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EE200000071A - Kristalliline 10,10-bis((2-fluoro-4-püridinüül)metüül)-9(10H)-antratsenoon ja selle valmistamise täiustatud protsess - Google Patents

Kristalliline 10,10-bis((2-fluoro-4-püridinüül)metüül)-9(10H)-antratsenoon ja selle valmistamise täiustatud protsess

Info

Publication number
EE200000071A
EE200000071A EEP200000071A EEP200000071A EE200000071A EE 200000071 A EE200000071 A EE 200000071A EE P200000071 A EEP200000071 A EE P200000071A EE P200000071 A EEP200000071 A EE P200000071A EE 200000071 A EE200000071 A EE 200000071A
Authority
EE
Estonia
Prior art keywords
anthracenone
pyridinyl
fluoro
crystalline
bis
Prior art date
Application number
EEP200000071A
Other languages
English (en)
Estonian (et)
Inventor
A. Pesti Jaan
M. Fortunak Joseph
F. Huhn George
B. Maurin Michael
Yin Jianguo
Original Assignee
Dupont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dupont Pharmaceuticals Company filed Critical Dupont Pharmaceuticals Company
Publication of EE200000071A publication Critical patent/EE200000071A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EEP200000071A 1997-08-14 1998-08-11 Kristalliline 10,10-bis((2-fluoro-4-püridinüül)metüül)-9(10H)-antratsenoon ja selle valmistamise täiustatud protsess EE200000071A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8022397P 1997-08-14 1997-08-14
US7739598P 1998-03-10 1998-03-10
PCT/US1998/016584 WO1999009010A1 (en) 1997-08-14 1998-08-11 Crystalline 10,10-bis((2-fluoro-4-pyridinyl)methyl)-9(10h)-anthracenone and an improved process for preparing the same

Publications (1)

Publication Number Publication Date
EE200000071A true EE200000071A (et) 2000-10-16

Family

ID=26759225

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000071A EE200000071A (et) 1997-08-14 1998-08-11 Kristalliline 10,10-bis((2-fluoro-4-püridinüül)metüül)-9(10H)-antratsenoon ja selle valmistamise täiustatud protsess

Country Status (16)

Country Link
US (1) US6214847B1 (xx)
EP (1) EP1003722A1 (xx)
JP (1) JP2001515067A (xx)
KR (1) KR20010022834A (xx)
CN (1) CN1268121A (xx)
AR (1) AR016818A1 (xx)
AU (1) AU8777498A (xx)
CA (1) CA2301074A1 (xx)
EE (1) EE200000071A (xx)
HR (1) HRP980429A2 (xx)
HU (1) HUP0003433A2 (xx)
IL (1) IL133953A0 (xx)
NO (1) NO20000676L (xx)
PL (1) PL338706A1 (xx)
SK (1) SK1582000A3 (xx)
WO (1) WO1999009010A1 (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100509740C (zh) * 2006-06-06 2009-07-08 中国科学院广州化学研究所 10,10-二苄基蒽酮及其衍生物和合成方法
CN105254592A (zh) * 2015-11-10 2016-01-20 石家庄市华新药业有限责任公司 一种瑞格列奈化合物及其制备方法
CN105343021A (zh) * 2015-11-10 2016-02-24 石家庄市华新药业有限责任公司 一种瑞格列奈片剂及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2823414B2 (ja) 1992-02-26 1998-11-11 セントラル硝子株式会社 ２−クロロ−メチルピリジン類の側鎖塩素化法
US5296478A (en) 1992-10-07 1994-03-22 The Dupont Merck Pharmaceutical Co. 1-substituted oxindoles as cognition enhancers
US5594001A (en) * 1993-04-08 1997-01-14 The Dupont Merck Pharmaceutical Company Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders
WO1995024131A1 (en) * 1994-03-09 1995-09-14 Wm. Wrigley Jr. Company Method and apparatus for forming miniature size confectionery products

Also Published As

Publication number Publication date
HUP0003433A2 (hu) 2001-01-29
WO1999009010A1 (en) 1999-02-25
IL133953A0 (en) 2001-04-30
AR016818A1 (es) 2001-08-01
CA2301074A1 (en) 1999-02-25
KR20010022834A (ko) 2001-03-26
NO20000676L (no) 2000-03-28
PL338706A1 (en) 2000-11-20
NO20000676D0 (no) 2000-02-10
AU8777498A (en) 1999-03-08
EP1003722A1 (en) 2000-05-31
SK1582000A3 (en) 2000-09-12
JP2001515067A (ja) 2001-09-18
CN1268121A (zh) 2000-09-27
US6214847B1 (en) 2001-04-10
HRP980429A2 (en) 1999-06-30

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