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DK3394057T3 - Syntetisk fremgangsmåde til fremstilling af (S)-(2R,3R,11BR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11B-hexahydro-1H-pyrido[2,1,-A]isoquinolin-2-yl 2-amino-3-methylbutanoat-di(4-methylbenzensulfonat) - Google Patents

Syntetisk fremgangsmåde til fremstilling af (S)-(2R,3R,11BR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11B-hexahydro-1H-pyrido[2,1,-A]isoquinolin-2-yl 2-amino-3-methylbutanoat-di(4-methylbenzensulfonat) Download PDF

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Publication number
DK3394057T3
DK3394057T3 DK16823529.9T DK16823529T DK3394057T3 DK 3394057 T3 DK3394057 T3 DK 3394057T3 DK 16823529 T DK16823529 T DK 16823529T DK 3394057 T3 DK3394057 T3 DK 3394057T3
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DK
Denmark
Prior art keywords
methylbutanoate
methylbenzenesulfonate
isoquinolin
pyrido
hexahydro
Prior art date
Application number
DK16823529.9T
Other languages
English (en)
Inventor
Bin-Feng Li
Kevin Mcgee
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Application granted granted Critical
Publication of DK3394057T3 publication Critical patent/DK3394057T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK16823529.9T 2015-12-23 2016-12-22 Syntetisk fremgangsmåde til fremstilling af (S)-(2R,3R,11BR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11B-hexahydro-1H-pyrido[2,1,-A]isoquinolin-2-yl 2-amino-3-methylbutanoat-di(4-methylbenzensulfonat) DK3394057T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562387442P 2015-12-23 2015-12-23
PCT/US2016/068277 WO2017112857A1 (en) 2015-12-23 2016-12-22 SYNTHETIC METHODS FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE)

Publications (1)

Publication Number Publication Date
DK3394057T3 true DK3394057T3 (da) 2022-04-11

Family

ID=57758848

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16823529.9T DK3394057T3 (da) 2015-12-23 2016-12-22 Syntetisk fremgangsmåde til fremstilling af (S)-(2R,3R,11BR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11B-hexahydro-1H-pyrido[2,1,-A]isoquinolin-2-yl 2-amino-3-methylbutanoat-di(4-methylbenzensulfonat)

Country Status (17)

Country Link
US (6) US10160757B2 (da)
EP (1) EP3394057B1 (da)
JP (4) JP6869988B2 (da)
CN (2) CN108925135B (da)
CA (1) CA3009169A1 (da)
CY (1) CY1125320T1 (da)
DK (1) DK3394057T3 (da)
ES (1) ES2911351T3 (da)
HR (1) HRP20220621T1 (da)
HU (1) HUE059065T2 (da)
LT (1) LT3394057T (da)
MA (1) MA44127A (da)
PL (1) PL3394057T3 (da)
PT (1) PT3394057T (da)
RS (1) RS63170B1 (da)
SI (1) SI3394057T1 (da)
WO (1) WO2017112857A1 (da)

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JP2019500372A (ja) 2019-01-10
US10160757B2 (en) 2018-12-25
US10906903B2 (en) 2021-02-02
JP2025096506A (ja) 2025-06-26
US20200347056A1 (en) 2020-11-05
EP3394057B1 (en) 2022-03-30
PT3394057T (pt) 2022-04-21
JP2021046454A (ja) 2021-03-25
US20200181140A1 (en) 2020-06-11
RS63170B1 (sr) 2022-05-31
JP6869988B2 (ja) 2021-05-12
EP3394057A1 (en) 2018-10-31
MA44127A (fr) 2018-10-31
WO2017112857A1 (en) 2017-06-29
CN121045173A (zh) 2025-12-02
JP2023068137A (ja) 2023-05-16
US20200347055A1 (en) 2020-11-05
ES2911351T3 (es) 2022-05-18
US10919892B2 (en) 2021-02-16
CY1125320T1 (el) 2025-03-28
LT3394057T (lt) 2022-06-27
US10906902B2 (en) 2021-02-02
CN108925135B (zh) 2025-09-19
HUE059065T2 (hu) 2022-10-28
US20200347054A1 (en) 2020-11-05
SI3394057T1 (sl) 2022-06-30
HRP20220621T1 (hr) 2022-06-24
US20170183346A1 (en) 2017-06-29
PL3394057T3 (pl) 2022-08-22
CA3009169A1 (en) 2017-06-29
CN108925135A (zh) 2018-11-30
US20200347057A1 (en) 2020-11-05

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