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DK3500668T3 - Identificering af mål for lægemiddel ved hurtig udvælgelse af lægemiddelresistente mutationer - Google Patents

Identificering af mål for lægemiddel ved hurtig udvælgelse af lægemiddelresistente mutationer Download PDF

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Publication number
DK3500668T3
DK3500668T3 DK17790663.3T DK17790663T DK3500668T3 DK 3500668 T3 DK3500668 T3 DK 3500668T3 DK 17790663 T DK17790663 T DK 17790663T DK 3500668 T3 DK3500668 T3 DK 3500668T3
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DK
Denmark
Prior art keywords
targets
medicine
identification
medicinal products
quick selection
Prior art date
Application number
DK17790663.3T
Other languages
English (en)
Inventor
Dirk Daelemans
Jasper Neggers
Original Assignee
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1614078.2A external-priority patent/GB201614078D0/en
Priority claimed from GBGB1711520.5A external-priority patent/GB201711520D0/en
Application filed by Univ Leuven Kath filed Critical Univ Leuven Kath
Application granted granted Critical
Publication of DK3500668T3 publication Critical patent/DK3500668T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102Mutagenizing nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1082Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/15011Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK17790663.3T 2016-08-17 2017-08-16 Identificering af mål for lægemiddel ved hurtig udvælgelse af lægemiddelresistente mutationer DK3500668T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1614078.2A GB201614078D0 (en) 2016-08-17 2016-08-17 Drug-target identification by rapid selection of drug resistance mutations
GBGB1711520.5A GB201711520D0 (en) 2017-07-18 2017-07-18 Drug-target identification by rapid selection of drug resistance mutations
PCT/BE2017/000037 WO2018032063A1 (en) 2016-08-17 2017-08-16 Drug-target identification by rapid selection of drug resistance mutations

Publications (1)

Publication Number Publication Date
DK3500668T3 true DK3500668T3 (da) 2020-08-17

Family

ID=60182301

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17790663.3T DK3500668T3 (da) 2016-08-17 2017-08-16 Identificering af mål for lægemiddel ved hurtig udvælgelse af lægemiddelresistente mutationer

Country Status (5)

Country Link
US (1) US20200216837A1 (da)
EP (1) EP3500668B1 (da)
CA (1) CA3034110A1 (da)
DK (1) DK3500668T3 (da)
WO (1) WO2018032063A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110938658B (zh) * 2018-09-21 2023-02-07 中国科学院分子细胞科学卓越创新中心 一种抗体进化方法及其应用
CN110343700A (zh) * 2019-07-05 2019-10-18 中山大学孙逸仙纪念医院 一种xpo1基因敲除的胰腺癌细胞系及其构建方法
CN111534578A (zh) * 2020-05-07 2020-08-14 西南大学 一种高通量筛选真核生物细胞与农药互作的靶点基因的方法
CN111534577A (zh) * 2020-05-07 2020-08-14 西南大学 一种高通量筛选真核生物必需基因和生长抑制基因的方法
WO2022090224A1 (en) * 2020-10-27 2022-05-05 KWS SAAT SE & Co. KGaA Use of enhanced pol theta activity for eukaryotic genome engineering

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10017760B2 (en) * 2016-06-24 2018-07-10 Inscripta, Inc. Methods for generating barcoded combinatorial libraries

Also Published As

Publication number Publication date
WO2018032063A1 (en) 2018-02-22
CA3034110A1 (en) 2018-02-22
US20200216837A1 (en) 2020-07-09
EP3500668A1 (en) 2019-06-26
EP3500668B1 (en) 2020-06-17

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