EP0429635A1 - Solid tooth-paste compositions - Google Patents
Solid tooth-paste compositionsInfo
- Publication number
- EP0429635A1 EP0429635A1 EP19900910124 EP90910124A EP0429635A1 EP 0429635 A1 EP0429635 A1 EP 0429635A1 EP 19900910124 EP19900910124 EP 19900910124 EP 90910124 A EP90910124 A EP 90910124A EP 0429635 A1 EP0429635 A1 EP 0429635A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- hydroxyethyl
- powder
- component
- tablets
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 239000000606 toothpaste Substances 0.000 title claims abstract description 11
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 11
- 239000007787 solid Substances 0.000 title claims abstract description 9
- 208000002064 Dental Plaque Diseases 0.000 claims abstract description 6
- 241001465754 Metazoa Species 0.000 claims abstract description 5
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract description 4
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 4
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 4
- 239000011737 fluorine Substances 0.000 claims abstract description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 13
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 13
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 11
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 7
- 230000002255 enzymatic effect Effects 0.000 claims description 7
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 7
- 239000000600 sorbitol Substances 0.000 claims description 7
- 239000000811 xylitol Substances 0.000 claims description 7
- 229960002675 xylitol Drugs 0.000 claims description 7
- 235000010447 xylitol Nutrition 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 6
- 229940008099 dimethicone Drugs 0.000 claims description 6
- 239000000377 silicon dioxide Substances 0.000 claims description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
- 102000016943 Muramidase Human genes 0.000 claims description 4
- 108010014251 Muramidase Proteins 0.000 claims description 4
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 4
- 235000010335 lysozyme Nutrition 0.000 claims description 4
- 239000004325 lysozyme Substances 0.000 claims description 4
- 229960000274 lysozyme Drugs 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 3
- 239000003205 fragrance Substances 0.000 claims description 3
- 239000002304 perfume Substances 0.000 claims description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 3
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 3
- TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 claims description 2
- 206010006326 Breath odour Diseases 0.000 claims description 2
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 2
- 240000009088 Fragaria x ananassa Species 0.000 claims description 2
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 claims description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 2
- 208000007565 gingivitis Diseases 0.000 claims description 2
- 229940010454 licorice Drugs 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 3
- 235000010234 sodium benzoate Nutrition 0.000 claims 3
- 239000004299 sodium benzoate Substances 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 1
- 229930002875 chlorophyll Natural products 0.000 claims 1
- 235000019804 chlorophyll Nutrition 0.000 claims 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims 1
- MDQRDWAGHRLBPA-UHFFFAOYSA-N fluoroamine Chemical compound FN MDQRDWAGHRLBPA-UHFFFAOYSA-N 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 208000006558 Dental Calculus Diseases 0.000 abstract description 5
- 230000003111 delayed effect Effects 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 6
- 241000282472 Canis lupus familiaris Species 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- KMXTYZBQPJXGNK-UHFFFAOYSA-N hexadecan-1-amine;hydron;fluoride Chemical compound F.CCCCCCCCCCCCCCCCN KMXTYZBQPJXGNK-UHFFFAOYSA-N 0.000 description 4
- 230000001680 brushing effect Effects 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-M 1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-M 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 229960002715 nicotine Drugs 0.000 description 2
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000009916 joint effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 229910002055 micronized silica Inorganic materials 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000395 remineralizing effect Effects 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940083037 simethicone Drugs 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
Definitions
- the present invention relates to a new form of presentation of compositions for use in oral hygiene and toothpaste, as well as a composition, also new in itself, and particularly suitable for said form.
- compositions for use as a toothpaste are currently presented most often in the form of a paste, gel or powder. For their use, it is necessary to take a certain amount and apply it to the teeth using a brush.
- compositions in the form of a solution applied in the form of an aerosol, which avoids the use of a brush.
- This new presentation does indeed offer very significant advantages.
- its mode of application requires a very low content of solid constituents, in particular the essential abrasive bodies, even in micronized form.
- dissolving inevitably involves a certain dilution of the active ingredients, which risks reducing their effectiveness.
- the invention eliminates these drawbacks thanks to a solid toothpaste composition presented in the form of tablets or chewable tablets.
- composition particularly suited to this mode of application comprises, according to the invention:
- At least one component having an antiseptic and / or anti ⁇ bacterial activity at least one component having an antiseptic and / or anti ⁇ bacterial activity
- the mild abrasive agent allows, with the joint action of chewing, a minimal cleaning and polishing effect.
- this composition is especially advantageous in addition to brushing, thus making it possible to protect the teeth between two brushing and to refresh the breath.
- composition is of course essentially intended for use by humans. In this case, it is presented in tablets or in tablets, which it suffices to chew for it to be applied to the teeth.
- the two examples below illustrate, without limitation, two compositions intended for adults and children respectively:
- composition according to the invention suitable for applying to the teeth after having been chewed in the form of tablet tablets - Lyocs - plastic or rubber covered with active products (artificial bone by example).
- active products artificial bone by example.
- Micronized silica extracts - mild abrasive Excipients: - sorbitol
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Composition dentifrice présentée sous forme solide, à usage humain et animal, caractérisée en ce qu'elle comprend: au moins un composant possédant une activité antiséptique et/ou anti-microbienne, au moins un composant exerçant une action abrasive, au moins un composant exerçant une action retard sur le dépôt de tartre, au moins un composant possédant la propriété de s'attaquer à la plaque dentaire, et ayant éventuellement des propriétés anti-microbiennes, et au moins un composé constituant une source de fluor.Toothpaste composition presented in solid form, for human and animal use, characterized in that it comprises: at least one component having an antiseptic and / or antimicrobial activity, at least one component exerting an abrasive action, at least one component exerting a delayed action on the deposit of tartar, at least one component having the property of attacking dental plaque, and possibly having anti-microbial properties, and at least one compound constituting a source of fluorine.
Description
COMPOSITIONS DE DENTIFRICE SOLIDE. SOLID TOOTHPASTE COMPOSITIONS.
La présente invention concerne une nouvelle forme de présentation des compositions à usage d'hygiène buccale et de dentifrice, ainsi qu'une composition, également nouvelle en elle-même, et particulièrement adaptée à ladite forme.The present invention relates to a new form of presentation of compositions for use in oral hygiene and toothpaste, as well as a composition, also new in itself, and particularly suitable for said form.
On sait que les compositions à usage de dentifrice sont actuellement présentées le plus souvent sous forme de pâte, de gel ou de poudre. Pour leur utilisation, il est nécessaire d'en prélever une certaine quantité et l'appliquer sur les dents au moyen d'une brosse.It is known that compositions for use as a toothpaste are currently presented most often in the form of a paste, gel or powder. For their use, it is necessary to take a certain amount and apply it to the teeth using a brush.
L'usage d'une telle brosse représente une contrainte pour de multiples raisons ; c'est, entre autres, la raison pour laquelle il est difficile d'obtenir des enfants qu'ils se brossent régulièrement les dents. De même, hors de chez soi, il n'est pas possible de se nettoyer les dents après un repas ou avant une visite. Il est également très difficile de parvenir à nettoyer les dents des animaux, notamment des chiens.The use of such a brush represents a constraint for multiple reasons; this is one of the reasons why it is difficult to get children to brush their teeth regularly. Similarly, outside your home, it is not possible to clean your teeth after a meal or before a visit. It is also very difficult to manage to clean the teeth of animals, especially dogs.
Pour éliminer ces limitations, il a été proposé de présenter la composition sous forme d'une solution appliquée sous forme d'aérosol, ce qui évite l'utilisation d'une brosse. Cette nouvelle présentation offre effectivement de très importants avantages. Toutefois son mode d'application impose une teneur très faible en constituants solides, notamment les corps abrasifs indispensables, même sous forme micronisée. Au surplus, la mise en solution implique inévitablement une certaine dilution des ingrédients actifs, ce qui risque d'en diminuer l'efficacité.To eliminate these limitations, it has been proposed to present the composition in the form of a solution applied in the form of an aerosol, which avoids the use of a brush. This new presentation does indeed offer very significant advantages. However, its mode of application requires a very low content of solid constituents, in particular the essential abrasive bodies, even in micronized form. In addition, dissolving inevitably involves a certain dilution of the active ingredients, which risks reducing their effectiveness.
L'invention élimine ces inconvénients grâce à une composition dentifrice solide présentée sous forme de comprimés ou de tablettes à croquer.The invention eliminates these drawbacks thanks to a solid toothpaste composition presented in the form of tablets or chewable tablets.
Une composition particulièrement adaptée à ce mode d'application comprend, selon l'invention :A composition particularly suited to this mode of application comprises, according to the invention:
- au moins un composant possédant une activité antiseptique et/ou anti¬ bactérienne,at least one component having an antiseptic and / or anti¬ bacterial activity,
- au moins un composant exerçant une action abrasive,- at least one component exerting an abrasive action,
- au moins un composant exerçant une action retard sur le dépôt de tartre,- at least one component exerting a delay action on the scale deposit,
- au moins un composant possédant la propriété de s'attaquer à la plaque dentaire, et ayant éventuellement des propriétés anti-microbiennes,- at least one component having the property of attacking dental plaque, and possibly having anti-microbial properties,
- et au moins un composé constituant une source de fluor, subsidiairement un anti-inflammatoire local contre les gingivites, un appétent et/ou arôme, un colorant et/ou un composé pour traiter la mauvaise haleine, le tout étant en solution solide (comprimé ou croquette).
Une telle composition est entièrement originale et possède un ensemble d'actions nouvelles très importantes :- and at least one compound constituting a source of fluorine, alternatively a local anti-inflammatory against gingivitis, a palatability and / or flavor, a colorant and / or a compound for treating bad breath, the whole being in solid solution (tablet or croquette). Such a composition is entirely original and has a set of very important new actions:
- Par une action de contact sur la plaque dentaire, elle retarde son apparition et sa transformation en plaque dure.- By a contact action on the dental plaque, it delays its appearance and its transformation into hard plaque.
- Son action antiseptique retarde la transformation de la pellicule neutre recouvrant les dents en plaque molle.- Its antiseptic action delays the transformation of the neutral film covering the teeth into a soft plate.
- Elle renforce la protection de l'émail dentaire contre les caries en fixant certains de ses constituants directement sur celui-ci.- It strengthens the protection of dental enamel against cavities by fixing some of its constituents directly on it.
- Son agent filmogène protège les dents contre les dépôts de tartre et contre l'apparition de tartre dû à des dépôts de nicotine chez les fumeurs. il est à noter que ces "actions sont de longue durée et qu'elles protègent les dents, même sans brossage.- Its film-forming agent protects the teeth against tartar deposits and against the appearance of tartar due to nicotine deposits in smokers. it should be noted that these " actions are long lasting and that they protect the teeth, even without brushing.
De plus, l'agent abrasif doux permet, avec l'action conjointe de la mastication, un effet de nettoyage et de polissage à minima.In addition, the mild abrasive agent allows, with the joint action of chewing, a minimal cleaning and polishing effect.
L'effet conjugué de ces différents éléments permet d'avoir une action intéressante en hygiène dentaire avec des éléments s'attaquant à la physio- pathologie de l'apparition de la plaque dentaire et du dépôt de tartre et une action préventive anti-carie ainsi qu'une protection de l'émail dentaire avec un résultat visible en laissant les dents lisses et brillantes.The combined effect of these different elements makes it possible to have an interesting action in dental hygiene with elements attacking the pathophysiology of the appearance of dental plaque and tartar deposit and a preventive anti-caries action as well that protection of the dental enamel with a visible result leaving the teeth smooth and shiny.
Chez l'homme et l'enfant, l'usage de cette composition est surtout intéressante en complément du brossage permettant ainsi de protéger les dents entre deux brossage et de rafraîchir l'haleine.In men and children, the use of this composition is especially advantageous in addition to brushing, thus making it possible to protect the teeth between two brushing and to refresh the breath.
Chez le chien, elle apporte une solution nouvelle à un problème jusqu'ici difficile à traiter : diminuer le dépôt de tartre et améliorer l'haleine.In dogs, it provides a new solution to a problem hitherto difficult to treat: to reduce the deposit of tartar and to improve the breath.
Cette composition est bien entendu essentiellement destinée à être utilisée par des humains. Dans ce cas, elle est présentée en comprimés ou en tablettes, qu'il suffit de croquer pour qu'elle s'applique sur les dents. Les deux exemples ci-après illustrent à titre non limitatif deux compositions destinées respectivement aux adultes et aux enfants :This composition is of course essentially intended for use by humans. In this case, it is presented in tablets or in tablets, which it suffices to chew for it to be applied to the teeth. The two examples below illustrate, without limitation, two compositions intended for adults and children respectively:
Exemple 1 :Example 1:
Composition dentifrice solide pour adultes :Solid toothpaste composition for adults:
Composants Pourcentage (écart type)Components Percentage (standard deviation)
Aminés FluoréesFluorinated Amines
- Hydrofluorure de cétylamine (CF) 0,1 - 0,3- Cetylamine hydrofluoride (CF) 0.1 - 0.3
- Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine (BF) 1.2 - - 1,6- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine (BF) dihydrofluoride 1.2 - - 1.6
- Diméthicone S (diméthyl polysiloxane) 2 - • 7 Benzoate de Na 0 - - 0,5
Saccharinate de Na 0 - 0,5- Dimethicone S (dimethyl polysiloxane) 2 - • 7 Na benzoate 0 - - 0.5 Na saccharin 0 - 0.5
Dentazium (complexes Enzymatiques) 1 - 6Dentazium (Enzymatic complexes) 1 - 6
Lysozime 0 - 3Lysozime 0 - 3
Lactoférine 0 - 1,5Lactoferin 0 - 1.5
Parfum (chlorophyle) 0,1 - 0,5Perfume (chlorophyle) 0.1 - 0.5
Poudre Silice 2 - 7Silica powder 2 - 7
Sorbitol (poudre QSP) 60 - 90Sorbitol (QSP powder) 60 - 90
Xylitol 1 - 6 Exemple 2 :Xylitol 1 - 6 Example 2:
Composition dentifrice solide pour enfants :Solid toothpaste composition for children:
Composants Pourcentage (écart type)Components Percentage (standard deviation)
Aminés FluoréesFluorinated Amines
- Hydrofluorure de cétylamine (CF) 0,1 - 0,3- Cetylamine hydrofluoride (CF) 0.1 - 0.3
- Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine (BF) 0,2 - 1,2- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine (BF) dihydrofluoride 0.2 - 1.2
- Diméthicone S (diméthyl polysiloxane) 1 - 5 Benzoate de Na 0 - 0,2 Saccharinate de Na 0 - 0,1 Dentazium (complexes Enzymatiques) 0,5 - 4 Lysozime 0 - 2 Lactoférine 0 - 1 Parfum (fraise) 0,1 - 0,5 Poudre Silice 1 - 6 Sorbitol (poudre QSP) 60 - 90 Xylitol 1 - 6- Dimethicone S (dimethyl polysiloxane) 1 - 5 Na benzoate 0 - 0.2 Na saccharinate 0 - 0.1 Dentazium (Enzymatic complexes) 0.5 - 4 Lysozime 0 - 2 Lactoferine 0 - 1 Fragrance (strawberry) 0, 1 - 0.5 Silica powder 1 - 6 Sorbitol (QSP powder) 60 - 90 Xylitol 1 - 6
Toutefois, elle peut également être utilisée par des animaux (chiens, chats etc..) ; à titre d'exemple, on donne ci-après, une composition selon l'invention, apte à s'appliquer sur les dents après avoir été croquée sous forme de comprimés tablettes - Lyocs - plastique ou caoutchouc recouverts des produits actifs (os factice par exemple). Exemple 3 :However, it can also be used by animals (dogs, cats, etc.); by way of example, a composition according to the invention is given below, suitable for applying to the teeth after having been chewed in the form of tablet tablets - Lyocs - plastic or rubber covered with active products (artificial bone by example). Example 3:
Composition dentifrice solide pour chiens.Solid toothpaste composition for dogs.
Composants Pourcentage (écart type)Components Percentage (standard deviation)
Aminés FluoréesFluorinated Amines
- Hydrofluorure de cétylamine (CF) 0,1 - 0,3- Cetylamine hydrofluoride (CF) 0.1 - 0.3
- Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine (BF) 0,3 - 1- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine (BF) dihydrofluoride 0.3 - 1
- Diméthicone S (diméthyl polysiloxane) 2 - 6
Benzoate de Na 0 - 0,2- Dimethicone S (dimethyl polysiloxane) 2 - 6 Na benzoate 0 - 0.2
Bromochlorophène 0,05 - 0,25Bromochlorophene 0.05 - 0.25
Apétant 0,10 - 0,20Appetizing 0.10 - 0.20
Parfum (arôme réglisse) 0,1 - 0,5Perfume (licorice aroma) 0.1 - 0.5
Dentazium (complexes Enzymatiques) 1 - 5Dentazium (Enzymatic complexes) 1 - 5
Lysozime 0 - 2Lysozime 0 - 2
Lactoférine 0 - 2Lactoferin 0 - 2
Silice (micronisée) 2 - 7Silica (micronized) 2 - 7
Sorbitol (poudre QSP) 60 - 90Sorbitol (QSP powder) 60 - 90
Xylitol 0 - 3Xylitol 0 - 3
Stéarate de Magnésium 1 - 4Magnesium stearate 1 - 4
Ac 18 B Glycérhétinique 0,1 - 3Ac 18 B Glycerhetinic 0.1 - 3
Dans ces trois exemples, les rôles respectifs de divers constituants sont les livants :In these three examples, the respective roles of various constituents are the deliverers:
* Complexes Enzymatiques : - anti-plaque dentaire* Enzymatic complexes: - anti-dental plaque
- anti-bactérien biologique- biological anti-bacterial
* Lysozyme : - antibiotique léger * Lysozyme: - light antibiotic
- anti-phlogistique- anti-phlogiston
- anti-inflammatoire- anti-inflammatory
Simethicone : - agent fiimogène (Diméthyl polysiloxane) - anti-fixation de tartreSimethicone: - film-forming agent (Dimethyl polysiloxane) - anti-tartar fixation
- évite le dépôt de taches (nicotine, etc..)- avoids the deposit of stains (nicotine, etc.)
Aminés fluorées (BF et CF) - apport de Fluor organiqueFluorinated amines (BF and CF) - contribution of organic fluorine
- anti-caries- anti-cavities
- propriétés antiseptiques et reminéralisantes- antiseptic and remineralizing properties
Extraits de silice micronisée : - abrasif doux Excipients : - sorbitolMicronized silica extracts: - mild abrasive Excipients: - sorbitol
- xylitol- xylitol
- saccharinate de Na- Na saccharinate
- arôme- aroma
- colorant alimentaire- food coloring
- Benzoate de Na- Na benzoate
Bien entendu, les exemples ci-dessus n'ont qu'un caractère illustratif et ne constituent pas une limitation à l'objet de l'invention.
Of course, the above examples are only illustrative and do not constitute a limitation on the subject of the invention.
Claims
1. Composition dentifrice présentée sous forme solide, à usage humain et animal, caractérisée en ce qu'elle comprend :1. Toothpaste composition presented in solid form, for human and animal use, characterized in that it comprises:
- au moins un composant possédant une activité antiseptique et/ou anti¬ microbienne,at least one component having an antiseptic and / or anti¬ microbial activity,
- au moins un composant exerçant une action abrasive,- at least one component exerting an abrasive action,
- au moins un composant exerçant une action retard sur le dépôt de tartre,- at least one component exerting a delay action on the scale deposit,
- au moins un composant possédant la propriété de s'attaquer à la plaque dentaire, et ayant éventuellement des propriétés anti-microbiennes,- at least one component having the property of attacking dental plaque, and possibly having anti-microbial properties,
- et au moins un composé constituant une source de fluor.- And at least one compound constituting a source of fluorine.
2. Composition dentifrice selon la revendication 1 , caractérisée en ce qu'elle contient au surplus :2. Toothpaste composition according to claim 1, characterized in that it additionally contains:
- un anti-inflammatoire local contre les gingivites,- a local anti-inflammatory against gingivitis,
- un arôme,- an aroma,
- un colorant- a dye
- et/ou un composé pour traiter la mauvaise haleine.- and / or a compound to treat bad breath.
3. Composition selon l'une des revendications 1 et 2, et destinée aux humains adultes, caractérisée en ce qu'elle comprend, sous forme de comprimés ou tablettes, destinés aux humais adultes :3. Composition according to one of claims 1 and 2, and intended for adult humans, characterized in that it comprises, in the form of tablets or tablets, intended for adult humans:
Composants PourcentageComponents Percent
Aminés FluoréesFluorinated Amines
- Hydrofluorure de cétylamine 0,1 - 0,3- Cetylamine hydrofluoride 0.1 - 0.3
- Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine 1,2 - 1 ,6- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine dihydrofluoride 1,2 - 1, 6
- Diméthicone S (diméthyl polysiloxane) 2 - 7 Benzoate de sodium 0 - 0,5 Saccharinate de sodium 0 - 0,5 Dentazium (complexe Enzymatique) 1 - 6 Lysozyme 0 - 3 Lactoférine 0 - 1 ,5 Parfum (chlorophylle) 0,1 - 0,5 Silice (poudre) 2 - 7 Sorbitol (poudre QSP) 60 - 90 Xylitol 1 - 6- Dimethicone S (dimethyl polysiloxane) 2 - 7 Sodium benzoate 0 - 0.5 Sodium saccharinate 0 - 0.5 Dentazium (Enzymatic complex) 1 - 6 Lysozyme 0 - 3 Lactoferine 0 - 1, 5 Perfume (chlorophyll) 0, 1 - 0.5 Silica (powder) 2 - 7 Sorbitol (QSP powder) 60 - 90 Xylitol 1 - 6
4. Composition selon l'une des revendications 1 et 2, destinée aux enfants, caractérisée en ce qu'elle comprend sous forme sous forme de comprimés ou tablettes, Composants Pourcentage Aminés Fluorées4. Composition according to one of claims 1 and 2, intended for children, characterized in that it comprises in the form of tablets or tablets, Percentage Amino Fluoride Components
- Hydrofluorure de cétylamine 0,1-0,3- Cetylamine hydrofluoride 0.1-0.3
- Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine 0,2-1,2- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine dihydrofluoride 0.2-1.2
- Diméthicone S (diméthyl polysiloxane) 1-5 Benzoate de sodium 0-0,2 Saccharinate de sodium 0-0,1 Dentazium (complexe Enzymatique) 0,5-4 Lysozyme 0-2 Lactoférine 0-1 Parfum (fraise) 0,1-0,5 Silice (poudre) 1-6 Sorbitol (poudre QSP) 60-90 Xylitol 1-6 5. Composition selon l'une des revendications 1 et 2, et destinée aux animaux, caractérisée en ce qu'elle comprend sous forme d'une couche déposée sur un support en plastique ou en caoutchouc : Composants Pourcentage- Dimethicone S (dimethyl polysiloxane) 1-5 Sodium benzoate 0-0.2 Sodium saccharinate 0-0.1 Dentazium (Enzymatic complex) 0.5-4 Lysozyme 0-2 Lactoferine 0-1 Fragrance (strawberry) 0, 1-0.5 Silica (powder) 1-6 Sorbitol (QSP powder) 60-90 Xylitol 1-6 5. Composition according to one of claims 1 and 2, and intended for animals, characterized in that it comprises under form of a layer deposited on a plastic or rubber support: Components Percent
Aminés FluoréesFluorinated Amines
- Hydrofluorure de cétylamine 0,1-0,3- Cetylamine hydrofluoride 0.1-0.3
- Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine 0,3-1- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine dihydrofluoride 0.3-1
- Diméthicone S (diméthyl polysiloxane) 2-6 Benzoate de sodium 0-0,2- Dimethicone S (dimethyl polysiloxane) 2-6 Sodium benzoate 0-0.2
Bromochlorophène 0,05-0,25 Apétant 0,10-0,20Bromochlorophene 0.05-0.25 Appetizing 0.10-0.20
Parfum (arôme réglisse) 0,1-0,5 Dentazium (complexe Enzymatique) 1-5 Lysozyme 0-2 Lactoférine 0-2 Silice (micronisée) 2-7 Sorbitol (poudre QSP) 60-90 Xylitol 0-3Fragrance (licorice aroma) 0.1-0.5 Dentazium (Enzymatic complex) 1-5 Lysozyme 0-2 Lactoferine 0-2 Silica (micronized) 2-7 Sorbitol (QSP powder) 60-90 Xylitol 0-3
Stéarate de Magnésium 1-4 Acide 8 bétaglycérrhétinique 0,1-3. Magnesium stearate 1-4 Betaglycerrhetinic acid 8 0.1-3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8908356A FR2648346B1 (en) | 1989-06-20 | 1989-06-20 | SOLID TOOTHPASTE COMPOSITIONS |
| FR8908356 | 1989-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0429635A1 true EP0429635A1 (en) | 1991-06-05 |
Family
ID=9383040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP19900910124 Ceased EP0429635A1 (en) | 1989-06-20 | 1990-06-20 | Solid tooth-paste compositions |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0429635A1 (en) |
| JP (1) | JPH04500368A (en) |
| AU (1) | AU5931590A (en) |
| CA (1) | CA2034498A1 (en) |
| FR (1) | FR2648346B1 (en) |
| WO (1) | WO1990015591A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4341139C1 (en) * | 1993-12-02 | 1995-04-13 | Upmeyer Hans Juergen | Dimethicone for the treatment of aphthae |
| TW414713B (en) | 1994-05-12 | 2000-12-11 | Dentsply Gmbh | Fluoride releasing liquid dental primer product and method |
| ES2079325B1 (en) * | 1994-08-18 | 1996-10-16 | Bio Cosmetics S L | LOW ABRASIVITY DENTRIFY, WHITENING, ANTI-PLATE AND ANTI-TARE PASTA. |
| ES2134738B1 (en) * | 1994-08-18 | 2000-05-01 | Biocosmetics Sl | LOW ABRASIVITY WHITE, ANTI-PLATE AND ANTI-TARE DENTIPHRICANE LEG ". |
| US5665333A (en) * | 1995-01-17 | 1997-09-09 | Homola; Andrew M. | Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth |
| US5961958A (en) * | 1996-07-16 | 1999-10-05 | Four Star Partners | Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth |
| US6432388B1 (en) * | 1997-11-14 | 2002-08-13 | Biocosmetics, S.L. | Whitening anti-plaque and anti-tartar low abrasivity tooth paste |
| JP4082782B2 (en) * | 1998-04-30 | 2008-04-30 | 雪印乳業株式会社 | Periodontal disease prevention and improvement agent |
| US20030003059A1 (en) * | 2001-04-03 | 2003-01-02 | Frederic Dana | Dentifrice compositions |
| FR3106059B1 (en) | 2020-01-14 | 2023-11-17 | Dana Jean Dominque | EDIBLE TOOTHPASTE COMPOSITION TO SUCK OR CHEW, METHOD FOR PREPARING SAID TOOTHPASTE COMPOSITION |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1293516A (en) * | 1958-10-31 | 1962-05-18 | Unilever Nv | Dental preparations for cleaning teeth |
| DE2523940A1 (en) * | 1975-05-30 | 1976-12-09 | Gerhard Fischer | Liq for tooth and oral care to replace use of tooth brush - contains particulate material and film loosening agent |
| DE2712161C2 (en) * | 1977-03-19 | 1983-01-05 | Blendax-Werke R. Schneider Gmbh & Co, 6500 Mainz | Dental and oral care products |
| DE2804093C3 (en) * | 1978-01-31 | 1980-12-04 | Ferrero Ohg, 3570 Stadtallendorf | Tooth-friendly, low-water, sugar-containing foods and tooth-friendly, low-water pharmaceutical preparations |
| US4308252A (en) * | 1979-10-31 | 1981-12-29 | Young Dental Mfg. Co. | Dentifrice composition |
| GB8421226D0 (en) * | 1984-08-21 | 1984-09-26 | Int Conferences Ab | Tooth cleaning tablet |
| FR2607704B1 (en) * | 1986-12-05 | 1990-05-04 | Boyer Danielle | HYGIENE PRODUCT, PARTICULARLY FOR THE DENTURE CARE OF DOGS |
-
1989
- 1989-06-20 FR FR8908356A patent/FR2648346B1/en not_active Expired - Lifetime
-
1990
- 1990-06-20 EP EP19900910124 patent/EP0429635A1/en not_active Ceased
- 1990-06-20 WO PCT/FR1990/000444 patent/WO1990015591A1/en not_active Ceased
- 1990-06-20 CA CA002034498A patent/CA2034498A1/en not_active Abandoned
- 1990-06-20 AU AU59315/90A patent/AU5931590A/en not_active Abandoned
- 1990-06-20 JP JP2509394A patent/JPH04500368A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| See references of WO9015591A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU5931590A (en) | 1991-01-08 |
| FR2648346B1 (en) | 1993-10-08 |
| WO1990015591A1 (en) | 1990-12-27 |
| CA2034498A1 (en) | 1990-12-21 |
| FR2648346A1 (en) | 1990-12-21 |
| JPH04500368A (en) | 1992-01-23 |
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