CL2013000390A1 - Anticuerpo monoclonal que se une al peptido beta amiloide n3pglu o fragmento de union a antigeno del mismo; composicion farmaceutica que lo comprende; y su uso para tratar la enfermedad de alzheimer. - Google Patents

Anticuerpo monoclonal que se une al peptido beta amiloide n3pglu o fragmento de union a antigeno del mismo; composicion farmaceutica que lo comprende; y su uso para tratar la enfermedad de alzheimer.

Info

Publication number: CL2013000390A1
Authority: CL; Chile
Prior art keywords: n3pglu; binds; disease; pharmaceutical composition; monoclonal antibody
Prior art date: 2010-08-12

Application number

CL2013000390A

Other languages

English (en)

Inventor

Jirong Lu

Ying Tang

Ronald Bradley Demattos

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-08-12

Filing date

2013-02-08

Publication date

2014-03-21

2013-02-08 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2014-03-21 Publication of CL2013000390A1 publication Critical patent/CL2013000390A1/es

Links

208000024827 Alzheimer disease Diseases 0.000 title 1
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
239000000427 antigen Substances 0.000 title 1
102000036639 antigens Human genes 0.000 title 1
108091007433 antigens Proteins 0.000 title 1
239000012634 fragment Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

CL2013000390A 2010-08-12 2013-02-08 Anticuerpo monoclonal que se une al peptido beta amiloide n3pglu o fragmento de union a antigeno del mismo; composicion farmaceutica que lo comprende; y su uso para tratar la enfermedad de alzheimer. CL2013000390A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37302610P	2010-08-12	2010-08-12

Publications (1)

Publication Number	Publication Date
CL2013000390A1 true CL2013000390A1 (es)	2014-03-21

Family

ID=44543826

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2013000390A CL2013000390A1 (es)	2010-08-12	2013-02-08	Anticuerpo monoclonal que se une al peptido beta amiloide n3pglu o fragmento de union a antigeno del mismo; composicion farmaceutica que lo comprende; y su uso para tratar la enfermedad de alzheimer.

Country Status (38)

Country	Link
US (2)	US8679498B2 (es)
EP (3)	EP2603523B1 (es)
JP (2)	JP5980207B2 (es)
KR (1)	KR101498833B1 (es)
CN (2)	CN105111308B (es)
AU (1)	AU2011289629B2 (es)
BR (1)	BR112013004056B8 (es)
CA (1)	CA2805114C (es)
CL (1)	CL2013000390A1 (es)
CO (1)	CO6670526A2 (es)
CR (1)	CR20130016A (es)
CY (2)	CY1120144T1 (es)
DK (3)	DK2603523T3 (es)
DO (1)	DOP2013000029A (es)
EA (1)	EA023021B1 (es)
EC (1)	ECSP13012436A (es)
ES (3)	ES2764728T3 (es)
GT (1)	GT201300036A (es)
HR (3)	HRP20160151T1 (es)
HU (2)	HUE037524T2 (es)
IL (2)	IL224030B (es)
LT (2)	LT3042917T (es)
MA (1)	MA34461B1 (es)
ME (3)	ME02352B (es)
MX (2)	MX342782B (es)
MY (2)	MY163521A (es)
NO (1)	NO3042917T3 (es)
NZ (2)	NZ626665A (es)
PE (1)	PE20130817A1 (es)
PH (1)	PH12013500277A1 (es)
PL (3)	PL2603523T3 (es)
PT (2)	PT3042917T (es)
RS (3)	RS54685B1 (es)
SG (2)	SG187586A1 (es)
SI (3)	SI3339323T1 (es)
UA (1)	UA107600C2 (es)
WO (1)	WO2012021469A1 (es)
ZA (1)	ZA201300437B (es)

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2011
- 2011-08-09 LT LTEP15196358.4T patent/LT3042917T/lt unknown
- 2011-08-09 KR KR1020137003412A patent/KR101498833B1/ko active Active
- 2011-08-09 PT PT151963584T patent/PT3042917T/pt unknown
- 2011-08-09 AU AU2011289629A patent/AU2011289629B2/en active Active
- 2011-08-09 BR BR112013004056A patent/BR112013004056B8/pt active IP Right Grant
- 2011-08-09 PT PT181504242T patent/PT3339323T/pt unknown
- 2011-08-09 ME MEP-2016-28A patent/ME02352B/me unknown
- 2011-08-09 NO NO15196358A patent/NO3042917T3/no unknown
- 2011-08-09 SI SI201131817T patent/SI3339323T1/sl unknown
- 2011-08-09 NZ NZ626665A patent/NZ626665A/en unknown
- 2011-08-09 RS RS20160129A patent/RS54685B1/sr unknown
- 2011-08-09 ME MEP-2018-79A patent/ME03032B/me unknown
- 2011-08-09 DK DK11745672.3T patent/DK2603523T3/en active
- 2011-08-09 EP EP11745672.3A patent/EP2603523B1/en active Active
- 2011-08-09 ME MEP-2019-356A patent/ME03661B/me unknown
- 2011-08-09 US US13/810,895 patent/US8679498B2/en active Active
- 2011-08-09 CN CN201510613319.6A patent/CN105111308B/zh active Active
- 2011-08-09 DK DK18150424.2T patent/DK3339323T3/da active
- 2011-08-09 PL PL11745672T patent/PL2603523T3/pl unknown
- 2011-08-09 HR HRP20160151TT patent/HRP20160151T1/hr unknown
- 2011-08-09 HU HUE15196358A patent/HUE037524T2/hu unknown
- 2011-08-09 PH PH1/2013/500277A patent/PH12013500277A1/en unknown
- 2011-08-09 ES ES18150424T patent/ES2764728T3/es active Active
- 2011-08-09 PL PL18150424T patent/PL3339323T3/pl unknown
- 2011-08-09 PL PL15196358T patent/PL3042917T3/pl unknown
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Also Published As

Publication number	Publication date
LT3042917T (lt)	2018-05-10
CN103068848B (zh)	2015-11-25
EP3339323A1 (en)	2018-06-27
IL285226B2 (en)	2023-02-01
MX355268B (es)	2018-04-11
PT3042917T (pt)	2018-05-02
NZ606095A (en)	2014-11-28
ECSP13012436A (es)	2013-03-28
HRP20160151T1 (hr)	2016-03-11
CN105111308A (zh)	2015-12-02
CN103068848A (zh)	2013-04-24
ME03661B (me)	2020-07-20
WO2012021469A1 (en)	2012-02-16
HK1180703A1 (zh)	2013-10-25
JP2013536191A (ja)	2013-09-19
ES2564252T3 (es)	2016-03-21
RS57026B1 (sr)	2018-05-31
BR112013004056B1 (pt)	2022-05-17
SG10201509330XA (en)	2015-12-30
PL3042917T3 (pl)	2018-07-31
PL2603523T3 (pl)	2016-07-29
AU2011289629B2 (en)	2014-07-03
MX2013001716A (es)	2013-10-28
PT3339323T (pt)	2020-01-14
BR112013004056A2 (pt)	2020-08-04
MA34461B1 (fr)	2013-08-01
ZA201300437B (en)	2014-06-25
EP3042917B1 (en)	2018-02-21
KR101498833B1 (ko)	2015-03-04
SG187586A1 (en)	2013-03-28
IL285226A (en)	2021-09-30
EP3339323B1 (en)	2019-11-13
EA201270813A1 (ru)	2013-05-30
ES2664128T3 (es)	2018-04-18
LT3339323T (lt)	2020-02-10
RS54685B1 (sr)	2016-08-31
SI3339323T1 (sl)	2019-12-31
US8679498B2 (en)	2014-03-25
CY1122458T1 (el)	2021-01-27
US20140065138A1 (en)	2014-03-06
DK2603523T3 (en)	2016-03-21
CR20130016A (es)	2013-03-21
EP2603523A1 (en)	2013-06-19
HRP20180616T1 (hr)	2018-07-13
PH12013500277A1 (en)	2017-04-21
CA2805114C (en)	2017-12-05
IL224030B (en)	2022-04-01
ME03032B (me)	2018-10-20
CY1120144T1 (el)	2018-12-12
UA107600C2 (uk)	2015-01-26
SI2603523T1 (sl)	2016-04-29
MX342782B (es)	2016-10-12
MY163521A (en)	2017-09-15
US20130142806A1 (en)	2013-06-06
MY181969A (en)	2021-01-15
BR112013004056B8 (pt)	2022-10-18
US8961972B2 (en)	2015-02-24
CN105111308B (zh)	2019-03-12
NO3042917T3 (es)	2018-07-21
CO6670526A2 (es)	2013-05-15
JP5980207B2 (ja)	2016-08-31
SI3042917T1 (en)	2018-04-30
PE20130817A1 (es)	2013-07-18
EP3042917A1 (en)	2016-07-13
GT201300036A (es)	2014-07-16
EP2603523B1 (en)	2016-01-27
ME02352B (me)	2016-06-20
JP6395755B2 (ja)	2018-09-26
CA2805114A1 (en)	2012-02-16
EA023021B1 (ru)	2016-04-29
DOP2013000029A (es)	2013-03-15
NZ626665A (en)	2016-04-29
DK3339323T3 (da)	2020-01-20
KR20130051989A (ko)	2013-05-21
JP2016179985A (ja)	2016-10-13
AU2011289629A1 (en)	2013-02-14
HUE028678T2 (en)	2016-12-28
PL3339323T3 (pl)	2020-05-18
DK3042917T3 (en)	2018-04-23
HUE037524T2 (hu)	2018-09-28
ES2764728T3 (es)	2020-06-04
HRP20192233T1 (hr)	2020-03-06
IL285226B (en)	2022-10-01
RS59652B1 (sr)	2020-01-31

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CL2013000390A1 (es)	2014-03-21	Anticuerpo monoclonal que se une al peptido beta amiloide n3pglu o fragmento de union a antigeno del mismo; composicion farmaceutica que lo comprende; y su uso para tratar la enfermedad de alzheimer.
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CL2013000843A1 (es)	2014-03-07	Anticuerpo aislado o fragmento de union a antigeno del mismo que se une especificamente a cd48 humano y bloquea la interaccion entre cd48 humano y un receptor de cd48; composicion farmaceutica que lo comprende; y su uso.
CY1122987T1 (el)	2021-10-29	Αντισωματα εναντι αμυλοειδους βητα
CL2014002750A1 (es)	2015-04-06	Anticuerpo aislado o fragmento que se enlaza a un estado inactiva de un receptor her; composición farmacéutica que lo comprende; uso del anticuerpo para tratar cancer
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MX374708B (es)	2025-03-06	Uso de moleculas de union a semaforina-4d para el tratamiento de trastornos neurodegenarativos.
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CO6602134A2 (es)	2013-01-18	Proteinas de union a antigeno especificas para componente amiloide serico p
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BR112015012708A2 (pt)	2017-09-12	anticorpos para bmp-6
BRPI1013649A2 (pt)	2019-09-24	anticorpo monoclonal humano que se liga especificamente a vcam-1 e composição para o tratamento de uma doença inflamatória ou câncer compreende o mesmo
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