[go: up one dir, main page]

DK3583214T3 - Fremgangsmåder og sammensætninger til identificering eller kvantificering af mål i en biologisk prøve - Google Patents

Fremgangsmåder og sammensætninger til identificering eller kvantificering af mål i en biologisk prøve Download PDF

Info

Publication number
DK3583214T3
DK3583214T3 DK18747697.3T DK18747697T DK3583214T3 DK 3583214 T3 DK3583214 T3 DK 3583214T3 DK 18747697 T DK18747697 T DK 18747697T DK 3583214 T3 DK3583214 T3 DK 3583214T3
Authority
DK
Denmark
Prior art keywords
identifying
compositions
methods
biological sample
quantifying targets
Prior art date
Application number
DK18747697.3T
Other languages
English (en)
Other versions
DK3583214T5 (da
Inventor
Marlon Stoeckius
Peter Smibert
Brian Houck-Loomis
Original Assignee
New York Genome Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Genome Center Inc filed Critical New York Genome Center Inc
Publication of DK3583214T3 publication Critical patent/DK3583214T3/da
Application granted granted Critical
Publication of DK3583214T5 publication Critical patent/DK3583214T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK18747697.3T 2017-02-02 2018-02-02 Fremgangsmåder og sammensætninger til identificering eller kvantificering af mål i en biologisk prøve DK3583214T5 (da)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762453726P 2017-02-02 2017-02-02
US201762515180P 2017-06-05 2017-06-05
US201762549189P 2017-08-23 2017-08-23
US201762559228P 2017-09-15 2017-09-15
US201762599450P 2017-12-15 2017-12-15
US201762609332P 2017-12-21 2017-12-21
PCT/US2018/016587 WO2018144813A1 (en) 2017-02-02 2018-02-02 Methods and compositions for identifying or quantifying targets in a biological sample

Publications (2)

Publication Number Publication Date
DK3583214T3 true DK3583214T3 (da) 2023-12-18
DK3583214T5 DK3583214T5 (da) 2024-09-02

Family

ID=63040173

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18747697.3T DK3583214T5 (da) 2017-02-02 2018-02-02 Fremgangsmåder og sammensætninger til identificering eller kvantificering af mål i en biologisk prøve

Country Status (7)

Country Link
US (3) US20180251825A1 (da)
EP (2) EP3583214B1 (da)
CN (2) CN117887804A (da)
DK (1) DK3583214T5 (da)
ES (1) ES2968290T3 (da)
FI (1) FI3583214T3 (da)
WO (1) WO2018144813A1 (da)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
CA2865575C (en) 2012-02-27 2024-01-16 Cellular Research, Inc. Compositions and kits for molecular counting
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4234716A3 (en) 2013-06-25 2023-12-06 Prognosys Biosciences, Inc. Methods for determining spatial patterns of biological targets in a sample
CN110964796B (zh) 2013-08-28 2024-04-05 贝克顿迪金森公司 大规模平行单细胞分析
CN113249435B (zh) * 2014-06-26 2024-09-03 10X基因组学有限公司 分析来自单个细胞或细胞群体的核酸的方法
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
EP3262192B1 (en) 2015-02-27 2020-09-16 Becton, Dickinson and Company Spatially addressable molecular barcoding
WO2016160844A2 (en) 2015-03-30 2016-10-06 Cellular Research, Inc. Methods and compositions for combinatorial barcoding
EP4119677B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
WO2016172373A1 (en) 2015-04-23 2016-10-27 Cellular Research, Inc. Methods and compositions for whole transcriptome amplification
CN108026524A (zh) 2015-09-11 2018-05-11 赛卢拉研究公司 用于核酸文库标准化的方法和组合物
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
KR102741603B1 (ko) 2016-05-02 2024-12-16 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
EP4269616A3 (en) 2016-05-02 2024-02-14 Becton, Dickinson and Company Accurate molecular barcoding
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
KR102638006B1 (ko) 2016-09-26 2024-02-20 셀룰러 리서치, 인크. 바코딩된 올리고뉴클레오티드 서열을 갖는 시약을 이용한 단백질 발현의 측정
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11319583B2 (en) 2017-02-01 2022-05-03 Becton, Dickinson And Company Selective amplification using blocking oligonucleotides
US10995333B2 (en) 2017-02-06 2021-05-04 10X Genomics, Inc. Systems and methods for nucleic acid preparation
WO2018156553A1 (en) * 2017-02-21 2018-08-30 Arizona Board Of Regents On Behalf Of Arizona State University A method for targeted protein quantification by bar-coding affinity reagents with unique dna sequences
EP4345172A3 (en) 2017-06-05 2024-07-03 Becton, Dickinson and Company Sample indexing for single cells
SG11202003923PA (en) 2017-10-31 2020-05-28 Encodia Inc Methods and kits using nucleic acid encoding and/or label
KR102556494B1 (ko) 2017-10-31 2023-07-18 엔코디아, 인코포레이티드 핵산 암호화 및/또는 표지를 이용한 분석용 키트
US11332736B2 (en) * 2017-12-07 2022-05-17 The Broad Institute, Inc. Methods and compositions for multiplexing single cell and single nuclei sequencing
US11946095B2 (en) 2017-12-19 2024-04-02 Becton, Dickinson And Company Particles associated with oligonucleotides
SG11202007686VA (en) 2018-02-12 2020-09-29 10X Genomics Inc Methods characterizing multiple analytes from individual cells or cell populations
AU2019262048B2 (en) 2018-05-03 2025-09-04 Becton, Dickinson And Company High throughput multiomics sample analysis
EP4545647A3 (en) 2018-05-03 2025-07-09 Becton, Dickinson and Company Molecular barcoding on opposite transcript ends
WO2019217758A1 (en) 2018-05-10 2019-11-14 10X Genomics, Inc. Methods and systems for molecular library generation
US11414699B2 (en) * 2018-05-15 2022-08-16 Mantra Bio, Inc. Barcode-free single vesicle multiplexed protein and RNA analysis
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
CN118853827A (zh) 2018-10-01 2024-10-29 贝克顿迪金森公司 确定5’转录物序列
CN112969789A (zh) 2018-11-08 2021-06-15 贝克顿迪金森公司 使用随机引发的单细胞全转录组分析
WO2020117914A1 (en) * 2018-12-04 2020-06-11 Roche Sequencing Solutions, Inc. Spatially oriented quantum barcoding of cellular targets
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
EP3894552A1 (en) 2018-12-13 2021-10-20 Becton, Dickinson and Company Selective extension in single cell whole transcriptome analysis
US20220062394A1 (en) 2018-12-17 2022-03-03 The Broad Institute, Inc. Methods for identifying neoantigens
US12169198B2 (en) * 2019-01-08 2024-12-17 10X Genomics, Inc. Systems and methods for sample analysis
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
WO2020150356A1 (en) * 2019-01-16 2020-07-23 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
EP3914728B1 (en) * 2019-01-23 2023-04-05 Becton, Dickinson and Company Oligonucleotides associated with antibodies
CN114008214A (zh) * 2019-01-28 2022-02-01 贝克顿·迪金森公司 含寡核苷酸的细胞成分结合试剂及其使用方法
WO2020163789A1 (en) * 2019-02-08 2020-08-13 The Trustees Of Columbia University In The City Of New York Single cell/exosome/vesicle protein profiling
US11851683B1 (en) 2019-02-12 2023-12-26 10X Genomics, Inc. Methods and systems for selective analysis of cellular samples
CN113454234B (zh) 2019-02-14 2025-03-18 贝克顿迪金森公司 杂合体靶向和全转录物组扩增
CA3113841A1 (en) * 2019-03-01 2020-09-10 Illumina, Inc. High-throughput single-nuclei and single-cell libraries and methods of making and of using
EP3947724A4 (en) * 2019-04-02 2023-06-14 Mission Bio, Inc. METHODS AND SYSTEMS FOR CHARACTERIZING TUMORS AND IDENTIFYING TUMOR HETEROGENEITY
WO2020206285A1 (en) * 2019-04-05 2020-10-08 Board Of Regents, The University Of Texas System Methods and applications for cell barcoding
WO2020214642A1 (en) 2019-04-19 2020-10-22 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
EP3963070A4 (en) 2019-04-30 2023-02-22 Encodia, Inc. METHODS OF PREPARATION OF ANALYTES AND RELATED KITS
CA3138806A1 (en) 2019-05-22 2020-11-26 Dalia Dhingra Method and apparatus for simultaneous targeted sequencing of dna, rna and protein
WO2021006353A1 (ja) * 2019-07-11 2021-01-14 学校法人東京理科大学 固相担体を用いた核酸増幅方法
EP4004231B1 (en) 2019-07-22 2025-11-12 Becton, Dickinson and Company Single cell chromatin immunoprecipitation sequencing assay
US12235262B1 (en) 2019-09-09 2025-02-25 10X Genomics, Inc. Methods and systems for single cell protein analysis
US11287422B2 (en) 2019-09-23 2022-03-29 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
CA3155289A1 (en) * 2019-09-23 2021-04-01 Element Biosciences, Inc. Methods for cellularly addressable nucleic acid sequencing
WO2021067162A1 (en) * 2019-09-30 2021-04-08 The General Hospital Corporation Droplet-based single extracellular vesicle sequencing
CN114616467A (zh) 2019-10-03 2022-06-10 瑞泽恩制药公司 筛选原代人类细胞中的同源t细胞和表位反应性的高通量方法
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
CN114729350A (zh) 2019-11-08 2022-07-08 贝克顿迪金森公司 使用随机引发获得用于免疫组库测序的全长v(d)j信息
EP4058597B1 (en) * 2019-11-14 2025-10-01 The Trustees of Columbia University in the City of New York Systems, methods, and compositions for generating multi-omic information from single cells
IT201900024159A1 (it) * 2019-12-16 2021-06-16 Menarini Silicon Biosystems Spa Metodo e kit per amplificazione totale del genoma e analisi di molecole bersaglio in un campione biologico
WO2021123062A1 (en) * 2019-12-20 2021-06-24 Keygene N.V. Ngs library preparation using covalently closed nucleic acid molecule ends
WO2021133842A1 (en) 2019-12-23 2021-07-01 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
CN114761577B (zh) * 2020-01-10 2025-10-24 新克赛特株式会社 新型细胞表型筛选方法
US11649497B2 (en) * 2020-01-13 2023-05-16 Becton, Dickinson And Company Methods and compositions for quantitation of proteins and RNA
US20210214770A1 (en) * 2020-01-13 2021-07-15 Becton, Dickinson And Company Cell capture using du-containing oligonucleotides
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
WO2021150821A1 (en) * 2020-01-24 2021-07-29 Vanderbilt University Methods for identification of ligand-blocking antibodies and for determining antibody potency
EP4097228B1 (en) 2020-01-29 2024-08-14 Becton, Dickinson and Company Barcoded wells for spatial mapping of single cells through sequencing
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
CN115087746A (zh) * 2020-02-12 2022-09-20 贝克顿迪金森公司 细胞内AbSeq
WO2021173719A1 (en) 2020-02-25 2021-09-02 Becton, Dickinson And Company Bi-specific probes to enable the use of single-cell samples as single color compensation control
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
WO2021178199A1 (en) 2020-03-05 2021-09-10 BioLegend, Inc. Methods and compositions for detecting targets
CA3175931A1 (en) * 2020-03-16 2021-09-23 Fluent Biosciences Inc. Multi-omic analysis in monodisperse droplets
IL296435A (en) * 2020-03-18 2022-11-01 Chan Zuckerberg Biohub Inc Single-cell combinatorial indexed cytometry sequencing
CN111370058B (zh) * 2020-03-19 2022-12-06 佛山科学技术学院 一种基于全基因组snp信息追溯水牛血统来源以及进行基因组选配的方法
CN111440846B (zh) * 2020-04-09 2020-12-18 江苏先声医学诊断有限公司 一种用于纳米孔测序建库的位置锚定条码系统
EP4150118A1 (en) 2020-05-14 2023-03-22 Becton Dickinson and Company Primers for immune repertoire profiling
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
US12265079B1 (en) 2020-06-02 2025-04-01 10X Genomics, Inc. Systems and methods for detecting analytes from captured single biological particles
EP4407030B1 (en) 2020-06-02 2025-12-17 Becton, Dickinson and Company Oligonucleotides and beads for 5 prime gene expression assay
WO2022009642A1 (ja) * 2020-07-06 2022-01-13 ソニーグループ株式会社 生体粒子分析方法及び生体粒子分析システム
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
EP4660318A2 (en) * 2020-07-17 2025-12-10 13.8, Inc. Methods, compositions, and systems for mapping locations of single molecules in multi-dimensional space
CN116194589A (zh) 2020-07-31 2023-05-30 贝克顿迪金森公司 用于转座酶可及染色质的单细胞测定
EP3950955A1 (en) 2020-08-06 2022-02-09 Albert-Ludwigs-Universität Freiburg Multianalyte assay for the simultaneous detection of nucleic acid and analytes
US20220090089A1 (en) * 2020-09-24 2022-03-24 The Broad Institute, Inc. Engineered multi-omic display constructs and display systems
WO2022109343A1 (en) 2020-11-20 2022-05-27 Becton, Dickinson And Company Profiling of highly expressed and lowly expressed proteins
US12467081B2 (en) 2020-11-23 2025-11-11 Pleno, Inc. Encoded endonuclease assays
US12392771B2 (en) 2020-12-15 2025-08-19 Becton, Dickinson And Company Single cell secretome analysis
IL303828A (en) * 2020-12-22 2023-08-01 Hifibio Sas Microfluidic methods and systems
WO2022182682A1 (en) 2021-02-23 2022-09-01 10X Genomics, Inc. Probe-based analysis of nucleic acids and proteins
JP2024509984A (ja) * 2021-03-19 2024-03-05 パリ シアンス エ レットル 細胞又は細胞小器官の選択的分析のための方法
WO2023023584A2 (en) 2021-08-19 2023-02-23 Eclipse Bioinnovations, Inc. Methods for detecting rna binding protein complexes
WO2023081850A1 (en) 2021-11-04 2023-05-11 Regeneron Pharmaceuticals, Inc. Viral particles retargeted to skeletal muscle
EP4448789A4 (en) * 2021-12-15 2025-12-10 Biolegend Inc COMPOSITIONS AND METHODS FOR IMPROVED SAMPLE MULTIPLEXING
CN114252602B (zh) * 2021-12-22 2023-09-12 清华大学深圳国际研究生院 微流控芯片、基于微流控芯片的检测系统及细菌的检测方法
WO2023122237A1 (en) * 2021-12-22 2023-06-29 St. Jude Children's Research Hospital, Inc. Kit and method for analyzing t cell receptors from single t cells
WO2023129973A2 (en) * 2021-12-30 2023-07-06 Eclipse Bioinnovations, Inc. Methods for detecting rna modification targets on a gene
WO2023141932A1 (en) * 2022-01-28 2023-08-03 Westlake University Conjugates of nucleic acids or derivatives thereof and cells, methods of preparation, and uses thereof
EP4490315A1 (en) * 2022-03-09 2025-01-15 Becton, Dickinson and Company Modified flow proxy assay prior to single-cell cite-seq
WO2024015952A1 (en) * 2022-07-15 2024-01-18 Seq Biomarque, Llc Methods for identifying and quantifying antigens in a sample
CN119301155A (zh) 2022-07-19 2025-01-10 百进生物科技公司 抗cd157抗体、其抗原结合片段和组合物及其制备和使用方法
CN119968395A (zh) 2022-08-18 2025-05-09 百进生物科技公司 抗axl抗体、其抗原结合片段及其制备和使用方法
CN116068198B (zh) * 2022-11-30 2024-01-09 深圳湾实验室 Ppi原位检测方法及其载体、诊断试剂、试剂盒和应用
AU2024220647A1 (en) 2023-02-13 2025-08-21 Regeneron Pharmaceuticals, Inc. Treatment of muscle related disorders with anti-human cacng1 antibodies
CN116024307B (zh) * 2023-02-20 2023-08-11 北京寻因生物科技有限公司 一种含组织位置信息的单细胞文库构建方法及测序方法
WO2024182571A2 (en) * 2023-02-28 2024-09-06 Oregon Health & Science University Compositions and methods for molecular barcoding
US20240309357A1 (en) * 2023-03-13 2024-09-19 California Institute Of Technology Methods and compositions for quantitative, high-throughput protein binding measurement
WO2024243217A1 (en) 2023-05-25 2024-11-28 BioLegend, Inc. Ceacam6 binding antibodies and antigen-binding fragments thereof
WO2024243511A1 (en) 2023-05-25 2024-11-28 Regeneron Pharmaceuticals, Inc. T cell receptors that bind presented hpv16-, mart1-, cmv-, ebv-, or influenza- peptides
WO2025006955A2 (en) * 2023-06-30 2025-01-02 Ionis Pharmaceuticals, Inc. Cd29 targeted oligonucleotides and uses thereof
WO2025072313A1 (en) 2023-09-27 2025-04-03 BioLegend, Inc. Anti-gpc4 antibodies
CN119920311A (zh) * 2025-01-24 2025-05-02 广州国家实验室 一种单细胞数据质控处理的方法和系统

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110171749A1 (en) * 2009-03-02 2011-07-14 Board Of Trustees Of Michigan State University Nanoparticle tracer-based electrochemical dna sensor for detection of pathogens-amplification by a universal nano-tracer (aunt)
EP2670863B1 (en) * 2011-01-31 2018-06-27 H. Hoffnabb-La Roche Ag Methods of identifying multiple epitopes in cells
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2014047561A1 (en) 2012-09-21 2014-03-27 The Broad Institute Inc. Compositions and methods for labeling of agents
WO2014108850A2 (en) * 2013-01-09 2014-07-17 Yeda Research And Development Co. Ltd. High throughput transcriptome analysis
US10975371B2 (en) * 2014-04-29 2021-04-13 Illumina, Inc. Nucleic acid sequence analysis from single cells
CN113249435B (zh) * 2014-06-26 2024-09-03 10X基因组学有限公司 分析来自单个细胞或细胞群体的核酸的方法
CN107873054B (zh) * 2014-09-09 2022-07-12 博德研究所 用于复合单细胞核酸分析的基于微滴的方法和设备
EP3268462B1 (en) 2015-03-11 2021-08-11 The Broad Institute, Inc. Genotype and phenotype coupling

Also Published As

Publication number Publication date
CN110475864B (zh) 2024-01-12
EP4324931A3 (en) 2024-05-29
ES2968290T3 (es) 2024-05-08
CN117887804A (zh) 2024-04-16
EP3583214A1 (en) 2019-12-25
US20240384333A1 (en) 2024-11-21
EP3583214B1 (en) 2023-11-22
US20180251825A1 (en) 2018-09-06
FI3583214T3 (fi) 2023-12-19
WO2018144813A1 (en) 2018-08-09
EP4324931A2 (en) 2024-02-21
US20210371914A1 (en) 2021-12-02
CN110475864A (zh) 2019-11-19
DK3583214T5 (da) 2024-09-02
EP3583214A4 (en) 2020-12-23
US12071656B2 (en) 2024-08-27

Similar Documents

Publication Publication Date Title
DK3583214T5 (da) Fremgangsmåder og sammensætninger til identificering eller kvantificering af mål i en biologisk prøve
DK3615690T3 (da) Sammensætninger og fremgangsmåder til forbedring af prøveidentificering i indekserede nukleinsyrebiblioteker
DK3615671T3 (da) Sammensætninger og fremgangsmåder til forbedring af prøveidentificering i indekserede nukleinsyrebiblioteker
IL283416A (en) Genomic infrastructure for on-site or cloud-based dna and rna processing and analysis
DK4026917T5 (da) Fremgangsmåde og kit til bestemmelse af cellers eller vævs død eller dna's vævs- eller celleoprindelse ved dna-methyleringsanalyse
DK3615691T3 (da) Sammensætninger og fremgangsmåder til forbedring af prøveidentifikation i indekserede nukleinsyrebiblioteker
DK3541956T3 (da) Fremgangsmåde til rumlig mærkning og analyse af nukleinsyrer i en biologisk prøve
DK3167962T3 (da) Prøveglasstativ og prøveglasanalysesystem
DK3882357T3 (da) Fremgangsmåder og sammensætninger til analyse af nukleinsyrer
SG11201706367WA (en) Systems and methods for assessing biological samples
DK3429543T3 (da) Selektivt ventilerede biologiske analyseanordninger og tilhørende fremgangsmåder
ZA201801680B (en) Method and test system for detecting and/or quantifying a target nucleic acid in a sample
DK3302804T3 (da) Prøveholder og analysesystem til udførelse af specifikke reaktioner
DK3204520T3 (da) Fremgangsmåde til identificering og kvantificering af nukleinsyreekspression, splejsningsvariant, translokation, kopiantal eller methyleringsændringer
DK3151964T3 (da) Systemer og metoder inklusive en rotationsventil for mindst en prøveforberedelse eller prøveanalyse
PL3513163T3 (pl) Systemy i sposoby laboratoryjnego badania przesiewowego próbki biologicznej
EP3569138C0 (de) Komponente, computerprogramm, system und kit zur augenglasbestimmung
PL3274469T3 (pl) Kompozycje i sposoby wykrywania zanieczyszczenia biologicznego
DK3426402T3 (da) En indretning og fremgangsmåde til opvarmning eller køling af en prøve
DK3350342T3 (da) Sondesæt til analyse af en DNA-prøve og fremgangsmåde til anvendelse deraf
EP3570980A4 (en) PROCESSES AND DEVICES FOR THE ANALYSIS OF SAMPLES
EP3705052C0 (en) BIOLOGICAL SAMPLE COLLECTION DEVICE
EP3355063A4 (en) SAMPLE INSPECTION AUTOMATION SYSTEM
PL3651162T3 (pl) Sposoby i urzadzenia do wykonywania pomiaru analitycznego
DK3454061T3 (da) Fremgangsmåde til kvantificering af pyritsvovl og organisk svovl i en bjergartsprøve