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EE04440B1 - Kaparetseptori opioidpeptiidid ja farmatseutilinekompositsioon - Google Patents

Kaparetseptori opioidpeptiidid ja farmatseutilinekompositsioon

Info

Publication number
EE04440B1
EE04440B1 EEP200000370A EEP200000370A EE04440B1 EE 04440 B1 EE04440 B1 EE 04440B1 EE P200000370 A EEP200000370 A EE P200000370A EE P200000370 A EEP200000370 A EE P200000370A EE 04440 B1 EE04440 B1 EE 04440B1
Authority
EE
Estonia
Prior art keywords
capareceptor
pharmaceutical composition
opioid peptides
opioid
peptides
Prior art date
Application number
EEP200000370A
Other languages
English (en)
Estonian (et)
Inventor
Louis Junien Jean
J. M. Riviere Pierre
D. Schteingart Claudio
Sueiras Diaz Javier
A. Trojnar Jerzy
W. Vanderah Todd
Original Assignee
Ferring B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring B.V. filed Critical Ferring B.V.
Publication of EE200000370A publication Critical patent/EE200000370A/xx
Publication of EE04440B1 publication Critical patent/EE04440B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EEP200000370A 1997-12-23 1998-12-22 Kaparetseptori opioidpeptiidid ja farmatseutilinekompositsioon EE04440B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides
PCT/US1998/027282 WO1999032510A1 (en) 1997-12-23 1998-12-22 Kappa receptor opioid peptides

Publications (2)

Publication Number Publication Date
EE200000370A EE200000370A (et) 2001-10-15
EE04440B1 true EE04440B1 (et) 2005-02-15

Family

ID=25543752

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000370A EE04440B1 (et) 1997-12-23 1998-12-22 Kaparetseptori opioidpeptiidid ja farmatseutilinekompositsioon

Country Status (32)

Country Link
US (1) US5965701A (xx)
EP (1) EP1042359B1 (xx)
JP (1) JP4275852B2 (xx)
KR (1) KR100629548B1 (xx)
CN (1) CN1154655C (xx)
AR (1) AR014167A1 (xx)
AT (1) ATE301670T1 (xx)
AU (1) AU747806B2 (xx)
BR (2) BR9814499B1 (xx)
CA (1) CA2315878C (xx)
CR (1) CR5936A (xx)
CZ (1) CZ297281B6 (xx)
DE (1) DE69831176T2 (xx)
DK (1) DK1042359T3 (xx)
EE (1) EE04440B1 (xx)
ES (1) ES2247735T3 (xx)
HR (1) HRP20000415B1 (xx)
HU (1) HU227640B1 (xx)
IL (3) IL136742A0 (xx)
MY (1) MY117542A (xx)
NO (1) NO327080B1 (xx)
NZ (1) NZ505183A (xx)
PL (1) PL195842B1 (xx)
PT (1) PT1042359E (xx)
RU (1) RU2217437C2 (xx)
SK (1) SK286135B6 (xx)
TR (1) TR200001985T2 (xx)
TW (1) TW580502B (xx)
UA (1) UA68366C2 (xx)
UY (1) UY25327A1 (xx)
WO (1) WO1999032510A1 (xx)
ZA (1) ZA9811801B (xx)

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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
WO2001036006A1 (en) * 1999-11-19 2001-05-25 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
DE10116978A1 (de) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
CA2451133C (en) * 2001-05-08 2012-09-18 Toray Industries, Inc. Therapeutic agent for sepsis
SI1494732T1 (sl) 2002-03-20 2008-08-31 Mannking Corp Inhalacijski aparat
KR101273120B1 (ko) 2004-08-20 2013-06-13 맨카인드 코포레이션 다이케토피페라진 합성의 촉매 작용
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
KR101486829B1 (ko) 2005-09-14 2015-01-29 맨카인드 코포레이션 결정질 미립자 표면에 대한 활성제의 친화력의 증가를 기반으로 하는 약물 제제의 방법
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
WO2007139921A2 (en) * 2006-05-26 2007-12-06 Cara Therapeutics, Inc. N-oxides of kappa opioid receptor peptides
EP2040733A2 (en) * 2006-05-26 2009-04-01 Cara Therapeutics, Inc. Method for elevating prolactin in mammals
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US7402564B1 (en) * 2006-11-10 2008-07-22 Cara Therapeutics, Inc. Synthetic peptide amides
US7842662B2 (en) * 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
TWI677355B (zh) 2008-06-13 2019-11-21 美商曼凱公司 用於藥物傳輸之乾粉吸入器及系統
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2421385T3 (es) 2008-06-20 2013-09-02 Mannkind Corp Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2676695A3 (en) 2009-03-11 2017-03-01 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
US9016147B2 (en) 2009-11-03 2015-04-28 Mannkind Corporation Apparatus and method for simulating inhalation efforts
MX359281B (es) 2010-06-21 2018-09-21 Mannkind Corp Sistema y metodos para suministrar un farmaco en polvo seco.
US8925726B2 (en) 2011-04-01 2015-01-06 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CA2852536A1 (en) * 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
EP2970149B1 (en) 2013-03-15 2019-08-21 MannKind Corporation Microcrystalline diketopiperazine compositions and methods
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
CN105517607A (zh) 2013-08-05 2016-04-20 曼金德公司 吹入设备和方法
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
CN106459150B (zh) * 2014-06-26 2020-01-24 丸石制药株式会社 合成五肽的制造方法
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
JP6651546B2 (ja) * 2015-05-11 2020-02-19 カディラ・ヘルスケア・リミテッド カッパ（κ）オピオイド受容体（ＫＯＲ）アゴニストとしての新規の短鎖ペプチド
CN107098876B (zh) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
JP6794602B2 (ja) * 2016-09-27 2020-12-02 シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド ポリアミド化合物及びその使用
TWI712615B (zh) * 2017-07-21 2020-12-11 大陸商四川海思科製藥有限公司 肽醯胺類化合物、其製備方法及醫藥用途
KR20200096588A (ko) 2017-12-06 2020-08-12 지앙수 헨그루이 메디슨 컴퍼니 리미티드 페닐프로피온아마이드 유도체의 염 및 이의 제조 방법
TW202015716A (zh) 2018-05-16 2020-05-01 大陸商江蘇恆瑞醫藥股份有限公司 一種ｋｏｒ受體激動劑醫藥組成物
CN114127086B (zh) * 2019-07-25 2023-10-20 四川海思科制药有限公司 氘代肽酰胺类化合物及其制备方法和在医药上的用途
WO2021013085A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 一种肽酰胺盐及其制备方法和在医药上的用途
CN114615976A (zh) * 2019-08-07 2022-06-10 人福医药美国公司 κ阿片受体肽酰胺激动剂
CN115884963A (zh) 2020-06-25 2023-03-31 人福医药美国公司 用于治疗医学病症的肽
WO2023278843A2 (en) 2021-07-02 2023-01-05 Acer Therapeutics, Inc. Solid forms of osanetant

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US5610271A (en) * 1995-06-07 1997-03-11 Torrey Pines Institute For Molecular Studies Kappa receptor selective opioid peptides

Also Published As

Publication number Publication date
HRP20000415B1 (en) 2004-06-30
CZ297281B6 (cs) 2006-10-11
AU1940299A (en) 1999-07-12
KR100629548B1 (ko) 2006-09-27
CZ20002382A3 (cs) 2000-12-13
MY117542A (en) 2004-07-31
RU2217437C2 (ru) 2003-11-27
IL136742A0 (en) 2001-06-14
CN1154655C (zh) 2004-06-23
EE200000370A (et) 2001-10-15
ES2247735T3 (es) 2006-03-01
HRP20000415A2 (en) 2000-12-31
HUP0100626A2 (hu) 2001-08-28
TW580502B (en) 2004-03-21
KR20010033450A (ko) 2001-04-25
US5965701A (en) 1999-10-12
WO1999032510A9 (en) 1999-09-23
CA2315878C (en) 2010-11-16
DK1042359T3 (da) 2005-11-28
EP1042359A1 (en) 2000-10-11
PT1042359E (pt) 2005-11-30
ATE301670T1 (de) 2005-08-15
BR9814499A (pt) 2000-10-10
PL341308A1 (en) 2001-04-09
SK9602000A3 (en) 2001-01-18
NO20003245D0 (no) 2000-06-21
HUP0100626A3 (en) 2001-12-28
EP1042359B1 (en) 2005-08-10
AU747806B2 (en) 2002-05-23
DE69831176D1 (de) 2005-09-15
BRPI9814499A (pt) 2000-10-10
UY25327A1 (es) 2000-12-29
TR200001985T2 (tr) 2000-11-21
CR5936A (es) 2006-08-18
NO327080B1 (no) 2009-04-20
BRPI9814499B8 (pt) 2021-11-09
PL195842B1 (pl) 2007-10-31
JP4275852B2 (ja) 2009-06-10
AR014167A1 (es) 2001-02-07
CA2315878A1 (en) 1999-07-01
UA68366C2 (en) 2004-08-16
JP2001526295A (ja) 2001-12-18
NZ505183A (en) 2001-09-28
IL178471A0 (en) 2007-02-11
HK1029349A1 (en) 2001-03-30
SK286135B6 (sk) 2008-04-07
BRPI9814499B1 (pt) 2014-10-21
WO1999032510A1 (en) 1999-07-01
ZA9811801B (en) 1999-06-22
DE69831176T2 (de) 2006-04-20
BR9814499B1 (pt) 2014-10-21
NO20003245L (no) 2000-08-23
CN1283201A (zh) 2001-02-07
HU227640B1 (en) 2011-10-28
IL136742A (en) 2006-12-31

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Effective date: 20051231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

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Effective date: 20121222