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EA200200062A1 - Высокопроизводительная тест-система - Google Patents

Высокопроизводительная тест-система

Info

Publication number
EA200200062A1
EA200200062A1 EA200200062A EA200200062A EA200200062A1 EA 200200062 A1 EA200200062 A1 EA 200200062A1 EA 200200062 A EA200200062 A EA 200200062A EA 200200062 A EA200200062 A EA 200200062A EA 200200062 A1 EA200200062 A1 EA 200200062A1
Authority
EA
Eurasian Patent Office
Prior art keywords
probes
test
present
molecules
anchors
Prior art date
Application number
EA200200062A
Other languages
English (en)
Other versions
EA007338B1 (ru
Inventor
Ричард М. Крис
Стефен Фелдер
Original Assignee
Ричард М. Крис
Стефен Фелдер
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ричард М. Крис, Стефен Фелдер filed Critical Ричард М. Крис
Publication of EA200200062A1 publication Critical patent/EA200200062A1/ru
Publication of EA007338B1 publication Critical patent/EA007338B1/ru

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
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Abstract

Настоящее изобретение касается композиций, устройства и способов, применимых для одновременного осуществления множественных высокопроизводительных биологических или химических тестов с использованием повторяющихся наборов зондов. Сочетание по настоящему изобретению включает поверхность, которая несет множество тест-участков, по крайней мере, два из которых, а в предпочтительном варианте, по крайней мере, двадцать из которых существенно идентичны друг другу, при том, что каждый из этих тест-участков включает набор родственных якорных молекул. Эти якоря связаны с бифункциональными линкерными молекулами, каждая из которых включает часть, специфичную в отношении, по крайней мере, одного из якорей, и часть в виде зонда, специфичного в отношении представляющей интерес мишени. Полученный в результате набор зондов используют для анализа присутствия или тестирования активности одной или большего числа молекул-мишеней, которые специфическим образом взаимодействуют с данными зондами. В одном из вариантов настоящего изобретения тест-участки (которые могут быть лунками) дополнительно подразделены на более мелкие суб-участки (углубления или “ямки”).Отчет о международном поиске был опубликован 2001.08.16.
EA200200062A 1999-06-21 2000-06-21 Способы выявления мишеней в образце и наборы для их осуществления EA007338B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/337,325 US6238869B1 (en) 1997-12-19 1999-06-21 High throughput assay system
PCT/US2000/016952 WO2000079008A2 (en) 1999-06-21 2000-06-21 High throughput assay system

Publications (2)

Publication Number Publication Date
EA200200062A1 true EA200200062A1 (ru) 2002-06-27
EA007338B1 EA007338B1 (ru) 2006-08-25

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EA200200062A EA007338B1 (ru) 1999-06-21 2000-06-21 Способы выявления мишеней в образце и наборы для их осуществления

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Country Link
US (1) US6238869B1 (ru)
EP (2) EP1190095A2 (ru)
JP (3) JP2003504011A (ru)
KR (1) KR100749185B1 (ru)
CN (1) CN1390263B (ru)
AU (1) AU775659B2 (ru)
CA (1) CA2377567C (ru)
CZ (1) CZ301618B6 (ru)
EA (1) EA007338B1 (ru)
HK (1) HK1052536A1 (ru)
MX (1) MXPA01013355A (ru)
NO (1) NO20016261L (ru)
WO (1) WO2000079008A2 (ru)

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JP2011135883A (ja) 2011-07-14
CA2377567C (en) 2011-11-29
US6238869B1 (en) 2001-05-29
WO2000079008A3 (en) 2001-08-16
KR20020011443A (ko) 2002-02-08
NO20016261D0 (no) 2001-12-20
CA2377567A1 (en) 2000-12-28
EP1847619A2 (en) 2007-10-24
EP1190095A2 (en) 2002-03-27
EP1847619A3 (en) 2007-12-05
CZ301618B6 (cs) 2010-05-05
WO2000079008A2 (en) 2000-12-28
KR100749185B1 (ko) 2007-08-13
JP2003504011A (ja) 2003-02-04
WO2000079008A9 (en) 2002-06-13
JP2010046071A (ja) 2010-03-04
AU775659B2 (en) 2004-08-12
EA007338B1 (ru) 2006-08-25
HK1052536A1 (zh) 2003-09-19
AU5498000A (en) 2001-01-09
CN1390263B (zh) 2012-09-05
NO20016261L (no) 2002-02-21
WO2000079008B1 (en) 2001-11-08
MXPA01013355A (es) 2002-11-04
CZ20014582A3 (cs) 2002-04-17
CN1390263A (zh) 2003-01-08

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