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DK3765525T3 - Biparatopiske anti-her2-antistof-lægemiddelkonjugater og anvendelsesfremgangsmåder - Google Patents

Biparatopiske anti-her2-antistof-lægemiddelkonjugater og anvendelsesfremgangsmåder Download PDF

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Publication number
DK3765525T3
DK3765525T3 DK19766478.2T DK19766478T DK3765525T3 DK 3765525 T3 DK3765525 T3 DK 3765525T3 DK 19766478 T DK19766478 T DK 19766478T DK 3765525 T3 DK3765525 T3 DK 3765525T3
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stof
methods
drug conjugates
her2
biparatopic
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DK19766478.2T
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DK3765525T5 (da
Inventor
Kevin Hamblett
Rupert H Davies
James R Rich
Gerald J Rowse
Vincent K C Fung
Stuart D Barnscher
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Zymeworks Bc Inc
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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