[go: up one dir, main page]

ES2046083A1 - Procedimiento para preparar composiciones de liberacion prolongada. - Google Patents

Procedimiento para preparar composiciones de liberacion prolongada.

Info

Publication number
ES2046083A1
ES2046083A1 ES9101785A ES9101785A ES2046083A1 ES 2046083 A1 ES2046083 A1 ES 2046083A1 ES 9101785 A ES9101785 A ES 9101785A ES 9101785 A ES9101785 A ES 9101785A ES 2046083 A1 ES2046083 A1 ES 2046083A1
Authority
ES
Spain
Prior art keywords
compositions
preparation process
sustained release
particles
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9101785A
Other languages
English (en)
Other versions
ES2046083B1 (es
Inventor
Ruiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of ES2046083A1 publication Critical patent/ES2046083A1/es
Application granted granted Critical
Publication of ES2046083B1 publication Critical patent/ES2046083B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Glanulating (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE COMPOSICIONES DE LIBERACION PROLONGADA, EN EL QUE SE PREPARAN PARTICULAS DISEÑADAS PARA LIBERAR UNA CANTIDAD EFICAZ DE INGREDIENTE ACTIVO DURANTE UN PERIODO DE TIEMPO PREDETERMINADO, COMPRENDIENDO DICHAS PARTICULAS UNO O MAS INGREDIENTES ACTIVOS MEZCLADOS CON UN POLIMERO O COPOLIMERO BIORRESORBIBLE Y/O BIODEGRADABLE, Y LAS PARTICULAS ASI OBTENIDAS EN UNA FORMA SUSTANCIALMENTE ESFEROIDAL Y SUSTANCIALMENTE EXENTAS DE INGREDIENTE ACTIVO EN EL REVESTIMIENTO EXTERNO.
ES09101785A 1990-08-01 1991-07-30 Procedimiento para preparar composiciones de liberacion prolongada. Expired - Fee Related ES2046083B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909016885A GB9016885D0 (en) 1990-08-01 1990-08-01 Sustained release pharmaceutical compositions

Publications (2)

Publication Number Publication Date
ES2046083A1 true ES2046083A1 (es) 1994-01-16
ES2046083B1 ES2046083B1 (es) 1994-08-01

Family

ID=10679993

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09101785A Expired - Fee Related ES2046083B1 (es) 1990-08-01 1991-07-30 Procedimiento para preparar composiciones de liberacion prolongada.

Country Status (30)

Country Link
US (1) US5213812A (es)
JP (1) JP2818704B2 (es)
KR (1) KR920003962A (es)
AT (1) AT396425B (es)
AU (2) AU649696B2 (es)
BE (1) BE1004772A3 (es)
CA (1) CA2048270C (es)
CH (1) CH682715A5 (es)
DE (1) DE4125542A1 (es)
DK (1) DK175756B1 (es)
ES (1) ES2046083B1 (es)
FI (1) FI104149B (es)
FR (1) FR2665360B1 (es)
GB (1) GB9016885D0 (es)
GR (1) GR1001512B (es)
HK (1) HK33294A (es)
IE (1) IE65124B1 (es)
IN (1) IN178446B (es)
IT (1) IT1251788B (es)
LU (1) LU87982A1 (es)
MA (1) MA22245A1 (es)
MY (1) MY107500A (es)
NL (1) NL194637C (es)
NO (1) NO300158B1 (es)
NZ (1) NZ238981A (es)
OA (1) OA09387A (es)
PT (1) PT98497B (es)
SE (1) SE505734C2 (es)
TN (1) TNSN91067A1 (es)
ZA (1) ZA915565B (es)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
GB9310030D0 (en) * 1993-05-15 1993-06-30 Scras Dry processed particles and process for the preparation of the same
US5569467A (en) * 1993-05-15 1996-10-29 Societe De Conseils De Recherches Et D'applications (S.C.R.A.S.) Process for the preparation of microballs and microballs thus obtained
EP0740548B1 (en) * 1994-02-28 2002-12-04 Nanopharm AG Drug targeting system, method for preparing same and its use
US5980945A (en) * 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
DE19604744A1 (de) 1996-02-09 1997-08-14 Henkel Kgaa Technische Di-/Triglyceridgemische
DE19617137C1 (de) * 1996-04-29 1997-02-27 Henkel Kgaa Verwendung von Copolymerestern für die Herstellung von Mikrosphären
EP0930874A2 (en) * 1996-10-09 1999-07-28 Takeda Chemical Industries, Ltd. A method for producing a microparticle
AR012448A1 (es) * 1997-04-18 2000-10-18 Ipsen Pharma Biotech Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada
AU3555599A (en) 1998-04-13 1999-11-01 Luminex Corporation Liquid labeling with fluorescent microparticles
CN1195497C (zh) * 1998-12-16 2005-04-06 阿温蒂斯药物公司 生物可降解聚合物包封的5－羟色胺受体拮抗剂及其制备方法
AU5644400A (en) * 1999-09-24 2001-03-29 Rohm And Haas Company Pellet compositions
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
ES2326209T3 (es) 2000-10-27 2009-10-05 Baxter Healthcare S.A. Produccion de microesferas.
US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
PT1418890E (pt) * 2001-08-16 2008-06-09 Baxter Int Formulações de micropartículas à base de propulsor
US20040166077A1 (en) * 2002-12-04 2004-08-26 L'oreal Process for treating keratin materials with aromatic active principles
FR2848113B1 (fr) * 2002-12-04 2005-02-25 Oreal Stabilisation de principes actifs aromatiques par des polymeres aromatiques
AU2004280158B2 (en) * 2003-07-18 2011-02-17 Baxter International, Inc. Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
EP1646354A4 (en) * 2003-07-22 2010-03-17 Baxter Int SMALL SPHERICAL PARTICLES OF LOW MOLECULAR WEIGHT MOLECULES AND PROCESSES FOR THEIR PREPARATION AND USE
US20060135277A1 (en) * 2003-09-10 2006-06-22 Marnocha Bendict F Golf club and practice arrangement
FR2865938B1 (fr) * 2004-02-05 2006-06-02 Sod Conseils Rech Applic Formulation retard solide comprenant de l'acetate de triptoreline
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
WO2005112893A1 (en) * 2004-05-12 2005-12-01 Baxter International Inc. Microspheres comprising protein and showing injectability at high concentrations of said agent
DK1765294T3 (da) 2004-05-12 2008-11-10 Baxter Int Nukleinsyremikrokugler samt deres fremstilling og afgivelse
DK1758558T3 (da) * 2004-05-12 2014-01-20 Baxter Int Oligonukleotidholdige mikrokugler samt deres anvendelse til fremstilling af et medikament til behandling af diabetes type 1
AU2005271781A1 (en) * 2004-07-13 2006-02-16 Altairnano, Inc. Ceramic structures for prevention of drug diversion
EP1773264A1 (en) * 2004-07-13 2007-04-18 Altairnano, Inc Ceramic structures for controlled release of drugs
JP2008528443A (ja) * 2004-10-29 2008-07-31 アドヒーシブズ・リサーチ・インコーポレイテッド セキュリティ・アイデンティフィケーションのための微視的なタグ付けシステム
EP1885335A1 (en) * 2005-04-27 2008-02-13 BAXTER INTERNATIONAL INC. (a Delaware corporation) Surface-modified microparticles and methods of forming and using the same
AU2006283170A1 (en) * 2005-08-23 2007-03-01 Altairnano, Inc. Highly photocatalytic phosphorus-doped anatase-TiO2 composition and related manufacturing methods
WO2007103820A1 (en) * 2006-03-02 2007-09-13 Altairnano, Inc. Nanostructured indium-doped iron oxide
US20080044638A1 (en) * 2006-03-02 2008-02-21 Fred Ratel Nanostructured Metal Oxides
US20080038482A1 (en) * 2006-03-02 2008-02-14 Fred Ratel Method for Low Temperature Production of Nano-Structured Iron Oxide Coatings
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
CN105168146A (zh) * 2006-08-04 2015-12-23 巴克斯特国际公司 预防和/或逆转新发作自身免疫糖尿病的基于微球的组合物
CA2663589A1 (en) * 2006-10-06 2008-05-22 Baxter International Inc. Microencapsules containing surface-modified microparticles and methods of forming and using the same
CA2702340C (en) 2006-10-12 2014-12-16 The University Of Queensland Compositions and methods for modulating immune responses
US20090169628A1 (en) * 2006-10-17 2009-07-02 Armark Authentication Technologies, Llc Article and method for focused delivery of therapeutic and/or diagnostic materials
WO2008128000A1 (en) * 2007-04-12 2008-10-23 Altairnano, Inc. Teflon replacements and related production methods
MX2009011218A (es) * 2007-04-17 2010-02-11 Baxter Int Microparticulas de acido nucleico para administracion pulmonar.
US9782300B2 (en) 2008-02-01 2017-10-10 Kci Licensing, Inc. Fiber-microsphere bioresorbable composite scaffold for wound healing
CN102007213B (zh) 2008-04-18 2014-08-06 巴克斯特国际公司 用于预防和/或逆转新发作的自身免疫性糖尿病的基于微球的组合物
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US20100078848A1 (en) * 2008-09-29 2010-04-01 Armark Authentication Technologies, Llc Spinneret and method of spinning fiber
US20100291214A1 (en) * 2008-12-23 2010-11-18 Armark Authentication Technologies, Llc Three-dimensional microfiber extrudate structure and process for forming three-dimensional microfiber extrudate structure
WO2010132763A1 (en) * 2009-05-15 2010-11-18 Armark Authentication Technologies, Llc Fiber having non-uniform composition and method for making same
WO2010138193A2 (en) 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents
US20110076771A1 (en) * 2009-09-25 2011-03-31 Armark Authentication Technologies, Llc Tissue fiber scaffold and method for making
WO2011150264A2 (en) 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Synthetic nanocarrier combination vaccines
EP2399931A1 (fr) * 2010-06-22 2011-12-28 Ipsen Pharma S.A.S. Nouveaux composés octapeptidiques et leur utilisation thérapeutique
DK2635596T3 (da) 2010-11-01 2019-11-25 Univ Sydney Technology Immun-moduleringsmidler og anvendelser dertil
CA2843274A1 (en) 2011-07-29 2013-02-07 Selecta Biosciences, Inc. Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses
EP4198059A1 (en) 2014-05-27 2023-06-21 The University of Queensland Modulation of cellular stress
FR3067226B1 (fr) * 2017-06-13 2021-10-08 Rossignol Lange Element de chaussure de ski

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4767628A (en) * 1981-02-16 1988-08-30 Imperial Chemical Industries Plc Continuous release pharmaceutical compositions
US4844910A (en) * 1986-12-02 1989-07-04 Euroceltique, S.A. Spheroids
US4867925A (en) * 1985-04-04 1989-09-19 Akzo N.V. Process for the manufacture of polyester industrial yarn
EP0366058A2 (en) * 1988-10-27 1990-05-02 Abbott Laboratories Controlled-release delivery device, method for producing device, and method of using device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3567650A (en) * 1969-02-14 1971-03-02 Ncr Co Method of making microscopic capsules
US4010125A (en) * 1975-06-12 1977-03-01 Schally Andrew Victor [D-Trp6 ]-LH-RH and intermediates therefor
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4666705A (en) * 1985-06-03 1987-05-19 E. R. Squibb & Sons, Inc. Controlled release formulation
GB8705083D0 (en) * 1987-03-04 1987-04-08 Euro Celtique Sa Spheroids

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4767628A (en) * 1981-02-16 1988-08-30 Imperial Chemical Industries Plc Continuous release pharmaceutical compositions
US4767628B1 (es) * 1981-02-16 1990-07-17 Ici Plc
US4867925A (en) * 1985-04-04 1989-09-19 Akzo N.V. Process for the manufacture of polyester industrial yarn
US4844910A (en) * 1986-12-02 1989-07-04 Euroceltique, S.A. Spheroids
EP0366058A2 (en) * 1988-10-27 1990-05-02 Abbott Laboratories Controlled-release delivery device, method for producing device, and method of using device

Also Published As

Publication number Publication date
IE65124B1 (en) 1995-10-04
AU649696B2 (en) 1994-06-02
JPH05178740A (ja) 1993-07-20
OA09387A (fr) 1992-09-15
ZA915565B (en) 1992-04-29
SE9102249D0 (sv) 1991-07-26
PT98497B (pt) 1997-10-31
PT98497A (pt) 1992-06-30
GR910100330A (en) 1992-08-31
HK33294A (en) 1994-04-22
IT1251788B (it) 1995-05-26
SE505734C2 (sv) 1997-10-06
NL194637C (nl) 2002-10-04
NO300158B1 (no) 1997-04-21
DK141891A (da) 1992-02-02
MY107500A (en) 1995-12-30
NL194637B (nl) 2002-06-03
NO912986L (no) 1992-02-03
ES2046083B1 (es) 1994-08-01
BE1004772A3 (fr) 1993-01-26
DK175756B1 (da) 2005-02-14
NL9101306A (nl) 1992-03-02
ITMI911953A0 (it) 1991-07-15
IE912700A1 (en) 1992-02-12
FR2665360B1 (fr) 1995-02-10
AU666808B2 (en) 1996-02-22
GB9016885D0 (en) 1990-09-12
TNSN91067A1 (fr) 1992-10-25
AU5939394A (en) 1994-06-02
NZ238981A (en) 1992-11-25
LU87982A1 (fr) 1992-04-15
SE9102249L (sv) 1992-02-02
KR920003962A (ko) 1992-03-27
IN178446B (es) 1997-05-03
DE4125542A1 (de) 1992-02-06
CA2048270C (en) 1997-02-25
ATA152591A (de) 1993-01-15
GR1001512B (el) 1994-02-28
AT396425B (de) 1993-09-27
JP2818704B2 (ja) 1998-10-30
FI913646A0 (fi) 1991-07-31
US5213812A (en) 1993-05-25
FR2665360A1 (fr) 1992-02-07
DK141891D0 (da) 1991-07-31
ITMI911953A1 (it) 1993-01-15
AU8146691A (en) 1992-02-06
MA22245A1 (fr) 1992-04-01
NO912986D0 (no) 1991-07-31
FI104149B1 (fi) 1999-11-30
FI913646L (fi) 1992-02-02
CH682715A5 (fr) 1993-11-15
CA2048270A1 (en) 1992-02-02
FI104149B (fi) 1999-11-30

Similar Documents

Publication Publication Date Title
ES2046083A1 (es) Procedimiento para preparar composiciones de liberacion prolongada.
CA2011171A1 (en) Biodegradable Poly (Phosphate Esters)
CA2088778A1 (en) Transdermal contraceptive formulations, methods and devices
ZA875897B (en) Estradiol implant composition and method for preparation
DE3378250D1 (en) Continuous release formulations
DK0486563T3 (da) Tyggegummipræparat med fremskyndet reguleret frigivelse af virksomme stoffer
NO983825D0 (no) Dosering av ibuprofen
CA2161903A1 (en) Polymer Composition, Absorbent Material Composition, Their Production and Use
ES8302031A1 (es) Un procedimiento para la preparacion de una composicion pesticida solida.
CA2073791A1 (en) Fabric Care Composition Comprising Water Soluble or Water Dispersible Copolymer Containing UV-Absorbing Monomer
IL109186A0 (en) Stable, ingestable and absorbable nadh and nadph therapeutic compositions
IL115138A0 (en) Implantable polymer-containing molded articles for the administration of active substances to plants and processes for the preparation thereof
IL52395A (en) Highly absorbent graft copolymer compositions derived from flour or meal and their preparation
AU3259099A (en) Pharmaceutical composition based on natural synthesis progesterone and oestradiol and preparation method
CA2197544A1 (en) Fungicidal composition comprising metalaxyl and fludioxonil
EP1275379A3 (en) Basic granulate comprising (7 alpha, 17 alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-one
IL106288A0 (en) Skin regenerating cosmetic compositions
IL96409A0 (en) Biodegradable,water-soluble polycarboxylic acid copolymers,compositions containing them,and their use
GR3018795T3 (en) Emulsion-free emulsion polymers in sustained-release pharmaceutical compositions and their production
BG100651A (en) Cardiovascular solid batched medicamentous forms of delayedrelease
NZ500150A (en) Controlled granular release pesticidal compositions containing a protectant such as sulphur, a fatty acid or citric acid
JPS52104567A (en) Thermoplastic resin compositions
MX9705611A (es) Composiciones farmaceuticas en forma de tabletas de liberacion prolongada con base de granulos polisacaridos de alto peso molecular.

Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20110819