ES2055688T3 - Un procedimiento para la preparacion de derivados 3-(2-aminoetil)indoles. - Google Patents
Un procedimiento para la preparacion de derivados 3-(2-aminoetil)indoles.Info
- Publication number
- ES2055688T3 ES2055688T3 ES86310010T ES86310010T ES2055688T3 ES 2055688 T3 ES2055688 T3 ES 2055688T3 ES 86310010 T ES86310010 T ES 86310010T ES 86310010 T ES86310010 T ES 86310010T ES 2055688 T3 ES2055688 T3 ES 2055688T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- procedure
- phenyl
- rent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 2-AMINO ETHYL Chemical class 0.000 title abstract 6
- 150000002475 indoles Chemical class 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 101100134927 Gallus gallus COR8 gene Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UN COMPUESTO DE FORI O UNA DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DONDE R1 ES HIDROGENO, ALQUILO C1-6, ALCOXI C1-6 O HALOGENO; R2 Y R3 SON HIDROGENO O JUNTOS REPRESENTAN UN ENLACE; R4 SE SELECCINA DE ALQUILO C1-6, FENILO, ALQUIL C1-4 FENILO, COR8 DONDE R8 ES HIDROXI, ALCOXI C1-6 O NR9R10 DONDE R9 Y R10 SON INDEPENDIENTEMENTE HIDROGENO O ALQUILO C1-4 Y CH2OR11 DONDE R11 ES HIDROGENO, ALQUILO C1-4 O ALCANOILO C1-4; R5 ES HIDROGENO, ALQUILO C1-6 O ALQUENILO C1-4 FENILO; R6 ES ALQUILO C1-7 FENILO EN EL QUE LA PARTE FENILO ESTA OPCIONALMENTE SUSTITUIDA POR UNO O DOS HALOGENOS, O-NITRO, M- O P-METOXI, METIL O NR12R13 DONDE R12 Y R13 SON INDEPENDIENTEMENTE HIDROGENO O ALQUILO C1-6, O R12 Y R13 JUNTOS SON POLIMETILENO, O LA PARTE FENILO ESTA SUSTITUIDA EN 2,3 POR METILENODIOXI O ETILENODIOXI; Y R7 ES HIDROGENO O ALQUILO C1-4; PROCEDIMIENTO PARA SU OBTENCION Y SU USO COMO FARMACO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858531612A GB8531612D0 (en) | 1985-12-23 | 1985-12-23 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2055688T3 true ES2055688T3 (es) | 1994-09-01 |
Family
ID=10590170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES86310010T Expired - Lifetime ES2055688T3 (es) | 1985-12-23 | 1986-12-22 | Un procedimiento para la preparacion de derivados 3-(2-aminoetil)indoles. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4980368A (es) |
| EP (1) | EP0233413B1 (es) |
| JP (1) | JPS62181252A (es) |
| AU (1) | AU597017B2 (es) |
| DE (1) | DE3688397T2 (es) |
| DK (1) | DK625286A (es) |
| ES (1) | ES2055688T3 (es) |
| GB (1) | GB8531612D0 (es) |
| IE (1) | IE60126B1 (es) |
| NZ (1) | NZ218754A (es) |
| PT (1) | PT84014B (es) |
| ZA (1) | ZA869616B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0636623B1 (en) * | 1990-06-07 | 2001-08-16 | AstraZeneca AB | Indole derivatives as 5-HT1- like agonists |
| US5145845A (en) * | 1991-05-14 | 1992-09-08 | Warner-Lambert Co. | Substituted 2-carboxylindoles having pharmaceutical activity |
| US5233050A (en) * | 1992-02-07 | 1993-08-03 | Merck & Co., Inc. | Antimigraine alkyl indole |
| ITRM20010356A1 (it) * | 2001-06-21 | 2002-12-23 | Sigma Tau Ind Farmaceuti | "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina. |
| NZ572707A (en) * | 2006-06-12 | 2011-12-22 | Novartis Ag | Process for making N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide and starting materials therefor |
| WO2014047427A2 (en) | 2012-09-21 | 2014-03-27 | Vanderbilt University | Substituted benzofuran, benzothiophene and indole mcl-1 inhibitors |
| US10005728B2 (en) | 2013-08-28 | 2018-06-26 | Vanderbilt University | Substituted indole Mcl-1 inhibitors |
| CA2943815C (en) | 2014-03-27 | 2023-04-04 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
| EP4292662A3 (en) | 2016-03-04 | 2024-02-21 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3042685A (en) * | 1962-07-03 | Process of making g-fluoro tryptamine | ||
| CA613852A (en) * | 1961-01-31 | L. Clark Robert | Substituted tryptamines | |
| GB781390A (en) * | 1954-04-28 | 1957-08-21 | Upjohn Co | Preparation of 3-(2-aminoethyl)-indoles |
| GB841524A (en) * | 1955-11-18 | 1960-07-20 | May & Baker Ltd | Improvements in or relating to indole derivatives |
| US2890223A (en) * | 1956-03-22 | 1959-06-09 | Research Corp | 1-benzyl, 2-methyl, 5-methoxy tryptamine |
| GB859223A (en) * | 1957-03-27 | 1961-01-18 | Merck & Co Inc | Tryptamine compounds |
| GB888426A (en) * | 1957-08-02 | 1962-01-31 | Lab Francais Chimiotherapie | Tryptamine-2-carboxylic acid derivatives and their preparation |
| US2908691A (en) * | 1958-07-14 | 1959-10-13 | Searle & Co | Hydroxyphenalkylaminoalkylindoles and ethers corresponding thereto |
| US3217029A (en) * | 1961-06-27 | 1965-11-09 | Warner Lambert Pharmaceutical | Method of preparing substituted indole derivatives |
| US3296072A (en) * | 1962-06-11 | 1967-01-03 | Upjohn Co | Method of treating mental depression |
| GB1189064A (en) * | 1967-05-01 | 1970-04-22 | Sterling Drug Inc | Indole Derivatives |
| US3686213A (en) * | 1970-08-28 | 1972-08-22 | American Cyanamid Co | Substituted aminoethyl indoles |
| FR2181559A1 (en) * | 1972-04-28 | 1973-12-07 | Aec Chimie Organique Bio | N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity |
| GB1374414A (en) * | 1972-06-12 | 1974-11-20 | Sterling Drug Inc | 1-acyl-3-amino-alkyl-indoles and their preparation |
| US3915990A (en) * | 1973-03-13 | 1975-10-28 | Nelson Res & Dev | Tryptamines |
| US3910953A (en) * | 1973-08-16 | 1975-10-07 | Richter Gedeon Vegyeszet | Process for the preparation of tryptamine or its derivatives |
-
1985
- 1985-12-23 GB GB858531612A patent/GB8531612D0/en active Pending
-
1986
- 1986-12-22 DE DE8686310010T patent/DE3688397T2/de not_active Expired - Lifetime
- 1986-12-22 IE IE337486A patent/IE60126B1/en not_active IP Right Cessation
- 1986-12-22 ES ES86310010T patent/ES2055688T3/es not_active Expired - Lifetime
- 1986-12-22 DK DK625286A patent/DK625286A/da not_active Application Discontinuation
- 1986-12-22 EP EP86310010A patent/EP0233413B1/en not_active Expired - Lifetime
- 1986-12-22 NZ NZ218754A patent/NZ218754A/xx unknown
- 1986-12-22 AU AU66826/86A patent/AU597017B2/en not_active Ceased
- 1986-12-22 ZA ZA869616A patent/ZA869616B/xx unknown
- 1986-12-23 PT PT84014A patent/PT84014B/pt unknown
- 1986-12-23 JP JP61307566A patent/JPS62181252A/ja active Pending
- 1986-12-23 US US06/946,387 patent/US4980368A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0233413B1 (en) | 1993-05-05 |
| EP0233413A3 (en) | 1989-04-26 |
| DK625286D0 (da) | 1986-12-22 |
| DE3688397T2 (de) | 1993-09-09 |
| IE863374L (en) | 1987-06-23 |
| GB8531612D0 (en) | 1986-02-05 |
| JPS62181252A (ja) | 1987-08-08 |
| NZ218754A (en) | 1991-05-28 |
| DK625286A (da) | 1987-06-24 |
| EP0233413A2 (en) | 1987-08-26 |
| AU6682686A (en) | 1987-06-25 |
| ZA869616B (en) | 1988-09-28 |
| AU597017B2 (en) | 1990-05-24 |
| DE3688397D1 (de) | 1993-06-09 |
| PT84014A (en) | 1987-01-01 |
| PT84014B (pt) | 1989-05-31 |
| IE60126B1 (en) | 1994-06-01 |
| US4980368A (en) | 1990-12-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2108727T3 (es) | Derivados de triazolopirimidina con actividad fungicida. | |
| AR011229A1 (es) | Compuestos derivados de adenosina antagonistas en el receptor ai adenosina, procesos para su preparacion, composiciones farmaceuticas que los contieneny su uso en medicina. | |
| ES2040276T3 (es) | Derivados de la indolizina, procedimiento para su preparacion y composiciones que los contienen. | |
| NO905306D0 (no) | Spirocykliske forbindelser som inneholder nitrogen. | |
| ATE106401T1 (de) | Benzodiazepin-analoge. | |
| ES2164758T3 (es) | Derivados de morfolina sustituidos y su uso como agentes terapeuticos. | |
| CO5630036A2 (es) | Nuevos derivados indol con afinidad por el receptor 5-ht6 | |
| ES549542A0 (es) | Un procedimiento para preparar nuevos derivados de benzo- triazol- y benzoxazolamina | |
| ES2113368T3 (es) | Antagonistas de serotonina. | |
| ES2123652T3 (es) | 7-(2-aminoetil)-benzotiazolonas. | |
| ES2055688T3 (es) | Un procedimiento para la preparacion de derivados 3-(2-aminoetil)indoles. | |
| DK1078928T3 (da) | Pyridinderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse | |
| AR007088A1 (es) | 2,4-diaminopirimidinas sustituidas, compuestos intermedios utilizados en su preparacion, procedimiento para la preparacion de dichas 2,4-diaminopirimidinas sustituidas, medicamentos que las contienen y empleos de dichas pirimidinas | |
| MX20222A (es) | Tetrahidrobenzo (c,d)indoles y procedimiento para su preparacion. | |
| NO20000737L (no) | Tetrahydro <gamma>-karboliner | |
| ES2060709T3 (es) | Derivados de piridilo y pirimidilo. | |
| DK226285A (da) | Beta-lactamforbindelser, deres fremstilling og anvendelse som laegemidler eller vaekstfremmende midler til dyr samt mellemprodukter til fremstillingen | |
| ES8802149A1 (es) | Un procedimiento para la preparacion de derivados de piperazinilo 1,4-disustituidos | |
| ES2063117T3 (es) | Derivados del tieno(2,3-d)acepina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. | |
| DE3880022D1 (de) | Cycloalkylamide von (8beta)-1-alkyl-6-(substituierten) ergolinen. | |
| PT83726B (pt) | Processo para preparacao de derivados da beta-carbolina substituidas por grupos fenoxi e de composicoes farmaceuticas que os contem | |
| ES8505369A1 (es) | Un procedimiento para la preparacion de derivados de pirimidona | |
| ES2038159T3 (es) | Procedimiento para preparar derivados sustituidos de 2-aminoacetamida. | |
| ES2123827T3 (es) | Derivados del acido poliamidico con actividad antigastrina, un metodo para su preparacion y su uso farmaceutico. | |
| PT916671E (pt) | Novos inibidores de metaloproteases processo para a sua preparacao e as suas composicoes farmaceuticas que os contem |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 233413 Country of ref document: ES |