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DK3551627T3 - Nye isoxazolyletherderivater som gaba a alpha5-pam - Google Patents

Nye isoxazolyletherderivater som gaba a alpha5-pam Download PDF

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Publication number
DK3551627T3
DK3551627T3 DK17816630.2T DK17816630T DK3551627T3 DK 3551627 T3 DK3551627 T3 DK 3551627T3 DK 17816630 T DK17816630 T DK 17816630T DK 3551627 T3 DK3551627 T3 DK 3551627T3
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DK
Denmark
Prior art keywords
alpha5
gaba
pam
ether derivatives
new
Prior art date
Application number
DK17816630.2T
Other languages
English (en)
Inventor
Bernd Buettelmann
Giuseppe Cecere
Bernhard Fasching
Zbinden Katrin Groebke
Maria-Clemencia Hernandez
Henner Knust
Andreas Koblet
Emmanuel Pinard
Andrew Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
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Publication of DK3551627T3 publication Critical patent/DK3551627T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/06Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK17816630.2T 2016-12-08 2017-12-07 Nye isoxazolyletherderivater som gaba a alpha5-pam DK3551627T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16202889 2016-12-08
PCT/EP2017/081768 WO2018104419A1 (en) 2016-12-08 2017-12-07 New isoxazolyl ether derivatives as gaba a alpha5 pam

Publications (1)

Publication Number Publication Date
DK3551627T3 true DK3551627T3 (da) 2022-04-19

Family

ID=57530563

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17816630.2T DK3551627T3 (da) 2016-12-08 2017-12-07 Nye isoxazolyletherderivater som gaba a alpha5-pam

Country Status (31)

Country Link
US (3) US11091471B2 (da)
EP (1) EP3551627B1 (da)
JP (1) JP7084405B2 (da)
KR (1) KR102564643B1 (da)
CN (2) CN117285525A (da)
AR (1) AR110498A1 (da)
AU (1) AU2017373734B2 (da)
BR (1) BR112019006571A2 (da)
CA (1) CA3040024A1 (da)
CL (1) CL2019001458A1 (da)
CO (1) CO2019002692A2 (da)
CR (1) CR20190268A (da)
DK (1) DK3551627T3 (da)
ES (1) ES2910110T3 (da)
HR (1) HRP20220468T1 (da)
HU (1) HUE058355T2 (da)
IL (1) IL267054B (da)
LT (1) LT3551627T (da)
MA (1) MA48594B1 (da)
MX (1) MX388725B (da)
MY (1) MY200641A (da)
PE (1) PE20191156A1 (da)
PH (1) PH12019500664B1 (da)
PL (1) PL3551627T3 (da)
PT (1) PT3551627T (da)
RS (1) RS63106B1 (da)
SI (1) SI3551627T1 (da)
TW (1) TWI642666B (da)
UA (1) UA125524C2 (da)
WO (1) WO2018104419A1 (da)
ZA (1) ZA201902225B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3551627B1 (en) 2016-12-08 2022-02-16 F. Hoffmann-La Roche AG New isoxazolyl ether derivatives as gaba a alpha5 pam
CA3102101A1 (en) 2018-06-13 2019-12-19 F. Hoffmann-La Roche Ag New isoxazolyl ether derivatives as gaba a alpha5 pam
BR102019014802A2 (pt) 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluorometil-fenil triazóis
HU231223B1 (hu) * 2018-09-28 2022-01-28 Richter Gedeon Nyrt. GABAA A5 receptor modulátor hatású biciklusos vegyületek
EP4126858A1 (en) * 2020-03-26 2023-02-08 Richter Gedeon Nyrt. Dihydro-2-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators
PH12022552340A1 (en) * 2020-03-26 2023-11-29 Richter Gedeon Nyrt APHTHYRIDINE AND PYRIDO[3,4-c]PYRIDAZINE DERIVATIVES AS GABAA a5 RECEPTOR MODULATORS
CA3216863A1 (en) 2021-05-05 2022-11-10 University College Cardiff Consultants Limited Heteroaryl compounds useful in the treatment of cognitive disorders
HU231691B1 (hu) 2021-09-29 2025-10-28 Richter Gedeon Nyrt GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok
JP2025519814A (ja) 2022-06-20 2025-06-26 エフ. ホフマン-ラ ロシュ アーゲー 6-((5-メチル-3-(6-メチルピリジン-3-イル)イソオキサゾール-4-イル)メトキシ)-n-(テトラヒドロピラン-4-イル)ピリダジン-3-カルボキサミドの結晶形態
AU2023370005A1 (en) 2022-10-25 2025-04-10 F. Hoffmann-La Roche Ag Process for manufacturing alogabat
AU2024262426A1 (en) 2023-04-24 2025-09-18 F. Hoffmann-La Roche Ag Tablet comprising 6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol-4-yl)methoxy)- n-(tetrahydrapyran-4-yl)pyridazine-3-carboxamidee
WO2024251133A1 (zh) * 2023-06-05 2024-12-12 武汉人福创新药物研发中心有限公司 作为α5-GABAA受体调节剂的杂环化合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101679444A (zh) 2007-04-18 2010-03-24 阿斯利康(瑞典)有限公司 具有正变构gabab受体调节剂作用的黄嘌呤化合物
US7943619B2 (en) * 2007-12-04 2011-05-17 Hoffmann-La Roche Inc. Isoxazolo-pyridazine derivatives
SI2227467T1 (sl) * 2007-12-04 2015-03-31 F. Hoffmann-La Roche Ag Derivati izoksazolo-piridina
US8222246B2 (en) 2009-04-02 2012-07-17 Hoffmann-La Roche Inc. Substituted isoxazoles
MX2011011489A (es) 2009-05-05 2011-11-18 Hoffmann La Roche Derivados de isoxazol-piridina.
BR112013010895A2 (pt) 2010-11-05 2016-08-02 Hoffmann La Roche uso de compostos farmacêuticos ativos para o tratamento de condições do sistema nervoso central
HUE047771T2 (hu) * 2011-09-15 2020-05-28 Hoffmann La Roche Új dihidrokinolin-2-on származékok
AU2016308717A1 (en) 2015-08-17 2018-01-25 Lupin Limited Heteroaryl derivatives as PARP inhibitors
CN108430473B (zh) 2016-01-08 2021-08-31 细胞基因公司 抗增殖化合物以及其药物组合物和用途
MY204877A (en) 2016-01-08 2024-09-20 Arcus Biosciences Inc Modulators of 5'-nucleotidase, ecto and the use thereof
EP3551627B1 (en) 2016-12-08 2022-02-16 F. Hoffmann-La Roche AG New isoxazolyl ether derivatives as gaba a alpha5 pam

Also Published As

Publication number Publication date
US20240279218A1 (en) 2024-08-22
PL3551627T3 (pl) 2022-05-16
CL2019001458A1 (es) 2019-10-18
EP3551627B1 (en) 2022-02-16
LT3551627T (lt) 2022-04-25
WO2018104419A1 (en) 2018-06-14
UA125524C2 (uk) 2022-04-13
PE20191156A1 (es) 2019-09-09
TW201827424A (zh) 2018-08-01
MA48594B1 (fr) 2022-05-31
RU2019118253A (ru) 2021-01-11
PH12019500664A1 (en) 2019-12-16
PT3551627T (pt) 2022-04-06
IL267054A (en) 2019-08-29
JP7084405B2 (ja) 2022-06-14
AR110498A1 (es) 2019-04-03
HRP20220468T1 (hr) 2022-05-27
CN109923113B (zh) 2023-10-13
BR112019006571A2 (pt) 2019-07-02
ES2910110T3 (es) 2022-05-11
JP2020510621A (ja) 2020-04-09
ZA201902225B (en) 2019-12-18
US11091471B2 (en) 2021-08-17
PH12019500664B1 (en) 2023-08-11
IL267054B (en) 2021-07-29
US20190300516A1 (en) 2019-10-03
RU2019118253A3 (da) 2021-04-07
CA3040024A1 (en) 2018-06-14
EP3551627A1 (en) 2019-10-16
AU2017373734A1 (en) 2019-04-11
CN109923113A (zh) 2019-06-21
MX2019006696A (es) 2019-08-21
SI3551627T1 (sl) 2022-05-31
CN117285525A (zh) 2023-12-26
AU2017373734B2 (en) 2022-02-17
US20220411415A1 (en) 2022-12-29
MX388725B (es) 2025-03-11
HUE058355T2 (hu) 2022-07-28
KR20190088485A (ko) 2019-07-26
TWI642666B (zh) 2018-12-01
CO2019002692A2 (es) 2019-04-12
MY200641A (en) 2024-01-08
MA48594A (fr) 2021-04-28
KR102564643B1 (ko) 2023-08-08
CR20190268A (es) 2019-07-11
RS63106B1 (sr) 2022-04-29

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