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DK1042359T3 - k-Opioidreceptorpeptider - Google Patents

k-Opioidreceptorpeptider

Info

Publication number
DK1042359T3
DK1042359T3 DK98964224T DK98964224T DK1042359T3 DK 1042359 T3 DK1042359 T3 DK 1042359T3 DK 98964224 T DK98964224 T DK 98964224T DK 98964224 T DK98964224 T DK 98964224T DK 1042359 T3 DK1042359 T3 DK 1042359T3
Authority
DK
Denmark
Prior art keywords
opioid peptides
opioid
peptides
Prior art date
Application number
DK98964224T
Other languages
English (en)
Inventor
Jean Louis Junien
Pierre J M Riviere
Claudio D Schteingart
Javier Sueiras Diaz
Jerzy A Trojnar
Todd W Vanderah
Original Assignee
Cara Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cara Therapeutics Inc filed Critical Cara Therapeutics Inc
Application granted granted Critical
Publication of DK1042359T3 publication Critical patent/DK1042359T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK98964224T 1997-12-23 1998-12-22 k-Opioidreceptorpeptider DK1042359T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides

Publications (1)

Publication Number Publication Date
DK1042359T3 true DK1042359T3 (da) 2005-11-28

Family

ID=25543752

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98964224T DK1042359T3 (da) 1997-12-23 1998-12-22 k-Opioidreceptorpeptider

Country Status (32)

Country Link
US (1) US5965701A (da)
EP (1) EP1042359B1 (da)
JP (1) JP4275852B2 (da)
KR (1) KR100629548B1 (da)
CN (1) CN1154655C (da)
AR (1) AR014167A1 (da)
AT (1) ATE301670T1 (da)
AU (1) AU747806B2 (da)
BR (2) BR9814499B1 (da)
CA (1) CA2315878C (da)
CR (1) CR5936A (da)
CZ (1) CZ297281B6 (da)
DE (1) DE69831176T2 (da)
DK (1) DK1042359T3 (da)
EE (1) EE04440B1 (da)
ES (1) ES2247735T3 (da)
HR (1) HRP20000415B1 (da)
HU (1) HU227640B1 (da)
IL (3) IL136742A0 (da)
MY (1) MY117542A (da)
NO (1) NO327080B1 (da)
NZ (1) NZ505183A (da)
PL (1) PL195842B1 (da)
PT (1) PT1042359E (da)
RU (1) RU2217437C2 (da)
SK (1) SK286135B6 (da)
TR (1) TR200001985T2 (da)
TW (1) TW580502B (da)
UA (1) UA68366C2 (da)
UY (1) UY25327A1 (da)
WO (1) WO1999032510A1 (da)
ZA (1) ZA9811801B (da)

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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
AU1623801A (en) * 1999-11-19 2001-05-30 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
DE10116978A1 (de) 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
CN1283317C (zh) * 2001-05-08 2006-11-08 东丽株式会社 类鸦片κ受体激动性化合物在制备治疗败血症的药物中的应用
ES2425392T3 (es) 2002-03-20 2013-10-15 Mannkind Corporation Cartucho para un aparato de inhalación
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
WO2007033372A2 (en) 2005-09-14 2007-03-22 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
DK1986679T3 (da) 2006-02-22 2017-11-20 Mannkind Corp Fremgangsmåde til forbedring af mikropartiklers farmaceutiske egenskaber omfattende diketopiperazin og et aktivt indholdsstof
EP2040733A2 (en) * 2006-05-26 2009-04-01 Cara Therapeutics, Inc. Method for elevating prolactin in mammals
EP2029617A2 (en) * 2006-05-26 2009-03-04 Cara Therapeutics, Inc. N-oxides of kappa opioid receptor peptides
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US7842662B2 (en) * 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
PL2064228T3 (pl) * 2006-11-10 2013-01-31 Cara Therapeutics Inc Syntetyczne amidy peptydowe
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CA3153292A1 (en) 2008-06-13 2009-12-17 Mannkind Corporation A dry powder inhaler and system for drug delivery
CN102065942B (zh) 2008-06-20 2013-12-11 曼金德公司 用于对吸入工作进行实时描绘的交互式设备和方法
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
KR20180036807A (ko) 2009-06-12 2018-04-09 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
KR101940832B1 (ko) 2011-04-01 2019-01-21 맨카인드 코포레이션 의약 카트리지용 블리스터 패키지
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2776053A1 (en) * 2011-10-24 2014-09-17 MannKind Corporation Methods and compositions for treating pain
CN104619369B (zh) 2012-07-12 2018-01-30 曼金德公司 干粉药物输送系统和方法
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
CA2918369C (en) 2013-07-18 2021-06-29 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
MX373659B (es) * 2014-06-26 2020-03-31 Maruishi Pharma Metodo para producir un pentapeptido sintetico.
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
JP6651546B2 (ja) * 2015-05-11 2020-02-19 カディラ・ヘルスケア・リミテッド カッパ（κ）オピオイド受容体（ＫＯＲ）アゴニストとしての新規の短鎖ペプチド
CN107098876B (zh) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
JP6794602B2 (ja) * 2016-09-27 2020-12-02 シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド ポリアミド化合物及びその使用
JP7008787B2 (ja) * 2017-07-21 2022-01-25 四川海思科制▲薬▼有限公司 ペプチドアミド系化合物及びその製造方法、並びに医薬品における用途
AU2018380170A1 (en) 2017-12-06 2020-06-11 Jiangsu Hengrui Medicine Co., Ltd. Salt of phenylpropionamide derivative and preparation method therefor
AU2019271812A1 (en) 2018-05-16 2021-01-07 Jiangsu Hengrui Medicine Co., Ltd. Pharmaceutical composition of KOR receptor agonist
WO2021013086A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 氘代肽酰胺类化合物及其制备方法和在医药上的用途
WO2021013085A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 一种肽酰胺盐及其制备方法和在医药上的用途
WO2021026492A1 (en) * 2019-08-07 2021-02-11 Humanwell Pharmaceutical US Kappa opioid receptor peptide amide agonists
AU2020454871A1 (en) 2020-06-25 2023-01-19 Humanwell Pharmaceutical US Peptides for treatment of medical disorders
TW202317533A (zh) 2021-07-02 2023-05-01 美商雅斯治療公司 奧沙奈坦(osanetant)之固體形式

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GB2013689B (en) * 1977-12-15 1982-03-24 Reckitt & Colmann Prod Ltd Compounds
GB8801304D0 (en) * 1988-01-21 1988-02-17 Ici Plc Diamine compounds
US5367053A (en) * 1993-05-19 1994-11-22 Houghten Pharmaceuticals, Inc. Opioid peptide inhibitors
RU2067000C1 (ru) * 1994-06-29 1996-09-27 Владислав Исакович Дейгин Пептид и способ его получения
US5610271A (en) * 1995-06-07 1997-03-11 Torrey Pines Institute For Molecular Studies Kappa receptor selective opioid peptides

Also Published As

Publication number Publication date
EE200000370A (et) 2001-10-15
AU747806B2 (en) 2002-05-23
DE69831176T2 (de) 2006-04-20
UA68366C2 (en) 2004-08-16
CZ20002382A3 (cs) 2000-12-13
NZ505183A (en) 2001-09-28
CN1283201A (zh) 2001-02-07
MY117542A (en) 2004-07-31
EE04440B1 (et) 2005-02-15
KR100629548B1 (ko) 2006-09-27
PL341308A1 (en) 2001-04-09
EP1042359B1 (en) 2005-08-10
CR5936A (es) 2006-08-18
HRP20000415B1 (en) 2004-06-30
ZA9811801B (en) 1999-06-22
AU1940299A (en) 1999-07-12
AR014167A1 (es) 2001-02-07
HUP0100626A3 (en) 2001-12-28
SK9602000A3 (en) 2001-01-18
PL195842B1 (pl) 2007-10-31
KR20010033450A (ko) 2001-04-25
NO20003245D0 (no) 2000-06-21
CN1154655C (zh) 2004-06-23
ATE301670T1 (de) 2005-08-15
HRP20000415A2 (en) 2000-12-31
WO1999032510A1 (en) 1999-07-01
DE69831176D1 (de) 2005-09-15
HU227640B1 (en) 2011-10-28
US5965701A (en) 1999-10-12
NO20003245L (no) 2000-08-23
NO327080B1 (no) 2009-04-20
PT1042359E (pt) 2005-11-30
UY25327A1 (es) 2000-12-29
TR200001985T2 (tr) 2000-11-21
EP1042359A1 (en) 2000-10-11
BR9814499B1 (pt) 2014-10-21
BRPI9814499B8 (pt) 2021-11-09
RU2217437C2 (ru) 2003-11-27
IL178471A0 (en) 2007-02-11
BRPI9814499A (pt) 2000-10-10
CZ297281B6 (cs) 2006-10-11
HUP0100626A2 (hu) 2001-08-28
BRPI9814499B1 (pt) 2014-10-21
JP4275852B2 (ja) 2009-06-10
SK286135B6 (sk) 2008-04-07
ES2247735T3 (es) 2006-03-01
TW580502B (en) 2004-03-21
WO1999032510A9 (en) 1999-09-23
JP2001526295A (ja) 2001-12-18
IL136742A0 (en) 2001-06-14
IL136742A (en) 2006-12-31
CA2315878A1 (en) 1999-07-01
HK1029349A1 (en) 2001-03-30
CA2315878C (en) 2010-11-16
BR9814499A (pt) 2000-10-10

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