EE200400059A - Diarüültsükloalküülderivaadid, nende kasutamine ravimite valmistamiseks ning neid sisaldav ravim - Google Patents

Diarüültsükloalküülderivaadid, nende kasutamine ravimite valmistamiseks ning neid sisaldav ravim

Info

Publication number: EE200400059A
Authority: EE; Estonia
Prior art keywords: medicaments; manufacture; diarylcycloalkyl derivatives; diarylcycloalkyl; derivatives
Prior art date: 2001-08-31

Application number

EEP200400059A

Other languages

English (en)

Inventor

Glombik Heiner

Falk Eugen

Frick Wendelin

Keil Stefanie

Sch�fer Hans-Ludwig

Schwink Lothar

Wendle Wolfgang

Original Assignee

Aventis Pharma Deutschland Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-31

Filing date

2002-08-17

Publication date

2004-04-15

2001-08-31 Priority claimed from DE10142734A external-priority patent/DE10142734A1/de

2002-05-24 Priority claimed from DE2002123273 external-priority patent/DE10223273A1/de

2002-08-17 Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh

2004-04-15 Publication of EE200400059A publication Critical patent/EE200400059A/et

2011-06-15 Publication of EE05418B1 publication Critical patent/EE05418B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Obesity (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EEP200400059A 2001-08-31 2002-08-17 Diarltskloalklderivaadid, nende kasutamine ravimite valmistamiseks ning neid sisaldav ravim EE05418B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10142734A DE10142734A1 (de)	2001-08-31	2001-08-31	Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE2002123273 DE10223273A1 (de)	2002-05-24	2002-05-24	Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP2002/009221 WO2003020269A1 (de)	2001-08-31	2002-08-17	Diarylcycloalkylderivate, verfahren zu ihrer herstellung und ihre verwendung als ppar-aktivatoren

Publications (2)

Publication Number	Publication Date
EE200400059A true EE200400059A (et)	2004-04-15
EE05418B1 EE05418B1 (et)	2011-06-15

Family

ID=26010044

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200400059A EE05418B1 (et)	2001-08-31	2002-08-17	Diarltskloalklderivaadid, nende kasutamine ravimite valmistamiseks ning neid sisaldav ravim

Country Status (35)

Country	Link
US (1)	US6624185B2 (et)
EP (1)	EP1425014B1 (et)
JP (1)	JP4436129B2 (et)
KR (1)	KR100915108B1 (et)
CN (1)	CN1255103C (et)
AR (1)	AR039063A1 (et)
AT (1)	ATE347890T1 (et)
AU (1)	AU2002333456B2 (et)
BG (1)	BG108598A (et)
BR (1)	BR0212158A (et)
CA (1)	CA2458210C (et)
CO (1)	CO5560562A2 (et)
CR (1)	CR7261A (et)
CY (1)	CY1106378T1 (et)
DE (1)	DE50208960D1 (et)
DK (1)	DK1425014T3 (et)
EE (1)	EE05418B1 (et)
ES (1)	ES2278077T3 (et)
HR (1)	HRP20040199A2 (et)
HU (1)	HUP0401564A3 (et)
IL (2)	IL160556A0 (et)
MA (1)	MA27134A1 (et)
MX (1)	MXPA04001850A (et)
MY (1)	MY132789A (et)
NZ (1)	NZ531440A (et)
OA (1)	OA12656A (et)
PE (1)	PE20030414A1 (et)
PL (1)	PL208515B1 (et)
PT (1)	PT1425014E (et)
RS (1)	RS50889B (et)
RU (1)	RU2330846C2 (et)
TN (1)	TNSN04039A1 (et)
TW (1)	TWI305724B (et)
UA (1)	UA76773C2 (et)
WO (1)	WO2003020269A1 (et)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2410382A1 (en) *	2000-05-26	2002-11-25	Nippon Shinyaku Co., Ltd.	Heterocyclic compounds
US6884812B2 (en) *	2001-08-31	2005-04-26	Aventis Pharma Deutschland Gmbh	Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmaceuticals
US7399777B2 (en) *	2001-08-31	2008-07-15	Sanofi-Aventis Deutschland Gmbh	Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals
US7078404B2 (en) *	2002-04-11	2006-07-18	Sanofi-Aventis Deutschland Gmbh	Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use
US7049341B2 (en) *	2002-06-07	2006-05-23	Aventis Pharma Deutschland Gmbh	N-benzoylureidocinnamic acid derivatives, processes for preparing them and their use
US7262220B2 (en) *	2002-07-11	2007-08-28	Sanofi-Aventis Deutschland Gmbh	Urea- and urethane-substituted acylureas, process for their preparation and their use
US7208504B2 (en)	2002-10-12	2007-04-24	Sanofi-Aventis Deutschland Gmbh	Bicyclic inhibitors of hormone sensitive lipase
DE10258008B4 (de) *	2002-12-12	2006-02-02	Sanofi-Aventis Deutschland Gmbh	Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
DE10258007B4 (de) *	2002-12-12	2006-02-09	Sanofi-Aventis Deutschland Gmbh	Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
US20040242583A1 (en) *	2003-01-20	2004-12-02	Aventis Pharma Deutschland Gmbh	Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
US7179941B2 (en)	2003-01-23	2007-02-20	Sanofi-Aventis Deutschland Gmbh	Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use
US7196114B2 (en) *	2003-02-17	2007-03-27	Sanofi-Aventis Deutschland Gmbh	Substituted 3-(benzoylureido) thiophene derivatives, processes for preparing them and their use
DE10308352A1 (de)	2003-02-27	2004-09-09	Aventis Pharma Deutschland Gmbh	Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
US7148246B2 (en)	2003-02-27	2006-12-12	Sanofi-Aventis Deutschland Gmbh	Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
US7094795B2 (en)	2003-02-27	2006-08-22	Sanofi-Aventis Deutschland Gmbh	Process for preparing the enantiomeric forms of cis-configured 1,3-cyclohexanediol derivatives
DE10308350B4 (de) *	2003-02-27	2006-06-01	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 1,3-Cyclohexandiol-Derivaten
DE10308355A1 (de)	2003-02-27	2004-12-23	Aventis Pharma Deutschland Gmbh	Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE10308353A1 (de)	2003-02-27	2004-12-02	Aventis Pharma Deutschland Gmbh	Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308351A1 (de)	2003-02-27	2004-11-25	Aventis Pharma Deutschland Gmbh	1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7173151B2 (en) *	2003-02-27	2007-02-06	Sanofi-Aventisdeutschand Gmbh	Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals
US7501440B2 (en) *	2003-03-07	2009-03-10	Sanofi-Aventis Deutschland Gmbh	Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use
DE10313228A1 (de) *	2003-03-25	2004-10-21	Aventis Pharma Deutschland Gmbh	Synthese von 2-Chlormethyl-6-methylbenzoesäureestern
US6989462B2 (en)	2003-03-25	2006-01-24	Sanofi-Aventis Deutschland Gmbh	Synthesis of 2-chloromethyl-6-methylbenzoic ester
DE10314610A1 (de) *	2003-04-01	2004-11-04	Aventis Pharma Deutschland Gmbh	Neues Diphenylazetidinon mit verbesserten physiologischen Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindungen enthaltende Arzneimittel und dessen Verwendung
CA2525367A1 (en) *	2003-05-09	2004-11-25	The Trustees Of The University Of Pennsylvania	Use of citrate lyase inhibitors and tricarboxylate transporter inhibitors in the treatment of cancer
US7553819B2 (en)	2003-05-12	2009-06-30	Theracarb Inc.	Multivalent inhibitors of serum amyloid P component
US7008957B2 (en) *	2003-07-25	2006-03-07	Sanofi-Aventis Deutschland Gmbh	Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments
US7094800B2 (en) *	2003-07-25	2006-08-22	Sanofi-Aventis Deutschland Gmbh	Cyanopyrrolidides, process for their preparation and their use as medicaments
US7094794B2 (en) *	2003-07-28	2006-08-22	Sanofi-Aventis Deutschland Gmbh	Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use
DE10335092B3 (de) *	2003-08-01	2005-02-03	Aventis Pharma Deutschland Gmbh	Substituierte Benzoylureido-o-benzoylamide, Verfahren zu deren Herstellung und deren Verwendung
CN100482649C (zh) *	2003-09-17	2009-04-29	诺瓦提斯公司	有机化合物
CA2546601A1 (en)	2003-11-19	2005-06-09	Metabasis Therapeutics, Inc.	Novel phosphorus-containing thyromimetics
US7498341B2 (en) *	2004-01-31	2009-03-03	Sanofi Aventis Deutschland Gmbh	Heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments
US7402674B2 (en) *	2004-01-31	2008-07-22	Sanofi-Aventis Deutschland Gmbh,	7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments
US7470706B2 (en) *	2004-01-31	2008-12-30	Sanofi-Aventis Deutschland Gmbh	Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments
DE102004005172A1 (de) *	2004-02-02	2005-08-18	Aventis Pharma Deutschland Gmbh	Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase
EP1586573B1 (en)	2004-04-01	2007-02-07	Sanofi-Aventis Deutschland GmbH	Oxadiazolones, processes for their preparation and their use as pharmaceuticals
DE102004038403B4 (de) *	2004-08-07	2006-08-31	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 3-Hydroxycyclohexancarbonsäure-Derivaten
CN101014595A (zh) *	2004-08-11	2007-08-08	杏林制药株式会社	新型环状氨基苯甲酸衍生物
DE102004039533B4 (de) *	2004-08-14	2006-09-28	Sanofi-Aventis Deutschland Gmbh	Essigsäurederivate mit Cyclohexylmethoxy-Substituenten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE102004039509B4 (de)	2004-08-14	2006-09-21	Sanofi-Aventis Deutschland Gmbh	Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102004039532B4 (de) *	2004-08-14	2006-09-21	Sanofi-Aventis Deutschland Gmbh	Cyclohexyl-methyloxy substituierte Essigsäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE102004040736B4 (de) *	2004-08-23	2007-01-11	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Diarylcycloalkylderivaten
AU2005315430B2 (en) *	2004-12-14	2010-05-27	Astrazeneca Ab	Oxadiazole derivatives as DGAT inhibitors
EP1671633A1 (en) *	2004-12-17	2006-06-21	Sanofi-Aventis Deutschland GmbH	Use of PPAR agonists for the treatment of congestive heart failure
WO2006101108A1 (ja) *	2005-03-23	2006-09-28	Kyorin Pharmaceutical Co., Ltd.	新規環状アミノフェニルアルカン酸誘導体
DE102005026762A1 (de)	2005-06-09	2006-12-21	Sanofi-Aventis Deutschland Gmbh	Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
BRPI0617207A2 (pt)	2005-09-29	2011-07-19	Sanofi Aventis	derivados de fenil-1,2,4-oxadiazolona, processos para sua preparação e seu uso como produtos farmacêuticos
AR058562A1 (es) *	2005-12-22	2008-02-13	Astrazeneca Ab	Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1
MX2008015228A (es) *	2006-05-30	2008-12-12	Astrazeneca Ab	Acido 5-fenilamino-1,3,4-oxadiazol-2-ilcarbonilamino-4-fenoxi-cicl ohexanocarboxilico sustituido como inhibidor de diacilglicerol aciltransferasa de acetil coenzima a.
EP2041099A1 (en) *	2006-05-30	2009-04-01	AstraZeneca AB	1, 3, 4 -oxadiazole derivatives as dgat1 inhibitors
DE602007012875D1 (de) *	2006-06-08	2011-04-14	Astrazeneca Ab	Benzimidazole und ihre verwendung zur behandlung von diabetes
GB0611507D0 (en) *	2006-06-10	2006-07-19	Astrazeneca Ab	Chemical compounds
DE102006028862A1 (de)	2006-06-23	2007-12-27	Merck Patent Gmbh	3-Amino-imidazo[1,2-a]pyridinderivate
DE102007002260A1 (de)	2007-01-16	2008-07-31	Sanofi-Aventis	Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms
DE102007008420A1 (de)	2007-02-21	2008-08-28	Merck Patent Gmbh	Benzimidazolderivate
US8115011B2 (en) *	2007-05-22	2012-02-14	Madrigal Pharmaceuticals, Inc.	Diacylglycerol acyltransferase inhibitors
CA2686951C (en) *	2007-05-22	2016-03-22	Via Pharmaceuticals, Inc.	Diacylglycerol acyltransferase inhibitors
US8058299B2 (en)	2007-05-22	2011-11-15	Via Pharmaceuticals, Inc.	Diacylglycerol acyltransferase inhibitors
US8153644B2 (en)	2007-05-22	2012-04-10	Madrigal Pharmaceuticals, Inc.	Diacylglycerol acyltransferase inhibitors
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
BRPI0815490A2 (pt) *	2007-08-17	2017-03-21	Astrazeneca Ab	composto, composição faramcêutica, método para tratar diabetes mellitus e/ou obesidade em um animal de sangue quente, e, processo para preparar um composto
CN101381302B (zh) *	2007-09-07	2013-04-03	上海睿智化学研究有限公司	2-溴甲基-6-甲基苯甲酰氯/溴的制备方法
DE102007048716A1 (de)	2007-10-11	2009-04-23	Merck Patent Gmbh	Imidazo[1,2-a]pyrimidinderivate
DE102007054497B3 (de) *	2007-11-13	2009-07-23	Sanofi-Aventis Deutschland Gmbh	Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
WO2009081195A1 (en)	2007-12-20	2009-07-02	Astrazeneca Ab	Carbamoyl compounds as dgat1 inhibitors 190
DE102008017590A1 (de)	2008-04-07	2009-10-08	Merck Patent Gmbh	Glucopyranosidderivate
US8470841B2 (en)	2008-07-09	2013-06-25	Sanofi	Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
US8211884B2 (en) *	2008-08-06	2012-07-03	Madrigal Pharmaceuticals, Inc.	Diacylglycerol acyltransferase inhibitors
US8324385B2 (en)	2008-10-30	2012-12-04	Madrigal Pharmaceuticals, Inc.	Diacylglycerol acyltransferase inhibitors
AU2009322774A1 (en)	2008-12-03	2011-06-30	Via Pharmaceuticals, Inc	Inhibitors of diacylglycerol acyltransferase
WO2010068601A1 (en)	2008-12-08	2010-06-17	Sanofi-Aventis	A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
CN102245024A (zh)	2008-12-17	2011-11-16	维尔制药公司	二酰甘油酰基转移酶抑制剂
CA2747306A1 (en) *	2008-12-19	2010-06-24	Astrazeneca Ab	1,3,4-oxadiazole derivatives and their uses to treat diabetes
WO2010093601A1 (en)	2009-02-10	2010-08-19	Metabasis Therapeutics, Inc.	Novel sulfonic acid-containing thyromimetics, and methods for their use
RU2011152517A (ru) *	2009-06-19	2013-07-27	Астразенека Аб	Пиразинкарбоксамиды в качестве ингибиторов dgat1
CN102482312A (zh)	2009-08-26	2012-05-30	赛诺菲	新颖的杂芳族氟代糖苷结晶水合物、含有这些化合物的药物和它们的用途
CN102753184A (zh)	2009-10-02	2012-10-24	赛诺菲	具有sglt-1/sglt-2抑制剂活性的化合物在制备用于治疗骨病的药物中的用途
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2012120056A1 (de)	2011-03-08	2012-09-13	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8901114B2 (en)	2011-03-08	2014-12-02	Sanofi	Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120053A1 (de)	2011-03-08	2012-09-13	Sanofi	Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683699B1 (de)	2011-03-08	2015-06-24	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683705B1 (de)	2011-03-08	2015-04-22	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en)	2011-09-27	2015-10-21	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP3478297A1 (en) *	2016-06-30	2019-05-08	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of cardiomyopathies

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3174901A (en)	1963-01-31	1965-03-23	Jan Marcel Didier Aron Samuel	Process for the oral treatment of diabetes
FR2663336B1 (fr)	1990-06-18	1992-09-04	Adir	Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
RU2032677C1 (ru) *	1992-05-05	1995-04-10	Бристоль-Мейерз Сквибб Компани	Производные оксазола
CA2179399A1 (en) *	1993-12-20	1995-06-29	Kiyoshi Taniguchi	4,5-diaryloxazole derivatives
IL125071A0 (en)	1996-01-17	1999-01-26	Novo Nordisk As	Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives their preparation and use
AU1856997A (en)	1996-02-02	1997-08-22	Merck & Co., Inc.	Method for raising hdl cholesterol levels
ES2283025T3 (es)	1996-08-30	2007-10-16	Novo Nordisk A/S	Derivados de glp-1.1.
JP4339402B2 (ja)	1996-12-31	2009-10-07	ドクター・レディーズ・ラボラトリーズ・リミテッド	新規なヘテロ環化合物、これらの製造方法及びこれらを含有する薬学的組成物、並びに糖尿病及び関連疾患の治療におけるこれらの使用
US5814647A (en)	1997-03-04	1998-09-29	Board Of Regents, The University Of Texas System	Use of troglitazone and related compounds for the treatment of the climacteric symptoms
DE19726167B4 (de)	1997-06-20	2008-01-24	Sanofi-Aventis Deutschland Gmbh	Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
CA2294830A1 (en)	1997-07-16	1999-01-28	John Bondo Hansen	Fused 1,2,4-thiadiazine derivatives, their preparation and use
CO4970713A1 (es)	1997-09-19	2000-11-07	Sanofi Synthelabo	Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen
US6221897B1 (en)	1998-06-10	2001-04-24	Aventis Pharma Deutschland Gmbh	Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
DE19845405C2 (de)	1998-10-02	2000-07-13	Aventis Pharma Gmbh	Arylsubstituierte Propanolaminderivate und deren Verwendung
GB9900416D0 (en)	1999-01-08	1999-02-24	Alizyme Therapeutics Ltd	Inhibitors
EP1173438A1 (en)	1999-04-16	2002-01-23	Novo Nordisk A/S	Substituted imidazoles, their preparation and use
EE200100558A (et) *	1999-04-28	2002-12-16	Aventis Pharma Deutschland Gmbh	Triarüülhappe derivaat, seda sisaldav farmatseutiline kompositsioon ja ühendi raviotstarbeline kasutamine
CN101070316A (zh)	1999-04-28	2007-11-14	萨诺费－阿文蒂斯德国有限公司	作为ppar受体配体的二芳基酸衍生物
EP1175421A1 (en)	1999-04-30	2002-01-30	Neurogen Corporation	9H-PYRIMIDO[4,5-b]INDOLE DERIVATIVES: CRF1 SPECIFIC LIGANDS
GB9911863D0 (en)	1999-05-21	1999-07-21	Knoll Ag	Therapeutic agents
JP2003502369A (ja)	1999-06-18	2003-01-21	メルクエンドカムパニーインコーポレーテッド	アリールチアゾリジンジオン誘導体およびアリールオキサゾリジンジオン誘導体
PT1204654E (pt)	1999-07-29	2003-11-28	Lilly Co Eli	Benzofurilpiperazinas agonistas do receptor 5-ht2c da serotonina
WO2001016094A1 (de)	1999-09-01	2001-03-08	Aventis Pharma Deutschland Gmbh	Sulfonylcarboxamidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2001083451A1 (en)	2000-04-28	2001-11-08	Asahi Kasei Kabushiki Kaisha	Novel bicyclic compounds
JP2004507456A (ja)	2000-05-11	2004-03-11	ブリストル−マイヤーズ　スクイブ　カンパニー	成長ホルモン分泌促進薬として有用なテトラヒドロイソキノリン類縁体
CA2410597A1 (en)	2000-05-30	2001-12-06	Merck & Co., Inc.	Melanocortin receptor agonists
DE10308353A1 (de) *	2003-02-27	2004-12-02	Aventis Pharma Deutschland Gmbh	Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7148246B2 (en) *	2003-02-27	2006-12-12	Sanofi-Aventis Deutschland Gmbh	Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals

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Publication number	Publication date
US6624185B2 (en)	2003-09-23
DK1425014T3 (da)	2007-04-10
HRP20040199A2 (en)	2005-04-30
RU2004109586A (ru)	2005-04-20
PE20030414A1 (es)	2003-06-10
BG108598A (bg)	2005-03-31
JP4436129B2 (ja)	2010-03-24
HK1067560A1 (en)	2005-04-15
AR039063A1 (es)	2005-02-09
HUP0401564A2 (hu)	2004-11-29
CO5560562A2 (es)	2005-09-30
CR7261A (es)	2008-08-04
CN1549713A (zh)	2004-11-24
AU2002333456B2 (en)	2008-07-17
PL367342A1 (en)	2005-02-21
WO2003020269A1 (de)	2003-03-13
MA27134A1 (fr)	2005-01-03
CA2458210A1 (en)	2003-03-13
MXPA04001850A (es)	2004-06-15
RU2330846C2 (ru)	2008-08-10
RS50889B (sr)	2010-08-31
KR100915108B1 (ko)	2009-09-03
TWI305724B (en)	2009-02-01
ES2278077T3 (es)	2007-08-01
ATE347890T1 (de)	2007-01-15
DE50208960D1 (de)	2007-01-25
EE05418B1 (et)	2011-06-15
KR20040036924A (ko)	2004-05-03
IL160556A0 (en)	2004-07-25
NZ531440A (en)	2005-10-28
PT1425014E (pt)	2007-03-30
IL160556A (en)	2010-05-31
OA12656A (en)	2006-06-19
JP2005525294A (ja)	2005-08-25
PL208515B1 (pl)	2011-05-31
EP1425014B1 (de)	2006-12-13
CN1255103C (zh)	2006-05-10
CA2458210C (en)	2011-09-20
RS16704A (sr)	2006-12-15
HUP0401564A3 (en)	2008-05-28
AU2002333456A2 (en)	2003-03-18
EP1425014A1 (de)	2004-06-09
BR0212158A (pt)	2004-07-13
US20030144332A1 (en)	2003-07-31
MY132789A (en)	2007-10-31
UA76773C2 (uk)	2006-09-15
CY1106378T1 (el)	2011-10-12
TNSN04039A1 (en)	2006-06-01

Publication	Publication Date	Title
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