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ES2058105T3 - Agentes antiarritmicos. - Google Patents

Agentes antiarritmicos.

Info

Publication number
ES2058105T3
ES2058105T3 ES87300978T ES87300978T ES2058105T3 ES 2058105 T3 ES2058105 T3 ES 2058105T3 ES 87300978 T ES87300978 T ES 87300978T ES 87300978 T ES87300978 T ES 87300978T ES 2058105 T3 ES2058105 T3 ES 2058105T3
Authority
ES
Spain
Prior art keywords
group
substituted
alkyl
amino
piridilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87300978T
Other languages
English (en)
Inventor
Peter Edward Cross
Roger Peter Dickinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER Ltd
Pfizer Ltd Great Britain
Original Assignee
PFIZER Ltd
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER Ltd, Pfizer Ltd Great Britain filed Critical PFIZER Ltd
Application granted granted Critical
Publication of ES2058105T3 publication Critical patent/ES2058105T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Insulating Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)

Abstract

UN COMPUESTO DE FORMULA (I) O SALES FARMACEUTICAMENTE ACEPTABLES DEL MISMO, EN LOS QUE "HET" SE SELECCIONA ENTRE: (A) UN GRUPO 3- O 4-PIRIDILO OPCIONALMENTE SUSTITUIDO CON UNO O DOS GRUPO SELECCIONADO CADA UNO INDEPENDIENTEMENTE ENTRE ALQUILO C1-C4 Y AMINO (B) 2-PIRIDILO SUSTITUIDO CON UN GRUPO AMINO, (C) UN GRUPO 2-IMIDAZOLILO SUSTITUIDO OPCIONALMENTE POR UNO O DOS ALQUILOS C1-C4, (D) UN GRUPO 2-,3- O 4-PIRIDILO SUSTITUIDO CON UN GRUPO NITRO O UN N-OXIDO, O UN GRUPO 2-,3- O 4-PIRIDILO SUSTITUIDO CON UN GRUPO -NHCOO (ALQUILO C1-C4). R SE SELECCIONA ENTRE: (A)-NHSO2R3 DONDE R3 ES ALQUILO C1-C4, CICLOALQUILO C3-C7 O NR1R2, SIENDO R1 Y R2 CADA UNO INDEPENDIENTEMENTE H O ALQUILO C1-C4, (B)-SO2NR1R2 SIENDO R1 Y R2 LOS MISMOS INDICADOS ANTERIORMENTE, (C) NITRO, (D) AMINO Y (E) ACETAMIDO. X ES UN GRUPO -(CH2)M- SIENDO M UN ENTERO DE 1 A 4, -CO(CH2)N- O -CH(OH)(CH2)N- SIENDO N, 1,2 O 3. EXCEPTUANDO LOS COMPUESTOS EN LOS QUE "HET"=(D), QUE SON COMPUESTOS INTERMEDIOS SINTETICOS, TODOS ELLOS SON UTILES COMO ANTIARRITMICOS.
ES87300978T 1986-02-07 1987-02-04 Agentes antiarritmicos. Expired - Lifetime ES2058105T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868603120A GB8603120D0 (en) 1986-02-07 1986-02-07 Anti-dysrhythmia agents

Publications (1)

Publication Number Publication Date
ES2058105T3 true ES2058105T3 (es) 1994-11-01

Family

ID=10592722

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87300978T Expired - Lifetime ES2058105T3 (es) 1986-02-07 1987-02-04 Agentes antiarritmicos.

Country Status (21)

Country Link
US (1) US4806536A (es)
EP (1) EP0233051B1 (es)
JP (1) JPH0670015B2 (es)
KR (1) KR890002290B1 (es)
CN (1) CN87100652A (es)
AT (1) ATE94534T1 (es)
AU (1) AU575740B2 (es)
CA (1) CA1303042C (es)
DE (1) DE3787384T2 (es)
DK (1) DK165445C (es)
ES (1) ES2058105T3 (es)
FI (1) FI89265C (es)
GB (1) GB8603120D0 (es)
HU (1) HU196990B (es)
IE (1) IE60300B1 (es)
IL (1) IL81483A0 (es)
NO (1) NO870483L (es)
NZ (1) NZ219193A (es)
PL (1) PL263972A1 (es)
PT (1) PT84248B (es)
ZA (1) ZA87871B (es)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
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GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
US4956382A (en) * 1987-02-07 1990-09-11 Pfizer Inc. Sulfonamide anti-arrhythmic agents
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives
US5162347A (en) * 1987-08-24 1992-11-10 Eisai Co., Ltd. Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same
GB8800694D0 (en) * 1988-01-13 1988-02-10 Pfizer Ltd Antiarrhythmic agents
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5112824A (en) * 1989-12-08 1992-05-12 Merck & Co., Inc. Benzofuran compounds as class III antiarrhythmic agents
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
US5215989A (en) * 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
US4994459A (en) * 1989-12-11 1991-02-19 American Home Products Corporation Aryloxypropane substituted piperazine derivatives with antiarrhythmic and antifibrillatory activity
EP1231208A3 (en) * 1991-08-14 2003-12-10 Procter & Gamble Pharmaceuticals 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents
US5569659A (en) * 1991-09-11 1996-10-29 Mcneilab, Inc. 4-arylpiperazines and 4-arylpiperidines
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
GB9406144D0 (en) * 1993-03-29 1994-05-18 Zeneca Ltd Heterocyclic compounds
NZ262941A (en) * 1993-03-29 1997-07-27 Zeneca Ltd Pyridine derivatives and medicaments
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5700801A (en) * 1994-12-23 1997-12-23 Karl Thomae, Gmbh Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
WO1997028128A1 (en) * 1996-02-02 1997-08-07 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
SK18499A3 (en) * 1996-08-14 1999-07-12 Zeneca Ltd Substituted pyrimidine derivatives and their pharmaceutical use
UA56197C2 (uk) * 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
US6440972B1 (en) 1997-02-13 2002-08-27 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
DK0966462T3 (da) 1997-02-13 2003-09-22 Astrazeneca Ab Heterocykliske forbindelser, der er egnede som oxidosqualencyklaseinhibitorer
US6083991A (en) 1997-06-04 2000-07-04 University Of Florida Research Foundation, Inc. Anti-arrhythmic composition and methods of treatment
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
BR9813279B1 (pt) * 1997-10-27 2010-11-16 derivado de homopiperazina, composição farmacêutica, e, uso do derivado de homopiperazina.
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
JP2002543070A (ja) * 1999-04-26 2002-12-17 ニューロサーチ、アクティーゼルスカブ ヘテロアリールジアザシクロアルカン類、その製造方法及びその使用方法
BR0209932A (pt) 2001-05-22 2004-10-13 Neurogen Corp Composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, preparação farmacêutica embalada, métodos para modular ligação de mch a um receptor de mch e de mvc, para alterar a atividade de transdução de sinal de um receptor de mch em uma célula, para tratar uma doença ou distúrbio associado com a ativação de receptor de mch patogênico obesidade e para determinar a presença ou ausência de receptor de mch em uma amostra, e, uso de um composto
CN1181065C (zh) * 2002-05-08 2004-12-22 上海医药工业研究院 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用
CN1172919C (zh) * 2002-06-03 2004-10-27 上海医药工业研究院 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用
WO2005110989A1 (en) * 2004-04-07 2005-11-24 Neurogen Corporation Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
US7253168B2 (en) * 2004-04-07 2007-08-07 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
TW200609219A (en) * 2004-06-17 2006-03-16 Neurogen Corp Aryl-substituted piperazine derivatives
BRPI0517032A (pt) * 2004-12-16 2008-09-30 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades e utilização desses compostos
GB0818241D0 (en) * 2008-10-06 2008-11-12 Cancer Res Technology Compounds and their use
GB0902173D0 (en) 2009-02-10 2009-03-25 Takeda Pharmaceutical Compounds and their use
US8673920B2 (en) * 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US8614201B2 (en) 2009-06-05 2013-12-24 Janssen Pharmaceutica Nv Heterocyclic amides as modulators of TRPA1
WO2012058116A1 (en) 2010-10-27 2012-05-03 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2012058134A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9062070B2 (en) 2011-08-19 2015-06-23 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
TW201317213A (zh) 2011-09-16 2013-05-01 Merck Sharp & Dohme 腎外髓質鉀通道抑制劑
EP2771005B1 (en) 2011-10-25 2016-05-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013062900A1 (en) 2011-10-25 2013-05-02 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9108947B2 (en) 2011-10-31 2015-08-18 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
US9139585B2 (en) 2011-10-31 2015-09-22 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
WO2013066718A2 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9206199B2 (en) 2011-12-16 2015-12-08 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
EP2925322B1 (en) 2012-11-29 2018-10-24 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
CN103087009B (zh) * 2012-12-17 2016-09-14 上海现代制药股份有限公司 羧酸衍生物类化合物及其制备方法和应用
EP2934533B1 (en) 2012-12-19 2017-11-15 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2956142B1 (en) 2013-02-18 2017-09-20 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2968288B1 (en) 2013-03-15 2018-07-04 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP3027625B1 (en) 2013-07-31 2018-05-30 Merck Sharp & Dohme Corp. Spiro-fused derivatives of piperidine useful for the treatment of inter alia hypertension and acute or chronic heart failure
WO2015065866A1 (en) 2013-10-31 2015-05-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
RU2565404C1 (ru) * 2014-12-02 2015-10-20 Общество с ограниченной ответственностью "Научно-исследовательский центр "Парк активных молекул" Средство, проявляющее антиаритмическую активность
WO2016127358A1 (en) 2015-02-12 2016-08-18 Merck Sharp & Dohme Corp. Inhibitors of renal outer medullary potassium channel

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US2958694A (en) * 1959-06-22 1960-11-01 Janssen Paul Adriaan Jan 1-(aroylalkyl)-4-(2'-pyridyl) piperazines
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BE757005A (fr) * 1969-10-02 1971-04-02 Bristol Myers Co Phenethanolamines substituees et procede pour leur preparation
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US4255575A (en) * 1979-05-04 1981-03-10 Richardson-Merrell Inc. 2-Hydroxy-5-(1-hydroxy-2-piperazinylethyl)-benzoic acid derivatives
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DE3508398A1 (de) * 1985-03-08 1986-11-06 Hoechst Ag, 6230 Frankfurt Fungizide mittel auf der basis von 3-(hetero)-arylpropylaminen sowie neue (hetero)-aryl-propylamine und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
AU575740B2 (en) 1988-08-04
DK165445C (da) 1993-04-13
FI870499A0 (fi) 1987-02-06
CN87100652A (zh) 1987-08-19
CA1303042C (en) 1992-06-09
ATE94534T1 (de) 1993-10-15
DE3787384T2 (de) 1994-01-13
EP0233051A3 (en) 1990-03-21
DE3787384D1 (de) 1993-10-21
JPS62185073A (ja) 1987-08-13
KR890002290B1 (ko) 1989-06-28
IL81483A0 (en) 1987-09-16
DK60887A (da) 1987-10-05
NZ219193A (en) 1989-01-06
JPH0670015B2 (ja) 1994-09-07
PL263972A1 (en) 1988-07-21
HUT43584A (en) 1987-11-30
FI870499A7 (fi) 1987-08-08
EP0233051B1 (en) 1993-09-15
ZA87871B (en) 1988-09-28
PT84248B (pt) 1989-09-14
IE60300B1 (en) 1994-06-29
EP0233051A2 (en) 1987-08-19
AU6858887A (en) 1987-08-13
KR870007916A (ko) 1987-09-22
NO870483D0 (no) 1987-02-06
GB8603120D0 (en) 1986-03-12
HU196990B (en) 1989-02-28
US4806536A (en) 1989-02-21
FI89265C (fi) 1993-09-10
PT84248A (en) 1987-03-01
FI89265B (fi) 1993-05-31
DK60887D0 (da) 1987-02-06
DK165445B (da) 1992-11-30
NO870483L (no) 1987-08-10
IE870318L (en) 1987-08-07

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