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WO1990015591A1 - Solid tooth-paste compositions - Google Patents

Solid tooth-paste compositions Download PDF

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Publication number
WO1990015591A1
WO1990015591A1 PCT/FR1990/000444 FR9000444W WO9015591A1 WO 1990015591 A1 WO1990015591 A1 WO 1990015591A1 FR 9000444 W FR9000444 W FR 9000444W WO 9015591 A1 WO9015591 A1 WO 9015591A1
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WO
WIPO (PCT)
Prior art keywords
hydroxyethyl
powder
component
tablets
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR1990/000444
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French (fr)
Inventor
Dominique Dana
Frédéric Dana
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Individual
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Individual
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Publication of WO1990015591A1 publication Critical patent/WO1990015591A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine

Definitions

  • the present invention relates to a new form of presentation of compositions for use in oral hygiene and toothpaste, as well as a composition, also new in itself, and particularly suitable for said form.
  • compositions for use as a toothpaste are currently presented most often in the form of a paste, gel or powder. For their use, it is necessary to take a certain amount and apply it to the teeth using a brush.
  • compositions in the form of a solution applied in the form of an aerosol, which avoids the use of a brush.
  • This new presentation does indeed offer very significant advantages.
  • its mode of application requires a very low content of solid constituents, in particular the essential abrasive bodies, even in micronized form.
  • dissolving inevitably involves a certain dilution of the active ingredients, which risks reducing their effectiveness.
  • the invention eliminates these drawbacks thanks to a solid toothpaste composition presented in the form of tablets or chewable tablets.
  • composition particularly suited to this mode of application comprises, according to the invention:
  • At least one component having an antiseptic and / or anti ⁇ bacterial activity at least one component having an antiseptic and / or anti ⁇ bacterial activity
  • the mild abrasive agent allows, with the joint action of chewing, a minimal cleaning and polishing effect.
  • this composition is especially advantageous in addition to brushing, thus making it possible to protect the teeth between two brushing and to refresh the breath.
  • composition is of course essentially intended for use by humans. In this case, it is presented in tablets or in tablets, which it suffices to chew for it to be applied to the teeth.
  • the two examples below illustrate, without limitation, two compositions intended for adults and children respectively:
  • composition according to the invention suitable for applying to the teeth after having been chewed in the form of tablet tablets - Lyocs - plastic or rubber covered with active products (artificial bone by example).
  • active products artificial bone by example.
  • Micronized silica extracts - mild abrasive Excipients: - sorbitol

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

A tooth-paste composition, in solid form, for human and animal use, is characterised by the fact that it contains at least one component with an antiseptic and/or an antimicrobic quality; at least one abrasive component; at least one component which delays tartar deposition; at least one component able to attack dental plaque and which possibly has antimicrobic properties; and at least one compound as a fluorine source.

Description

COMPOSITIONS DE DENTIFRICE SOLIDE. SOLID TOOTHPASTE COMPOSITIONS.

La présente invention concerne une nouvelle forme de présentation des compositions à usage d'hygiène buccale et de dentifrice, ainsi qu'une composition, également nouvelle en elle-même, et particulièrement adaptée à ladite forme.The present invention relates to a new form of presentation of compositions for use in oral hygiene and toothpaste, as well as a composition, also new in itself, and particularly suitable for said form.

On sait que les compositions à usage de dentifrice sont actuellement présentées le plus souvent sous forme de pâte, de gel ou de poudre. Pour leur utilisation, il est nécessaire d'en prélever une certaine quantité et l'appliquer sur les dents au moyen d'une brosse.It is known that compositions for use as a toothpaste are currently presented most often in the form of a paste, gel or powder. For their use, it is necessary to take a certain amount and apply it to the teeth using a brush.

L'usage d'une telle brosse représente une contrainte pour de multiples raisons ; c'est, entre autres, la raison pour laquelle il est difficile d'obtenir des enfants qu'ils se brossent régulièrement les dents. De même, hors de chez soi, il n'est pas possible de se nettoyer les dents après un repas ou avant une visite. Il est également très difficile de parvenir à nettoyer les dents des animaux, notamment des chiens.The use of such a brush represents a constraint for multiple reasons; this is one of the reasons why it is difficult to get children to brush their teeth regularly. Similarly, outside your home, it is not possible to clean your teeth after a meal or before a visit. It is also very difficult to manage to clean the teeth of animals, especially dogs.

Pour éliminer ces limitations, il a été proposé de présenter la composition sous forme d'une solution appliquée sous forme d'aérosol, ce qui évite l'utilisation d'une brosse. Cette nouvelle présentation offre effectivement de très importants avantages. Toutefois son mode d'application impose une teneur très faible en constituants solides, notamment les corps abrasifs indispensables, même sous forme micronisée. Au surplus, la mise en solution implique inévitablement une certaine dilution des ingrédients actifs, ce qui risque d'en diminuer l'efficacité.To eliminate these limitations, it has been proposed to present the composition in the form of a solution applied in the form of an aerosol, which avoids the use of a brush. This new presentation does indeed offer very significant advantages. However, its mode of application requires a very low content of solid constituents, in particular the essential abrasive bodies, even in micronized form. In addition, dissolving inevitably involves a certain dilution of the active ingredients, which risks reducing their effectiveness.

L'invention élimine ces inconvénients grâce à une composition dentifrice solide présentée sous forme de comprimés ou de tablettes à croquer.The invention eliminates these drawbacks thanks to a solid toothpaste composition presented in the form of tablets or chewable tablets.

Une composition particulièrement adaptée à ce mode d'application comprend, selon l'invention :A composition particularly suited to this mode of application comprises, according to the invention:

- au moins un composant possédant une activité antiseptique et/ou anti¬ bactérienne,at least one component having an antiseptic and / or anti¬ bacterial activity,

- au moins un composant exerçant une action abrasive,- at least one component exerting an abrasive action,

- au moins un composant exerçant une action retard sur le dépôt de tartre,- at least one component exerting a delay action on the scale deposit,

- au moins un composant possédant la propriété de s'attaquer à la plaque dentaire, et ayant éventuellement des propriétés anti-microbiennes,- at least one component having the property of attacking dental plaque, and possibly having anti-microbial properties,

- et au moins un composé constituant une source de fluor, subsidiairement un anti-inflammatoire local contre les gingivites, un appétent et/ou arôme, un colorant et/ou un composé pour traiter la mauvaise haleine, le tout étant en solution solide (comprimé ou croquette). Une telle composition est entièrement originale et possède un ensemble d'actions nouvelles très importantes :- and at least one compound constituting a source of fluorine, alternatively a local anti-inflammatory against gingivitis, a palatability and / or flavor, a colorant and / or a compound for treating bad breath, the whole being in solid solution (tablet or croquette). Such a composition is entirely original and has a set of very important new actions:

- Par une action de contact sur la plaque dentaire, elle retarde son apparition et sa transformation en plaque dure.- By a contact action on the dental plaque, it delays its appearance and its transformation into hard plaque.

- Son action antiseptique retarde la transformation de la pellicule neutre recouvrant les dents en plaque molle.- Its antiseptic action delays the transformation of the neutral film covering the teeth into a soft plate.

- Elle renforce la protection de l'émail dentaire contre les caries en fixant certains de ses constituants directement sur celui-ci.- It strengthens the protection of dental enamel against cavities by fixing some of its constituents directly on it.

- Son agent filmogène protège les dents contre les dépôts de tartre et contre l'apparition de tartre dû à des dépôts de nicotine chez les fumeurs. il est à noter que ces "actions sont de longue durée et qu'elles protègent les dents, même sans brossage.- Its film-forming agent protects the teeth against tartar deposits and against the appearance of tartar due to nicotine deposits in smokers. it should be noted that these " actions are long lasting and that they protect the teeth, even without brushing.

De plus, l'agent abrasif doux permet, avec l'action conjointe de la mastication, un effet de nettoyage et de polissage à minima.In addition, the mild abrasive agent allows, with the joint action of chewing, a minimal cleaning and polishing effect.

L'effet conjugué de ces différents éléments permet d'avoir une action intéressante en hygiène dentaire avec des éléments s'attaquant à la physio- pathologie de l'apparition de la plaque dentaire et du dépôt de tartre et une action préventive anti-carie ainsi qu'une protection de l'émail dentaire avec un résultat visible en laissant les dents lisses et brillantes.The combined effect of these different elements makes it possible to have an interesting action in dental hygiene with elements attacking the pathophysiology of the appearance of dental plaque and tartar deposit and a preventive anti-caries action as well that protection of the dental enamel with a visible result leaving the teeth smooth and shiny.

Chez l'homme et l'enfant, l'usage de cette composition est surtout intéressante en complément du brossage permettant ainsi de protéger les dents entre deux brossage et de rafraîchir l'haleine.In men and children, the use of this composition is especially advantageous in addition to brushing, thus making it possible to protect the teeth between two brushing and to refresh the breath.

Chez le chien, elle apporte une solution nouvelle à un problème jusqu'ici difficile à traiter : diminuer le dépôt de tartre et améliorer l'haleine.In dogs, it provides a new solution to a problem hitherto difficult to treat: to reduce the deposit of tartar and to improve the breath.

Cette composition est bien entendu essentiellement destinée à être utilisée par des humains. Dans ce cas, elle est présentée en comprimés ou en tablettes, qu'il suffit de croquer pour qu'elle s'applique sur les dents. Les deux exemples ci-après illustrent à titre non limitatif deux compositions destinées respectivement aux adultes et aux enfants :This composition is of course essentially intended for use by humans. In this case, it is presented in tablets or in tablets, which it suffices to chew for it to be applied to the teeth. The two examples below illustrate, without limitation, two compositions intended for adults and children respectively:

Exemple 1 :Example 1:

Composition dentifrice solide pour adultes :Solid toothpaste composition for adults:

Composants Pourcentage (écart type)Components Percentage (standard deviation)

Aminés FluoréesFluorinated Amines

- Hydrofluorure de cétylamine (CF) 0,1 - 0,3- Cetylamine hydrofluoride (CF) 0.1 - 0.3

- Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine (BF) 1.2 - - 1,6- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine (BF) dihydrofluoride 1.2 - - 1.6

- Diméthicone S (diméthyl polysiloxane) 2 - • 7 Benzoate de Na 0 - - 0,5 Saccharinate de Na 0 - 0,5- Dimethicone S (dimethyl polysiloxane) 2 - • 7 Na benzoate 0 - - 0.5 Na saccharin 0 - 0.5

Dentazium (complexes Enzymatiques) 1 - 6Dentazium (Enzymatic complexes) 1 - 6

Lysozime 0 - 3Lysozime 0 - 3

Lactoférine 0 - 1,5Lactoferin 0 - 1.5

Parfum (chlorophyle) 0,1 - 0,5Perfume (chlorophyle) 0.1 - 0.5

Poudre Silice 2 - 7Silica powder 2 - 7

Sorbitol (poudre QSP) 60 - 90Sorbitol (QSP powder) 60 - 90

Xylitol 1 - 6 Exemple 2 :Xylitol 1 - 6 Example 2:

Composition dentifrice solide pour enfants :Solid toothpaste composition for children:

Composants Pourcentage (écart type)Components Percentage (standard deviation)

Aminés FluoréesFluorinated Amines

- Hydrofluorure de cétylamine (CF) 0,1 - 0,3- Cetylamine hydrofluoride (CF) 0.1 - 0.3

- Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine (BF) 0,2 - 1,2- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine (BF) dihydrofluoride 0.2 - 1.2

- Diméthicone S (diméthyl polysiloxane) 1 - 5 Benzoate de Na 0 - 0,2 Saccharinate de Na 0 - 0,1 Dentazium (complexes Enzymatiques) 0,5 - 4 Lysozime 0 - 2 Lactoférine 0 - 1 Parfum (fraise) 0,1 - 0,5 Poudre Silice 1 - 6 Sorbitol (poudre QSP) 60 - 90 Xylitol 1 - 6- Dimethicone S (dimethyl polysiloxane) 1 - 5 Na benzoate 0 - 0.2 Na saccharinate 0 - 0.1 Dentazium (Enzymatic complexes) 0.5 - 4 Lysozime 0 - 2 Lactoferine 0 - 1 Fragrance (strawberry) 0, 1 - 0.5 Silica powder 1 - 6 Sorbitol (QSP powder) 60 - 90 Xylitol 1 - 6

Toutefois, elle peut également être utilisée par des animaux (chiens, chats etc..) ; à titre d'exemple, on donne ci-après, une composition selon l'invention, apte à s'appliquer sur les dents après avoir été croquée sous forme de comprimés tablettes - Lyocs - plastique ou caoutchouc recouverts des produits actifs (os factice par exemple). Exemple 3 :However, it can also be used by animals (dogs, cats, etc.); by way of example, a composition according to the invention is given below, suitable for applying to the teeth after having been chewed in the form of tablet tablets - Lyocs - plastic or rubber covered with active products (artificial bone by example). Example 3:

Composition dentifrice solide pour chiens.Solid toothpaste composition for dogs.

Composants Pourcentage (écart type)Components Percentage (standard deviation)

Aminés FluoréesFluorinated Amines

- Hydrofluorure de cétylamine (CF) 0,1 - 0,3- Cetylamine hydrofluoride (CF) 0.1 - 0.3

- Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine (BF) 0,3 - 1- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine (BF) dihydrofluoride 0.3 - 1

- Diméthicone S (diméthyl polysiloxane) 2 - 6 Benzoate de Na 0 - 0,2- Dimethicone S (dimethyl polysiloxane) 2 - 6 Na benzoate 0 - 0.2

Bromochlorophène 0,05 - 0,25Bromochlorophene 0.05 - 0.25

Apétant 0,10 - 0,20Appetizing 0.10 - 0.20

Parfum (arôme réglisse) 0,1 - 0,5Perfume (licorice aroma) 0.1 - 0.5

Dentazium (complexes Enzymatiques) 1 - 5Dentazium (Enzymatic complexes) 1 - 5

Lysozime 0 - 2Lysozime 0 - 2

Lactoférine 0 - 2Lactoferin 0 - 2

Silice (micronisée) 2 - 7Silica (micronized) 2 - 7

Sorbitol (poudre QSP) 60 - 90Sorbitol (QSP powder) 60 - 90

Xylitol 0 - 3Xylitol 0 - 3

Stéarate de Magnésium 1 - 4Magnesium stearate 1 - 4

Ac 18 B Glycérhétinique 0,1 - 3Ac 18 B Glycerhetinic 0.1 - 3

Dans ces trois exemples, les rôles respectifs de divers constituants sont les livants :In these three examples, the respective roles of various constituents are the deliverers:

* Complexes Enzymatiques : - anti-plaque dentaire* Enzymatic complexes: - anti-dental plaque

- anti-bactérien biologique- biological anti-bacterial

* Lysozyme : - antibiotique léger * Lysozyme: - light antibiotic

- anti-phlogistique- anti-phlogiston

- anti-inflammatoire- anti-inflammatory

Simethicone : - agent fiimogène (Diméthyl polysiloxane) - anti-fixation de tartreSimethicone: - film-forming agent (Dimethyl polysiloxane) - anti-tartar fixation

- évite le dépôt de taches (nicotine, etc..)- avoids the deposit of stains (nicotine, etc.)

Aminés fluorées (BF et CF) - apport de Fluor organiqueFluorinated amines (BF and CF) - contribution of organic fluorine

- anti-caries- anti-cavities

- propriétés antiseptiques et reminéralisantes- antiseptic and remineralizing properties

Extraits de silice micronisée : - abrasif doux Excipients : - sorbitolMicronized silica extracts: - mild abrasive Excipients: - sorbitol

- xylitol- xylitol

- saccharinate de Na- Na saccharinate

- arôme- aroma

- colorant alimentaire- food coloring

- Benzoate de Na- Na benzoate

Bien entendu, les exemples ci-dessus n'ont qu'un caractère illustratif et ne constituent pas une limitation à l'objet de l'invention. Of course, the above examples are only illustrative and do not constitute a limitation on the subject of the invention.

Claims

REVENDICATIONS 1. Composition dentifrice présentée sous forme solide, à usage humain et animal, caractérisée en ce qu'elle comprend :1. Toothpaste composition presented in solid form, for human and animal use, characterized in that it comprises: - au moins un composant possédant une activité antiseptique et/ou anti¬ microbienne,at least one component having an antiseptic and / or anti¬ microbial activity, - au moins un composant exerçant une action abrasive,- at least one component exerting an abrasive action, - au moins un composant exerçant une action retard sur le dépôt de tartre,- at least one component exerting a delay action on the scale deposit, - au moins un composant possédant la propriété de s'attaquer à la plaque dentaire, et ayant éventuellement des propriétés anti-microbiennes,- at least one component having the property of attacking dental plaque, and possibly having anti-microbial properties, - et au moins un composé constituant une source de fluor.- And at least one compound constituting a source of fluorine. 2. Composition dentifrice selon la revendication 1 , caractérisée en ce qu'elle contient au surplus :2. Toothpaste composition according to claim 1, characterized in that it additionally contains: - un anti-inflammatoire local contre les gingivites,- a local anti-inflammatory against gingivitis, - un arôme,- an aroma, - un colorant- a dye - et/ou un composé pour traiter la mauvaise haleine.- and / or a compound to treat bad breath. 3. Composition selon l'une des revendications 1 et 2, et destinée aux humains adultes, caractérisée en ce qu'elle comprend, sous forme de comprimés ou tablettes, destinés aux humais adultes :3. Composition according to one of claims 1 and 2, and intended for adult humans, characterized in that it comprises, in the form of tablets or tablets, intended for adult humans: Composants PourcentageComponents Percent Aminés FluoréesFluorinated Amines - Hydrofluorure de cétylamine 0,1 - 0,3- Cetylamine hydrofluoride 0.1 - 0.3 - Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine 1,2 - 1 ,6- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine dihydrofluoride 1,2 - 1, 6 - Diméthicone S (diméthyl polysiloxane) 2 - 7 Benzoate de sodium 0 - 0,5 Saccharinate de sodium 0 - 0,5 Dentazium (complexe Enzymatique) 1 - 6 Lysozyme 0 - 3 Lactoférine 0 - 1 ,5 Parfum (chlorophylle) 0,1 - 0,5 Silice (poudre) 2 - 7 Sorbitol (poudre QSP) 60 - 90 Xylitol 1 - 6- Dimethicone S (dimethyl polysiloxane) 2 - 7 Sodium benzoate 0 - 0.5 Sodium saccharinate 0 - 0.5 Dentazium (Enzymatic complex) 1 - 6 Lysozyme 0 - 3 Lactoferine 0 - 1, 5 Perfume (chlorophyll) 0, 1 - 0.5 Silica (powder) 2 - 7 Sorbitol (QSP powder) 60 - 90 Xylitol 1 - 6 4. Composition selon l'une des revendications 1 et 2, destinée aux enfants, caractérisée en ce qu'elle comprend sous forme sous forme de comprimés ou tablettes, Composants Pourcentage Aminés Fluorées4. Composition according to one of claims 1 and 2, intended for children, characterized in that it comprises in the form of tablets or tablets, Percentage Amino Fluoride Components - Hydrofluorure de cétylamine 0,1-0,3- Cetylamine hydrofluoride 0.1-0.3 - Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine 0,2-1,2- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine dihydrofluoride 0.2-1.2 - Diméthicone S (diméthyl polysiloxane) 1-5 Benzoate de sodium 0-0,2 Saccharinate de sodium 0-0,1 Dentazium (complexe Enzymatique) 0,5-4 Lysozyme 0-2 Lactoférine 0-1 Parfum (fraise) 0,1-0,5 Silice (poudre) 1-6 Sorbitol (poudre QSP) 60-90 Xylitol 1-6 5. Composition selon l'une des revendications 1 et 2, et destinée aux animaux, caractérisée en ce qu'elle comprend sous forme d'une couche déposée sur un support en plastique ou en caoutchouc : Composants Pourcentage- Dimethicone S (dimethyl polysiloxane) 1-5 Sodium benzoate 0-0.2 Sodium saccharinate 0-0.1 Dentazium (Enzymatic complex) 0.5-4 Lysozyme 0-2 Lactoferine 0-1 Fragrance (strawberry) 0, 1-0.5 Silica (powder) 1-6 Sorbitol (QSP powder) 60-90 Xylitol 1-6 5. Composition according to one of claims 1 and 2, and intended for animals, characterized in that it comprises under form of a layer deposited on a plastic or rubber support: Components Percent Aminés FluoréesFluorinated Amines - Hydrofluorure de cétylamine 0,1-0,3- Cetylamine hydrofluoride 0.1-0.3 - Dihydrofluorure de bis (hydroxyéthyl)-amino- propyl-N-hydroxyéthyl-octadécylamine 0,3-1- Bis (hydroxyethyl) -amino-propyl-N-hydroxyethyl-octadecylamine dihydrofluoride 0.3-1 - Diméthicone S (diméthyl polysiloxane) 2-6 Benzoate de sodium 0-0,2- Dimethicone S (dimethyl polysiloxane) 2-6 Sodium benzoate 0-0.2 Bromochlorophène 0,05-0,25 Apétant 0,10-0,20Bromochlorophene 0.05-0.25 Appetizing 0.10-0.20 Parfum (arôme réglisse) 0,1-0,5 Dentazium (complexe Enzymatique) 1-5 Lysozyme 0-2 Lactoférine 0-2 Silice (micronisée) 2-7 Sorbitol (poudre QSP) 60-90 Xylitol 0-3Fragrance (licorice aroma) 0.1-0.5 Dentazium (Enzymatic complex) 1-5 Lysozyme 0-2 Lactoferine 0-2 Silica (micronized) 2-7 Sorbitol (QSP powder) 60-90 Xylitol 0-3 Stéarate de Magnésium 1-4 Acide 8 bétaglycérrhétinique 0,1-3. Magnesium stearate 1-4 Betaglycerrhetinic acid 8 0.1-3.
PCT/FR1990/000444 1989-06-20 1990-06-20 Solid tooth-paste compositions Ceased WO1990015591A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8908356A FR2648346B1 (en) 1989-06-20 1989-06-20 SOLID TOOTHPASTE COMPOSITIONS
FR89/08356 1989-06-20

Publications (1)

Publication Number Publication Date
WO1990015591A1 true WO1990015591A1 (en) 1990-12-27

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PCT/FR1990/000444 Ceased WO1990015591A1 (en) 1989-06-20 1990-06-20 Solid tooth-paste compositions

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EP (1) EP0429635A1 (en)
JP (1) JPH04500368A (en)
AU (1) AU5931590A (en)
CA (1) CA2034498A1 (en)
FR (1) FR2648346B1 (en)
WO (1) WO1990015591A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5393745A (en) * 1993-12-02 1995-02-28 Schmidt; Alfred Method for treating aphthae using dimethylpolysiloxane
ES2079325A1 (en) * 1994-08-18 1996-01-01 Bio Cosmetics S L Toothpaste with whitening, anti-plaque and anti-tartar properties and low abrasiveness.
US5888480A (en) * 1995-01-17 1999-03-30 Four Star Partners Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
WO1999025315A1 (en) * 1997-11-14 1999-05-27 Biocosmetics, S.L. Whitening, antiplaque and antitartar low abrasivity tooth paste
ES2134738A1 (en) * 1994-08-18 1999-10-01 Biocosmetics Sl Improvements made to the object of Spanish Patent Application No. 9401832 for: "Anti-plaque and anti-tartar whitening toothpaste with low abrasiveness".
US5961958A (en) * 1996-07-16 1999-10-05 Four Star Partners Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
WO2003043517A3 (en) * 2001-04-03 2003-09-18 Frederic Dana Dentifrice compositions

Families Citing this family (3)

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TW414713B (en) 1994-05-12 2000-12-11 Dentsply Gmbh Fluoride releasing liquid dental primer product and method
JP4082782B2 (en) * 1998-04-30 2008-04-30 雪印乳業株式会社 Periodontal disease prevention and improvement agent
FR3106059B1 (en) 2020-01-14 2023-11-17 Dana Jean Dominque EDIBLE TOOTHPASTE COMPOSITION TO SUCK OR CHEW, METHOD FOR PREPARING SAID TOOTHPASTE COMPOSITION

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US5393745A (en) * 1993-12-02 1995-02-28 Schmidt; Alfred Method for treating aphthae using dimethylpolysiloxane
ES2079325A1 (en) * 1994-08-18 1996-01-01 Bio Cosmetics S L Toothpaste with whitening, anti-plaque and anti-tartar properties and low abrasiveness.
ES2095812A1 (en) * 1994-08-18 1997-02-16 Biocosmetic S L Toothpaste with whitening, anti-plaque and anti-tartar properties and low abrasiveness.
ES2134738A1 (en) * 1994-08-18 1999-10-01 Biocosmetics Sl Improvements made to the object of Spanish Patent Application No. 9401832 for: "Anti-plaque and anti-tartar whitening toothpaste with low abrasiveness".
US5888480A (en) * 1995-01-17 1999-03-30 Four Star Partners Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
US5980868A (en) * 1995-01-17 1999-11-09 Homola; Andrew M. Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
US5961958A (en) * 1996-07-16 1999-10-05 Four Star Partners Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
WO1999025315A1 (en) * 1997-11-14 1999-05-27 Biocosmetics, S.L. Whitening, antiplaque and antitartar low abrasivity tooth paste
WO2003043517A3 (en) * 2001-04-03 2003-09-18 Frederic Dana Dentifrice compositions

Also Published As

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CA2034498A1 (en) 1990-12-21
EP0429635A1 (en) 1991-06-05
FR2648346B1 (en) 1993-10-08
JPH04500368A (en) 1992-01-23
AU5931590A (en) 1991-01-08
FR2648346A1 (en) 1990-12-21

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