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EE200100075A - 2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid - Google Patents

2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid

Info

Publication number
EE200100075A
EE200100075A EEP200100075A EEP200100075A EE200100075A EE 200100075 A EE200100075 A EE 200100075A EE P200100075 A EEP200100075 A EE P200100075A EE P200100075 A EEP200100075 A EE P200100075A EE 200100075 A EE200100075 A EE 200100075A
Authority
EE
Estonia
Prior art keywords
piperidylbenzimidazole
orl
substituted
compounds
receptor agonists
Prior art date
Application number
EEP200100075A
Other languages
English (en)
Estonian (et)
Inventor
Ito Fumitaka
Noguchi Hirohide
Kondo Hiroshi
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of EE200100075A publication Critical patent/EE200100075A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200100075A 1998-08-06 1999-07-05 2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid EE200100075A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IBPCT/IB98/01206 1998-08-06
PCT/IB1999/001239 WO2000008013A2 (en) 1998-08-06 1999-07-05 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Publications (1)

Publication Number Publication Date
EE200100075A true EE200100075A (et) 2002-06-17

Family

ID=11004738

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100075A EE200100075A (et) 1998-08-06 1999-07-05 2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid

Country Status (44)

Country Link
US (1) US6172067B1 (xx)
EP (1) EP1102762B1 (xx)
JP (1) JP3367945B2 (xx)
CN (1) CN1317968A (xx)
AP (1) AP2001002063A0 (xx)
AR (1) AR018686A1 (xx)
AT (1) ATE227716T1 (xx)
AU (1) AU749166B2 (xx)
BG (1) BG105301A (xx)
BR (1) BR9912778A (xx)
CA (1) CA2339621C (xx)
CZ (1) CZ2001397A3 (xx)
DE (1) DE69903953T2 (xx)
DK (1) DK1102762T3 (xx)
EA (1) EA200100104A1 (xx)
EE (1) EE200100075A (xx)
ES (1) ES2185357T3 (xx)
GE (1) GEP20033000B (xx)
GT (1) GT199900125A (xx)
HK (1) HK1040188A1 (xx)
HN (1) HN1999000105A (xx)
HR (1) HRP20010089B1 (xx)
HU (1) HUP0103567A3 (xx)
ID (1) ID27212A (xx)
IL (1) IL141029A0 (xx)
IS (1) IS5812A (xx)
MA (1) MA26659A1 (xx)
NO (1) NO20010603L (xx)
NZ (1) NZ509299A (xx)
OA (1) OA11590A (xx)
PA (1) PA8477701A1 (xx)
PE (1) PE20000868A1 (xx)
PL (1) PL346211A1 (xx)
PT (1) PT1102762E (xx)
SI (1) SI1102762T1 (xx)
SK (1) SK1602001A3 (xx)
SV (1) SV1999000099A (xx)
TN (1) TNSN99142A1 (xx)
TR (1) TR200100403T2 (xx)
TW (1) TW513424B (xx)
UY (1) UY25659A1 (xx)
WO (1) WO2000008013A2 (xx)
YU (1) YU8201A (xx)
ZA (1) ZA200100900B (xx)

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SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
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GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
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EP1975164B1 (en) * 2001-04-18 2010-01-27 Euro-Celtique S.A. Octahydrobenzimidazolone compounds as analgetics
UA74439C2 (uk) 2001-04-18 2005-12-15 Еро-Селтік, С.А. Сполуки спіропіразолу
JP4489354B2 (ja) 2001-04-18 2010-06-23 ユーロ−セルティーク エス．エイ． スピロインデンおよびスピロインダン化合物類
MXPA03009602A (es) 2001-04-18 2004-04-02 Euro Celtique Sa Analogos de nociceptina.
EP1406629A1 (en) * 2001-07-02 2004-04-14 Omeros Corporation Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
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AU2002360561A1 (en) * 2001-12-11 2003-06-23 Sepracor, Inc. 4-substituted piperidines, and methods of use thereof
US7566728B2 (en) 2002-03-29 2009-07-28 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
DE10252665A1 (de) 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
DE10252666A1 (de) 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
SE0301369D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
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BRPI0911031B8 (pt) 2008-07-21 2021-05-25 Purdue Pharma Lp compostos de piperidina ligada do tipo quinoxalina substituídos e os usos destes
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Also Published As

Publication number Publication date
BG105301A (en) 2001-12-29
YU8201A (sh) 2003-07-07
SK1602001A3 (en) 2002-09-10
SV1999000099A (es) 2000-09-05
EP1102762A2 (en) 2001-05-30
EP1102762B1 (en) 2002-11-13
AR018686A1 (es) 2001-11-28
IL141029A0 (en) 2002-02-10
ATE227716T1 (de) 2002-11-15
MA26659A1 (fr) 2004-12-20
PT1102762E (pt) 2003-02-28
CZ2001397A3 (cs) 2002-05-15
ID27212A (id) 2001-03-08
HRP20010089A2 (en) 2002-02-28
SI1102762T1 (en) 2003-04-30
OA11590A (en) 2004-08-18
HRP20010089B1 (en) 2003-04-30
ES2185357T3 (es) 2003-04-16
NZ509299A (en) 2003-05-30
TR200100403T2 (tr) 2001-07-23
US6172067B1 (en) 2001-01-09
HN1999000105A (es) 2000-11-11
NO20010603L (no) 2001-04-05
HUP0103567A2 (hu) 2002-02-28
TNSN99142A1 (fr) 2005-11-10
IS5812A (is) 2001-01-16
DE69903953T2 (de) 2003-03-27
AU4385999A (en) 2000-02-28
WO2000008013A3 (en) 2000-03-23
PL346211A1 (en) 2002-01-28
JP3367945B2 (ja) 2003-01-20
TW513424B (en) 2002-12-11
NO20010603D0 (no) 2001-02-05
ZA200100900B (en) 2002-08-28
WO2000008013A2 (en) 2000-02-17
PA8477701A1 (es) 2000-09-29
BR9912778A (pt) 2001-09-25
AU749166B2 (en) 2002-06-20
GEP20033000B (en) 2003-06-25
PE20000868A1 (es) 2000-08-31
AP2001002063A0 (en) 2001-03-31
CA2339621C (en) 2005-04-05
HK1040188A1 (zh) 2002-05-31
UY25659A1 (es) 2000-02-23
GT199900125A (es) 2001-01-27
JP2002522431A (ja) 2002-07-23
DK1102762T3 (da) 2002-12-16
CA2339621A1 (en) 2000-02-17
CN1317968A (zh) 2001-10-17
EA200100104A1 (ru) 2001-08-27
HUP0103567A3 (en) 2003-01-28
DE69903953D1 (de) 2002-12-19

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