PL3551627T3 - Nowe pochodne eterowe izoksazolilu jako PAM dla GABA A alfa-5 - Google Patents
Nowe pochodne eterowe izoksazolilu jako PAM dla GABA A alfa-5Info
- Publication number
- PL3551627T3 PL3551627T3 PL17816630T PL17816630T PL3551627T3 PL 3551627 T3 PL3551627 T3 PL 3551627T3 PL 17816630 T PL17816630 T PL 17816630T PL 17816630 T PL17816630 T PL 17816630T PL 3551627 T3 PL3551627 T3 PL 3551627T3
- Authority
- PL
- Poland
- Prior art keywords
- alpha5
- gaba
- pam
- ether derivatives
- new
- Prior art date
Links
- LRJJZSXDNXHKQV-UHFFFAOYSA-N 3-(1,2-oxazol-3-yloxy)-1,2-oxazole Chemical class C1=CON=C1OC=1C=CON=1 LRJJZSXDNXHKQV-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16202889 | 2016-12-08 | ||
| PCT/EP2017/081768 WO2018104419A1 (en) | 2016-12-08 | 2017-12-07 | New isoxazolyl ether derivatives as gaba a alpha5 pam |
| EP17816630.2A EP3551627B1 (en) | 2016-12-08 | 2017-12-07 | New isoxazolyl ether derivatives as gaba a alpha5 pam |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3551627T3 true PL3551627T3 (pl) | 2022-05-16 |
Family
ID=57530563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17816630T PL3551627T3 (pl) | 2016-12-08 | 2017-12-07 | Nowe pochodne eterowe izoksazolilu jako PAM dla GABA A alfa-5 |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US11091471B2 (pl) |
| EP (1) | EP3551627B1 (pl) |
| JP (1) | JP7084405B2 (pl) |
| KR (1) | KR102564643B1 (pl) |
| CN (2) | CN117285525A (pl) |
| AR (1) | AR110498A1 (pl) |
| AU (1) | AU2017373734B2 (pl) |
| BR (1) | BR112019006571A2 (pl) |
| CA (1) | CA3040024A1 (pl) |
| CL (1) | CL2019001458A1 (pl) |
| CO (1) | CO2019002692A2 (pl) |
| CR (1) | CR20190268A (pl) |
| DK (1) | DK3551627T3 (pl) |
| ES (1) | ES2910110T3 (pl) |
| HR (1) | HRP20220468T1 (pl) |
| HU (1) | HUE058355T2 (pl) |
| IL (1) | IL267054B (pl) |
| LT (1) | LT3551627T (pl) |
| MA (1) | MA48594B1 (pl) |
| MX (1) | MX388725B (pl) |
| MY (1) | MY200641A (pl) |
| PE (1) | PE20191156A1 (pl) |
| PH (1) | PH12019500664B1 (pl) |
| PL (1) | PL3551627T3 (pl) |
| PT (1) | PT3551627T (pl) |
| RS (1) | RS63106B1 (pl) |
| SI (1) | SI3551627T1 (pl) |
| TW (1) | TWI642666B (pl) |
| UA (1) | UA125524C2 (pl) |
| WO (1) | WO2018104419A1 (pl) |
| ZA (1) | ZA201902225B (pl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3551627B1 (en) | 2016-12-08 | 2022-02-16 | F. Hoffmann-La Roche AG | New isoxazolyl ether derivatives as gaba a alpha5 pam |
| CA3102101A1 (en) | 2018-06-13 | 2019-12-19 | F. Hoffmann-La Roche Ag | New isoxazolyl ether derivatives as gaba a alpha5 pam |
| BR102019014802A2 (pt) | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluorometil-fenil triazóis |
| HU231223B1 (hu) * | 2018-09-28 | 2022-01-28 | Richter Gedeon Nyrt. | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
| EP4126858A1 (en) * | 2020-03-26 | 2023-02-08 | Richter Gedeon Nyrt. | Dihydro-2-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators |
| PH12022552340A1 (en) * | 2020-03-26 | 2023-11-29 | Richter Gedeon Nyrt | APHTHYRIDINE AND PYRIDO[3,4-c]PYRIDAZINE DERIVATIVES AS GABAA a5 RECEPTOR MODULATORS |
| CA3216863A1 (en) | 2021-05-05 | 2022-11-10 | University College Cardiff Consultants Limited | Heteroaryl compounds useful in the treatment of cognitive disorders |
| HU231691B1 (hu) | 2021-09-29 | 2025-10-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
| JP2025519814A (ja) | 2022-06-20 | 2025-06-26 | エフ. ホフマン-ラ ロシュ アーゲー | 6-((5-メチル-3-(6-メチルピリジン-3-イル)イソオキサゾール-4-イル)メトキシ)-n-(テトラヒドロピラン-4-イル)ピリダジン-3-カルボキサミドの結晶形態 |
| AU2023370005A1 (en) | 2022-10-25 | 2025-04-10 | F. Hoffmann-La Roche Ag | Process for manufacturing alogabat |
| AU2024262426A1 (en) | 2023-04-24 | 2025-09-18 | F. Hoffmann-La Roche Ag | Tablet comprising 6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol-4-yl)methoxy)- n-(tetrahydrapyran-4-yl)pyridazine-3-carboxamidee |
| WO2024251133A1 (zh) * | 2023-06-05 | 2024-12-12 | 武汉人福创新药物研发中心有限公司 | 作为α5-GABAA受体调节剂的杂环化合物及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101679444A (zh) | 2007-04-18 | 2010-03-24 | 阿斯利康(瑞典)有限公司 | 具有正变构gabab受体调节剂作用的黄嘌呤化合物 |
| US7943619B2 (en) * | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| SI2227467T1 (sl) * | 2007-12-04 | 2015-03-31 | F. Hoffmann-La Roche Ag | Derivati izoksazolo-piridina |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| MX2011011489A (es) | 2009-05-05 | 2011-11-18 | Hoffmann La Roche | Derivados de isoxazol-piridina. |
| BR112013010895A2 (pt) | 2010-11-05 | 2016-08-02 | Hoffmann La Roche | uso de compostos farmacêuticos ativos para o tratamento de condições do sistema nervoso central |
| HUE047771T2 (hu) * | 2011-09-15 | 2020-05-28 | Hoffmann La Roche | Új dihidrokinolin-2-on származékok |
| AU2016308717A1 (en) | 2015-08-17 | 2018-01-25 | Lupin Limited | Heteroaryl derivatives as PARP inhibitors |
| CN108430473B (zh) | 2016-01-08 | 2021-08-31 | 细胞基因公司 | 抗增殖化合物以及其药物组合物和用途 |
| MY204877A (en) | 2016-01-08 | 2024-09-20 | Arcus Biosciences Inc | Modulators of 5'-nucleotidase, ecto and the use thereof |
| EP3551627B1 (en) | 2016-12-08 | 2022-02-16 | F. Hoffmann-La Roche AG | New isoxazolyl ether derivatives as gaba a alpha5 pam |
-
2017
- 2017-12-07 EP EP17816630.2A patent/EP3551627B1/en active Active
- 2017-12-07 HR HRP20220468TT patent/HRP20220468T1/hr unknown
- 2017-12-07 CN CN202311216893.9A patent/CN117285525A/zh active Pending
- 2017-12-07 UA UAA201907047A patent/UA125524C2/uk unknown
- 2017-12-07 PH PH1/2019/500664A patent/PH12019500664B1/en unknown
- 2017-12-07 LT LTEPPCT/EP2017/081768T patent/LT3551627T/lt unknown
- 2017-12-07 RS RS20220321A patent/RS63106B1/sr unknown
- 2017-12-07 TW TW106142872A patent/TWI642666B/zh active
- 2017-12-07 PL PL17816630T patent/PL3551627T3/pl unknown
- 2017-12-07 HU HUE17816630A patent/HUE058355T2/hu unknown
- 2017-12-07 CA CA3040024A patent/CA3040024A1/en active Pending
- 2017-12-07 AR ARP170103429A patent/AR110498A1/es unknown
- 2017-12-07 WO PCT/EP2017/081768 patent/WO2018104419A1/en not_active Ceased
- 2017-12-07 CR CR20190268A patent/CR20190268A/es unknown
- 2017-12-07 KR KR1020197016011A patent/KR102564643B1/ko active Active
- 2017-12-07 ES ES17816630T patent/ES2910110T3/es active Active
- 2017-12-07 DK DK17816630.2T patent/DK3551627T3/da active
- 2017-12-07 BR BR112019006571A patent/BR112019006571A2/pt active Search and Examination
- 2017-12-07 AU AU2017373734A patent/AU2017373734B2/en active Active
- 2017-12-07 SI SI201731124T patent/SI3551627T1/sl unknown
- 2017-12-07 PE PE2019001006A patent/PE20191156A1/es unknown
- 2017-12-07 MX MX2019006696A patent/MX388725B/es unknown
- 2017-12-07 MY MYPI2019001529A patent/MY200641A/en unknown
- 2017-12-07 CN CN201780069758.2A patent/CN109923113B/zh active Active
- 2017-12-07 PT PT178166302T patent/PT3551627T/pt unknown
- 2017-12-07 JP JP2019530755A patent/JP7084405B2/ja active Active
- 2017-12-07 MA MA48594A patent/MA48594B1/fr unknown
-
2019
- 2019-03-26 CO CONC2019/0002692A patent/CO2019002692A2/es unknown
- 2019-04-09 ZA ZA2019/02225A patent/ZA201902225B/en unknown
- 2019-05-29 CL CL2019001458A patent/CL2019001458A1/es unknown
- 2019-06-03 IL IL267054A patent/IL267054B/en unknown
- 2019-06-05 US US16/432,584 patent/US11091471B2/en active Active
-
2021
- 2021-07-16 US US17/378,410 patent/US20220411415A1/en not_active Abandoned
-
2024
- 2024-02-28 US US18/590,606 patent/US20240279218A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL267054B (en) | New derivatives of isoxazolyl ether as gaba a alpha5 pam | |
| GB201406235D0 (en) | A table arrangement | |
| PL3221372T3 (pl) | Modyfikator reologii | |
| IL279266A (en) | New Isoxazolyl Ether History as GABA A ALPHA5 PAM | |
| GB201408170D0 (en) | A clamp mechanism | |
| GB201513082D0 (en) | A water turbine | |
| SG11201607649XA (en) | A dam | |
| PL3087867T3 (pl) | Część wysuwana elementu szafy | |
| IL253603A0 (en) | Enema for rectal use | |
| HK40096511A (en) | New isoxazolyl ether derivatives as gaba a alpha5 pam | |
| GB201408986D0 (en) | A casing arrangement | |
| HK40005975B (en) | Isoxazolyl ether derivatives as gaba a alpha5 pam | |
| LT3368779T (lt) | Lengvai pradedamas įsukti varžtas | |
| GB201618284D0 (en) | A pipe | |
| GB2525305B (en) | A turbine | |
| GB2522489B (en) | A collapsible airer for clothes | |
| SG11201700014XA (en) | A gasifier | |
| GB201417632D0 (en) | Tap | |
| TWI561320B (en) | Tube expander | |
| ZA201508308B (en) | A push tap | |
| GB2536412B (en) | A casing | |
| GB201400206D0 (en) | A tap | |
| AU5526P (en) | Lompet1 Lomandra longifolia | |
| PH32015000515S1 (en) | A faucet | |
| PH32015000516S1 (en) | A faucet |