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DK3339323T3 - Anti-n3pglu-amyloid-beta-peptid-antistoffer og anvendelser deraf - Google Patents

Anti-n3pglu-amyloid-beta-peptid-antistoffer og anvendelser deraf Download PDF

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Publication number
DK3339323T3
DK3339323T3 DK18150424.2T DK18150424T DK3339323T3 DK 3339323 T3 DK3339323 T3 DK 3339323T3 DK 18150424 T DK18150424 T DK 18150424T DK 3339323 T3 DK3339323 T3 DK 3339323T3
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DK
Denmark
Prior art keywords
n3pglu
amyloid
beta
applications
peptide antibodies
Prior art date
Application number
DK18150424.2T
Other languages
English (en)
Inventor
Ronald Bradley Demattos
Jirong Lu
Ying Tang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
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Publication of DK3339323T3 publication Critical patent/DK3339323T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK18150424.2T 2010-08-12 2011-08-09 Anti-n3pglu-amyloid-beta-peptid-antistoffer og anvendelser deraf DK3339323T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37302610P 2010-08-12 2010-08-12
EP15196358.4A EP3042917B1 (en) 2010-08-12 2011-08-09 Anti-n3pglu amyloid beta peptide antibodies and uses thereof

Publications (1)

Publication Number Publication Date
DK3339323T3 true DK3339323T3 (da) 2020-01-20

Family

ID=44543826

Family Applications (3)

Application Number Title Priority Date Filing Date
DK18150424.2T DK3339323T3 (da) 2010-08-12 2011-08-09 Anti-n3pglu-amyloid-beta-peptid-antistoffer og anvendelser deraf
DK15196358.4T DK3042917T3 (da) 2010-08-12 2011-08-09 Anti-n3pglu-amyloid-beta-peptid-antistoffer og anvendelser deraf
DK11745672.3T DK2603523T3 (da) 2010-08-12 2011-08-09 ANTI-N3pGlu-AMYLOIDBETAPEPTIDANTISTOFFER OG ANVENDELSER DERAF

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK15196358.4T DK3042917T3 (da) 2010-08-12 2011-08-09 Anti-n3pglu-amyloid-beta-peptid-antistoffer og anvendelser deraf
DK11745672.3T DK2603523T3 (da) 2010-08-12 2011-08-09 ANTI-N3pGlu-AMYLOIDBETAPEPTIDANTISTOFFER OG ANVENDELSER DERAF

Country Status (38)

Country Link
US (2) US8679498B2 (da)
EP (3) EP3042917B1 (da)
JP (2) JP5980207B2 (da)
KR (1) KR101498833B1 (da)
CN (2) CN105111308B (da)
AU (1) AU2011289629B2 (da)
BR (1) BR112013004056B8 (da)
CA (1) CA2805114C (da)
CL (1) CL2013000390A1 (da)
CO (1) CO6670526A2 (da)
CR (1) CR20130016A (da)
CY (2) CY1120144T1 (da)
DK (3) DK3339323T3 (da)
DO (1) DOP2013000029A (da)
EA (1) EA023021B1 (da)
EC (1) ECSP13012436A (da)
ES (3) ES2764728T3 (da)
GT (1) GT201300036A (da)
HR (3) HRP20160151T1 (da)
HU (2) HUE028678T2 (da)
IL (2) IL224030B (da)
LT (2) LT3339323T (da)
MA (1) MA34461B1 (da)
ME (3) ME02352B (da)
MX (2) MX342782B (da)
MY (2) MY181969A (da)
NO (1) NO3042917T3 (da)
NZ (2) NZ626665A (da)
PE (1) PE20130817A1 (da)
PH (1) PH12013500277A1 (da)
PL (3) PL3339323T3 (da)
PT (2) PT3042917T (da)
RS (3) RS54685B1 (da)
SG (2) SG187586A1 (da)
SI (3) SI2603523T1 (da)
UA (1) UA107600C2 (da)
WO (1) WO2012021469A1 (da)
ZA (1) ZA201300437B (da)

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Also Published As

Publication number Publication date
ME03661B (me) 2020-07-20
PL3042917T3 (pl) 2018-07-31
MX2013001716A (es) 2013-10-28
MX355268B (es) 2018-04-11
PH12013500277A1 (en) 2017-04-21
IL224030B (en) 2022-04-01
SG10201509330XA (en) 2015-12-30
EP3339323A1 (en) 2018-06-27
ZA201300437B (en) 2014-06-25
CN105111308B (zh) 2019-03-12
IL285226B2 (en) 2023-02-01
EP3339323B1 (en) 2019-11-13
HRP20160151T1 (hr) 2016-03-11
ECSP13012436A (es) 2013-03-28
CR20130016A (es) 2013-03-21
EP2603523A1 (en) 2013-06-19
HUE028678T2 (en) 2016-12-28
CY1120144T1 (el) 2018-12-12
US8679498B2 (en) 2014-03-25
ME03032B (me) 2018-10-20
GT201300036A (es) 2014-07-16
CA2805114C (en) 2017-12-05
MA34461B1 (fr) 2013-08-01
HRP20192233T1 (hr) 2020-03-06
HK1180703A1 (zh) 2013-10-25
EA023021B1 (ru) 2016-04-29
EA201270813A1 (ru) 2013-05-30
RS57026B1 (sr) 2018-05-31
HRP20180616T1 (hr) 2018-07-13
PL2603523T3 (pl) 2016-07-29
JP2016179985A (ja) 2016-10-13
CO6670526A2 (es) 2013-05-15
RS59652B1 (sr) 2020-01-31
KR101498833B1 (ko) 2015-03-04
SG187586A1 (en) 2013-03-28
LT3042917T (lt) 2018-05-10
US8961972B2 (en) 2015-02-24
CA2805114A1 (en) 2012-02-16
CY1122458T1 (el) 2021-01-27
BR112013004056B1 (pt) 2022-05-17
BR112013004056A2 (pt) 2020-08-04
AU2011289629A1 (en) 2013-02-14
KR20130051989A (ko) 2013-05-21
NZ626665A (en) 2016-04-29
CN103068848A (zh) 2013-04-24
EP3042917B1 (en) 2018-02-21
MY163521A (en) 2017-09-15
JP2013536191A (ja) 2013-09-19
IL285226B (en) 2022-10-01
CN103068848B (zh) 2015-11-25
NO3042917T3 (da) 2018-07-21
CN105111308A (zh) 2015-12-02
PL3339323T3 (pl) 2020-05-18
BR112013004056B8 (pt) 2022-10-18
UA107600C2 (uk) 2015-01-26
HUE037524T2 (hu) 2018-09-28
US20130142806A1 (en) 2013-06-06
SI3339323T1 (sl) 2019-12-31
JP5980207B2 (ja) 2016-08-31
IL285226A (en) 2021-09-30
AU2011289629B2 (en) 2014-07-03
WO2012021469A1 (en) 2012-02-16
PT3339323T (pt) 2020-01-14
SI3042917T1 (en) 2018-04-30
RS54685B1 (sr) 2016-08-31
DK3042917T3 (da) 2018-04-23
MX342782B (es) 2016-10-12
LT3339323T (lt) 2020-02-10
MY181969A (en) 2021-01-15
EP3042917A1 (en) 2016-07-13
NZ606095A (en) 2014-11-28
ME02352B (me) 2016-06-20
ES2764728T3 (es) 2020-06-04
SI2603523T1 (sl) 2016-04-29
US20140065138A1 (en) 2014-03-06
DOP2013000029A (es) 2013-03-15
ES2564252T3 (es) 2016-03-21
PE20130817A1 (es) 2013-07-18
DK2603523T3 (da) 2016-03-21
EP2603523B1 (en) 2016-01-27
PT3042917T (pt) 2018-05-02
JP6395755B2 (ja) 2018-09-26
CL2013000390A1 (es) 2014-03-21
ES2664128T3 (es) 2018-04-18

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