[go: up one dir, main page]

ES2004215A6 - Procedimiento para preparar quinazolinas tetraciclicas - Google Patents

Procedimiento para preparar quinazolinas tetraciclicas

Info

Publication number
ES2004215A6
ES2004215A6 ES8700334A ES8700334A ES2004215A6 ES 2004215 A6 ES2004215 A6 ES 2004215A6 ES 8700334 A ES8700334 A ES 8700334A ES 8700334 A ES8700334 A ES 8700334A ES 2004215 A6 ES2004215 A6 ES 2004215A6
Authority
ES
Spain
Prior art keywords
quinazolins
procedure
tetracyclic
preparing
preparing tetracyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8700334A
Other languages
English (en)
Inventor
Goetz Eduard Hardtmann
William Joseph Houlihan
Rudolf Karl And Giger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES2004215A6 publication Critical patent/ES2004215A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR TETRACICLICAS SUSTRAIDAS POR TRIFLUORMETILO Y SUS ISOMEROS OPTICOS, DE FORMULA IEN DONDE NO SIGNIFICA 1 O 2 Y P SIGNIFICA 0 O 1. COMPRENDE REACCIONAR UN COMPUESTO DE FORMULA (II)CON UN COMPUESTO DE FORMULA (III):LOS COMPUESTOS (I) TIENEN UTILIDAD COMO ANXIOLITICOS.
ES8700334A 1986-02-13 1987-02-11 Procedimiento para preparar quinazolinas tetraciclicas Expired ES2004215A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/829,594 US4760065A (en) 1986-02-13 1986-02-13 Trifluoromethyl substituted tetracyclic quinazolin-ones having tranquilizing activity

Publications (1)

Publication Number Publication Date
ES2004215A6 true ES2004215A6 (es) 1988-12-16

Family

ID=25254954

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8700334A Expired ES2004215A6 (es) 1986-02-13 1987-02-11 Procedimiento para preparar quinazolinas tetraciclicas

Country Status (22)

Country Link
US (1) US4760065A (es)
JP (1) JPS62223183A (es)
KR (1) KR870007900A (es)
AT (1) AT390062B (es)
AU (1) AU597936B2 (es)
BE (1) BE1002099A3 (es)
CH (1) CH671019A5 (es)
DE (1) DE3702943A1 (es)
DK (1) DK69787A (es)
ES (1) ES2004215A6 (es)
FI (1) FI870510A7 (es)
FR (1) FR2601013A1 (es)
GB (1) GB2186574B (es)
GR (1) GR870232B (es)
HU (1) HU198932B (es)
IL (1) IL81536A0 (es)
IT (1) IT1216790B (es)
LU (1) LU86769A1 (es)
NL (1) NL8700233A (es)
NZ (1) NZ219242A (es)
SE (1) SE8700566L (es)
ZA (1) ZA871077B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2113115A1 (en) * 1991-07-29 1993-02-18 Vlad E. Gregor Quinazoline derivatives as acetylcholinesterase inhibitors
US6133002A (en) 1997-09-25 2000-10-17 Dsm N.V. Process for preparing optically active 2-amino-ω-oxoalkanoic acid derivatives
EP2447239A1 (en) * 2010-10-29 2012-05-02 Saltigo GmbH Copper-catalysed process for the production of substituted or unsubstituted trifluormethylated aryl and heteroaryl compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3280117A (en) * 1964-04-20 1966-10-18 Sandoz Ag Tricyclic quinazolinones
US3598823A (en) * 1969-05-28 1971-08-10 Sandoz Ag Tricyclic quinazolinones
US3631046A (en) * 1969-05-28 1971-12-28 Sandoz Ag Tetracyclic quinazolin-ones
US3772230A (en) * 1969-05-28 1973-11-13 Sandoz Ag Polyhydro-imidazo(1,5-a)pyrimidine-3(2h)-thione and pyrido(1,2-c)pyrimidine-1-thione
US4000275A (en) * 1969-11-24 1976-12-28 Eli Lilly And Company Immunosuppressants
BE760013A (fr) * 1969-12-18 1971-06-08 Smith Kline French Lab Imidazo et pyrimido -(2,1-b)quinazolines, leurs procedes de preparationet compositions pharmaceutiques en contenant
US3868372A (en) * 1971-07-09 1975-02-25 Sandoz Ag Organomercapto-substituted polyhydro imidazo{8 1,5-a{9 pyridenes and pyride{8 1,2-c{9 pyrimidines
US3963720A (en) * 1972-10-27 1976-06-15 Sandoz, Inc. Tetracyclic imidazo [2,1-b] quinazolinone derivatives
FR2512674B1 (fr) * 1981-09-16 1986-01-10 Sandoz Sa Nouveaux derives tricycliques de la quinazolinone, leur preparation et medicaments contenant ces derives
PH17745A (en) * 1981-09-16 1984-11-27 Sandoz Ag Trifluoromethyl substituted tricyclic quinazolinones
US4452787A (en) * 1981-09-16 1984-06-05 Sandoz, Inc. 1-Substituted tricyclic quinazolinones having biological activity as tranquilizers
PH19788A (en) * 1981-09-16 1986-07-02 Sandoz Ag 1-substituted tricyclic quinazolinones,pharmaceutical composition containing same and method of use thereof

Also Published As

Publication number Publication date
NZ219242A (en) 1990-04-26
GB2186574B (en) 1990-03-28
AT390062B (de) 1990-03-12
IT8747634A0 (it) 1987-02-12
FI870510L (fi) 1987-08-14
AU597936B2 (en) 1990-06-14
ATA29687A (de) 1989-08-15
JPS62223183A (ja) 1987-10-01
LU86769A1 (fr) 1987-09-15
NL8700233A (nl) 1987-09-01
US4760065A (en) 1988-07-26
GR870232B (en) 1987-06-12
BE1002099A3 (fr) 1990-07-03
SE8700566D0 (sv) 1987-02-12
ZA871077B (en) 1988-09-28
DK69787A (da) 1987-08-14
CH671019A5 (es) 1989-07-31
IL81536A0 (en) 1987-09-16
DK69787D0 (da) 1987-02-11
GB8702938D0 (en) 1987-03-18
KR870007900A (ko) 1987-09-22
FI870510A0 (fi) 1987-02-09
DE3702943A1 (de) 1987-08-20
IT1216790B (it) 1990-03-14
FI870510A7 (fi) 1987-08-14
AU6869487A (en) 1987-08-20
GB2186574A (en) 1987-08-19
SE8700566L (sv) 1987-08-14
HU198932B (en) 1989-12-28
FR2601013A1 (fr) 1988-01-08
HUT43607A (en) 1987-11-30

Similar Documents

Publication Publication Date Title
ES542323A0 (es) Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina
ES2138691T3 (es) Procedimiento para la obtencion de derivados de n-acil-5-fluorocitidina.
FI931708A0 (fi) Herbicida substituerade aryl-haloalkylpyrazoler
MX9204327A (es) Beta-lactamas substituidas compuestos utiles como agentes hipocolesteromicos y procedimientos para preparar los mismos.
SE7805949L (sv) Spiroaminderivat och forfarande for framstellning derav och anvendning derav
FI833918A0 (fi) -karboliner, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska preparat
DZ1468A1 (fr) Composés nouveaux.
DK0532515T3 (da) Fremstilling af substituerede piperidiner
FI863836A0 (fi) Kinolinderivat.
IS4367A (is) CCK eða gastrín temprandi 5-heterósýklísk-1,5-bensódíazepín
DE3360904D1 (de) A fungicidal indanylbenzamide
ES8105053A1 (es) Procedimiento para la preparacion de mezclas de aclaradores opticos
ES8705421A1 (es) Un procedimiento para la preparacion de 4-amino-2-fenil-quinolinas
ES493375A0 (es) Procedimiento para la preparacion de mezclas de aclaradores opticos
BR9400016A (pt) Processo para preparação de compostos, e compostos
DK0487319T3 (da) Hidtil ukendt heptamethylindanforbindelse
PT99468A (pt) Processo para a preparacao de compostos cefem 7-actil-3-(carbamoiloxi substituido) com propriedades antibacterianas
ES2004215A6 (es) Procedimiento para preparar quinazolinas tetraciclicas
ES2012519A6 (es) Procedimiento para preparar compuestos polifluorados.
ES2038684T3 (es) Procedimiento de preparacion de derivados de octahidroindol y de compuestos intermedios de su preparacion.
FI892681A0 (fi) Nya jodade icke-joniska trijodbenzenfoereningar och dessa innehaollande kontrastmedel.
PT98268A (pt) Processo para a preparacao de indano-pirrolidino-carbamatos
ES2038159T3 (es) Procedimiento para preparar derivados sustituidos de 2-aminoacetamida.
DK0397042T3 (da) Fremstilling af isoquinolinderivater
ES519005A0 (es) Procedimiento para preparar 3-(1h-tetrazol-5-il)-4 (3 h)-quinazolinonas.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991007