DK1368336T3 - Thiophensubstituerede aminderivater som GlyT-1-inhibitorer - Google Patents

Thiophensubstituerede aminderivater som GlyT-1-inhibitorer

Info

Publication number: DK1368336T3
Authority: DK; Denmark
Prior art keywords: glyt; thiophene; inhibitors; substituted amine; amine derivatives
Prior art date: 2001-02-16

Application number

DK02702186T

Other languages

English (en)

Inventor

Shawn Maddaford

Zhao-Qing Wang

Allen T Hopper

Ashok Tehim

Richard Schumacher

William Delaney

Ian Egle

Original Assignee

Allelix Neuroscience Inc

Nps Allelix Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-16

Filing date

2002-02-15

Publication date

2006-10-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23026417&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1368336(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-02-15 Application filed by Allelix Neuroscience Inc, Nps Allelix Corp filed Critical Allelix Neuroscience Inc

2006-10-02 Application granted granted Critical

2006-10-02 Publication of DK1368336T3 publication Critical patent/DK1368336T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Epoxy Compounds (AREA)

DK02702186T 2001-02-16 2002-02-15 Thiophensubstituerede aminderivater som GlyT-1-inhibitorer DK1368336T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US26924101P	2001-02-16	2001-02-16

Publications (1)

Publication Number	Publication Date
DK1368336T3 true DK1368336T3 (da)	2006-10-02

Family

ID=23026417

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02702186T DK1368336T3 (da)	2001-02-16	2002-02-15	Thiophensubstituerede aminderivater som GlyT-1-inhibitorer

Country Status (30)

Country	Link
US (1)	US6667336B2 (da)
EP (1)	EP1368336B9 (da)
JP (2)	JP2004523548A (da)
KR (1)	KR100900020B1 (da)
CN (1)	CN1219776C (da)
AT (1)	ATE327986T1 (da)
AU (1)	AU2002235682C1 (da)
BG (1)	BG108164A (da)
BR (1)	BR0207307A (da)
CA (1)	CA2438367A1 (da)
CY (1)	CY1105529T1 (da)
CZ (1)	CZ20032503A3 (da)
DE (1)	DE60211866T2 (da)
DK (1)	DK1368336T3 (da)
EA (1)	EA006636B1 (da)
EE (1)	EE05329B1 (da)
ES (1)	ES2266446T3 (da)
HR (1)	HRP20030696A2 (da)
HU (1)	HUP0303185A3 (da)
IL (1)	IL157194A (da)
MX (1)	MXPA03007309A (da)
NO (1)	NO329038B1 (da)
NZ (1)	NZ527695A (da)
PL (1)	PL365024A1 (da)
PT (1)	PT1368336E (da)
SI (1)	SI1368336T1 (da)
SK (1)	SK287304B6 (da)
UA (1)	UA75114C2 (da)
WO (1)	WO2002066456A2 (da)
ZA (1)	ZA200307201B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6191165B1 (en) *	1996-05-31	2001-02-20	Allelix Neuroscience Inc.	Pharmaceutical for treatment of neurological and neuropsychiatric disorders
PL1830833T3 (pl) *	2004-12-16	2010-06-30	Janssen Pharmaceutica Nv	Połączenie inhibitora transportera glicyny (GLYT1) i środka przeciwpsychotycznego do leczenia objawów schizofrenii jak również sposoby jego wytwarzania oraz zastosowanie
WO2008040669A2 (en) *	2006-10-02	2008-04-10	Janssen Pharmaceutica N.V.	Novel intermediates for the preparation of a glyt1 inhibitor
WO2008065500A2 (en) *	2006-11-30	2008-06-05	Pfizer Products Inc.	Heteroaryl amides as type i glycine transport inhibitors
CN103374057B (zh) *	2012-04-16	2015-08-19	中国医药集团总公司四川抗菌素工业研究所	一种对甘氨酸转运子具有抑制活性的化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3010599A1 (de)	1979-03-22	1980-10-09	Continental Pharma	Derivate von glycinamid, deren herstellung und verwendung
BE885303A (fr)	1980-09-19	1981-03-19	Continental Pharma	Glycinamides
AU552050B2 (en)	1981-05-26	1986-05-22	Smithkline Beckman Corporation	N-substituted azeheterocyclic carboxylic acids and their esters
US4383999A (en)	1981-05-26	1983-05-17	Smithkline Beckman Corporation	Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
US4514414A (en)	1982-10-25	1985-04-30	Smithkline Beckman Corporation	N-Substituted pyrrolidineacetic acids and their esters
DK288385D0 (da)	1985-06-26	1985-06-26	Novo Industri As	Aminosyrederivater
FI864246A7 (fi)	1985-11-08	1987-05-09	Warner Lambert Co	N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat.
US4772615A (en)	1985-11-08	1988-09-20	Warner-Lambert Company	Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
DE3787657T2 (de)	1986-01-07	1994-02-03	Novo Ind A S Bagsvaerd	Aminosäure-Derivate.
JPH02129158A (ja)	1988-11-07	1990-05-17	Nippon Steel Corp	光学活性なグリシン誘導体及びその製造方法
IE913279A1 (en) *	1990-09-26	1992-04-08	Astra Ab	(2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties
ES2036926B1 (es)	1991-08-08	1994-01-16	Uriach & Cia Sa J	"procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
WO1997020552A1 (en)	1995-12-07	1997-06-12	Albert Einstein College Of Medicine Of Yeshiva University	Treatment of negative and cognitive symptoms of schizophrenia with glycine and its precursors
US6191165B1 (en)	1996-05-31	2001-02-20	Allelix Neuroscience Inc.	Pharmaceutical for treatment of neurological and neuropsychiatric disorders
CA2254833C (en) *	1996-05-31	2008-04-29	Allelix Neuroscience Inc.	Pharmaceutical for treatment of neurological and neuropsychiatric disorders
EP0923539B1 (en) *	1996-07-22	2002-06-05	Novo Nordisk A/S	Compounds with growth hormone releasing properties
NZ504683A (en) *	1998-01-09	2002-06-28	Pfizer	Amide derivatives and pharmaceutical compositions thereof and their use as matrix metalloprotease inhibitors
US6103743A (en) *	1999-08-06	2000-08-15	Allelix Neuroscience, Inc.	Unsaturated amino acid derivatives

2002
- 2002-02-15 AT AT02702186T patent/ATE327986T1/de not_active IP Right Cessation
- 2002-02-15 SK SK1144-2003A patent/SK287304B6/sk not_active IP Right Cessation
- 2002-02-15 WO PCT/CA2002/000176 patent/WO2002066456A2/en not_active Ceased
- 2002-02-15 EP EP02702186A patent/EP1368336B9/en not_active Expired - Lifetime
- 2002-02-15 DE DE60211866T patent/DE60211866T2/de not_active Expired - Lifetime
- 2002-02-15 EA EA200300900A patent/EA006636B1/ru not_active IP Right Cessation
- 2002-02-15 CA CA002438367A patent/CA2438367A1/en not_active Abandoned
- 2002-02-15 PL PL02365024A patent/PL365024A1/xx unknown
- 2002-02-15 UA UA2003087630A patent/UA75114C2/uk unknown
- 2002-02-15 ES ES02702186T patent/ES2266446T3/es not_active Expired - Lifetime
- 2002-02-15 US US10/077,579 patent/US6667336B2/en not_active Expired - Fee Related
- 2002-02-15 MX MXPA03007309A patent/MXPA03007309A/es active IP Right Grant
- 2002-02-15 CZ CZ20032503A patent/CZ20032503A3/cs unknown
- 2002-02-15 DK DK02702186T patent/DK1368336T3/da active
- 2002-02-15 KR KR1020037010609A patent/KR100900020B1/ko not_active Expired - Fee Related
- 2002-02-15 NZ NZ527695A patent/NZ527695A/en unknown
- 2002-02-15 AU AU2002235682A patent/AU2002235682C1/en not_active Ceased
- 2002-02-15 EE EEP200300394A patent/EE05329B1/xx not_active IP Right Cessation
- 2002-02-15 HU HU0303185A patent/HUP0303185A3/hu unknown
- 2002-02-15 CN CNB028050819A patent/CN1219776C/zh not_active Expired - Fee Related
- 2002-02-15 SI SI200230381T patent/SI1368336T1/sl unknown
- 2002-02-15 BR BR0207307-2A patent/BR0207307A/pt not_active IP Right Cessation
- 2002-02-15 HR HR20030696A patent/HRP20030696A2/xx not_active Application Discontinuation
- 2002-02-15 JP JP2002565971A patent/JP2004523548A/ja active Pending
- 2002-02-15 PT PT02702186T patent/PT1368336E/pt unknown
2003
- 2003-07-31 IL IL157194A patent/IL157194A/en not_active IP Right Cessation
- 2003-08-15 NO NO20033634A patent/NO329038B1/no not_active IP Right Cessation
- 2003-09-09 BG BG108164A patent/BG108164A/xx unknown
- 2003-09-15 ZA ZA200307201A patent/ZA200307201B/en unknown
2006
- 2006-08-22 CY CY20061101160T patent/CY1105529T1/el unknown
2009
- 2009-11-09 JP JP2009255663A patent/JP2010059182A/ja active Pending

Also Published As

Publication number	Publication date
JP2010059182A (ja)	2010-03-18
KR100900020B1 (ko)	2009-06-01
EE05329B1 (et)	2010-08-16
PT1368336E (pt)	2006-10-31
WO2002066456A2 (en)	2002-08-29
EP1368336A2 (en)	2003-12-10
HUP0303185A3 (en)	2008-12-29
CA2438367A1 (en)	2002-08-29
CY1105529T1 (el)	2010-07-28
PL365024A1 (en)	2004-12-27
EA006636B1 (ru)	2006-02-24
NZ527695A (en)	2005-05-27
WO2002066456A3 (en)	2002-10-17
EA200300900A1 (ru)	2004-02-26
HRP20030696A2 (en)	2005-04-30
ES2266446T3 (es)	2007-03-01
JP2004523548A (ja)	2004-08-05
HUP0303185A2 (hu)	2003-12-29
IL157194A (en)	2006-12-31
MXPA03007309A (es)	2004-06-30
CN1491221A (zh)	2004-04-21
AU2002235682B2 (en)	2007-04-26
EP1368336B1 (en)	2006-05-31
US6667336B2 (en)	2003-12-23
SK287304B6 (sk)	2010-06-07
HK1061025A1 (en)	2004-09-03
BR0207307A (pt)	2004-08-17
SK11442003A3 (sk)	2004-03-02
EE200300394A (et)	2003-12-15
UA75114C2 (en)	2006-03-15
KR20040028719A (ko)	2004-04-03
DE60211866T2 (de)	2007-06-14
NO20033634D0 (no)	2003-08-15
BG108164A (en)	2004-07-30
SI1368336T1 (sl)	2006-10-31
NO329038B1 (no)	2010-08-02
US20030176489A1 (en)	2003-09-18
ATE327986T1 (de)	2006-06-15
CN1219776C (zh)	2005-09-21
EP1368336B9 (en)	2007-02-14
AU2002235682C1 (en)	2008-12-11
ZA200307201B (en)	2004-07-28
DE60211866D1 (de)	2006-07-06
CZ20032503A3 (cs)	2004-02-18
NO20033634L (no)	2003-10-08

Publication	Publication Date	Title
ATE440603T1 (de)	2009-09-15	8-hydroxychinolinderivate
ATE371656T1 (de)	2007-09-15	Heteroaryl-pyrimidinderivate als jak-inhibitoren
NO985711D0 (no)	1998-12-07	Farmas°ytikum for behandling av neurologiske og neuropsykiatriske mangler
TR200201505T2 (tr)	2003-01-21	Terapötik maddeler olarak pirazolopirimidinler
BR0109703A (pt)	2003-02-04	Derivados de piperazina
MXPA03006248A (es)	2004-04-02	Derivados de acido fumarico como inhibidores de nf-kappab.
ECSP034744A (es)	2003-10-28	Antagonistas de nmda/nr2b no arilo-heterociclico n-sustituidos
ATE360633T1 (de)	2007-05-15	N-substituierte hydromorphone und ihre anwendung
SE0101932D0 (sv)	2001-05-31	Pharmaceutical combinations
DE69834500D1 (de)	2006-06-14	Xanthinderivative zur behandlung von hirnischämie
DE60104697D1 (de)	2004-09-09	Sulfonamid-derivate
IS6087A (is)	2001-09-26	N-(2-fenýl-4-amínó-bútýl)-1-naftamíð sem virka á móti taugakínín-1 viðtaka
DE69917005D1 (de)	2004-06-09	Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
DK1368336T3 (da)	2006-10-02	Thiophensubstituerede aminderivater som GlyT-1-inhibitorer
MXPA05014143A (es)	2006-02-24	Derivados de cumarina para el tratamiento de trastornos oftalmicos.
WO2004048381A3 (en)	2004-08-05	Pyrazoloazepine compounds as pharmaceutical agents
ATE298742T1 (de)	2005-07-15	Zykloalkenylsulfonamidderivate
TNSN99158A1 (ar)	2005-11-10	طريقة لمنع الاصابة بالربو
SE0100295D0 (sv)	2001-02-01	New compounds
ZA200400824B (en)	2004-07-20	Pyridin-2-yl-methlyamine derivatives for treating opioid dependence.
EP1210948A4 (en)	2004-07-28	DRUGS FOR NERVOUS DISEASES