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EP2801355A1 - Compositions pharmaceutiques à libération contrôlée comportant un ester d'acide fumarique - Google Patents

Compositions pharmaceutiques à libération contrôlée comportant un ester d'acide fumarique Download PDF

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Publication number
EP2801355A1
EP2801355A1 EP20140172398 EP14172398A EP2801355A1 EP 2801355 A1 EP2801355 A1 EP 2801355A1 EP 20140172398 EP20140172398 EP 20140172398 EP 14172398 A EP14172398 A EP 14172398A EP 2801355 A1 EP2801355 A1 EP 2801355A1
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EP
European Patent Office
Prior art keywords
fumaric acid
composition
acid ester
active substance
hours
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20140172398
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German (de)
English (en)
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EP2801355B1 (fr
Inventor
Henrik Nilsson
Florian SCHÖNHARTING
Bernd W. MÜLLER
Joseph R. Robinson
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FWP IP ApS
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Forward Pharma AS
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Priority to PL14172398T priority Critical patent/PL2801355T3/pl
Priority to SI200531993T priority patent/SI2801355T1/sl
Priority to MEP-2015-540A priority patent/ME02253B/fr
Priority to DE14172398.1T priority patent/DE14172398T1/de
Application filed by Forward Pharma AS filed Critical Forward Pharma AS
Publication of EP2801355A1 publication Critical patent/EP2801355A1/fr
Publication of EP2801355B1 publication Critical patent/EP2801355B1/fr
Application granted granted Critical
Priority to CY20151100679T priority patent/CY1116599T1/el
Priority to HUS1500057C priority patent/HUS1500057I1/hu
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
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Definitions

  • Fumaric acid esters i.e. dimethylfumarate in combination with ethylhydrogenfumarat have been used in the treatment of psoriasis for many years.
  • the combination is marketed under the tradename Fumaderm®. It is in the form of tablets intended for oral use and it is available in two different dosage strengths (Fumaderm® initial and Fumaderm®): Fumaderm® Initial Fumaderm® Dimethylfumarate 30 mg 120 mg Ethylhydrogenfumarate, calcium salt 67 mg 87 mg Ethylhydrogenfumarate, Magnesium salt 5 mg 5 mg Etylhydrogenfumarate, Zinc salt 3 mg 3 mg 3 mg
  • the present invention relates in a further aspect to a controlled release pharmaceutical composition for oral use comprising as an active substance one or more fumaric acid esters selected from di-(C 1 -C 5 )alkylesters of fumaric acid and mono-(C 1 -C 5 )alkylesters of fumaric acid, or a pharmaceutically acceptable salt thereof, wherein the release of the fumaric acid ester - when subjected to an in vitro dissolution test employing 0.1 N hydrochloric acid as dissolution medium during the first 2 hours of the test and then 0.05 M phosphate buffer pH 6.5 as dissolution medium - is as follows:
  • mice e.g. mice, rats, dogs etc.
  • the animals receive the compositions under investigation and after specified periods of time, the animals are sacrificed and the content of the active ingredient (or metabolite thereof, if relevant) is determined in plasma or specific organs or extracted from the intestinal contents.
  • the active substance in a composition of the invention is any fumaric acid ester.
  • the fumaric acid ester is preferably selected from the group consisting of dimethylfumarate, diethylfumarate, dipropylfumarate, dibutylfumarate, dipentylfumarate, methyl-ethylfumarate, methyl-propylfumarate, methyl-butylfumarate, methyl-pentylfumarate, monomethylfumarate, monoethylfumarate, monopropylfumarate, monobutylfumarate and monopentylfumarate, including pharmaceutically acceptable salts thereof.
  • a further specific example of a suitable formulation comprises the formulation of the active substance together with Vitamin E concentrate in soft or hard gelatin capsules.
  • This formulation in a modified form, is the basis of the commercial cyclosporine product, Neoral ® , containing, among other things, corn oil-mono-di-triglycerides, polyoxyl 40 hydrogenated castor oil NF, DL- ⁇ -tocopherol USP (part of the vitamin E family), gelatin NF, glycerol, Iron oxide black, propylene glycol USP, titanium dioxide USP, carmine, and alcohol in addition to cyclosporine.
  • Neoral ® containing, among other things, corn oil-mono-di-triglycerides, polyoxyl 40 hydrogenated castor oil NF, DL- ⁇ -tocopherol USP (part of the vitamin E family), gelatin NF, glycerol, Iron oxide black, propylene glycol USP, titanium dioxide USP, carmine, and alcohol in addition to cyclosporine
  • a further example of a suitable formulation Is an oral pulsed dose drug delivery system.
  • This dosage form can be perceived as a modified form of the Schering Repetab tablets.
  • a portion of the composition of the present invention is put in the core of a tablet.
  • a controlled release pharmaceutical composition for oral use comprising as an active substance one or more fumaric acid esters selected from di-(C 1 -C 5 )alkylesters of fumaric acid and mono-(C 1 -C 5 )alkylesters of fumaric acid, or a pharmaceutically acceptable salt thereof, characterized in that it consists of a controlled-release dosage form adapted to release di-(C 1 -C 5 )alkylester and/or a mono-(C 1 -C 5 )alkylester of fumaric acid or a pharmaceutically acceptable salt thereof over a predetermined time period, according to a in vitro profile of dissolution when measured according to USP.
  • composition of the simulated intestinal fluid can e.g. be found in the United States Pharmacopeia (USP) 2005:
  • the invention relates to a controlled release pharmaceutical composition for oral use comprising as an active substance one or more fumaric acid esters selected from di-(C 1 -C 5 )alkylesters of fumaric acid and mono-(C 1 -C 5 )alkylesters of fumaric acid, or a pharmaceutically acceptable salt thereof, wherein the release of the fumaric acid ester - when subjected to an in vitro dissolution test employing water as dissolution medium - is as follows:
  • the invention relates to a controlled release pharmaceutical composition for oral use comprising as an active substance one or more fumaric acid esters selected from di-(C 1 -C 5 )alkylesters of fumaric acid and mono-(C 1 -C 5 )alkylesters of fumaric acid, or a pharmaceutically acceptable salt thereof, wherein the release of the fumaric acid ester - when subjected to an In vitro dissolution test employing water as dissolution medium - is as follows:
  • W 50 i.e. the time period in which the plasma concentration is 50% of C max or more
  • W 50 is prolonged compared to the marketed treatment with at least 10% such as, e.g. at least 20%, at least 30%, at least 40% or at least 50%.
  • a suitable W 50 is believed to be at least 2 hours such as in a range of from about 2 to about 15 hours or from about 2.5 to about 10 hours or from about 3 to about 8 hours.
  • One aspect of the invention relates to a zero-order dissolution release profile. Another aspect relates to a first-order dissolution release profile. A further aspect relates to a square-root (Higuchi's equation) dissolution release profile.
  • Examples of “pharmaceutically acceptable polymer(s)” comprises but are not limited to ethylcellulose, or methacrylic/acrylic acid copolymers, such as ammonio methacrylate copolymer type A and B or methacrylic acid copolymer A and B.
  • Hydrophilic excipients such as polyethylene glycol (PEG), povidone, hydroxyl propyl cellulose (HPC), hydroxyethyl starch (HES) or hydroxypropyl methyl cellulose (HPMC) at a concentration of about 1 to about 40 % and/or pharmaceutical acceptable surfactants with HLB values above 8 at a concentration of about 0.01 to about 3% may be incorporated.
  • PEG polyethylene glycol
  • HPC hydroxyl propyl cellulose
  • HES hydroxyethyl starch
  • HPMC hydroxypropyl methyl cellulose
  • Crystallization is performed in any suitable organic solvent for re-crystallisation, such as isopropanol, at an appropriate temperature such as e.g. between +70°C and -20°C.
  • a hydrocolloid e.g. HPMC
  • a surfactant e.g. polysorbate
  • Any granulating/coating excipient such as pharmaceutically acceptable polymers, may be used e.g. ethylcellulose at a concentration of about 10 to about 50%, especially about 20 to about 35%, polymethacryllates such as ammonio methacrylate copolymer type A and B or methacrylic acid copolymer A and B.
  • a hydrophilic excipient mention can be made of e.g PEG 400.
  • kits containing two or more containers e.g. with compositions having various amounts of the fumaric acid included. Such kits are suitable for use in those situations where an increasing dosage is required over time.
  • Week Morning Noon Evening Strength 1 1 - - A 2 1 - 1 A 3 1 - 1 B 4 1 - - B 5 1 - 1 B 6 1 1 1 B 7 2 1 1 B 8 2 1 2 B 9 2 2 2 B A corresponds to a low strength such as about 30 mg dimethylfumarate (or a corresponding effective dose of another fumaric acid ester)
  • B corresponds to a higher strength such as about 120 mg dimethylfumarate (or a corresponding effective dose of another fumaric acid ester)
  • compositions and kits according to the invention are contemplated to be suitable to use in the treatment of one or more of the following conditions:
  • novel composition or kit according to the invention may be used in the treatment of
  • Psoriasis has been proposed to potentially be associated with Crohn's disease ( Najarian DJ, Gottlieb AB, Connections between psoriasis and Crohn's disease. J Am Acad Dermatol. 2003 Jun;48(6):805-21 ), celiac disease ( Ojetti V et al, High prevalence of celiac disease in psoriasis. Am J Gastroenterol. 2003 Nov;98(11):2574-5 .), psychiatric or psychological disease, such as depression or a life crisis ( Gupta MA, Gupta AK, Psychiatric and psychological co-morbidity in patients with dermatologic disorders: epidemiology and management. Am J Clin Dermatol.
  • the present invention thus relates in one aspect to a method of treating psoriasis, psoriatic arthritis, neurodermatitis, inflammatory bowel disease, such as Crohn's disease and ulcerative colitis, autoimmune diseases, such as polyarthritis, multiple sclerosis (MS); juvenile-onset diabetes mellitus, Hashimoto's thyroiditis, Grave's disease, SLE (systemic lupus erythematosus), Sjögren's syndrome, Pernicious anemia, Chronic active (lupoid) hepatitis, Rheumatoid arthritis (RA) and optic neuritis, pain such as radicular pain, pain associated with radiculopathy, neuropathic pain or sciatica/sciatic pain, organ transplantation (prevention of rejection), sarcoidosis, necrobiosis lipoidica or granuloma annulare, which method comprises administering orally to a patient in need thereof, an effective dosage of a controlled release pharmaceutical composition according the
  • the invention also relates to treating an individual suffering from one of the conditions in the abovementioned lists, more specifically psoriasis or psoriatic arthritis, with a composition or kit according to the invention, said individual further being in treatment with
  • the active substance is a fumaric acid ester containing compound.
  • the fumaric ester containing compound is any and all of the salts contained in Fumaderm ® or Fumaraat ® or Panaclar ® (BG-12) or described in US 6,277,882 , US 6,355,676 or US 6,509,376 or a formulation according to the present invention.
  • the active pharmaceutical ingredient may be provided in a formulation according to the present invention,or any Fumaderm ® or Fumaraat ® or Panaclar ® formulation or as e.g. described In US 6,277,882 , US 6,355,676 or US 6,509,376 .
  • Ethylcellulose e.g. Ethocel ® NF premium
  • Polyethylenglycole 400 which is dissolved in 150 ml Ethanol 96%, passed through a 1,0 mm sieve, dried at 50° to 60°C over 30 min and again passed through a sieve 1,0 mm.
  • a placebo granulate is prepared as follows: Tablettose ® and Avicel ® 102 are mixed in equal shares and granulated with 2% povidone (e.g.
  • a saturated solution of 50 g DMF in 300 ml 2-propanol is prepared at 60°C and slowly cooled under permanent stirring.
  • the precipitated crystals are filtered off and dried at 50°C.
  • the crystals are sieved and the 315 - 710 ⁇ m fraction is used for a coating process in either a pan coater or a fluid-bed coater (Mini-Glatt).
  • a coating solution of 12 g ethyl cellulose (e.g. Ethocel ® NF premium) and 3 g hydroxylpropylcellulose (HPC) in 500 g ethanol is sprayed at 60 °C onto the powder surface. After drying the coated crystals are sieved through a 1.00 mm sieve.
  • These coated DMF crystals can be manufactured to tablets and capsules using the processes described in Examples 2 and 3.
  • Example 15 50 g DMF crystals prepared as described in Example 15 are coated in a fluid-bed coater (Mini-Glatt) at a temperature of 80°C with 20 g of an aqueous dispersion of a 1:1 mixture of Eudragit ® RL30D/RS30D. These coated DMF crystals are manufactured to tablets and capsules using the processes described in Examples 2 and 3.
  • a fluid-bed coater Mini-Glatt
  • DMF crystals prepared as described in Example 15 are coated in a fluid-bed coater (Mini-Glatt) with an amount of 5% (related to the mass of the crystals) aqueous dispersion of polyvinyl acetate (e.g. Kollicoat ® SR 30D). These coated DMF crystals can be manufactured to tablets and capsules using the processes described in Examples 2 and 3.
  • diethylfumarate (DEF) is mixed with 15% ethyl cellulose (e.g. Ethocel ® NF premium) which is dissolved in an appropriate amount of ethanol 96%.
  • ethyl cellulose e.g. Ethocel ® NF premium
  • polyethylene glycole 6000 is added to the granulation liquid.
  • the mixture is passed through a sieve 1.00 mm and dried at 50° to 60°C for 30 min.
  • a granulate is prepared as described in Example 24 but instead of PEG 6000, 10% of povidone (e.g. Kollidon ® 25) is added. This mixture can be manufactured to tablets or capsules using the processes described in Examples 1 and 3.
  • povidone e.g. Kollidon ® 25
  • a granulate is prepared as described in Example 24 but instead of PEG 6000, 10% hydroxyl propyl methylcellulose is added. This mixture can be manufactured to tablets or capsules using the processes described in Examples 1 and 3.
  • the dissolution profile is determined as described in the United States Pharmacopoeia using a rotating basket with 6 so called Levy-glasses with a capacity of 1 liter and 6 basket stirring elements powered by an electric motor (at 100 rpm).
  • the Levy-glasses are filled with 0,1N HCl (the water bath has a temperature of 37°C+/- 0.5°C) and the capsules are applied to the baskets. After 2 hours, the acid Is removed from the vessels and replaced with dissolution medium (USP phosphate buffer, pH 6.5) and tested for another 6 hours.
  • dissolution medium USP phosphate buffer, pH 6.5
  • Samples (5ml) are taken after 0, 60 and 120 minutes from the acid medium, and after 30, 60, 90, 120, 180, 240, 300 and 360 minutes from the buffer medium after replacing the dissolution medium with USP buffer. Instead of replacing the amount of drawn buffer solution after each sample, the loss of buffer is taken into account when calculating the amount of released DMF.
  • the amount of DMF is determined by HPLC (Kontron XXX) using a Merck LIChroCART RP8 5 ⁇ M, 20 cm column, tempered at 25 °C.
  • the mobile phase consists of a mixture (35:65) of acetonitrile and 0.0725 mol/l NaH 2 PO 4 *H 2 0-buffer adjusted to pH 3.2 with phosphoric acid.
  • the UV detector is set at a wavelength of 230 nm and a flow rate of 1.0 ml per minute.
  • the DMF peak is detectable after a retention time of about 5 min.
  • the dissolution profile is determined using 6 so called Levy-glasses with a capacity of 1 liter and 6 paddles as stirring elements powered by an electric motor.
  • the rotating speed of the paddles Is 100 rpm.
  • the Levy-glasses are filled with USP phosphate buffer, pH 6.5 (the water bath has a temperature of 37°C+/- 0.5°C) and the tables are into the Levy-glasses.
  • Samples (5ml) are taken after 0, 30, 60, 90, 120, 180, 240, 300 and 360 minutes from the buffer medium after replacing the dissolution medium with USP buffer. Instead of replacing the amount of drawn buffer solution after each sample, the loss of buffer is taken into account when calculating the amount of released DMF.
  • the dissolution profile of capsules prepared as described in Example 5 is determined as described in Example 30.
  • the dissolution profile of the tablets (before the enteric coating is applied) prepared as described in example 16 is determined as described in Example 31.
  • the dissolution profile is shown in Figure 2 .

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PL14172398T PL2801355T3 (pl) 2004-10-08 2005-10-07 Kompozycje farmaceutycznie o kontrolowanym uwalnianiu zawierające ester kwasu fumarowego
SI200531993T SI2801355T1 (sl) 2004-10-08 2005-10-07 Farmacevtski sestavki z nadziranim sproščanjem, ki obsegajo ester fumarne kisline
MEP-2015-540A ME02253B (fr) 2004-10-08 2005-10-07 Compositions pharmaceutiques à libération contrôlée comportant un ester d'acide fumarique
DE14172398.1T DE14172398T1 (de) 2004-10-08 2005-10-07 Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester
CY20151100679T CY1116599T1 (el) 2004-10-08 2015-08-04 Φαρμακευτικες συνθεσεις ελεγχομενης απελευθερωσης που περιλαμβανουν εστερα φουμαρικου οξεος
HUS1500057C HUS1500057I1 (hu) 2004-10-08 2015-11-18 Fumársav-észtert tartalmazó, szabályozott hatóanyagfelszabadulású gyógyászati készítmények

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EP2792349A2 (fr) 2004-10-08 2014-10-22 Forward Pharma A/S Compositions pharmaceutiques à libération contrôlée comportant un ester d'acide fumarique
EP2965751A1 (fr) 2004-10-08 2016-01-13 Forward Pharma A/S Compositions pharmaceutiques à libération contrôlée comportant un ester d´acide fumarique
EP3093012A1 (fr) 2004-10-08 2016-11-16 Forward Pharma A/S Compositions pharmaceutiques à libération contrôlée comportant un ester d'acide fumarique
EP3459532A1 (fr) 2004-10-08 2019-03-27 Fwp Ip Aps Compositions pharmaceutiques à libération contrôlée comportant un ester d'acide fumarique

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