DK3565806T3 - Nye phenylderivater - Google Patents
Nye phenylderivater Download PDFInfo
- Publication number
- DK3565806T3 DK3565806T3 DK18709129.3T DK18709129T DK3565806T3 DK 3565806 T3 DK3565806 T3 DK 3565806T3 DK 18709129 T DK18709129 T DK 18709129T DK 3565806 T3 DK3565806 T3 DK 3565806T3
- Authority
- DK
- Denmark
- Prior art keywords
- phenyl derivatives
- new phenyl
- new
- derivatives
- phenyl
- Prior art date
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762443244P | 2017-01-06 | 2017-01-06 | |
| US201762581355P | 2017-11-03 | 2017-11-03 | |
| US201762585326P | 2017-11-13 | 2017-11-13 | |
| PCT/US2018/012491 WO2018129258A1 (en) | 2017-01-06 | 2018-01-05 | Novel phenyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3565806T3 true DK3565806T3 (da) | 2022-05-16 |
Family
ID=61569353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18709129.3T DK3565806T3 (da) | 2017-01-06 | 2018-01-05 | Nye phenylderivater |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US10618875B2 (da) |
| EP (2) | EP4086242A1 (da) |
| JP (3) | JP7090088B2 (da) |
| KR (1) | KR102579648B1 (da) |
| CN (2) | CN110167918B (da) |
| AU (1) | AU2018205811B2 (da) |
| CA (1) | CA3047138C (da) |
| CL (1) | CL2019001842A1 (da) |
| CO (1) | CO2019006865A2 (da) |
| CY (1) | CY1125182T1 (da) |
| DK (1) | DK3565806T3 (da) |
| ES (1) | ES2913431T3 (da) |
| GE (1) | GEP20217227B (da) |
| IL (1) | IL267868B (da) |
| LT (1) | LT3565806T (da) |
| MX (1) | MX388198B (da) |
| MY (1) | MY192778A (da) |
| PE (1) | PE20191243A1 (da) |
| PH (1) | PH12019501318A1 (da) |
| PL (1) | PL3565806T3 (da) |
| PT (1) | PT3565806T (da) |
| SA (1) | SA519402076B1 (da) |
| SI (1) | SI3565806T1 (da) |
| UA (1) | UA124026C2 (da) |
| WO (1) | WO2018129258A1 (da) |
| ZA (1) | ZA201903808B (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| SG11201807543YA (en) | 2016-03-07 | 2018-09-27 | Enanta Pharm Inc | Hepatitis b antiviral agents |
| JP7090088B2 (ja) * | 2017-01-06 | 2022-06-23 | リーヴス ファーマシューティカルズ、インコーポレイテッド | 新規フェニル誘導体 |
| AU2018326474B2 (en) | 2017-08-28 | 2024-07-25 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| CN112955142A (zh) | 2018-09-21 | 2021-06-11 | 英安塔制药有限公司 | 官能化杂环化合物作为抗病毒剂 |
| CN113271946A (zh) | 2018-11-21 | 2021-08-17 | 英安塔制药有限公司 | 官能化杂环化合物作为抗病毒剂 |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
| WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| JP2024521709A (ja) | 2021-05-20 | 2024-06-04 | リーバス ファーマシューティカルズ， インコーポレイテッド | ミトコンドリア関連障害の治療方法 |
| CA3243643A1 (en) | 2022-02-07 | 2023-08-10 | Rivus Pharmaceuticals, Inc. | WEIGHT LOSS METHODS FOR A SUBJECT WITH HIGH HbA1C |
| US20250134864A1 (en) | 2022-02-07 | 2025-05-01 | Rivus Pharmaceuticals, Inc. | Methods of weight loss and preserving skeletal muscle mass |
| EP4622963A1 (en) | 2022-11-21 | 2025-10-01 | Rivus Pharmaceuticals, Inc. | Crystalline forms of 5-[(2,4-dinitrophenoxy)methyl]-1-methyl-2-nitro-1h-imidazole |
| WO2024112663A1 (en) | 2022-11-21 | 2024-05-30 | Rivus Pharmaceuticals, Inc. | Deuterium enriched phenyl derivatives for treating mitochondriarelated disorders or conditions |
| CN121001992A (zh) * | 2023-05-30 | 2025-11-21 | 北京双鹤润创科技有限公司 | 咪唑基与二硝基苯基结合的衍生物及其用途 |
| CN121013841A (zh) * | 2023-06-07 | 2025-11-25 | 北京双鹤润创科技有限公司 | 咪唑基与二硝基苯基衍生物及其用途 |
| TW202515545A (zh) * | 2023-08-10 | 2025-04-16 | 大陸商深圳君聖泰生物技術有限公司 | ２，４－二硝苯酚之衍生物以及前藥、以及其組成物以及方法 |
| WO2025077675A2 (en) * | 2023-10-12 | 2025-04-17 | Shenzhen Hightide Biopharmaceutical Ltd. | Prodrugs and conjugates of 2, 4-dinitrophenol, and compositions and methods thereof |
| WO2025107532A1 (en) * | 2023-11-20 | 2025-05-30 | Beijing Double-Crane Runchuang Technology Co., Ltd. | Imidazolyl binds with dinitrophenyl derivatives and use thereof |
| CN118206492A (zh) * | 2024-03-26 | 2024-06-18 | 江南大学 | 一类2，4-二硝基苯氧基类化合物及其制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3828056A (en) * | 1972-09-11 | 1974-08-06 | Searle & Co | (2-(2-methyl-5-nitro-1-imidazolyl)ethyl)heteroaryloxy ethers |
| EG11928A (en) * | 1974-12-16 | 1979-03-31 | Hoechst Ag | Process for preparing of 1-alkyl-2-(phenoxy-methyl)-5-nitro-imidazoles |
| US5359078A (en) * | 1989-05-19 | 1994-10-25 | The United States Of America As Represented By The Department Of Health And Human Services | Signal transduction inhibitor compounds |
| EP1575575B1 (en) | 2002-11-08 | 2010-05-19 | High Point Pharmaceuticals, LLC | Safe chemical uncouplers for the treatment of obesity |
| EP1625112B1 (en) | 2003-05-14 | 2009-07-22 | High Point Pharmaceuticals, LLC | Novel compounds for treatment of obesity |
| WO2004106307A2 (fr) * | 2003-05-27 | 2004-12-09 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Nouveaux derives d’imidazoles, leur preparation et leur utilisation en tant que medicament |
| JP2007512262A (ja) | 2003-11-25 | 2007-05-17 | ノボ ノルディスク アクティーゼルスカブ | 肥満症の治療のための新規な化合物 |
| EP1689700A1 (en) | 2003-11-25 | 2006-08-16 | Novo Nordisk A/S | Novel salicylic anilides |
| US20070010559A1 (en) | 2003-11-25 | 2007-01-11 | Novo Nordisk A/S | Indole derivatives for use as chemical uncoupler |
| ES2389532T3 (es) | 2005-06-29 | 2012-10-29 | Threshold Pharmaceuticals, Inc. | Profármacos alquilantes de fosforamidato |
| CA2669884A1 (en) | 2006-11-15 | 2008-05-22 | High Point Pharmaceuticals, Llc | Novel 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes |
| CA2669867A1 (en) | 2006-11-15 | 2008-05-22 | High Point Pharmaceuticals, Llc | 2- ( 2 -hydroxyphenyl) -quinazolin-4-ones useful for treating obesity and diabetes |
| EP2097380A1 (en) | 2006-11-15 | 2009-09-09 | High Point Pharmaceuticals, LLC | New haloalkylsulfone substituted compounds useful for treating obesity and diabetes |
| EP2086951B1 (en) | 2006-11-15 | 2011-12-21 | High Point Pharmaceuticals, LLC | Novel 2-(2-hydroxyphenyl) benzothiadiazines useful for treating obesity and diabetes |
| US8946275B2 (en) | 2008-10-21 | 2015-02-03 | Threshold Pharmaceuticals, Inc. | Treatment of cancer using hypoxia activated prodrugs |
| EP2179984A1 (en) * | 2008-10-27 | 2010-04-28 | Congenia S.r.l. | Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition |
| CN101560189B (zh) * | 2009-05-20 | 2011-02-16 | 南京大学 | 甲硝唑和取代水杨酸的复合物及其制法与用途 |
| EP2586776A4 (en) | 2010-06-24 | 2014-02-19 | Ltd Liability Company Mitotech | SOFT CATIONIC MITOCHONDRIENENT COUPLER |
| WO2013192388A1 (en) | 2012-06-20 | 2013-12-27 | University Of Virginia Patent Foundation | Compositions and methods for regulating glucose homeostasis and insulin action |
| JP6706204B2 (ja) | 2013-08-30 | 2020-06-03 | イエール ユニバーシティ | 新規２，４−ジニトロフェノール製剤およびその使用法 |
| US10457629B2 (en) | 2013-08-30 | 2019-10-29 | Yale University | Therapeutic DNP derivatives and methods using same |
| ES2965033T3 (es) | 2014-07-03 | 2024-04-10 | Silti Ag | Métodos y composiciones para tratar la obesidad, prevenir el aumento de peso, promover la pérdida de peso, promover el adelgazamiento o tratar o prevenir el desarrollo de diabetes |
| US20160008298A1 (en) * | 2014-07-14 | 2016-01-14 | Oregon State University | Xanthohumol-based compounds and compositions thereof, and methods of making and using the same |
| CN116617195A (zh) | 2015-01-22 | 2023-08-22 | 米托充制药公司 | 脑源性神经营养因子的诱导表达 |
| KR102436172B1 (ko) | 2016-03-07 | 2022-08-24 | 미토콘 파마슈티칼스, 인크. | 신경근 질환, 신경 퇴행성 질환, 자가면역 질환, 발달 질환, 진탕, 안구 건조증, 및/또는 대사 질환의 dnp 및 dnp 프로드럭 치료 |
| JP7090088B2 (ja) * | 2017-01-06 | 2022-06-23 | リーヴス ファーマシューティカルズ、インコーポレイテッド | 新規フェニル誘導体 |
| JP2020520949A (ja) | 2017-05-22 | 2020-07-16 | ユニバーシティ オブ ヴァージニア パテント ファウンデーションＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｖｅｒｇｉｎｉａ Ｐａｔｅｎｔ Ｆｏｕｎｄａｔｉｏｎ | 組成物、並びにミトコンドリア脱共役剤を調製及び使用する方法 |
-
2018
- 2018-01-05 JP JP2019537086A patent/JP7090088B2/ja active Active
- 2018-01-05 US US16/475,390 patent/US10618875B2/en active Active
- 2018-01-05 ES ES18709129T patent/ES2913431T3/es active Active
- 2018-01-05 KR KR1020197018983A patent/KR102579648B1/ko active Active
- 2018-01-05 CN CN201880005988.7A patent/CN110167918B/zh active Active
- 2018-01-05 SI SI201830676T patent/SI3565806T1/sl unknown
- 2018-01-05 WO PCT/US2018/012491 patent/WO2018129258A1/en not_active Ceased
- 2018-01-05 CN CN202310980210.0A patent/CN117024351A/zh active Pending
- 2018-01-05 CA CA3047138A patent/CA3047138C/en active Active
- 2018-01-05 MX MX2019007745A patent/MX388198B/es unknown
- 2018-01-05 PE PE2019001339A patent/PE20191243A1/es unknown
- 2018-01-05 UA UAA201906673A patent/UA124026C2/uk unknown
- 2018-01-05 EP EP22157494.0A patent/EP4086242A1/en active Pending
- 2018-01-05 EP EP18709129.3A patent/EP3565806B1/en active Active
- 2018-01-05 PT PT187091293T patent/PT3565806T/pt unknown
- 2018-01-05 DK DK18709129.3T patent/DK3565806T3/da active
- 2018-01-05 MY MYPI2019003195A patent/MY192778A/en unknown
- 2018-01-05 AU AU2018205811A patent/AU2018205811B2/en active Active
- 2018-01-05 GE GEAP201815132A patent/GEP20217227B/en unknown
- 2018-01-05 LT LTEPPCT/US2018/012491T patent/LT3565806T/lt unknown
- 2018-01-05 PL PL18709129T patent/PL3565806T3/pl unknown
-
2019
- 2019-06-11 PH PH12019501318A patent/PH12019501318A1/en unknown
- 2019-06-12 ZA ZA2019/03808A patent/ZA201903808B/en unknown
- 2019-06-27 CO CONC2019/0006865A patent/CO2019006865A2/es unknown
- 2019-07-03 CL CL2019001842A patent/CL2019001842A1/es unknown
- 2019-07-04 IL IL267868A patent/IL267868B/en unknown
- 2019-07-07 SA SA519402076A patent/SA519402076B1/ar unknown
-
2020
- 2020-09-02 US US17/010,547 patent/US20200399225A1/en not_active Abandoned
-
2021
- 2021-04-15 US US17/231,168 patent/US20210238144A1/en not_active Abandoned
- 2021-10-28 US US17/513,235 patent/US20220048865A1/en not_active Abandoned
-
2022
- 2022-05-18 CY CY20221100338T patent/CY1125182T1/el unknown
- 2022-06-13 JP JP2022095049A patent/JP2022120118A/ja active Pending
-
2024
- 2024-06-12 JP JP2024095420A patent/JP2024116328A/ja active Pending
-
2025
- 2025-03-19 US US19/084,367 patent/US20250214944A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3565806T3 (da) | Nye phenylderivater | |
| IL269196A (en) | Novel inhibitors | |
| DK3883936T3 (da) | Nye heterocykliske forbindelser | |
| DK3615527T3 (da) | Nye azaquinolin-derivater | |
| DK3319956T3 (da) | Substituerede oxopyridinderivater | |
| EP3496717A4 (en) | 4-substituted aminoisoquinoline derivatives | |
| DK3436444T3 (da) | Heterocyklisk forbindelse | |
| DK3356358T3 (da) | Mikrobiocide oxadiazolderivater | |
| DK3498693T3 (da) | Heterocyklisk forbindelse | |
| DK3642202T3 (da) | Dihydro-pyrrolo-pyridin-derivater | |
| HUE058009T2 (hu) | 1,3-Tiazol-2-il szubsztituált benzamid-származékok | |
| LT3830085T (lt) | Deuterinti lanifibranoro dariniai | |
| DK3468975T3 (da) | Nye antibakterielle forbindelser | |
| LT3402792T (lt) | Chinolin-2-ono dariniai | |
| DK3768669T3 (da) | Piperazinazaspiroderivater | |
| LT3457851T (lt) | Sobetiromo dariniai | |
| DK3387930T3 (da) | Stofanordning | |
| EP3541200C0 (en) | POWDERED FORMULATIONS | |
| LT3371168T (lt) | Indolin-2-ono dariniai | |
| BR112017014839A2 (pt) | novos microbicidas | |
| DK3298022T3 (da) | Nye annelerede phenoxyacetamider | |
| DK3867247T3 (da) | Nye forbindelser | |
| SMT202200213T1 (it) | Nuovi antiestrogeni eterociclici | |
| DK3097084T3 (da) | Nye kallikrein 7-hæmmere | |
| EP3444345C0 (en) | MICRO-143 RNA DERIVATIVE |