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EE05329B1 - GlyT-1 inhibiitorid, neid sisaldavad kompositsioonid, nende kasutamine ja nende valmistamise vahehendid - Google Patents

GlyT-1 inhibiitorid, neid sisaldavad kompositsioonid, nende kasutamine ja nende valmistamise vahehendid

Info

Publication number
EE05329B1
EE05329B1 EEP200300394A EEP200300394A EE05329B1 EE 05329 B1 EE05329 B1 EE 05329B1 EE P200300394 A EEP200300394 A EE P200300394A EE P200300394 A EEP200300394 A EE P200300394A EE 05329 B1 EE05329 B1 EE 05329B1
Authority
EE
Estonia
Prior art keywords
glyt
intermediates
inhibitors
preparation
compositions containing
Prior art date
Application number
EEP200300394A
Other languages
English (en)
Inventor
Egle Ian
Delaney William
Wang Zhaoqing
Shumacher Richard
T. Hopper Allen
Tehim Ashok
Maddaford Shawn
Original Assignee
Allelix Neuroscience, Inc.
Nps Allelix Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23026417&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE05329(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allelix Neuroscience, Inc., Nps Allelix Corp. filed Critical Allelix Neuroscience, Inc.
Publication of EE200300394A publication Critical patent/EE200300394A/et
Publication of EE05329B1 publication Critical patent/EE05329B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200300394A 2001-02-16 2002-02-15 GlyT-1 inhibiitorid, neid sisaldavad kompositsioonid, nende kasutamine ja nende valmistamise vahehendid EE05329B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26924101P 2001-02-16 2001-02-16
PCT/CA2002/000176 WO2002066456A2 (en) 2001-02-16 2002-02-15 Thiophene substituted amine derivatives as glyt-1 inhibitors

Publications (2)

Publication Number Publication Date
EE200300394A EE200300394A (et) 2003-12-15
EE05329B1 true EE05329B1 (et) 2010-08-16

Family

ID=23026417

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300394A EE05329B1 (et) 2001-02-16 2002-02-15 GlyT-1 inhibiitorid, neid sisaldavad kompositsioonid, nende kasutamine ja nende valmistamise vahehendid

Country Status (30)

Country Link
US (1) US6667336B2 (et)
EP (1) EP1368336B9 (et)
JP (2) JP2004523548A (et)
KR (1) KR100900020B1 (et)
CN (1) CN1219776C (et)
AT (1) ATE327986T1 (et)
AU (1) AU2002235682C1 (et)
BG (1) BG108164A (et)
BR (1) BR0207307A (et)
CA (1) CA2438367A1 (et)
CY (1) CY1105529T1 (et)
CZ (1) CZ20032503A3 (et)
DE (1) DE60211866T2 (et)
DK (1) DK1368336T3 (et)
EA (1) EA006636B1 (et)
EE (1) EE05329B1 (et)
ES (1) ES2266446T3 (et)
HR (1) HRP20030696A2 (et)
HU (1) HUP0303185A3 (et)
IL (1) IL157194A (et)
MX (1) MXPA03007309A (et)
NO (1) NO329038B1 (et)
NZ (1) NZ527695A (et)
PL (1) PL365024A1 (et)
PT (1) PT1368336E (et)
SI (1) SI1368336T1 (et)
SK (1) SK287304B6 (et)
UA (1) UA75114C2 (et)
WO (1) WO2002066456A2 (et)
ZA (1) ZA200307201B (et)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191165B1 (en) * 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
WO2006066121A2 (en) * 2004-12-16 2006-06-22 Janssen Pharmaceutica N.V. Combination of a glycine transporter (glyt1) inhibitor and an antipsychotic for the treatment of symptoms of schizophrenia as well as its preparation and use thereof
US20090253918A1 (en) * 2006-10-02 2009-10-08 Janssen Pharmaceuticals, N.V. Novel intermediate for glyt1 inhibitor
WO2008065500A2 (en) * 2006-11-30 2008-06-05 Pfizer Products Inc. Heteroaryl amides as type i glycine transport inhibitors
CN103374057B (zh) * 2012-04-16 2015-08-19 中国医药集团总公司四川抗菌素工业研究所 一种对甘氨酸转运子具有抑制活性的化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3010599A1 (de) 1979-03-22 1980-10-09 Continental Pharma Derivate von glycinamid, deren herstellung und verwendung
BE885303A (fr) 1980-09-19 1981-03-19 Continental Pharma Glycinamides
US4383999A (en) 1981-05-26 1983-05-17 Smithkline Beckman Corporation Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
AU552050B2 (en) 1981-05-26 1986-05-22 Smithkline Beckman Corporation N-substituted azeheterocyclic carboxylic acids and their esters
US4514414A (en) 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
DK288385D0 (da) 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
FI864246A7 (fi) 1985-11-08 1987-05-09 Warner Lambert Co N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat.
US4772615A (en) 1985-11-08 1988-09-20 Warner-Lambert Company Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
DK165692C (da) 1986-01-07 1993-11-08 Novo Nordisk As Phenylbutenderivater, fremgangsmaade til fremstilling heraf, farmaceutisk praeparat indeholdende disse, samt anvendelse af disse til fremstilling af et medikament nyttigt til inhibering af gaba-optagelse i mennesker
JPH02129158A (ja) 1988-11-07 1990-05-17 Nippon Steel Corp 光学活性なグリシン誘導体及びその製造方法
IE913279A1 (en) * 1990-09-26 1992-04-08 Astra Ab (2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties
ES2036926B1 (es) 1991-08-08 1994-01-16 Uriach & Cia Sa J "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
WO1997020553A1 (en) 1995-12-07 1997-06-12 Javitt Daniel C Treatment of negative and cognitive symptoms of schizophrenia with glycine uptake antagonists
US6191165B1 (en) 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
NZ332780A (en) * 1996-05-31 2000-07-28 Allelix Neuroscience Inc Substituted amines for the treatment of neurological and neuropsychiatric disorders
WO1998003473A1 (en) * 1996-07-22 1998-01-29 Novo Nordisk A/S Compounds with growth hormone releasing properties
NZ504683A (en) * 1998-01-09 2002-06-28 Pfizer Amide derivatives and pharmaceutical compositions thereof and their use as matrix metalloprotease inhibitors
US6103743A (en) * 1999-08-06 2000-08-15 Allelix Neuroscience, Inc. Unsaturated amino acid derivatives

Also Published As

Publication number Publication date
ZA200307201B (en) 2004-07-28
UA75114C2 (en) 2006-03-15
US20030176489A1 (en) 2003-09-18
NO20033634L (no) 2003-10-08
HK1061025A1 (en) 2004-09-03
CN1491221A (zh) 2004-04-21
SI1368336T1 (sl) 2006-10-31
WO2002066456A2 (en) 2002-08-29
WO2002066456A3 (en) 2002-10-17
SK11442003A3 (sk) 2004-03-02
NZ527695A (en) 2005-05-27
EE200300394A (et) 2003-12-15
MXPA03007309A (es) 2004-06-30
KR20040028719A (ko) 2004-04-03
BG108164A (en) 2004-07-30
HUP0303185A3 (en) 2008-12-29
DE60211866T2 (de) 2007-06-14
JP2010059182A (ja) 2010-03-18
PT1368336E (pt) 2006-10-31
HRP20030696A2 (en) 2005-04-30
DK1368336T3 (da) 2006-10-02
ES2266446T3 (es) 2007-03-01
ATE327986T1 (de) 2006-06-15
JP2004523548A (ja) 2004-08-05
KR100900020B1 (ko) 2009-06-01
EP1368336B1 (en) 2006-05-31
NO20033634D0 (no) 2003-08-15
EP1368336A2 (en) 2003-12-10
IL157194A (en) 2006-12-31
NO329038B1 (no) 2010-08-02
EA200300900A1 (ru) 2004-02-26
PL365024A1 (en) 2004-12-27
AU2002235682B2 (en) 2007-04-26
BR0207307A (pt) 2004-08-17
EP1368336B9 (en) 2007-02-14
DE60211866D1 (de) 2006-07-06
SK287304B6 (sk) 2010-06-07
AU2002235682C1 (en) 2008-12-11
HUP0303185A2 (hu) 2003-12-29
CA2438367A1 (en) 2002-08-29
CN1219776C (zh) 2005-09-21
CZ20032503A3 (cs) 2004-02-18
EA006636B1 (ru) 2006-02-24
US6667336B2 (en) 2003-12-23
CY1105529T1 (el) 2010-07-28

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Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20110215