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TR200003130T2 - Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler - Google Patents

Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler

Info

Publication number
TR200003130T2
TR200003130T2 TR2000/03130T TR200003130T TR200003130T2 TR 200003130 T2 TR200003130 T2 TR 200003130T2 TR 2000/03130 T TR2000/03130 T TR 2000/03130T TR 200003130 T TR200003130 T TR 200003130T TR 200003130 T2 TR200003130 T2 TR 200003130T2
Authority
TR
Turkey
Prior art keywords
hydroxyindoles
phosphodiesterase
inhibitors
novel
processes
Prior art date
Application number
TR2000/03130T
Other languages
English (en)
Inventor
H�Fgen Norbert
Egerland Ute
Poppe Hildegard
Marx Degenhard
Szelenyi Stefan
Kronbach Thomas
Polymeropoulos Emmanuel
Heer Sabine
Original Assignee
Arzneimittelwerk Dresden Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19818964A external-priority patent/DE19818964A1/de
Priority claimed from DE1999117504 external-priority patent/DE19917504A1/de
Application filed by Arzneimittelwerk Dresden Gmbh filed Critical Arzneimittelwerk Dresden Gmbh
Publication of TR200003130T2 publication Critical patent/TR200003130T2/tr

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
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    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Bulus (1) formülünün hidroksiindollerine iliskindir, bu formülde, R1 ve R5, -C1...12-alkil, -C2...12-alkenil, tek-, iki- ya da üç-siklik karbosikler, tek-, iki- ya da üç-siklik heterosikler, karbo- ya da heterosiklik spirosiklerdir, ve R2 ve R3 hidrojen ya da -OH olabilmektedir, bu durumda, iki ikame edicinin en azindan birinin -OH olmasi gerekmektedir. Bulus, ayni zamanda, bu bilesiklerin fosfodiesteraz 4 inhibitörleri olarak kullanimi ve bunlarin üretilmesi için bir yönteme iliskindir.
TR2000/03130T 1998-04-28 1999-04-24 Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler TR200003130T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19818964A DE19818964A1 (de) 1998-04-28 1998-04-28 Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
DE1999117504 DE19917504A1 (de) 1999-04-17 1999-04-17 Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen

Publications (1)

Publication Number Publication Date
TR200003130T2 true TR200003130T2 (tr) 2001-01-22

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ID=26045814

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TR2000/03130T TR200003130T2 (tr) 1998-04-28 1999-04-24 Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler

Country Status (27)

Country Link
US (8) US6251923B1 (tr)
EP (2) EP1076657B1 (tr)
JP (2) JP3842043B2 (tr)
KR (1) KR100448748B1 (tr)
CN (1) CN1234705C (tr)
AR (1) AR016236A1 (tr)
AT (2) ATE330955T1 (tr)
AU (1) AU748403B2 (tr)
BG (1) BG65023B1 (tr)
BR (1) BR9910029A (tr)
CY (1) CY1105075T1 (tr)
CZ (1) CZ20003985A3 (tr)
DE (2) DE59910142D1 (tr)
DK (2) DK1475377T3 (tr)
ES (2) ES2262072T3 (tr)
HU (1) HUP0101625A3 (tr)
IL (2) IL138847A0 (tr)
NO (1) NO321867B1 (tr)
NZ (1) NZ507406A (tr)
PL (1) PL198983B1 (tr)
PT (2) PT1475377E (tr)
SI (2) SI1475377T1 (tr)
SK (1) SK286192B6 (tr)
TR (1) TR200003130T2 (tr)
TW (1) TW530048B (tr)
UA (1) UA59443C2 (tr)
WO (1) WO1999055696A1 (tr)

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