[go: up one dir, main page]

DK3307878T3 - Fremgangsmåder til fremstilling og oprensning af nukleinsyreholdige sammensætninger - Google Patents

Fremgangsmåder til fremstilling og oprensning af nukleinsyreholdige sammensætninger Download PDF

Info

Publication number
DK3307878T3
DK3307878T3 DK16732426.8T DK16732426T DK3307878T3 DK 3307878 T3 DK3307878 T3 DK 3307878T3 DK 16732426 T DK16732426 T DK 16732426T DK 3307878 T3 DK3307878 T3 DK 3307878T3
Authority
DK
Denmark
Prior art keywords
purification
preparation
methods
nucleic acid
containing compositions
Prior art date
Application number
DK16732426.8T
Other languages
English (en)
Inventor
Trevor Lane Broadt
Samir Hussein Shaban
Yueqing Xie
Jianwei Sean Zhu
George Mitra
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of DK3307878T3 publication Critical patent/DK3307878T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32651—Methods of production or purification of viral material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK16732426.8T 2015-06-10 2016-06-10 Fremgangsmåder til fremstilling og oprensning af nukleinsyreholdige sammensætninger DK3307878T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562173777P 2015-06-10 2015-06-10
PCT/US2016/036888 WO2016201224A1 (en) 2015-06-10 2016-06-10 Processes for production and purification of nucleic acid-containing compositions

Publications (1)

Publication Number Publication Date
DK3307878T3 true DK3307878T3 (da) 2021-10-11

Family

ID=56236111

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16732426.8T DK3307878T3 (da) 2015-06-10 2016-06-10 Fremgangsmåder til fremstilling og oprensning af nukleinsyreholdige sammensætninger

Country Status (7)

Country Link
US (1) US10954492B2 (da)
EP (1) EP3307878B1 (da)
JP (1) JP6886410B2 (da)
CN (1) CN108291210B (da)
DK (1) DK3307878T3 (da)
ES (1) ES2895148T3 (da)
WO (1) WO2016201224A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017023782A1 (en) 2015-07-31 2017-02-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of analyzing virus-derived therapeutics
JP2019519589A (ja) * 2016-06-29 2019-07-11 デューク ユニバーシティー キメラポリオウイルスで抗原提示細胞を活性化するための組成物及び方法
CN107043767A (zh) * 2017-05-05 2017-08-15 谭淼 一种基于纳米多向层析固相载体提取核酸的方法
CN112143693B (zh) 2019-06-28 2024-12-27 杭州康万达医药科技有限公司 一种生产病毒的方法及收获液组合物
WO2021091964A1 (en) 2019-11-04 2021-05-14 Duke University Treatment for primary and metastatic cancer
CN112480216A (zh) * 2020-12-21 2021-03-12 金宇保灵生物药品有限公司 一种塞尼卡谷病毒抗原的纯化方法
CN114134212A (zh) * 2021-12-16 2022-03-04 青岛汉唐生物科技有限公司 用于质粒定量的引物探针组合和试剂盒
CN115505578A (zh) * 2022-09-20 2022-12-23 苏州博腾生物制药有限公司 可放大的用于纯化重组病毒的方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719177A (en) 1981-04-20 1988-01-12 Massachusetts Institute Of Technology Production of complementary DNA representing RNA viral sequences by recombinant DNA methods and uses therefor
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
IL99232A0 (en) 1990-08-20 1992-07-15 Univ Columbia Methods for producing rna viruses from cdna
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
EP0772619B2 (en) 1994-07-15 2010-12-08 The University of Iowa Research Foundation Immunomodulatory oligonucleotides
AU738513B2 (en) 1997-02-28 2001-09-20 University Of Iowa Research Foundation, The Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
DE69838294T2 (de) 1997-05-20 2009-08-13 Ottawa Health Research Institute, Ottawa Verfahren zur Herstellung von Nukleinsäurekonstrukten
ES2284247T3 (es) 1998-04-03 2007-11-01 University Of Iowa Research Foundation Metodos y productos para estimular el sistema inmunitario usando oligonucleotidos y citoquinas inmunoterapeuticos.
US6518033B1 (en) 1998-08-05 2003-02-11 The Research Foundation Of State University Of New York Method of detecting the presence of CD155 for diagnosis of cancer and to determine treatment
US6264940B1 (en) 1998-08-05 2001-07-24 The Research Foundation Of State University Of New York Recombinant poliovirus for the treatment of cancer
US20040213805A1 (en) 1999-10-12 2004-10-28 Verheije Monique Helene Deletions in arterivirus replicons
WO2003046138A2 (en) 2001-11-26 2003-06-05 Duke University Genetically stable expression vector
PT1625210E (pt) 2003-05-21 2011-03-15 Genzyme Corp Métodos para produzir preparações de vírions de aav recombinantes substancialmente livres de capsídeos vazios
AU2004249199B2 (en) * 2003-06-18 2008-07-24 Onyx Pharmaceuticals, Inc. Method for purifying virus
ES2329607T3 (es) * 2004-02-23 2009-11-27 Crucell Holland B.V. Metodos de purificacion de virus.
CN1297313C (zh) 2004-09-16 2007-01-31 中国医学科学院医学生物学研究所 减毒株脊髓灰质炎灭活疫苗后处理方法
US7901921B2 (en) * 2004-10-22 2011-03-08 Oncolytics Biotech Inc. Viral purification methods
ES2579758T3 (es) * 2005-01-28 2016-08-16 Zymogenetics, Inc. Preparaciones homogéneas de IL-31
JP2011511640A (ja) * 2008-02-12 2011-04-14 サノフィ パストゥール リミテッド ポックス・ウイルスの精製方法
US8066983B2 (en) 2008-03-14 2011-11-29 The Research Foundation Of State University Of New York Attenuated poliovirus
ES2688653T3 (es) 2012-11-21 2018-11-06 Duke University Poliovirus oncolítico para tumores humanos
BR112017001177B1 (pt) 2014-07-24 2022-05-24 Janssen Vaccines & Prevention B.V Método de purificação e de potenciação da liberação de poliovírus a partir de uma colheita de cultura celular bruta contendo poliovírus e uso de um detergente catiônico
WO2017023782A1 (en) 2015-07-31 2017-02-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of analyzing virus-derived therapeutics

Also Published As

Publication number Publication date
JP6886410B2 (ja) 2021-06-16
WO2016201224A1 (en) 2016-12-15
US20180163182A1 (en) 2018-06-14
CN108291210B (zh) 2022-03-11
EP3307878B1 (en) 2021-08-04
ES2895148T3 (es) 2022-02-17
US10954492B2 (en) 2021-03-23
CN108291210A (zh) 2018-07-17
JP2018527885A (ja) 2018-09-27
EP3307878A1 (en) 2018-04-18

Similar Documents

Publication Publication Date Title
DK3386534T3 (da) Sammensætninger og fremgangsmåder til internalisering af enzymer
DK3102673T3 (da) Fremgangsmåder og sammensætninger til behandling af beta-talassæmi
DK3882357T3 (da) Fremgangsmåder og sammensætninger til analyse af nukleinsyrer
DK3307872T3 (da) Fremgangsmåder og sammensætninger til effektiv indgivelse af nukleinsyrer og rna-baserede antimikrober
DK3144001T3 (da) Sammensætninger af selenoorganiske forbindelser og fremgangsmåder til anvendelse deraf
DK3303317T3 (da) Fremgangsmåder og sammensætninger til inhibering af interaktionen af menin med MLL-proteiner
DK3325669T3 (da) Sammensætninger og fremgangsmåder til RNA-analyse
DK3495023T3 (da) Semifluorerede forbindelser og sammensætninger deraf
DK3317284T3 (da) Benzoxazepin-oxazolidinonforbindelser og fremgangsmåder til anvendelse
KR20180084891A (ko) 구조 조성물 및 방법
DK3207130T3 (da) Sammensætninger af Adenosin Deaminase-2 (ADA2), varianter deraf og fremgangsmåder til anvendelse af samme
DK3393655T3 (da) Fenfluramin-sammensætninger og fremgangsmåder til fremstilling af samme
DK2924093T3 (da) Multicarboxylat-sammensætninger og fremgangsmåde til fremstilling af disse
DK3350201T3 (da) Manipulerede fytaser og fremgangsmåder til anvendelse af samme
DK3102555T3 (da) Sammensætninger af forbindelser og anvendelser deraf
DK3307296T3 (da) Timp2 til anvendelse til behandling af aldringsassocierede tilstande
DK3307878T3 (da) Fremgangsmåder til fremstilling og oprensning af nukleinsyreholdige sammensætninger
DK3331879T3 (da) Benzazolforbindelser og fremgangsmåder til fremstilling og anvendelse af forbindelserne
DK3394259T3 (da) Sammensætninger og fremgangsmåder til reducering af tau-ekspression
DK3242947T3 (da) Genterapi og elektroporese til behandling af maligniteter
DK3394272T3 (da) Sammensætninger og fremgangsmåder til effektiv målretning af transgener
DK3606929T3 (da) Beta-nicotinat-ester-nukleotider og fremgangsmåder til fremstilling af samme
DK3148517T3 (da) Sammensætninger og fremgangsmåder til fremme af knogledannelse
DK3288379T3 (da) Peptidsammensætninger og anvendelsesmåder
DK3212776T3 (da) Sammensætninger og fremgangsmåder i forbindelse med beta-glucosidase