[go: up one dir, main page]

FR2976001B1 - Modele de cuir chevelu reconstruit et procede de screening de molecules actives - Google Patents

Modele de cuir chevelu reconstruit et procede de screening de molecules actives

Info

Publication number
FR2976001B1
FR2976001B1 FR1154684A FR1154684A FR2976001B1 FR 2976001 B1 FR2976001 B1 FR 2976001B1 FR 1154684 A FR1154684 A FR 1154684A FR 1154684 A FR1154684 A FR 1154684A FR 2976001 B1 FR2976001 B1 FR 2976001B1
Authority
FR
France
Prior art keywords
active molecules
screening active
leather model
reconstructed
reconstructed scalp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1154684A
Other languages
English (en)
Other versions
FR2976001A1 (fr
Inventor
Khalid Bakkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1154684A priority Critical patent/FR2976001B1/fr
Application filed by LOreal SA filed Critical LOreal SA
Priority to US14/122,539 priority patent/US10281457B2/en
Priority to JP2014513176A priority patent/JP6144672B2/ja
Priority to CN201280026055.9A priority patent/CN103764816B/zh
Priority to KR1020137034775A priority patent/KR101974672B1/ko
Priority to EP12724995.1A priority patent/EP2714893B1/fr
Priority to ES12724995T priority patent/ES2710577T3/es
Priority to PCT/EP2012/060164 priority patent/WO2012163974A1/fr
Priority to BR112013030828-1A priority patent/BR112013030828B1/pt
Publication of FR2976001A1 publication Critical patent/FR2976001A1/fr
Application granted granted Critical
Publication of FR2976001B1 publication Critical patent/FR2976001B1/fr
Priority to JP2017054177A priority patent/JP6839003B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/04—Screening or testing on artificial tissues
    • C12N2503/06—Screening or testing on artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
FR1154684A 2011-05-30 2011-05-30 Modele de cuir chevelu reconstruit et procede de screening de molecules actives Expired - Fee Related FR2976001B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR1154684A FR2976001B1 (fr) 2011-05-30 2011-05-30 Modele de cuir chevelu reconstruit et procede de screening de molecules actives
BR112013030828-1A BR112013030828B1 (pt) 2011-05-30 2012-05-30 Processo para preparar um equivalente de couro cabeludo
CN201280026055.9A CN103764816B (zh) 2011-05-30 2012-05-30 重建头皮模型和筛选活性分子的方法
KR1020137034775A KR101974672B1 (ko) 2011-05-30 2012-05-30 재현된 두피 모델 및 활성 분자 스크리닝 방법
EP12724995.1A EP2714893B1 (fr) 2011-05-30 2012-05-30 Modèle de cuir chevelu reconstruit, et traitement pour le criblage de molécules actives
ES12724995T ES2710577T3 (es) 2011-05-30 2012-05-30 Modelo de cuero cabelludo reconstruido, y procedimiento para cribar moléculas activas
US14/122,539 US10281457B2 (en) 2011-05-30 2012-05-30 Reconstructed scalp model and process for screening active molecules
JP2014513176A JP6144672B2 (ja) 2011-05-30 2012-05-30 再構成頭皮モデルおよび活性分子のスクリーニング方法
PCT/EP2012/060164 WO2012163974A1 (fr) 2011-05-30 2012-05-30 Modèle de cuir chevelu reconstruit, et traitement pour le criblage de molécules actives
JP2017054177A JP6839003B2 (ja) 2011-05-30 2017-03-21 再構成頭皮モデルおよび活性分子のスクリーニング方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1154684A FR2976001B1 (fr) 2011-05-30 2011-05-30 Modele de cuir chevelu reconstruit et procede de screening de molecules actives

Publications (2)

Publication Number Publication Date
FR2976001A1 FR2976001A1 (fr) 2012-12-07
FR2976001B1 true FR2976001B1 (fr) 2014-10-31

Family

ID=45463716

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1154684A Expired - Fee Related FR2976001B1 (fr) 2011-05-30 2011-05-30 Modele de cuir chevelu reconstruit et procede de screening de molecules actives

Country Status (9)

Country Link
US (1) US10281457B2 (fr)
EP (1) EP2714893B1 (fr)
JP (2) JP6144672B2 (fr)
KR (1) KR101974672B1 (fr)
CN (1) CN103764816B (fr)
BR (1) BR112013030828B1 (fr)
ES (1) ES2710577T3 (fr)
FR (1) FR2976001B1 (fr)
WO (1) WO2012163974A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2976001B1 (fr) * 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
CN105176917B (zh) * 2015-11-02 2018-07-24 广州赛莱拉干细胞科技股份有限公司 一种培养基及其应用与角质形成细胞的培养方法
DE102015119880B4 (de) 2015-11-17 2018-05-24 Technische Universität Berlin Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2967509D1 (en) 1978-12-26 1985-10-10 Massachusetts Inst Technology Skin-equivalent
US4604346A (en) 1984-10-09 1986-08-05 Massachusetts Institute Of Technology Skin-equivalent prepared by the use of punch biopsy
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
FR2612938B1 (fr) 1987-03-26 1989-06-23 Cird Procede d'obtention d'un equivalent de peau et equivalent de peau correspondant
FR2612939B1 (fr) 1987-03-26 1989-06-23 Cird Equivalent de peau
IL95429A (en) 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
EP0526550B1 (fr) 1990-04-24 1997-12-29 EISENBERG, Mark Equivalents composites de peau vivante
FR2665175B1 (fr) 1990-07-27 1993-12-31 Rosdy Martin Equivalent d'epiderme, son procede d'obtention et son utilisation.
FR2689904B1 (fr) 1992-04-08 1994-12-16 Martin Rosdy Test de bronzage épidermique in vitro.
JPH11199A (ja) * 1997-06-09 1999-01-06 Shiseido Co Ltd 生理活性物質の新規なスクリーニング法
DK1131410T3 (da) 1998-11-19 2005-10-31 Organogenesis Inc Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf
DE10162814B4 (de) * 2001-12-19 2005-06-23 Henkel Kgaa Rekonstruiertes Haarfollikelmodell
CN1363398A (zh) * 2002-01-16 2002-08-14 吉林大学 以壳多糖或其衍生物为基质网架的复层人工皮肤
FR2903702B1 (fr) * 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation
CN100522264C (zh) * 2006-09-14 2009-08-05 中国人民解放军第三军医大学第三附属医院 一种含基底膜结构的双层组织工程皮肤制备方法
FR2976001B1 (fr) * 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives

Also Published As

Publication number Publication date
EP2714893A1 (fr) 2014-04-09
CN103764816A (zh) 2014-04-30
FR2976001A1 (fr) 2012-12-07
JP6144672B2 (ja) 2017-06-07
ES2710577T3 (es) 2019-04-25
US10281457B2 (en) 2019-05-07
WO2012163974A1 (fr) 2012-12-06
KR101974672B1 (ko) 2019-05-02
KR20140036271A (ko) 2014-03-25
CN103764816B (zh) 2017-07-04
JP2017113030A (ja) 2017-06-29
EP2714893B1 (fr) 2018-11-07
US20140199721A1 (en) 2014-07-17
BR112013030828A2 (pt) 2016-12-06
JP2014518099A (ja) 2014-07-28
BR112013030828B1 (pt) 2020-02-27
JP6839003B2 (ja) 2021-03-03

Similar Documents

Publication Publication Date Title
EP2667802A4 (fr) Procédé et appareil de restructuration de la peau
BR112014002201A2 (pt) método e aparelho para cuidados cosméticos com a pele
PL2747565T3 (pl) Sposoby zaprawiania nasion
BR112013011874A2 (pt) compostos e métodos para tratar dor
BR112014016240A2 (pt) dispositivo para tratamento de pele
BR112013022525A2 (pt) dispositivos e métodos para enrijecimento de pele
EP2773182A4 (fr) Procédé et système pour cultiver des plantes
EP2629913A4 (fr) Procédé de microencapsulation et produit associé
BR112015005749A2 (pt) sitema e método para produzir cosméticos
PT2709604T (pt) Canabidivarina para utilização no tratamento de dor neuropática
BR212013028314U2 (pt) método para tratar câncer e dor de câncer de osso
BR112014015511A2 (pt) método para tingir as fibras queratínicas humanas e dispositivo
EP2758933A4 (fr) Analyse clinique au moyen d'une activité électrodermique
EP2788925A4 (fr) Système et procédé pour évaluer et commercialiser des centres de recherche clinique
BR112013030381A2 (pt) reagentes e métodos para tratar doença dental
DK2734658T3 (da) Rammekoncept for elektrolysator, fremgangsmåde og anvendelse
BRDI7106622S (pt) Configuração aplicada em remédio para alívio de dor
BR112014004306A2 (pt) fotossensibilizadores de (bacterio)clorofila para tratamento de doenças e distúrbios do olho
BR112014012753A2 (pt) composição para pele e método de hidratação da pele
BR112013023570A2 (pt) método e aparelhagem médica para cartucho
EP2718406A4 (fr) Appareil et procédé d'hydroconversion
BR112013023142A2 (pt) método de tratamento de cabelos
CO6811865A2 (es) Método de tratamiento de la fiebre dengue
IL231094A0 (en) Fish anesthetic and method
BR112013002697A2 (pt) método para estimular o crescimento do cabelo

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 6

PLFP Fee payment

Year of fee payment: 7

PLFP Fee payment

Year of fee payment: 8

PLFP Fee payment

Year of fee payment: 10

ST Notification of lapse

Effective date: 20220105