EE200000733A - Tetrahüdrokinoliini derivaadid kui glütsiini antagonistid - Google Patents

Tetrahüdrokinoliini derivaadid kui glütsiini antagonistid

Info

Publication number: EE200000733A
Authority: EE; Estonia
Prior art keywords: tetrahydroquinoline derivatives; glycine antagonists; antagonists; glycine; tetrahydroquinoline
Prior art date: 1998-06-10

Application number

EEP200000733A

Other languages

English (en)

Inventor

Di Fabio Romano

Original Assignee

Glaxo Wellcome S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-10

Filing date

1999-06-08

Publication date

2002-06-17

1998-06-10 Priority claimed from GBGB9812408.4A external-priority patent/GB9812408D0/en

1998-06-10 Priority claimed from GBGB9812410.0A external-priority patent/GB9812410D0/en

1999-06-08 Application filed by Glaxo Wellcome S.P.A. filed Critical Glaxo Wellcome S.P.A.

2002-06-17 Publication of EE200000733A publication Critical patent/EE200000733A/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EEP200000733A 1998-06-10 1999-06-08 Tetrahüdrokinoliini derivaadid kui glütsiini antagonistid EE200000733A (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9812408.4A GB9812408D0 (en)	1998-06-10	1998-06-10	Heterocyclic compounds
GBGB9812410.0A GB9812410D0 (en)	1998-06-10	1998-06-10	Heterocyclic derivatives
PCT/EP1999/003936 WO1999064411A1 (en)	1998-06-10	1999-06-08	Tetrahydroquinoline derivatives as glycine antagonists

Publications (1)

Publication Number	Publication Date
EE200000733A true EE200000733A (et)	2002-06-17

Family

ID=26313826

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000733A EE200000733A (et)	1998-06-10	1999-06-08	Tetrahüdrokinoliini derivaadid kui glütsiini antagonistid

Country Status (33)

Country	Link
US (3)	US6362199B1 (et)
EP (1)	EP1086093B1 (et)
JP (1)	JP2002517492A (et)
KR (1)	KR100586762B1 (et)
CN (1)	CN1173970C (et)
AP (1)	AP2000002008A0 (et)
AR (1)	AR018632A1 (et)
AT (1)	ATE301650T1 (et)
AU (1)	AU753867B2 (et)
BG (1)	BG105123A (et)
BR (1)	BR9911145A (et)
CA (1)	CA2334727C (et)
CO (1)	CO5080785A1 (et)
CZ (1)	CZ293605B6 (et)
DE (1)	DE69926632T2 (et)
DK (1)	DK1086093T3 (et)
EA (1)	EA003276B1 (et)
EE (1)	EE200000733A (et)
ES (1)	ES2249010T3 (et)
HR (1)	HRP20000845A2 (et)
HU (1)	HUP0102767A3 (et)
ID (1)	ID27845A (et)
IL (2)	IL140062A0 (et)
IS (1)	IS5746A (et)
MY (1)	MY125037A (et)
NO (1)	NO321904B1 (et)
NZ (1)	NZ508638A (et)
OA (1)	OA11564A (et)
PE (1)	PE20000724A1 (et)
PL (1)	PL197160B1 (et)
TR (1)	TR200003652T2 (et)
TW (1)	TWI229079B (et)
WO (1)	WO1999064411A1 (et)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY125037A (en) *	1998-06-10	2006-07-31	Glaxo Wellcome Spa	1,2,3,4 tetrahydroquinoline derivatives
US6455734B1 (en) *	2000-08-09	2002-09-24	Magnesium Diagnostics, Inc.	Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
GB9929037D0 (en) *	1999-12-08	2000-02-02	Glaxo Wellcome Spa	Heterocyclic derivatives
DE10000311A1 (de)	2000-01-05	2001-07-12	Gruenenthal Gmbh	Aminomethyl-Phonyl-Cyclohexanonderivate
DE10005302A1 (de) *	2000-02-07	2002-01-17	Gruenenthal Gmbh	Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
DE10137488A1 (de) *	2001-08-03	2003-02-20	Gruenenthal Gmbh	Salze substituierter 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
DE10137487A1 (de) *	2001-08-03	2003-03-27	Gruenenthal Gmbh	Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate
KR20050055747A (ko) *	2002-10-04	2005-06-13	밀레니엄 파머슈티컬스 인코퍼레이티드	염증 질환 치료용의 ｐｇｄ2 수용체 길항제
US7504508B2 (en) *	2002-10-04	2009-03-17	Millennium Pharmaceuticals, Inc.	PGD2 receptor antagonists for the treatment of inflammatory diseases
US20090181966A1 (en) *	2002-10-04	2009-07-16	Millennium Pharmaceuticals, Inc.	PGD2 receptor antagonists for the treatment of inflammatory diseases
GB0327912D0 (en) *	2003-12-02	2004-01-07	Glaxo Group Ltd	Medicament
JP2008543726A (ja) *	2005-02-24	2008-12-04	ミレニアム・ファーマシューティカルズ・インコーポレイテッド	炎症性疾患の処置のためのｐｇｄ２受容体アンタゴニスト

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2024516C1 (ru) *	1989-02-02	1994-12-15	Яманути Фармасьютикал Ко., Лтд.	Способ получения производного тетрагидробензимидазола или его фармацевтически приемлемой соли
US4902695A (en) *	1989-02-13	1990-02-20	Eli Lilly And Company	Excitatory amino acid receptor antagonists
DE69029668T2 (de) *	1989-03-08	1997-08-07	Merck Sharp & Dohme	Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten
US5231102A (en) *	1989-03-08	1993-07-27	Merck Sharp & Dohme, Ltd.	Tetrahydroquinoline derivatives useful for neurodegenerative disorders
US5529999A (en)	1994-03-04	1996-06-25	Eli Lilly And Company	Antitumor compositions and methods of treatment
PL186781B1 (pl) *	1995-09-29	2004-02-27	Glaxo Wellcome Spa	Nowy związek, pochodna tetrahydrochinoliny, sposób wytwarzania pochodnej tetrahydrochinoliny, środek farmaceutyczny i zastosowanie
GB9617305D0 (en) *	1996-08-17	1996-09-25	Glaxo Wellcome Spa	Heterocyclic compounds
MY125037A (en) *	1998-06-10	2006-07-31	Glaxo Wellcome Spa	1,2,3,4 tetrahydroquinoline derivatives

1999
- 1999-06-07 MY MYPI99002298A patent/MY125037A/en unknown
- 1999-06-08 TR TR2000/03652T patent/TR200003652T2/xx unknown
- 1999-06-08 BR BR9911145-4A patent/BR9911145A/pt not_active Application Discontinuation
- 1999-06-08 JP JP2000553420A patent/JP2002517492A/ja active Pending
- 1999-06-08 KR KR1020007013994A patent/KR100586762B1/ko not_active Expired - Fee Related
- 1999-06-08 PE PE1999000511A patent/PE20000724A1/es not_active Application Discontinuation
- 1999-06-08 WO PCT/EP1999/003936 patent/WO1999064411A1/en not_active Ceased
- 1999-06-08 CO CO99035699A patent/CO5080785A1/es unknown
- 1999-06-08 EE EEP200000733A patent/EE200000733A/et unknown
- 1999-06-08 DK DK99927911T patent/DK1086093T3/da active
- 1999-06-08 OA OA1200000335A patent/OA11564A/en unknown
- 1999-06-08 US US09/719,188 patent/US6362199B1/en not_active Expired - Fee Related
- 1999-06-08 PL PL344694A patent/PL197160B1/pl not_active IP Right Cessation
- 1999-06-08 ID IDW20010061A patent/ID27845A/id unknown
- 1999-06-08 AP APAP/P/2000/002008A patent/AP2000002008A0/en unknown
- 1999-06-08 CN CNB998094145A patent/CN1173970C/zh not_active Expired - Fee Related
- 1999-06-08 HU HU0102767A patent/HUP0102767A3/hu unknown
- 1999-06-08 HR HR20000845A patent/HRP20000845A2/hr not_active Application Discontinuation
- 1999-06-08 NZ NZ508638A patent/NZ508638A/en not_active IP Right Cessation
- 1999-06-08 CZ CZ20004587A patent/CZ293605B6/cs not_active IP Right Cessation
- 1999-06-08 ES ES99927911T patent/ES2249010T3/es not_active Expired - Lifetime
- 1999-06-08 AT AT99927911T patent/ATE301650T1/de active
- 1999-06-08 EA EA200001165A patent/EA003276B1/ru not_active IP Right Cessation
- 1999-06-08 DE DE69926632T patent/DE69926632T2/de not_active Expired - Lifetime
- 1999-06-08 CA CA002334727A patent/CA2334727C/en not_active Expired - Fee Related
- 1999-06-08 IL IL14006299A patent/IL140062A0/xx active IP Right Grant
- 1999-06-08 AU AU45092/99A patent/AU753867B2/en not_active Ceased
- 1999-06-08 EP EP99927911A patent/EP1086093B1/en not_active Expired - Lifetime
- 1999-06-08 AR ARP990102714A patent/AR018632A1/es active IP Right Grant
- 1999-06-17 TW TW088110159A patent/TWI229079B/zh not_active IP Right Cessation
2000
- 2000-11-30 IS IS5746A patent/IS5746A/is unknown
- 2000-12-04 IL IL140062A patent/IL140062A/en not_active IP Right Cessation
- 2000-12-07 NO NO20006227A patent/NO321904B1/no not_active IP Right Cessation
2001
- 2001-01-08 BG BG105123A patent/BG105123A/xx unknown
- 2001-11-16 US US09/990,513 patent/US6413985B1/en not_active Expired - Fee Related
2002
- 2002-05-14 US US10/145,258 patent/US6495566B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ID27845A (id)	2001-04-26
HUP0102767A2 (hu)	2001-12-28
KR100586762B1 (ko)	2006-06-08
CA2334727A1 (en)	1999-12-16
DE69926632D1 (de)	2005-09-15
KR20010052722A (ko)	2001-06-25
BR9911145A (pt)	2001-03-06
CN1311785A (zh)	2001-09-05
AR018632A1 (es)	2001-11-28
IS5746A (is)	2000-11-30
HRP20000845A2 (en)	2001-10-31
EA003276B1 (ru)	2003-04-24
TR200003652T2 (tr)	2001-04-20
IL140062A0 (en)	2002-02-10
NO20006227L (no)	2001-02-08
HK1034079A1 (en)	2001-10-12
DE69926632T2 (de)	2006-01-19
US20020052391A1 (en)	2002-05-02
US6413985B1 (en)	2002-07-02
BG105123A (en)	2001-11-30
CZ293605B6 (cs)	2004-06-16
HUP0102767A3 (en)	2003-01-28
AU753867B2 (en)	2002-10-31
OA11564A (en)	2004-05-24
US6495566B2 (en)	2002-12-17
IL140062A (en)	2007-05-15
NO321904B1 (no)	2006-07-17
TWI229079B (en)	2005-03-11
EA200001165A1 (ru)	2001-06-25
PE20000724A1 (es)	2000-08-17
NO20006227D0 (no)	2000-12-07
WO1999064411A1 (en)	1999-12-16
ATE301650T1 (de)	2005-08-15
MY125037A (en)	2006-07-31
US6362199B1 (en)	2002-03-26
PL344694A1 (en)	2001-11-19
CN1173970C (zh)	2004-11-03
CZ20004587A3 (en)	2001-05-16
NZ508638A (en)	2003-08-29
AP2000002008A0 (en)	2000-12-31
AU4509299A (en)	1999-12-30
EP1086093B1 (en)	2005-08-10
CO5080785A1 (es)	2001-09-25
DK1086093T3 (da)	2005-11-28
CA2334727C (en)	2009-08-04
ES2249010T3 (es)	2006-03-16
PL197160B1 (pl)	2008-03-31
US20020169186A1 (en)	2002-11-14
EP1086093A1 (en)	2001-03-28
JP2002517492A (ja)	2002-06-18

Publication	Publication Date	Title
NO20013003D0 (no)	2001-06-15	Kinolin-derivater
DK1073639T3 (da)	2003-03-24	Chinolinderivater
IS2208B (is)	2007-02-15	Quinoline afleiður
EP0986385A4 (en)	2001-05-16	GONADORELIN ANTAGONISTS
ATE229005T1 (de)	2002-12-15	Chinolinderivate
IS4953A (is)	1999-01-22	Tetrahýdrókínólín afleiður sem EAA mótlyf
ID26223A (id)	2000-12-07	Antagonis reseptor vitronektin
ID26665A (id)	2001-01-25	Antagonis vla-4
EE200000733A (et)	2002-06-17	Tetrahüdrokinoliini derivaadid kui glütsiini antagonistid
ID28811A (id)	2001-07-05	Antagonis reseptor vitronektin
FI970745A7 (fi)	1997-02-21	Dihydropyridiinijohdannaisia bradykiiniantagonisteina
ATE292143T1 (de)	2005-04-15	Angiotensinderivate
DE69838303D1 (de)	2007-10-04	Hydroxyprolin derivate
SI1086093T1 (sl)	2005-12-31	Derivati tetrahidrokinolina kot antagonisti glicina
FI970143A7 (fi)	1997-01-14	Kinoliinijohdannaiset leukotrieeniantagonisteina
NO20013095L (no)	2001-08-17	Arrangement for sömforberedelse
GB9711030D0 (en)	1997-07-23	Quinoline leukrotriene antagonists