EE200200578A - Antihüpertensiivsete ja antiangiogeensete ainete terapeutilised kombinatsioonid - Google Patents
Antihüpertensiivsete ja antiangiogeensete ainete terapeutilised kombinatsioonidInfo
- Publication number
- EE200200578A EE200200578A EEP200200578A EEP200200578A EE200200578A EE 200200578 A EE200200578 A EE 200200578A EE P200200578 A EEP200200578 A EE P200200578A EE P200200578 A EEP200200578 A EE P200200578A EE 200200578 A EE200200578 A EE 200200578A
- Authority
- EE
- Estonia
- Prior art keywords
- antihypertensive
- agent
- angiogenic agents
- therapeutic combinations
- angiogenesis
- Prior art date
Links
- 239000004037 angiogenesis inhibitor Substances 0.000 title abstract 4
- 239000002220 antihypertensive agent Substances 0.000 title abstract 4
- 230000003276 anti-hypertensive effect Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 3
- 230000033115 angiogenesis Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0008269.3A GB0008269D0 (en) | 2000-04-05 | 2000-04-05 | Combination chemotherapy |
| PCT/GB2001/001522 WO2001074360A1 (en) | 2000-04-05 | 2001-04-02 | Therapeutic combinations of antihypertensive and antiangiogenic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE200200578A true EE200200578A (et) | 2004-06-15 |
Family
ID=9889176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200200578A EE200200578A (et) | 2000-04-05 | 2001-04-02 | Antihüpertensiivsete ja antiangiogeensete ainete terapeutilised kombinatsioonid |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7829573B2 (xx) |
| EP (3) | EP1272186B1 (xx) |
| JP (1) | JP2003528917A (xx) |
| KR (2) | KR20080034523A (xx) |
| CN (1) | CN1431902A (xx) |
| AT (1) | ATE355065T1 (xx) |
| AU (2) | AU2001244386B2 (xx) |
| BR (1) | BR0109729A (xx) |
| CA (1) | CA2401854A1 (xx) |
| CY (1) | CY1107615T1 (xx) |
| CZ (1) | CZ299410B6 (xx) |
| DE (1) | DE60126923T2 (xx) |
| DK (1) | DK1272186T3 (xx) |
| EE (1) | EE200200578A (xx) |
| ES (1) | ES2280349T3 (xx) |
| GB (1) | GB0008269D0 (xx) |
| HU (1) | HUP0300426A2 (xx) |
| IL (1) | IL151503A0 (xx) |
| IS (2) | IS2455B (xx) |
| MX (1) | MXPA02009743A (xx) |
| NO (2) | NO323467B1 (xx) |
| NZ (2) | NZ534455A (xx) |
| PL (1) | PL357605A1 (xx) |
| PT (1) | PT1272186E (xx) |
| RU (1) | RU2002129353A (xx) |
| SI (1) | SI1272186T1 (xx) |
| SK (1) | SK14302002A3 (xx) |
| WO (1) | WO2001074360A1 (xx) |
| ZA (1) | ZA200206959B (xx) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381413B1 (en) * | 1998-04-17 | 2008-06-03 | University Of Vermont And State Agricultural College | Methods and products related to metabolic interactions in disease |
| HK1049664B (en) * | 1999-11-05 | 2006-11-10 | Genzyme Corporation | Quinazoline derivatives as vegf inhibitors |
| ATE300303T1 (de) | 2000-03-06 | 2005-08-15 | Astrazeneca Ab | Verwendung von quinazolinderivate als inhibitoren der angiogenese |
| BR0109828A (pt) * | 2000-04-07 | 2002-12-17 | Astrazeneca Ab | Composto, processo para a prepapação do mesmo ou de um sal deste, composição farmacêutica, uso do composto ou de um sal deste farmaceuticamente aceitável, e, método para a produção de um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente em necessidade de tal tratamento |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| RU2365588C2 (ru) | 2002-02-01 | 2009-08-27 | Астразенека Аб | Хиназолиновые соединения |
| DE60311788T2 (de) * | 2002-04-16 | 2007-11-22 | Astrazeneca Ab | Kombinationstherapie zur behandlung von krebs |
| US7358236B1 (en) * | 2002-06-21 | 2008-04-15 | Oxigene, Inc. | Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents |
| EP2280003B1 (en) | 2002-07-15 | 2014-04-02 | Symphony Evolution, Inc. | Process for preparing receptor-type kinase modulators |
| US7435419B2 (en) * | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
| US7335362B2 (en) | 2002-07-19 | 2008-02-26 | Beth Israel Deaconess Medical Center | Methods of treating pre-eclampsia or eclampsia |
| DK2305301T3 (en) * | 2002-07-19 | 2015-04-13 | Beth Israel Hospital | Methods for the treatment of pre-eclampsia |
| GB0218526D0 (en) * | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
| GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
| JP4593464B2 (ja) | 2002-11-04 | 2010-12-08 | アストラゼネカ アクチボラグ | Srcチロシンキナーゼ阻害剤としてのキナゾリン誘導体 |
| PT1592423E (pt) * | 2003-02-13 | 2011-06-16 | Astrazeneca Ab | Terapia de combinação de zd6474 com 5-fu e/ou cpt-11 |
| GB0307333D0 (en) * | 2003-03-29 | 2003-05-07 | Astrazeneca Ab | Therapeutic agent |
| GB0310401D0 (en) * | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
| CA2529409A1 (en) * | 2003-06-18 | 2004-12-29 | Angiogene Pharmaceuticals Limited | Compositions comprising zd6126 together with 5-fu, cpt-11 or 5-fu and cpt-11 having vascular damaging activity for treating e.g. colorectal cancer |
| GB0316127D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
| AU2004255022B2 (en) * | 2003-07-10 | 2007-08-23 | Astrazeneca Ab | Use of the quinazoline derivative ZD6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
| GB0316123D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
| GB0318422D0 (en) * | 2003-08-06 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
| ES2314444T3 (es) | 2003-08-29 | 2009-03-16 | Pfizer Inc. | Tienopiridina-fenilacetaminasy sus derivados utiles como nuevos agentes antiangiogenicos. |
| JP4503022B2 (ja) * | 2003-12-23 | 2010-07-14 | ファイザー・インク | 新規キノリン誘導体 |
| GB0330002D0 (en) | 2003-12-24 | 2004-01-28 | Astrazeneca Ab | Quinazoline derivatives |
| GB0406445D0 (en) * | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
| EP1740170A2 (en) * | 2004-03-23 | 2007-01-10 | AstraZeneca AB | Combination therapy with azd2171 and platinum anti-tumour agent |
| EP1737452A1 (en) * | 2004-04-06 | 2007-01-03 | Angiogenetics Sweden AB | Angiogenesis-affecting compounds and methods of use thereof |
| US20070142308A1 (en) * | 2005-04-06 | 2007-06-21 | Helmut Augustin | Angiogenesis-affecting compounds and methods for use thereof |
| US20070142433A1 (en) * | 2004-04-06 | 2007-06-21 | Helmut Augustin | Angiogenesis-affecting compounds and methods of use thereof |
| AU2005244167A1 (en) * | 2004-05-04 | 2005-11-24 | Beth Israel Deaconess Medical Center | Methods and compositions for treatment of preeclampsia |
| AU2005249794A1 (en) | 2004-06-04 | 2005-12-15 | Teva Pharmaceutical Industries, Ltd. | Pharmaceutical composition containing irbesartan |
| US7740849B2 (en) * | 2004-09-24 | 2010-06-22 | Beth Israel Deaconess Medical Center | Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders |
| US20060067937A1 (en) | 2004-09-24 | 2006-03-30 | Karumanchi S A | Methods of diagnosing and treating complications of pregnancy |
| CA2578956A1 (en) * | 2004-09-27 | 2006-04-06 | Astrazeneca Ab | Combination comprising zd6474 and an imatinib |
| GB0424339D0 (en) * | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
| MX2007006777A (es) | 2004-12-06 | 2007-08-06 | Avigen Inc | Ibudilast para tratar dolor neuropatico y sindromes asociados. |
| BRPI0519096A2 (pt) * | 2004-12-15 | 2008-12-23 | Beth Israel Hospital | Ácidos nuclÉicos e polipeptÍdeos éteis para o diagnàstico e tratamento de complicaÇÕes na gravidez |
| WO2006086544A2 (en) | 2005-02-11 | 2006-08-17 | Regeneron Pharmaceuticals, Inc. | Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent |
| CN101137380A (zh) * | 2005-03-09 | 2008-03-05 | 默克公司 | 喹唑啉酮t-型钙通道拮抗剂 |
| JP2009500384A (ja) * | 2005-07-06 | 2009-01-08 | アストラゼネカ アクチボラグ | 併用療法 |
| MX2008001838A (es) | 2005-08-08 | 2008-04-09 | Pfizer | Sales y polimorfos de un inhibidor de vegf-r. |
| RU2414924C2 (ru) | 2005-08-12 | 2011-03-27 | Ридженерон Фармасьютикалз, Инк. | Способы лечения заболеваний антагонистами vegf |
| HRP20110360T1 (hr) * | 2005-12-22 | 2011-06-30 | Astrazeneca Ab | Kombinacija zd6474 i pemetrekseda |
| KR20080077678A (ko) * | 2005-12-22 | 2008-08-25 | 아스트라제네카 아베 | Azd2171 및 페메트렉시드의 조합물 |
| US20090286271A1 (en) * | 2006-05-31 | 2009-11-19 | Karumanchi Ananth S | Methods of Diagnosing and Treating Complications of Pregnancy |
| US20100092466A1 (en) * | 2006-09-29 | 2010-04-15 | Anderson Joseph Ryan | Combination of zd6474 and bevacizumab for cancer therapy |
| WO2008080110A1 (en) * | 2006-12-21 | 2008-07-03 | Alcon, Inc. | Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor |
| DK2131841T3 (da) * | 2007-01-30 | 2012-10-15 | Avigen Inc | Fremgangsmåder til behandling af akut smerte |
| US20080190689A1 (en) * | 2007-02-12 | 2008-08-14 | Ballard Ebbin C | Inserts for engine exhaust systems |
| CA2684938A1 (en) * | 2007-05-02 | 2008-11-13 | Tau Therapeutics Llc | Dihydropyridine derivative for treating cancer or a pre-cancerous condition and other conditions |
| WO2008137012A1 (en) * | 2007-05-03 | 2008-11-13 | Avigen, Inc. | Use of a glial attenuator to prevent amplified pain responses caused by glial priming |
| CA2692783A1 (en) * | 2007-07-10 | 2009-01-15 | Merck Sharp & Dohme Corp. | Quinazolinone t-type calcium channel antagonists |
| CA2730773A1 (en) | 2008-07-14 | 2010-01-21 | Martha Karen Newell | Methods and products for treating proliferative diseases |
| ES2557407T3 (es) | 2010-03-01 | 2016-01-25 | Tau Therapeutics Llc | Procedimiento de imaginología de una enfermedad |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| CN103110614B (zh) * | 2013-01-18 | 2015-02-18 | 杭州雷索药业有限公司 | 舒洛地尔在制备抗血管生成类药物中的应用 |
| AU2014219024B2 (en) * | 2013-02-20 | 2018-04-05 | KALA BIO, Inc. | Therapeutic compounds and uses thereof |
| CN106572988B (zh) | 2014-04-08 | 2022-04-08 | 卫理公会医院 | Inos抑制性组合物及其作为乳腺癌治疗剂的用途 |
| DK3170005T3 (da) | 2014-07-18 | 2019-07-08 | Sanofi Sa | Fremgangsmåde til forudsigelse af resultatet af en behandling med aflibercept hos en patient, der mistænkes for at lide af cancer |
| US10265111B2 (en) | 2016-04-26 | 2019-04-23 | Medtronic Holding Company Sárl | Inflatable bone tamp with flow control and methods of use |
| US10799138B2 (en) | 2018-04-05 | 2020-10-13 | University Of Maryland, Baltimore | Method of administering sotalol IV/switch |
| WO2020028007A1 (en) * | 2018-07-31 | 2020-02-06 | Colorado State University Research Foundation | Compositions, methods and uses for modulating the tumor microenvironment to enhance antitumor immunity |
| US11344518B2 (en) | 2018-08-14 | 2022-05-31 | AltaThera Pharmaceuticals LLC | Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame |
| US10512620B1 (en) | 2018-08-14 | 2019-12-24 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| US12396970B2 (en) | 2021-08-20 | 2025-08-26 | AltaThera Pharmaceuticals LLC | Anti-arrhythmic compositions and methods |
| US11696902B2 (en) | 2018-08-14 | 2023-07-11 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| US11610660B1 (en) | 2021-08-20 | 2023-03-21 | AltaThera Pharmaceuticals LLC | Antiarrhythmic drug dosing methods, medical devices, and systems |
| US11484355B2 (en) | 2020-03-02 | 2022-11-01 | Medtronic Holding Company Sàrl | Inflatable bone tamp and method for use of inflatable bone tamp |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
| US5646136A (en) * | 1994-01-04 | 1997-07-08 | Duke University | Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids |
| GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| PT880508E (pt) * | 1996-02-13 | 2003-07-31 | Astrazeneca Ab | Derivados de quinazolina como inibidores de vegf |
| IL125954A (en) * | 1996-03-05 | 2003-06-24 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect |
| DE69734149T2 (de) * | 1996-03-15 | 2006-07-06 | Astrazeneca Ab | Cinoline derivate und verwendung als heilmittel |
| GB9707800D0 (en) * | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
| CA2263479A1 (en) * | 1996-09-25 | 1998-04-02 | Zeneca Limited | Quinoline derivatives inhibiting the effect of growth factors such as vegf |
| GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| CA2275708A1 (en) | 1996-12-23 | 1998-07-02 | Cambridge University Technical Services Limited | Diagnosis and treatment of pathological pregnancies |
| US6294532B1 (en) * | 1997-08-22 | 2001-09-25 | Zeneca Limited | Oxindolylquinazoline derivatives as angiogenesis inhibitors |
| ATE405651T1 (de) * | 1998-03-17 | 2008-09-15 | Genentech Inc | Zu vegf und bmp1 homologe polypeptide |
| US6191144B1 (en) * | 1998-08-17 | 2001-02-20 | Warner-Lambert Company | Method of using angiotensin converting enzyme inhibitor to stimulate angiogenesis |
| AU5910599A (en) | 1998-09-09 | 2000-03-27 | Scios Inc. | Treatment of microvascular angiopathies |
| EP1146891B1 (en) * | 1999-01-15 | 2006-12-20 | Medstar Research Institute | Therapy of restenosis and atherosclerosis with a soluble vegf receptor and angiopoeitin-1 |
| CZ305827B6 (cs) * | 1999-02-10 | 2016-03-30 | Astrazeneca Ab | Indolové deriváty |
| HK1049664B (en) * | 1999-11-05 | 2006-11-10 | Genzyme Corporation | Quinazoline derivatives as vegf inhibitors |
| AU2001280546B2 (en) * | 2000-07-13 | 2005-10-20 | Alteon, Inc. | Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disorders associated with protein aging |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| GB0218526D0 (en) | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
| JP2006502132A (ja) | 2002-08-09 | 2006-01-19 | アストラゼネカ アクチボラグ | 癌の治療における血管内皮細胞増殖因子受容体の阻害薬zd6474と放射線療法との併用 |
| GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
| PT1592423E (pt) * | 2003-02-13 | 2011-06-16 | Astrazeneca Ab | Terapia de combinação de zd6474 com 5-fu e/ou cpt-11 |
| GB0310401D0 (en) | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
| GB0316123D0 (en) | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
| GB0316127D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
| AU2004255022B2 (en) | 2003-07-10 | 2007-08-23 | Astrazeneca Ab | Use of the quinazoline derivative ZD6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
| GB0406445D0 (en) | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
| EP1740170A2 (en) * | 2004-03-23 | 2007-01-10 | AstraZeneca AB | Combination therapy with azd2171 and platinum anti-tumour agent |
| GB0406446D0 (en) | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
| CA2578956A1 (en) * | 2004-09-27 | 2006-04-06 | Astrazeneca Ab | Combination comprising zd6474 and an imatinib |
| MX2007003506A (es) | 2004-09-27 | 2007-05-10 | Aztrazeneca Ab | Terapia de combinacion de cancer que comprende azd2171 e imatinib. |
| GB0424339D0 (en) | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
| JP2009500384A (ja) | 2005-07-06 | 2009-01-08 | アストラゼネカ アクチボラグ | 併用療法 |
| NZ569787A (en) * | 2005-12-15 | 2011-07-29 | Astrazeneca Ab | Combination of angiopoietin-2 antagonist and of VEGF-A, KDR and/or FLT1 antagonist for treating cancer |
| KR20080077678A (ko) * | 2005-12-22 | 2008-08-25 | 아스트라제네카 아베 | Azd2171 및 페메트렉시드의 조합물 |
| HRP20110360T1 (hr) * | 2005-12-22 | 2011-06-30 | Astrazeneca Ab | Kombinacija zd6474 i pemetrekseda |
| US20100092466A1 (en) | 2006-09-29 | 2010-04-15 | Anderson Joseph Ryan | Combination of zd6474 and bevacizumab for cancer therapy |
| EP2134340A1 (en) | 2007-04-13 | 2009-12-23 | AstraZeneca AB | Combination therapy comprising azd2171 and azd6244 or mek-inhibitor ii |
-
2000
- 2000-04-05 GB GBGB0008269.3A patent/GB0008269D0/en not_active Ceased
-
2001
- 2001-04-02 KR KR1020087007835A patent/KR20080034523A/ko not_active Ceased
- 2001-04-02 US US10/240,413 patent/US7829573B2/en not_active Expired - Fee Related
- 2001-04-02 NZ NZ534455A patent/NZ534455A/en unknown
- 2001-04-02 EP EP01917305A patent/EP1272186B1/en not_active Expired - Lifetime
- 2001-04-02 HU HU0300426A patent/HUP0300426A2/hu unknown
- 2001-04-02 KR KR1020027013170A patent/KR100849149B1/ko not_active Expired - Fee Related
- 2001-04-02 AU AU2001244386A patent/AU2001244386B2/en not_active Ceased
- 2001-04-02 PT PT01917305T patent/PT1272186E/pt unknown
- 2001-04-02 NZ NZ520938A patent/NZ520938A/en unknown
- 2001-04-02 AU AU4438601A patent/AU4438601A/xx active Pending
- 2001-04-02 IL IL15150301A patent/IL151503A0/xx unknown
- 2001-04-02 SK SK1430-2002A patent/SK14302002A3/sk unknown
- 2001-04-02 EE EEP200200578A patent/EE200200578A/xx unknown
- 2001-04-02 WO PCT/GB2001/001522 patent/WO2001074360A1/en not_active Ceased
- 2001-04-02 CZ CZ20023304A patent/CZ299410B6/cs not_active IP Right Cessation
- 2001-04-02 BR BR0109729-6A patent/BR0109729A/pt not_active Application Discontinuation
- 2001-04-02 DK DK01917305T patent/DK1272186T3/da active
- 2001-04-02 SI SI200130715T patent/SI1272186T1/sl unknown
- 2001-04-02 DE DE60126923T patent/DE60126923T2/de not_active Expired - Lifetime
- 2001-04-02 AT AT01917305T patent/ATE355065T1/de active
- 2001-04-02 CA CA002401854A patent/CA2401854A1/en not_active Abandoned
- 2001-04-02 ES ES01917305T patent/ES2280349T3/es not_active Expired - Lifetime
- 2001-04-02 CN CN01807430A patent/CN1431902A/zh active Pending
- 2001-04-02 MX MXPA02009743A patent/MXPA02009743A/es active IP Right Grant
- 2001-04-02 JP JP2001572104A patent/JP2003528917A/ja active Pending
- 2001-04-02 RU RU2002129353/14A patent/RU2002129353A/ru unknown
- 2001-04-02 PL PL01357605A patent/PL357605A1/xx not_active Application Discontinuation
- 2001-04-02 EP EP06003576A patent/EP1658849A3/en not_active Withdrawn
- 2001-04-02 EP EP07003863A patent/EP1790340A3/en not_active Withdrawn
-
2002
- 2002-08-29 ZA ZA200206959A patent/ZA200206959B/en unknown
- 2002-09-20 IS IS6557A patent/IS2455B/is unknown
- 2002-10-04 NO NO20024814A patent/NO323467B1/no not_active IP Right Cessation
-
2006
- 2006-05-08 NO NO20062050A patent/NO326277B1/no not_active IP Right Cessation
-
2007
- 2007-04-17 CY CY20071100523T patent/CY1107615T1/el unknown
-
2008
- 2008-04-16 IS IS8726A patent/IS8726A/is unknown
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