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EA200600233A1 - Специфические связующие агенты, взаимодействующие с факторами роста гепатоцитов - Google Patents

Специфические связующие агенты, взаимодействующие с факторами роста гепатоцитов

Info

Publication number
EA200600233A1
EA200600233A1 EA200600233A EA200600233A EA200600233A1 EA 200600233 A1 EA200600233 A1 EA 200600233A1 EA 200600233 A EA200600233 A EA 200600233A EA 200600233 A EA200600233 A EA 200600233A EA 200600233 A1 EA200600233 A1 EA 200600233A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hepatocytes
interacting
growth factors
specific connecting
hgf
Prior art date
Application number
EA200600233A
Other languages
English (en)
Other versions
EA015363B1 (ru
Inventor
Тереза Л. Бюргесс
Анджела Коксон
Лэрри Л. Грин
Ке Жанг
Original Assignee
Эмджен Инк.
Эбдженикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмджен Инк., Эбдженикс, Инк. filed Critical Эмджен Инк.
Publication of EA200600233A1 publication Critical patent/EA200600233A1/ru
Publication of EA015363B1 publication Critical patent/EA015363B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Cosmetics (AREA)

Abstract

Описываются специфические связывающие агенты, взаимодействующие с фактором роста гепатоцитов (ФРГ). Описываются способы лечения рака путем назначения фармацевтически эффективного количества специфического связывающего вещества, взаимодействующего с ФРГ. Описываются способы детектирования количества ФРГ (фактора роста гепатоцитов) в образце, используя специфический связывающий с ФРГ агент.
EA200600233A 2003-07-18 2004-07-16 Агенты, специфически связывающие фактор роста гепатоцитов, и их применение EA015363B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48868103P 2003-07-18 2003-07-18
PCT/US2004/018936 WO2005017107A2 (en) 2003-07-18 2004-07-16 Specific binding agents to hepatocyte growth factor

Publications (2)

Publication Number Publication Date
EA200600233A1 true EA200600233A1 (ru) 2007-04-27
EA015363B1 EA015363B1 (ru) 2011-06-30

Family

ID=34193077

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600233A EA015363B1 (ru) 2003-07-18 2004-07-16 Агенты, специфически связывающие фактор роста гепатоцитов, и их применение

Country Status (26)

Country Link
US (2) US8609090B2 (ru)
EP (2) EP2341067A1 (ru)
JP (4) JP5105874B2 (ru)
KR (2) KR101254371B1 (ru)
CN (3) CN103755807A (ru)
AR (3) AR042955A1 (ru)
AU (1) AU2004265595B2 (ru)
BR (1) BRPI0412885A (ru)
CA (1) CA2532027C (ru)
DK (1) DK1648998T3 (ru)
EA (1) EA015363B1 (ru)
ES (1) ES2523837T3 (ru)
HK (1) HK1199266A1 (ru)
IL (1) IL172906A0 (ru)
ME (1) MEP31408A (ru)
MX (1) MXPA06000508A (ru)
NO (1) NO20060600L (ru)
NZ (1) NZ544797A (ru)
PL (1) PL1648998T3 (ru)
PT (1) PT1648998E (ru)
RS (1) RS53476B (ru)
SG (1) SG131943A1 (ru)
SI (1) SI1648998T1 (ru)
TW (3) TW201319088A (ru)
WO (1) WO2005017107A2 (ru)
ZA (2) ZA200601353B (ru)

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KR101254371B1 (ko) 2013-05-02
US20140154243A1 (en) 2014-06-05
JP2007530003A (ja) 2007-11-01
CN101124240B (zh) 2013-12-18
EP1648998A4 (en) 2007-11-14
KR20060054321A (ko) 2006-05-22
US8609090B2 (en) 2013-12-17
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WO2005017107A3 (en) 2007-03-01
US20050118643A1 (en) 2005-06-02
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DK1648998T3 (en) 2015-01-05
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