1988-09-27
AU1374388A (en) 1988-09-29
JPS648974A (en) 1989-01-12
DE3861532D1 (de) 1991-02-21
NO171222B (no) 1992-11-02

Similar Documents

Publication Publication Date Title
ES2004843T3 (es) Procedimiento de obtencion de un equivalente de piel y equivalente de piel correspondiente.
AR241314A1 (es) Aislado de adn, vector en base en dicho aislado cultivo de celulas tratadas con dicho vector y preparacion de factor viii humano funcional.
ATE100858T1 (de) Pflanzengewebe-transformation.
ES2111566T3 (es) Equivalentes compuestos de piel viva.
ES2041832T3 (es) Dispositivos para contacto,durante el uso, con un flujo de sangre.
ES489204A1 (es) Elemento destinado a implantarse en tejido corporal, parti- cularmente tejido oseo
ES2145836T3 (es) Copolimeros elastomericos termoplasticos injertados de silicona, y composiciones que los contienen para el cuidado del pelo y la piel.
PE799A1 (es) Composicion cosmetica que contiene un antagonista de los receptores del neuropeptido y
Gustus et al. Ultrastructural Similarities Between Setae of Brachiopods and Polychaetes 1
ES8400241A1 (es) Procedimiento para la obtencion de medios antimicoticos con mayor liberacion de sustancia activa.
IT7826703A0 (it) Dispositivo per coltivare cellule di tessuti animali e umani.
ES2000196A4 (es) Utilizacion de dipropilenglicolmonometileter como sustancia en productos moldeadores para el cabello.
TR200002388T2 (tr) ''Sabun jel esaslı yapışkan çubuk''
ES2073277T3 (es) Sustancias de naturaleza polipeptida utiles en la terapia humana.
DK230186A (da) Kosmetiske midler, der regenererer huden og holder den fugtig, og fremgangsmaade til fremstilling af den aktive bestanddel
BR9007808A (pt) Complexo de elementos para a producao de partes biologicas,especialmente orgaos de seres vivos,processo para a producao de dito complexo e sua aplicacao
Rahm Jr et al. LXXIII The Effects of Topical Anesthetics upon the Ear
Westoll The mammalian middle ear
ES2004099A6 (es) Procedimiento de preparacion de polipeptidos biologicamente activos
ES2114849T1 (es) Producto y procedimiento para el moldeado permanente del cabello.
ES2040240T3 (es) Agente citostatico de platino.
PT91513A (pt) Processo para a preparacao de composicoes solidas a base de silicones com accao biologica agricola
Baker Morphological aspects of the third instar larva of Haematobia irritans
FR2435464A1 (fr) Nouvelle phenyluree substituee herbicide
HAYAKAWA Description of Haematopota shinonagai n. sp. from Honshu Island, Japan (Diptera, Tabanidae)

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 285471

Country of ref document: ES