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ES2075040T3 - 2',3'-dideoxi-2',2'-difluoronucleosidos. - Google Patents

2',3'-dideoxi-2',2'-difluoronucleosidos.

Info

Publication number
ES2075040T3
ES2075040T3 ES89301309T ES89301309T ES2075040T3 ES 2075040 T3 ES2075040 T3 ES 2075040T3 ES 89301309 T ES89301309 T ES 89301309T ES 89301309 T ES89301309 T ES 89301309T ES 2075040 T3 ES2075040 T3 ES 2075040T3
Authority
ES
Spain
Prior art keywords
rent
azido
amino
refers
dideoxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89301309T
Other languages
English (en)
Inventor
Larry Wayne Hertel
Cora Sue Grossman
Julian Stanley Kroin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2075040T3 publication Critical patent/ES2075040T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A 2'',3''- DIDESOXI - 2'',2''-DIFLUORNUCLEOSIDOS UTILES PARA EL TRATAMIENTO DE NEOPLASMAS SUSCEPTIBLES E INFECCIONES VIRICAS EN MAMIFEROS, QUE TIENEN LA FORMULA(I), EN LA QUE R1 ES H, ALQUILO DE 1 A 4 C O - CO - R5 (SIENDO R5 ALQUILO DE 1 A 4 C O H); R2 ES UNA BASE HETEROCICLICA NITROGENADA DE LA QUE SE INDICAN LAS POSIBLES FORMULAS; R3 ES H, AMINO, AZIDO O FLUOR; Y R4 ES H O F/LUOR. TAMBIEN SE REFIERE LA INVENCION A UNA SAL FARMACEUTICAMENTE ACEPTABLE DE (I), CON LA CONDICION QUE CUANDO R4 ES FLUOR, R3 NO SEA AMINO NI AZIDO.
ES89301309T 1988-02-16 1989-02-10 2',3'-dideoxi-2',2'-difluoronucleosidos. Expired - Lifetime ES2075040T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15611688A 1988-02-16 1988-02-16

Publications (1)

Publication Number Publication Date
ES2075040T3 true ES2075040T3 (es) 1995-10-01

Family

ID=22558157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89301309T Expired - Lifetime ES2075040T3 (es) 1988-02-16 1989-02-10 2',3'-dideoxi-2',2'-difluoronucleosidos.

Country Status (16)

Country Link
EP (1) EP0329348B1 (es)
JP (1) JP3142128B2 (es)
KR (1) KR890013049A (es)
CN (1) CN1035117A (es)
AU (1) AU607840B2 (es)
CA (1) CA1312599C (es)
DE (1) DE68923387T2 (es)
DK (1) DK66389A (es)
ES (1) ES2075040T3 (es)
HU (1) HU203363B (es)
IL (1) IL89258A0 (es)
MX (1) MX14910A (es)
NZ (1) NZ227960A (es)
PH (1) PH25381A (es)
PT (1) PT89705B (es)
ZA (1) ZA891076B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
FI95384C (fi) * 1989-04-06 1996-01-25 Squibb Bristol Myers Co Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
FI95269C (fi) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
AU629988B2 (en) * 1989-10-11 1992-10-15 Merrell Dow Pharmaceuticals Inc. Inosine/guanosine derivatives as antineoplastic agents
CA2073063A1 (en) * 1989-11-06 1991-05-07 Jo Klaveness Nucleoside derivatives
WO1991010671A1 (en) * 1990-01-11 1991-07-25 Isis Pharmaceuticals, Inc. Compositions and methods for detecting and modulating rna activity and gene expression
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
CA2079796A1 (en) * 1990-04-04 1991-10-05 Jo Klaveness Nucleoside derivatives
ZA914894B (en) * 1990-07-02 1992-04-29 Squibb & Sons Inc Purinyl and pyrimidinyl tetrahydrofurans
US6262241B1 (en) 1990-08-13 2001-07-17 Isis Pharmaceuticals, Inc. Compound for detecting and modulating RNA activity and gene expression
AU4134793A (en) * 1992-06-22 1993-12-23 Eli Lilly And Company 2'-deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
US6013790A (en) * 1996-09-25 2000-01-11 Board Of Regents University Of Nebraska-Lincoln Heavily fluorinated sugar analogs
GB2321454A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Gemcitabine esters and amides
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
DK1465615T3 (da) 2002-01-15 2012-11-12 Dartmouth College Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf
AU2003291726A1 (en) 2002-11-04 2004-06-07 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2008064132A2 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
EP2094651A1 (en) 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
EP2217247A4 (en) 2007-11-06 2011-12-28 Pharmaessentia Corp NEW PROCESS FOR SYNTHESIS OF BETA NUCLEOSIDES
US8129429B2 (en) 2008-01-11 2012-03-06 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
TW201004627A (en) 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
BRPI0911208B1 (pt) 2008-04-18 2021-05-25 Reata Pharmaceuticals, Inc Compostos moduladores inflamatórios antioxidantes, seu uso, e composição farmacêutica
TW201006474A (en) 2008-04-18 2010-02-16 Reata Pharmaceuticals Inc Natural products including an anti-flammatory pharmacore and methods of use
LT2276493T (lt) 2008-04-18 2019-01-10 Reata Pharmaceuticals, Inc. Antioksidaciniai uždegimo moduliatoriai: oleanolio rūgšties dariniai su amino ir kitomis modifikacijomis c-17
NZ588711A (en) 2008-04-18 2012-10-26 Reata Pharmaceuticals Inc C-17 homologated oleanolic acid derivatives for treating cancer
JP6042527B2 (ja) 2012-04-04 2016-12-14 ハロザイム インコーポレイテッド 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
DE3587500T2 (de) * 1984-12-04 1993-12-16 Lilly Co Eli Tumorbehandlung bei Säugetieren.
IL84842A0 (en) * 1986-12-24 1988-06-30 Lilly Co Eli Immunoglobulin conjugates

Also Published As

Publication number Publication date
NZ227960A (en) 1990-11-27
JP3142128B2 (ja) 2001-03-07
PH25381A (en) 1991-06-03
DK66389A (da) 1989-08-17
EP0329348A3 (en) 1990-09-12
JPH01249797A (ja) 1989-10-05
EP0329348A2 (en) 1989-08-23
CA1312599C (en) 1993-01-12
KR890013049A (ko) 1989-09-21
DE68923387D1 (de) 1995-08-17
PT89705A (pt) 1989-10-04
HUT49366A (en) 1989-09-28
MX14910A (es) 1993-11-01
EP0329348B1 (en) 1995-07-12
HU203363B (en) 1991-07-29
IL89258A0 (en) 1989-09-10
AU2992689A (en) 1989-08-17
CN1035117A (zh) 1989-08-30
ZA891076B (en) 1990-10-31
DE68923387T2 (de) 1996-01-25
DK66389D0 (da) 1989-02-13
AU607840B2 (en) 1991-03-14
PT89705B (pt) 1994-04-29

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