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ES2093099T3 - Preparacion de piperidinas sustituidas. - Google Patents

Preparacion de piperidinas sustituidas.

Info

Publication number
ES2093099T3
ES2093099T3 ES91908255T ES91908255T ES2093099T3 ES 2093099 T3 ES2093099 T3 ES 2093099T3 ES 91908255 T ES91908255 T ES 91908255T ES 91908255 T ES91908255 T ES 91908255T ES 2093099 T3 ES2093099 T3 ES 2093099T3
Authority
ES
Spain
Prior art keywords
preparation
substituted piperidines
processes
piperidines
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91908255T
Other languages
English (en)
Inventor
Dennis M Godek
Terry J Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2093099T3 publication Critical patent/ES2093099T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE MUESTRAN NUEVOS PROCESOS PARA LA PREPARACION Y RESOLUCION DE PIPERIDINAS SUSTITUIDAS DE FORMULA (I), DONDE R1 Y R2 SE DEFINEN POSTERIORMENTE, Y COMPUESTOS RELACIONADOS, ASI COMO INTERMEDIOS NUEVOS UTILIZADOS EN DICHOS PROCESOS.
ES91908255T 1990-05-31 1991-04-12 Preparacion de piperidinas sustituidas. Expired - Lifetime ES2093099T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53126590A 1990-05-31 1990-05-31

Publications (1)

Publication Number Publication Date
ES2093099T3 true ES2093099T3 (es) 1996-12-16

Family

ID=24116944

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91908255T Expired - Lifetime ES2093099T3 (es) 1990-05-31 1991-04-12 Preparacion de piperidinas sustituidas.

Country Status (26)

Country Link
EP (1) EP0532515B1 (es)
JP (2) JPH0794439B2 (es)
KR (1) KR0160142B1 (es)
CN (2) CN1037768C (es)
AT (1) ATE144498T1 (es)
AU (1) AU648558B2 (es)
BR (1) BR9106518A (es)
CA (1) CA2080249C (es)
CZ (1) CZ284663B6 (es)
DE (1) DE69122866T2 (es)
DK (1) DK0532515T3 (es)
ES (1) ES2093099T3 (es)
FI (1) FI101376B (es)
GR (1) GR3022079T3 (es)
HU (1) HU226529B1 (es)
IE (1) IE911841A1 (es)
IL (3) IL113011A (es)
MY (1) MY107819A (es)
NO (1) NO180083C (es)
NZ (2) NZ238340A (es)
PL (2) PL169187B1 (es)
PT (1) PT97796B (es)
RU (1) RU2077531C1 (es)
WO (1) WO1991018878A1 (es)
YU (1) YU48030B (es)
ZA (1) ZA914133B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA41251C2 (uk) * 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
US5332817A (en) * 1990-01-04 1994-07-26 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles
US5364943A (en) * 1991-11-27 1994-11-15 Pfizer Inc. Preparation of substituted piperidines
CZ293955B6 (cs) * 1991-03-26 2004-08-18 Pfizeráinc Postup přípravy substituovaných piperidinů
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
HUT70741A (en) * 1991-11-12 1995-10-30 Pfizer Acyclic ethylenediamine derivatives as substance p receptor antagonists
JP2722279B2 (ja) * 1992-12-10 1998-03-04 ファイザー・インク． アミノメチレンで置換した非芳香族複素環式化合物及びサブスタンスｐのアンタゴニストとしての使用
EP0700384B1 (en) * 1993-05-28 1997-07-16 Pfizer Inc. Process for preparing and resolving 2-phenyl-3-aminopiperidine
TW397825B (en) * 1994-10-14 2000-07-11 Novartis Ag Aroyl-piperidine derivatives
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
US6214846B1 (en) 1997-06-27 2001-04-10 Merck Sharp & Dohme Limited Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents
EP1098881A1 (en) * 1998-07-21 2001-05-16 Syngenta Participations AG 3-substituted pyridine compounds and related synthesis
RU2238264C2 (ru) * 1999-02-24 2004-10-20 Ф.Хоффманн-Ля Рош Аг Производные бензола или пиридина и фармацевтическая композиция на их основе
JP4068305B2 (ja) * 1999-02-24 2008-03-26 エフ．ホフマン−ラ ロシュ アーゲー ３−フェニルピリジン誘導体、およびそのｎｋ−１受容体拮抗薬としての用途
RS49964B (sr) * 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
JP2011016751A (ja) * 2009-07-08 2011-01-27 Sumitomo Chemical Co Ltd 光学活性３−アミノピペリジン−１−カルボキシレート化合物の製造方法およびその製造方法に用いられる中間体
CN111808017B (zh) * 2020-08-05 2023-11-28 国家纳米科学中心 一种含氮杂环化合物及其制备方法和应用
CN116162055B (zh) * 2023-03-10 2023-09-12 山东汇智药物研究有限公司 一种用n-氧化吡啶衍生物制备哌啶衍生物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52125170A (en) * 1976-04-12 1977-10-20 Yoshitomi Pharmaceut Ind Ltd Pyridine derivatives
CA1160229A (en) * 1979-03-13 1984-01-10 Pieter T. Haken Pyridyliminomethylbenzene derivatives
GB2056974B (en) * 1979-07-19 1984-02-29 Shell Int Research Heterocyclic acylamino compounds having fungicidal herbicidal and plant-growth regulating properties
CA1231710A (en) * 1979-07-19 1988-01-19 Haken Pieter Ten Heterocyclic compounds having fungicidal, herbicidal and plant-growth regulating properties
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
US4552960A (en) * 1983-06-20 1985-11-12 Eli Lilly And Company Fungicidal amines
FR2662696A2 (fr) * 1989-12-13 1991-12-06 Rhone Poulenc Sante Antagonistes de la serotonine, leur preparation et medicaments les contenant.
UA41251C2 (uk) * 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі

Also Published As

Publication number Publication date
NO924598L (no) 1992-11-27
EP0532515A1 (en) 1993-03-24
IL113011A0 (en) 1995-06-29
YU96291A (sh) 1994-06-10
KR0160142B1 (ko) 1998-12-01
YU48030B (sh) 1996-10-09
CA2080249A1 (en) 1991-12-01
JPH07206819A (ja) 1995-08-08
FI925415A0 (fi) 1992-11-27
NZ238340A (en) 1994-06-27
DK0532515T3 (da) 1997-04-21
NO180083B (no) 1996-11-04
IL113011A (en) 1999-09-22
GR3022079T3 (en) 1997-03-31
PL168236B1 (pl) 1996-01-31
DE69122866D1 (de) 1996-11-28
MY107819A (en) 1996-06-29
JPH05502238A (ja) 1993-04-22
EP0532515B1 (en) 1996-10-23
IE911841A1 (en) 1991-12-04
CA2080249C (en) 1996-11-19
FI101376B1 (fi) 1998-06-15
WO1991018878A1 (en) 1991-12-12
IL98256A (en) 1995-11-27
FI925415L (fi) 1992-11-27
CN1154636C (zh) 2004-06-23
IL98256A0 (en) 1992-06-21
ZA914133B (en) 1993-01-27
HU226529B1 (en) 2009-03-30
JP2549609B2 (ja) 1996-10-30
DE69122866T2 (de) 1997-02-20
FI101376B (fi) 1998-06-15
HUT68166A (en) 1995-05-29
CS162391A3 (en) 1992-02-19
PT97796B (pt) 1998-10-30
CZ284663B6 (cs) 1999-01-13
AU648558B2 (en) 1994-04-28
CN1037768C (zh) 1998-03-18
CN1183408A (zh) 1998-06-03
PL169187B1 (pl) 1996-06-28
CN1056876A (zh) 1991-12-11
AU7770391A (en) 1991-12-31
HU9203761D0 (en) 1993-03-29
JPH0794439B2 (ja) 1995-10-11
ATE144498T1 (de) 1996-11-15
NZ250217A (en) 1995-05-26
KR930700443A (ko) 1993-03-15
NO180083C (no) 1997-02-12
PT97796A (pt) 1992-02-28
RU2077531C1 (ru) 1997-04-20
NO924598D0 (no) 1992-11-27
BR9106518A (pt) 1993-05-25

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