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ES2090024T3 - Compuestos de cefemo y procedimientos para su preparacion. - Google Patents

Compuestos de cefemo y procedimientos para su preparacion.

Info

Publication number
ES2090024T3
ES2090024T3 ES89110068T ES89110068T ES2090024T3 ES 2090024 T3 ES2090024 T3 ES 2090024T3 ES 89110068 T ES89110068 T ES 89110068T ES 89110068 T ES89110068 T ES 89110068T ES 2090024 T3 ES2090024 T3 ES 2090024T3
Authority
ES
Spain
Prior art keywords
group
preparation
formula
hydroxide
protected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89110068T
Other languages
English (en)
Inventor
Hideaki Yamanaka
Yoshiki Yoshida
Jiro Goto
Takeshi Terasawa
Shinya Okuda
Kazuo Sakane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888813308A external-priority patent/GB8813308D0/en
Priority claimed from GB888814196A external-priority patent/GB8814196D0/en
Priority claimed from GB888825518A external-priority patent/GB8825518D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2090024T3 publication Critical patent/ES2090024T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

SE PRESENTA UN COMPUESTO DE LA FORMULA I EN DONDE, R1 ES AMINO O UN GRUPO AMINO PROTEGIDO, Z ES N O CH, R2 ES UN GRUPO ORGANICO Y R ES UN GRUPO DE LA FORMULA II, EN LA CUAL R3 Y R4 SON CADA UNO ALKIL INFERIOR , O R3 Y R4 ESTAN ENLAZADOS JUNTOS PARA FORMAR UN ALKILENO C3 - C5, A ES UN ALKILENO INFERIOR Y R5 ES HIDROXIDO O UN GRUPO DE HIDROGENO PROTEGIDO O UN GRUPO DE LA FORMULA III EN LA CUAL, R5 ES ALKIL INFERIOR, R 7 Y R8 SON CADA UNO HIDROXIDO O UN GRUPO HIDROXIDO PROTEGIDO, Y ES N O CH Y UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS, TAMBIEN SE PRESENTAN PROCESOS PARA SU PREPARACION Y COMPUESTOS FARMECEUTICOS QUE LOS COMPRENDEN COMO INGREDIENTES ACTIVOS. EL INVENTO SE REFIERE TAMBIEN A LOS INTERMEDIOS DE LA FORMULA IV Y SU PREPARACION.
ES89110068T 1988-06-06 1989-06-03 Compuestos de cefemo y procedimientos para su preparacion. Expired - Lifetime ES2090024T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888813308A GB8813308D0 (en) 1988-06-06 1988-06-06 New cephem compounds & processes for preparation thereof
GB888814196A GB8814196D0 (en) 1988-06-15 1988-06-15 New cepham compounds & process for preparation thereof
GB888825518A GB8825518D0 (en) 1988-11-01 1988-11-01 New cephem compounds & process for preparation thereof

Publications (1)

Publication Number Publication Date
ES2090024T3 true ES2090024T3 (es) 1996-10-16

Family

ID=27263933

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89110068T Expired - Lifetime ES2090024T3 (es) 1988-06-06 1989-06-03 Compuestos de cefemo y procedimientos para su preparacion.

Country Status (16)

Country Link
EP (1) EP0345671B1 (es)
JP (1) JP2817203B2 (es)
KR (1) KR910000751A (es)
AT (1) ATE141606T1 (es)
AU (1) AU622906B2 (es)
DE (1) DE68926981T2 (es)
DK (1) DK268289A (es)
ES (1) ES2090024T3 (es)
FI (1) FI93732C (es)
HU (1) HU204531B (es)
IL (1) IL90424A (es)
NO (1) NO172893C (es)
NZ (1) NZ229347A (es)
OA (1) OA09119A (es)
PH (1) PH25965A (es)
PT (1) PT90725B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143910A (en) * 1989-09-07 1992-09-01 Shionogi & Co., Ltd. Piperaziniocephalosporins
GB9107973D0 (en) * 1991-04-15 1991-05-29 Fujisawa Pharmaceutical Co New cephem compounds and process for preparation thereof
GB9111406D0 (en) * 1991-05-28 1991-07-17 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
KR101655961B1 (ko) 2008-10-31 2016-09-08 시오노기세야쿠 가부시키가이샤 카테콜기를 갖는 세팔로스포린류
IN2012CN09242A (es) 2010-04-05 2015-08-21 Shionogi & Co
US8883773B2 (en) 2010-04-05 2014-11-11 Shionogi & Co., Ltd. Cephem compound having pseudo-catechol group
US9085589B2 (en) 2010-04-28 2015-07-21 Shionogi & Co., Ltd. Cephem derivative
KR20140039202A (ko) 2011-04-28 2014-04-01 시오노기세야쿠 가부시키가이샤 카테콜 또는 의사 카테콜 구조를 갖는 신규 세펨 화합물
CN103619853A (zh) 2011-06-27 2014-03-05 盐野义制药株式会社 具有吡啶鎓基的头孢烯化合物
CN103958527A (zh) 2011-10-04 2014-07-30 盐野义制药株式会社 具有儿茶酚基团的头孢烯衍生物
TWI547496B (zh) * 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物
US9212147B2 (en) 2011-11-15 2015-12-15 Takeda Pharmaceutical Company Limited Dihydroxy aromatic heterocyclic compound
UY35103A (es) 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos
BR112015008905A2 (pt) 2012-10-29 2017-07-04 Shionogi & Co processos para a produção de intermediários de compostos de 2-alquil cefem
GB201222711D0 (en) * 2012-12-17 2013-01-30 Takeda Pharmaceutical Novel compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3419013A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Neue cephalosporine und verfahren zu ihrer herstellung
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
DE3506159A1 (de) * 1985-02-22 1986-08-28 Bayer Ag, 5090 Leverkusen Neue cephalosporine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPS6310792A (ja) * 1986-03-10 1988-01-18 Takeda Chem Ind Ltd 新規セフエム化合物
ZA877987B (en) * 1986-11-12 1988-08-31 Ici Pharma Antibiotic compounds

Also Published As

Publication number Publication date
EP0345671A2 (en) 1989-12-13
JP2817203B2 (ja) 1998-10-30
DE68926981T2 (de) 1997-01-16
AU3583989A (en) 1989-12-07
DK268289D0 (da) 1989-06-01
HUT50349A (en) 1990-01-29
NZ229347A (en) 1991-09-25
HU204531B (en) 1992-01-28
PT90725B (pt) 1994-11-30
OA09119A (fr) 1991-10-31
FI93732B (fi) 1995-02-15
AU622906B2 (en) 1992-04-30
NO172893B (no) 1993-06-14
NO172893C (no) 1993-09-22
DK268289A (da) 1989-12-07
NO892295D0 (no) 1989-06-05
NO892295L (no) 1989-12-07
EP0345671A3 (en) 1991-10-16
ATE141606T1 (de) 1996-09-15
DE68926981D1 (de) 1996-09-26
KR910000751A (ko) 1991-01-30
FI892637A7 (fi) 1989-12-07
EP0345671B1 (en) 1996-08-21
PT90725A (pt) 1989-12-29
IL90424A0 (en) 1990-01-18
FI892637A0 (fi) 1989-05-31
FI93732C (fi) 1995-05-26
JPH0228187A (ja) 1990-01-30
IL90424A (en) 1994-05-30
PH25965A (en) 1992-01-13

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