MX14910A - 2',3' -dideoxi-2',2'-difluoronucleosidos y procedimiento para su preparacion. - Google Patents

2',3' -dideoxi-2',2'-difluoronucleosidos y procedimiento para su preparacion.

Info

Publication number: MX14910A
Authority: MX; Mexico
Prior art keywords: dideoxi; difluoronucleosides; procedure; preparation
Prior art date: 1988-02-16

Application number

MX1491089A

Other languages

English (en)

Inventor

Larry Wayne Hertel

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-16

Filing date

1989-02-13

Publication date

1993-11-01

1989-02-13 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1993-11-01 Publication of MX14910A publication Critical patent/MX14910A/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

MX1491089A 1988-02-16 1989-02-13 2',3' -dideoxi-2',2'-difluoronucleosidos y procedimiento para su preparacion. MX14910A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US15611688A	1988-02-16	1988-02-16

Publications (1)

Publication Number	Publication Date
MX14910A true MX14910A (es)	1993-11-01

Family

ID=22558157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MX1491089A MX14910A (es)	1988-02-16	1989-02-13	2',3' -dideoxi-2',2'-difluoronucleosidos y procedimiento para su preparacion.

Country Status (16)

Country	Link
EP (1)	EP0329348B1 (es)
JP (1)	JP3142128B2 (es)
KR (1)	KR890013049A (es)
CN (1)	CN1035117A (es)
AU (1)	AU607840B2 (es)
CA (1)	CA1312599C (es)
DE (1)	DE68923387T2 (es)
DK (1)	DK66389A (es)
ES (1)	ES2075040T3 (es)
HU (1)	HU203363B (es)
IL (1)	IL89258A0 (es)
MX (1)	MX14910A (es)
NZ (1)	NZ227960A (es)
PH (1)	PH25381A (es)
PT (1)	PT89705B (es)
ZA (1)	ZA891076B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5047407A (en) *	1989-02-08	1991-09-10	Iaf Biochem International, Inc.	2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
FI95384C (fi) *	1989-04-06	1996-01-25	Squibb Bristol Myers Co	Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
FI95269C (fi) *	1989-05-15	1996-01-10	Squibb Bristol Myers Co	2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
AU629988B2 (en) *	1989-10-11	1992-10-15	Merrell Dow Pharmaceuticals Inc.	Inosine/guanosine derivatives as antineoplastic agents
CA2073063A1 (en) *	1989-11-06	1991-05-07	Jo Klaveness	Nucleoside derivatives
WO1991010671A1 (en) *	1990-01-11	1991-07-25	Isis Pharmaceuticals, Inc.	Compositions and methods for detecting and modulating rna activity and gene expression
US5459255A (en) *	1990-01-11	1995-10-17	Isis Pharmaceuticals, Inc.	N-2 substituted purines
CA2079796A1 (en) *	1990-04-04	1991-10-05	Jo Klaveness	Nucleoside derivatives
ZA914894B (en) *	1990-07-02	1992-04-29	Squibb & Sons Inc	Purinyl and pyrimidinyl tetrahydrofurans
US6262241B1 (en)	1990-08-13	2001-07-17	Isis Pharmaceuticals, Inc.	Compound for detecting and modulating RNA activity and gene expression
AU4134793A (en) *	1992-06-22	1993-12-23	Eli Lilly And Company	2'-deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates
YU43193A (sh) *	1992-06-22	1997-01-08	Eli Lilly And Company	2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
US6013790A (en) *	1996-09-25	2000-01-11	Board Of Regents University Of Nebraska-Lincoln	Heavily fluorinated sugar analogs
GB2321454A (en) *	1997-01-24	1998-07-29	Norsk Hydro As	Gemcitabine esters and amides
US6326507B1 (en)	1998-06-19	2001-12-04	Trustees Of Dartmouth College	Therapeutic compounds and methods of use
US7435755B2 (en)	2000-11-28	2008-10-14	The Trustees Of Dartmouth College	CDDO-compounds and combination therapies thereof
DK1465615T3 (da)	2002-01-15	2012-11-12	Dartmouth College	Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf
AU2003291726A1 (en)	2002-11-04	2004-06-07	Xenoport, Inc.	Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US8921340B2 (en)	2006-11-17	2014-12-30	Trustees Of Dartmouth College	Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2008064132A2 (en)	2006-11-17	2008-05-29	Trustees Of Dartmouth College	Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
EP2094651A1 (en)	2006-11-17	2009-09-02	Trustees Of Dartmouth College	Synthesis and biological activities of new tricyclic-bis-enones (tbes)
EP2217247A4 (en)	2007-11-06	2011-12-28	Pharmaessentia Corp	NEW PROCESS FOR SYNTHESIS OF BETA NUCLEOSIDES
US8129429B2 (en)	2008-01-11	2012-03-06	Reata Pharmaceuticals, Inc.	Synthetic triterpenoids and methods of use in the treatment of disease
TW201004627A (en)	2008-04-18	2010-02-01	Reata Pharmaceuticals Inc	Antioxidant inflammation modulators: novel derivatives of oleanolic acid
BRPI0911208B1 (pt)	2008-04-18	2021-05-25	Reata Pharmaceuticals, Inc	Compostos moduladores inflamatórios antioxidantes, seu uso, e composição farmacêutica
TW201006474A (en)	2008-04-18	2010-02-16	Reata Pharmaceuticals Inc	Natural products including an anti-flammatory pharmacore and methods of use
LT2276493T (lt)	2008-04-18	2019-01-10	Reata Pharmaceuticals, Inc.	Antioksidaciniai uždegimo moduliatoriai: oleanolio rūgšties dariniai su amino ir kitomis modifikacijomis c-17
NZ588711A (en)	2008-04-18	2012-10-26	Reata Pharmaceuticals Inc	C-17 homologated oleanolic acid derivatives for treating cancer
JP6042527B2 (ja)	2012-04-04	2016-12-14	ハロザイムインコーポレイテッド	抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療
US8921419B2 (en)	2012-05-08	2014-12-30	Trustees Of Dartmouth College	Triterpenoids and compositions containing the same
WO2019222435A1 (en)	2018-05-16	2019-11-21	Halozyme, Inc.	Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4526988A (en) *	1983-03-10	1985-07-02	Eli Lilly And Company	Difluoro antivirals and intermediate therefor
DE3587500T2 (de) *	1984-12-04	1993-12-16	Lilly Co Eli	Tumorbehandlung bei Säugetieren.
IL84842A0 (en) *	1986-12-24	1988-06-30	Lilly Co Eli	Immunoglobulin conjugates

1989
- 1989-02-10 CA CA000590693A patent/CA1312599C/en not_active Expired - Fee Related
- 1989-02-10 IL IL89258A patent/IL89258A0/xx not_active IP Right Cessation
- 1989-02-10 EP EP89301309A patent/EP0329348B1/en not_active Expired - Lifetime
- 1989-02-10 ES ES89301309T patent/ES2075040T3/es not_active Expired - Lifetime
- 1989-02-10 ZA ZA891076A patent/ZA891076B/xx unknown
- 1989-02-10 DE DE68923387T patent/DE68923387T2/de not_active Expired - Fee Related
- 1989-02-13 PT PT89705A patent/PT89705B/pt not_active IP Right Cessation
- 1989-02-13 PH PH38188A patent/PH25381A/en unknown
- 1989-02-13 MX MX1491089A patent/MX14910A/es unknown
- 1989-02-13 NZ NZ227960A patent/NZ227960A/en unknown
- 1989-02-13 DK DK066389A patent/DK66389A/da not_active Application Discontinuation
- 1989-02-14 HU HU89650A patent/HU203363B/hu unknown
- 1989-02-14 AU AU29926/89A patent/AU607840B2/en not_active Ceased
- 1989-02-15 JP JP01035955A patent/JP3142128B2/ja not_active Expired - Fee Related
- 1989-02-15 CN CN89100441A patent/CN1035117A/zh active Pending
- 1989-02-15 KR KR1019890001711A patent/KR890013049A/ko not_active Ceased

Also Published As

Publication number	Publication date
NZ227960A (en)	1990-11-27
JP3142128B2 (ja)	2001-03-07
PH25381A (en)	1991-06-03
DK66389A (da)	1989-08-17
EP0329348A3 (en)	1990-09-12
JPH01249797A (ja)	1989-10-05
EP0329348A2 (en)	1989-08-23
CA1312599C (en)	1993-01-12
KR890013049A (ko)	1989-09-21
DE68923387D1 (de)	1995-08-17
PT89705A (pt)	1989-10-04
HUT49366A (en)	1989-09-28
EP0329348B1 (en)	1995-07-12
HU203363B (en)	1991-07-29
IL89258A0 (en)	1989-09-10
ES2075040T3 (es)	1995-10-01
AU2992689A (en)	1989-08-17
CN1035117A (zh)	1989-08-30
ZA891076B (en)	1990-10-31
DE68923387T2 (de)	1996-01-25
DK66389D0 (da)	1989-02-13
AU607840B2 (en)	1991-03-14
PT89705B (pt)	1994-04-29

Publication	Publication Date	Title
MX14910A (es)	1993-11-01	2',3' -dideoxi-2',2'-difluoronucleosidos y procedimiento para su preparacion.
MX9205032A (es)	1993-05-01	1,2-dihidro-2-oxo-piridinas y procedimiento para su preparacion.
MX9845A (es)	1993-12-01	Propanaminas 3-ariloxi-3-substituidas y procedimiento para su preparacion.
MX24568A (es)	1993-09-01	3-arilcarbonil-1h-indoles y procedimiento para su preparacion.
MX7372A (es)	1993-09-01	Drivados de tetrahidronaftalina e indano y procedimiento para su preparacion.
MX16687A (es)	1994-01-31	Compuestos de biarilo y procedimiento para su preparacion.
MX15701A (es)	1993-11-01	Composiciones de macrolidas y procedimiento para su preparacion.
MX26267A (es)	1993-09-01	Aminobenzodiacepinas y procedimiento para su prepaacion.
MX9201780A (es)	1992-10-01	Eteres oximicos y procedimiento para su preparacion.
NO903169L (no)	1991-01-18	4,1,2-1h-benzoksadiaziner og deres fremstilling.
MX22255A (es)	1993-09-01	Compuestos de piridinil-quinolona y procedimiento para su preparacion.
NO893826D0 (no)	1989-09-26	Fremgangsmaate for fremstilling av 2'-halomethyliden, 2'-ethenyliden og 2'-ethenyladenosinderivater.
MX21243A (es)	1994-01-31	Indenoindoles y procedimiento para su preparacion.
MX9205747A (es)	1993-04-01	Pirazolinas y procedimiento para su preparacion.
IT8821300A0 (it)	1988-07-08	Procedimento di preparazione di morniflumato e analoghi.
NO903347D0 (no)	1990-07-27	Fremgangsmaate for fremstilling av 14,17alfa-ethano- og ethanooestratriener.
MX9205746A (es)	1993-04-01	Pirazolinas y procedimiento para su preparacion.
MX9205821A (es)	1993-04-01	Pirimidinil- y triazinileteres y -tioeteres y procedimiento para su preparacion.
IT1236969B (it)	1993-05-07	Procedimento di preparazione di 3-ciano-3,5,5'-trimetil-1-cicloesanone.
MX17041A (es)	1994-02-28	Procedimiento para la preparacion de benzopirano pirazoles.
ES545701A0 (es)	1986-06-16	Procedimiento para preparar 9-oxo-15 a-hidroxi-16-fenoxi y 16-fenoxi sustituido-17,18,19,20-tetranorprosta-4,5,13 (e)- trienoatos
DK388986D0 (da)	1986-08-15	7-oxo-4-thia-1-azabicyclo(3.2.0)hept-2-en-derivater, deres fremstillingog anvendelse
IT8821079A0 (it)	1988-06-23	Copoliestere termotropico, procedimento per la sua preparazione e sua utilizzazione.
MX17042A (es)	1994-01-31	(1) benzotiopirano (4,3-c)-pirazoles y procedimiento para su preparacion.
IT1213536B (it)	1989-12-20	2-bromo,1',2',-dicloro-perfluoro dietil-etere e procedimento per lasua preparazione.