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ES2040276T3 - Derivados de la indolizina, procedimiento para su preparacion y composiciones que los contienen. - Google Patents

Derivados de la indolizina, procedimiento para su preparacion y composiciones que los contienen.

Info

Publication number
ES2040276T3
ES2040276T3 ES198787870019T ES87870019T ES2040276T3 ES 2040276 T3 ES2040276 T3 ES 2040276T3 ES 198787870019 T ES198787870019 T ES 198787870019T ES 87870019 T ES87870019 T ES 87870019T ES 2040276 T3 ES2040276 T3 ES 2040276T3
Authority
ES
Spain
Prior art keywords
alkylene
radical
phenyl
derivatives
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787870019T
Other languages
English (en)
Inventor
Jean Gubin
Marcel Descamps
Pierre Chatelain
Dino Nisato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of ES2040276T3 publication Critical patent/ES2040276T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS DERIVADOS DE INDOLICINA DE FORMULA GENERAL (I) EN LA QUE B REPRESENTA UN AGRUPAMIENTO -S-, -SO- O -SO2-; R REPRESENTA EL HIDROGENO, UN ALQUILO, UN CICLOALQUILO O UN FENILO; R1 Y R2, IGUALES O DIFERENTES, REPRESENTAN CADA UNO HIDROGENO, METILO, ETILO O HALOGENO; A REPRESENTA UN ALQUILENO O UN HIDROXI-2-PROPILENO; R3 REPRESENTA UN ALQUILO O UN RADICAL DE FORMULA: -ALK-R5 EN LA QUE ALK REPRESENTA UN ENLACE SIMPLE O UN RADICAL ALQUILENO, R5 REPRESENTA UN RADICAL PIRIDINO, FENILO, METILENODIOXI-2,3 FENILO, METILENODIOXI-3,4 FENILO O UN AGRUPAMIENTO FENILO; R4 REPRESENTA EL HIDROGENO O UN ALQUILO; O R3 Y R4, CUANDO SE HAN PUESTO JUNTOS, REPRESENTAN UN RADICAL ALQUILENO O ALQUENILENO. APLICACION: TRATAMIENTO DE CIERTOS SINDROMES PATOLOGICOS DEL SISTEMA CARDIOVASCULAR.
ES198787870019T 1986-02-14 1987-02-10 Derivados de la indolizina, procedimiento para su preparacion y composiciones que los contienen. Expired - Lifetime ES2040276T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8602045A FR2594438B1 (fr) 1986-02-14 1986-02-14 Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant

Publications (1)

Publication Number Publication Date
ES2040276T3 true ES2040276T3 (es) 1993-10-16

Family

ID=9332147

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787870019T Expired - Lifetime ES2040276T3 (es) 1986-02-14 1987-02-10 Derivados de la indolizina, procedimiento para su preparacion y composiciones que los contienen.

Country Status (33)

Country Link
US (5) US4957925A (es)
EP (1) EP0235111B1 (es)
JP (1) JP2547004B2 (es)
KR (1) KR870007931A (es)
AR (1) AR245127A1 (es)
AT (1) ATE62485T1 (es)
AU (1) AU587525B2 (es)
BE (1) BE1006666A4 (es)
CA (1) CA1310965C (es)
CZ (1) CZ281209B6 (es)
DD (1) DD264436A5 (es)
DE (1) DE3769174D1 (es)
DK (1) DK170403B1 (es)
ES (1) ES2040276T3 (es)
FI (1) FI84353C (es)
FR (1) FR2594438B1 (es)
GR (1) GR3001883T3 (es)
HU (1) HU196401B (es)
IE (1) IE59656B1 (es)
IL (1) IL81358A (es)
MA (1) MA20878A1 (es)
MY (1) MY101541A (es)
NO (1) NO165344C (es)
NZ (1) NZ219274A (es)
OA (1) OA08481A (es)
PH (1) PH24830A (es)
PL (2) PL152609B1 (es)
PT (1) PT84277B (es)
SK (1) SK279557B6 (es)
SU (2) SU1486064A3 (es)
TN (1) TNSN87021A1 (es)
YU (2) YU21287A (es)
ZA (1) ZA87471B (es)

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* Cited by examiner, † Cited by third party
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FR2594438B1 (fr) * 1986-02-14 1990-01-26 Labaz Sanofi Nv Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
US5182291A (en) * 1986-02-14 1993-01-26 Sanofi Pyrozala-pyridyl aminoabkoxyphenol compounds
US5215988A (en) * 1986-02-14 1993-06-01 Sanofi Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same
IL87181A (en) * 1987-08-07 1993-08-18 Sanofi Sa Aminoalkoxyphenyl derivatives, their preparation and pharmaceutical and veterinary compositions containing them
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FR2642755B1 (es) * 1989-02-07 1993-11-05 Sanofi
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Also Published As

Publication number Publication date
SU1528321A3 (ru) 1989-12-07
MY101541A (en) 1991-12-17
DK170403B1 (da) 1995-08-21
BE1006666A4 (fr) 1994-11-16
SK97787A3 (en) 1998-12-02
DK74087A (da) 1987-08-15
MA20878A1 (fr) 1987-10-01
FI870629A7 (fi) 1987-08-15
HU196401B (en) 1988-11-28
DD264436A5 (de) 1989-02-01
JPS62192380A (ja) 1987-08-22
IL81358A (en) 1991-03-10
JP2547004B2 (ja) 1996-10-23
FI84353B (fi) 1991-08-15
FR2594438A1 (fr) 1987-08-21
AU587525B2 (en) 1989-08-17
YU46588A (en) 1989-08-31
US4994474A (en) 1991-02-19
DK74087D0 (da) 1987-02-13
DE3769174D1 (de) 1991-05-16
PT84277B (pt) 1989-09-14
NO870579L (no) 1987-08-17
NZ219274A (en) 1989-04-26
CZ97787A3 (en) 1996-07-17
PH24830A (en) 1990-10-30
IE59656B1 (en) 1994-03-09
YU21287A (en) 1988-08-31
EP0235111B1 (fr) 1991-04-10
US5147878A (en) 1992-09-15
KR870007931A (ko) 1987-09-23
CA1310965C (en) 1992-12-01
HUT43604A (en) 1987-11-30
US5039700A (en) 1991-08-13
US5017579A (en) 1991-05-21
NO165344B (no) 1990-10-22
OA08481A (fr) 1988-07-29
ZA87471B (en) 1988-09-28
PT84277A (en) 1987-03-01
EP0235111A1 (fr) 1987-09-02
AU6884687A (en) 1987-08-20
CZ281209B6 (cs) 1996-07-17
ATE62485T1 (de) 1991-04-15
PL264078A1 (en) 1988-07-21
FR2594438B1 (fr) 1990-01-26
IL81358A0 (en) 1987-08-31
PL152609B1 (en) 1991-01-31
AR245127A1 (es) 1993-12-30
NO165344C (no) 1991-01-30
US4957925A (en) 1990-09-18
SK279557B6 (sk) 1998-12-02
FI84353C (fi) 1991-11-25
TNSN87021A1 (fr) 1990-01-01
SU1486064A3 (ru) 1989-06-07
IE870345L (en) 1987-08-14
NO870579D0 (no) 1987-02-13
FI870629A0 (fi) 1987-02-13
GR3001883T3 (en) 1992-11-23
PL153650B1 (en) 1991-05-31

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