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ECSP10010389A - Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteina quinasa - Google Patents

Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteina quinasa

Info

Publication number
ECSP10010389A
ECSP10010389A EC2010010389A ECSP10010389A ECSP10010389A EC SP10010389 A ECSP10010389 A EC SP10010389A EC 2010010389 A EC2010010389 A EC 2010010389A EC SP10010389 A ECSP10010389 A EC SP10010389A EC SP10010389 A ECSP10010389 A EC SP10010389A
Authority
EC
Ecuador
Prior art keywords
inhibitors
akt
pyrimidil
quinasa
cyclopentanes
Prior art date
Application number
EC2010010389A
Other languages
English (en)
Inventor
Jun Liang
James F Blake
Ian S Mitchell
Rui Xu
Nicholas C Kallan
Dengming Xiao
Keith Lee Spencer
Josef R Bencsik
Brian Safina
Birong Zhang
Steven Do
Christine Chabot
Original Assignee
Array Biopharma Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc, Genentech Inc filed Critical Array Biopharma Inc
Publication of ECSP10010389A publication Critical patent/ECSP10010389A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion provee compuestos, que incluyen sales aceptables para uso farmaceutico, que comprenden la Formula I: Ademas se proveen metodos para utilizar los compuestos de esta invencion como inhibidores de la AKT proteina quinasa y para el tratamiento de enfermedades hiperproliferativas, tal como el cancer.
EC2010010389A 2008-01-09 2010-08-06 Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteina quinasa ECSP10010389A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2009208P 2008-01-09 2008-01-09

Publications (1)

Publication Number Publication Date
ECSP10010389A true ECSP10010389A (es) 2010-11-30

Family

ID=40552865

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010389A ECSP10010389A (es) 2008-01-09 2010-08-06 Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteina quinasa

Country Status (18)

Country Link
US (1) US8835434B2 (es)
EP (1) EP2247578B1 (es)
JP (1) JP5346345B2 (es)
KR (1) KR101624753B1 (es)
CN (1) CN101932564B (es)
AU (1) AU2009204025B2 (es)
BR (1) BRPI0906798A2 (es)
CA (1) CA2711699A1 (es)
CR (1) CR11601A (es)
EC (1) ECSP10010389A (es)
ES (1) ES2422733T3 (es)
IL (1) IL206575A0 (es)
MA (1) MA32183B1 (es)
NZ (1) NZ586346A (es)
RU (1) RU2504542C2 (es)
UA (1) UA100545C2 (es)
WO (1) WO2009089459A1 (es)
ZA (1) ZA201004769B (es)

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ES2588878T3 (es) 2012-05-17 2016-11-07 Array Biopharma, Inc. Proceso para preparar compuestos de ciclopentilpirimidina hidroxilada
EP3719014A1 (en) * 2012-05-17 2020-10-07 Genentech, Inc. Solid forms of an akt inhibiting pyrimidinyl-cyclopentane compound, compositions and methods thereof
CN112898210B (zh) * 2013-11-15 2025-02-21 豪夫迈·罗氏有限公司 用于制备嘧啶基环戊烷化合物的方法

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Also Published As

Publication number Publication date
WO2009089459A1 (en) 2009-07-16
RU2504542C2 (ru) 2014-01-20
KR20100118110A (ko) 2010-11-04
JP5346345B2 (ja) 2013-11-20
EP2247578B1 (en) 2013-05-22
EP2247578A1 (en) 2010-11-10
JP2011509308A (ja) 2011-03-24
AU2009204025B2 (en) 2014-02-20
ES2422733T3 (es) 2013-09-13
CR11601A (es) 2010-08-19
AU2009204025A1 (en) 2009-07-16
CN101932564A (zh) 2010-12-29
ZA201004769B (en) 2011-12-28
BRPI0906798A2 (pt) 2015-07-14
MA32183B1 (fr) 2011-04-01
NZ586346A (en) 2012-02-24
IL206575A0 (en) 2010-12-30
UA100545C2 (ru) 2013-01-10
KR101624753B1 (ko) 2016-05-26
US8835434B2 (en) 2014-09-16
RU2010132911A (ru) 2012-02-20
CN101932564B (zh) 2012-12-26
US20110065716A1 (en) 2011-03-17
CA2711699A1 (en) 2009-07-16

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