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EE200200169A - Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid - Google Patents

Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid

Info

Publication number
EE200200169A
EE200200169A EEP200200169A EEP200200169A EE200200169A EE 200200169 A EE200200169 A EE 200200169A EE P200200169 A EEP200200169 A EE P200200169A EE P200200169 A EEP200200169 A EE P200200169A EE 200200169 A EE200200169 A EE 200200169A
Authority
EE
Estonia
Prior art keywords
indolyl
acid derivatives
glyoxylic acid
therapeutically valuable
valuable properties
Prior art date
Application number
EEP200200169A
Other languages
English (en)
Estonian (et)
Inventor
Nickel Bernd
Klenner Thomas
Bacher Gerald
Beckers Thomas
Emig Peter
Engel J�rgen
Bruyneel Erik
Kamp G�nter
Peters Kirsten
Original Assignee
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19946301A external-priority patent/DE19946301A1/de
Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
Publication of EE200200169A publication Critical patent/EE200200169A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
EEP200200169A 1999-09-28 2000-09-26 Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid EE200200169A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19946301A DE19946301A1 (de) 1998-04-02 1999-09-28 Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
PCT/EP2000/009390 WO2001022954A2 (de) 1999-09-28 2000-09-26 Indolyl-3-glyoxylsäurederivate als antitumormittel

Publications (1)

Publication Number Publication Date
EE200200169A true EE200200169A (et) 2003-04-15

Family

ID=7923485

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200169A EE200200169A (et) 1999-09-28 2000-09-26 Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid

Country Status (32)

Country Link
EP (1) EP1218006B1 (xx)
JP (1) JP2003510274A (xx)
KR (1) KR100759242B1 (xx)
CN (1) CN1301712C (xx)
AR (1) AR025885A1 (xx)
AT (1) ATE459356T1 (xx)
AU (1) AU783436B2 (xx)
BG (1) BG106639A (xx)
BR (1) BR0014378A (xx)
CA (1) CA2386069C (xx)
CZ (1) CZ303246B6 (xx)
DE (1) DE50015879D1 (xx)
DZ (1) DZ3196A1 (xx)
EE (1) EE200200169A (xx)
ES (1) ES2342042T3 (xx)
GE (1) GEP20043250B (xx)
HK (1) HK1048941B (xx)
HR (1) HRP20020369A2 (xx)
HU (1) HUP0202788A3 (xx)
IL (2) IL148670A0 (xx)
IS (1) IS6319A (xx)
MX (1) MXPA02002824A (xx)
NO (1) NO322614B1 (xx)
NZ (1) NZ517988A (xx)
PL (1) PL199576B1 (xx)
RS (1) RS51302B (xx)
RU (1) RU2282444C2 (xx)
SK (1) SK287533B6 (xx)
TW (1) TWI269654B (xx)
UA (1) UA75872C2 (xx)
WO (1) WO2001022954A2 (xx)
ZA (1) ZA200202556B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
AU2001258628A1 (en) 2000-05-31 2001-12-11 Astrazeneca Ab Indole derivatives with vascular damaging activity
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
EP1484329A1 (de) * 2003-06-06 2004-12-08 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
RU2327696C2 (ru) * 2003-06-05 2008-06-27 Центарис Гмбх Производные индола, обладающие индуцирующим апоптоз эффектом (варианты), фармацевтическая композиция на их основе
EP1595878A1 (de) * 2004-05-15 2005-11-16 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
KR101347830B1 (ko) * 2004-05-23 2014-01-07 에이치엠아이, 인코포레이티드 테라뮤틴 조절물질
WO2006052712A1 (en) * 2004-11-08 2006-05-18 Baxter International Inc. Nanoparticulate compositions of tubulin inhibitor
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
KR101238525B1 (ko) 2004-12-31 2013-02-28 레디 유에스 테라퓨틱스 인코포레이티드 Ｃｅｔｐ 저해제로서의 신규 벤질아민 유도체
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
JP2010511041A (ja) * 2006-11-28 2010-04-08 ジオファーム オンコロジー， インコーポレイテッド インジブリンを含むインドリル−３−グリオキシル酸誘導体の癌を処置するための単独またはさらなる薬剤との組み合わせでの使用
WO2013024358A2 (en) 2011-08-18 2013-02-21 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors
KR101803866B1 (ko) 2011-09-27 2017-12-04 닥터 레디스 레보러터리즈 리미티드 동맥경화증 치료에 유용한 콜레스테릴 에스테르-전달 단백질(cetp) 억제제로서 5-벤질아미노메틸-6-아미노피라졸로[3,4-b]피리딘 유도체
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
CA2905509A1 (en) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center Hsp90-targeted cardiac imaging and therapy
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
CN109111501B (zh) * 2017-06-23 2022-04-22 首都医科大学 脂肪氨基酸修饰的吲哚乙醇衍生物, 其合成，活性和应用
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
US12030888B2 (en) 2021-02-24 2024-07-09 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
RU2047603C1 (ru) * 1991-12-09 1995-11-10 Матвей Абрамович Рехтер 1-алкил-2-ацилиндолы и способы их получения
NZ314207A (en) * 1992-09-28 2000-12-22 Vertex Pharma 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
CA2126217A1 (en) * 1992-10-20 1994-04-28 Katsuhiro Shibayama Agent for suppressing infiltration of eosinophilis
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
AU6523598A (en) 1997-04-08 1998-10-30 Banyu Pharmaceutical Co., Ltd. Cancerous metastasis-associated gene
SK12752000A3 (sk) * 1998-02-25 2001-03-12 Genetics Institute, Inc. Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie
KR20010041811A (ko) * 1998-03-12 2001-05-25 온토젠 코포레이션 단백질 티로신 포스파타제의 조절제
DE19814838C2 (de) 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
TR200003130T2 (tr) * 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
JP2000239252A (ja) * 1999-02-16 2000-09-05 Mitsubishi Chemicals Corp インドール誘導体
WO2000067802A1 (en) * 1999-05-10 2000-11-16 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof

Also Published As

Publication number Publication date
SK4072002A3 (en) 2003-11-04
YU22702A (sh) 2004-12-31
HRP20020369A2 (en) 2004-12-31
AR025885A1 (es) 2002-12-18
HUP0202788A3 (en) 2003-02-28
HUP0202788A2 (hu) 2003-01-28
WO2001022954A3 (de) 2002-03-28
CZ20021005A3 (cs) 2004-01-14
SK287533B6 (sk) 2011-01-04
AU7782900A (en) 2001-04-30
RS51302B (sr) 2010-12-31
NZ517988A (en) 2004-10-29
TWI269654B (en) 2007-01-01
AU783436B2 (en) 2005-10-27
IS6319A (is) 2002-03-21
IL148670A (en) 2009-09-01
ES2342042T3 (es) 2010-07-01
BR0014378A (pt) 2003-07-29
PL199576B1 (pl) 2008-10-31
ATE459356T1 (de) 2010-03-15
KR20030019295A (ko) 2003-03-06
JP2003510274A (ja) 2003-03-18
DZ3196A1 (fr) 2001-04-05
GEP20043250B (en) 2004-06-25
NO322614B1 (no) 2006-11-06
EP1218006B1 (de) 2010-03-03
HK1048941A1 (en) 2003-04-25
HK1048941B (zh) 2007-09-21
DE50015879D1 (de) 2010-04-15
IL148670A0 (en) 2002-09-12
CZ303246B6 (cs) 2012-06-20
EP1218006A2 (de) 2002-07-03
ZA200202556B (en) 2003-08-27
NO20021367D0 (no) 2002-03-19
BG106639A (bg) 2002-12-29
NO20021367L (no) 2002-05-22
WO2001022954A2 (de) 2001-04-05
PL364811A1 (en) 2004-12-13
CN1301712C (zh) 2007-02-28
CA2386069C (en) 2012-08-14
UA75872C2 (en) 2006-06-15
CN1376064A (zh) 2002-10-23
RU2282444C2 (ru) 2006-08-27
MXPA02002824A (es) 2003-07-21
KR100759242B1 (ko) 2007-09-18
CA2386069A1 (en) 2001-04-05

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Legal Events

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GB1A Change in the ownership or in the address of the owner