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DK3390364T3 - Små molekyler til hæmning af kemokinaktivitet og/eller cancercellevækst - Google Patents

Små molekyler til hæmning af kemokinaktivitet og/eller cancercellevækst Download PDF

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Publication number
DK3390364T3
DK3390364T3 DK16875067.7T DK16875067T DK3390364T3 DK 3390364 T3 DK3390364 T3 DK 3390364T3 DK 16875067 T DK16875067 T DK 16875067T DK 3390364 T3 DK3390364 T3 DK 3390364T3
Authority
DK
Denmark
Prior art keywords
kemokin
inhibition
activity
cancer cell
cell growth
Prior art date
Application number
DK16875067.7T
Other languages
English (en)
Inventor
Amnon Peled
Michal Abraham
Orly Eizenberg
Original Assignee
Biokine Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biokine Therapeutics Ltd filed Critical Biokine Therapeutics Ltd
Application granted granted Critical
Publication of DK3390364T3 publication Critical patent/DK3390364T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/24Oxygen atoms attached in position 8
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/24Oxygen atoms attached in position 8
    • C07D215/26Alcohols; Ethers thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK16875067.7T 2015-12-17 2016-12-15 Små molekyler til hæmning af kemokinaktivitet og/eller cancercellevækst DK3390364T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562268586P 2015-12-17 2015-12-17
PCT/IL2016/051347 WO2017103932A1 (en) 2015-12-17 2016-12-15 Small molecules for inhibiting chemokine activity, a kinase activity and/or cancer cells growth

Publications (1)

Publication Number Publication Date
DK3390364T3 true DK3390364T3 (da) 2020-10-12

Family

ID=59056164

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16875067.7T DK3390364T3 (da) 2015-12-17 2016-12-15 Små molekyler til hæmning af kemokinaktivitet og/eller cancercellevækst

Country Status (12)

Country Link
US (3) US11129824B2 (da)
EP (2) EP3390364B1 (da)
JP (1) JP6941611B2 (da)
KR (1) KR102828755B1 (da)
CN (1) CN108699000B (da)
AU (2) AU2016371466B2 (da)
CA (1) CA3008107C (da)
DK (1) DK3390364T3 (da)
ES (2) ES2818531T3 (da)
IL (1) IL260081B (da)
MX (2) MX382300B (da)
WO (1) WO2017103932A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3390378B1 (en) 2015-12-17 2022-03-30 AlonBio Ltd. Small molecules against cancer
CA3008107C (en) 2015-12-17 2023-06-27 Biokine Therapeutics Ltd. 8-phenoxy-quinoline derivatives for inhibiting chemokine activity and/or cancer cells growth
CA3090315C (en) * 2019-05-15 2023-09-19 Biokine Therapeutics Ltd. 8-phenoxy-quinolinone derivatives for treating cancer, inhibiting chemokine activity and/or inducing cell death
JP2020193249A (ja) * 2019-05-27 2020-12-03 信越化学工業株式会社 量子ドット、量子ドット組成物、波長変換材料、波長変換フィルム、バックライトユニット及び画像表示装置
CN119365193A (zh) * 2022-06-13 2025-01-24 梅约医学教育与研究基金会 类黄酮化合物和使用类黄酮化合物治疗纤维化病症的方法和材料

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JPH04178647A (ja) 1990-11-14 1992-06-25 Konica Corp 有機着色物質の光褪色防止方法及びカラー写真材料
WO1992020642A1 (en) 1991-05-10 1992-11-26 Rhone-Poulenc Rorer International (Holdings) Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
FR2682107B1 (fr) * 1991-10-03 1995-04-21 Orstom Inst Fs Rech Scient Quinoleines 2-substituees pour le traitement des leishmanioses.
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BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
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KR102016889B1 (ko) 2009-06-12 2019-08-30 아비박스 조기 노화, 구체적으로 조로증을 치료하는데 유용한 화합물
WO2010146584A1 (en) 2009-06-15 2010-12-23 Biokine Therapeutics Ltd. Novel chemokine binding polypeptides capable of inhibiting the course of autoimmunity, inflammation and cancer
KR101624020B1 (ko) * 2011-03-07 2016-05-24 글락소스미스클라인 엘엘씨 퀴놀리논 유도체
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GB201519340D0 (en) 2015-11-02 2015-12-16 Cambridge Entpr Ltd Methods of T-lymphocyte expansion
EP3390378B1 (en) 2015-12-17 2022-03-30 AlonBio Ltd. Small molecules against cancer
CA3008107C (en) 2015-12-17 2023-06-27 Biokine Therapeutics Ltd. 8-phenoxy-quinoline derivatives for inhibiting chemokine activity and/or cancer cells growth
CA3090315C (en) 2019-05-15 2023-09-19 Biokine Therapeutics Ltd. 8-phenoxy-quinolinone derivatives for treating cancer, inhibiting chemokine activity and/or inducing cell death

Also Published As

Publication number Publication date
US11129824B2 (en) 2021-09-28
EP3741432A1 (en) 2020-11-25
AU2016371466B2 (en) 2020-04-09
AU2020204524B2 (en) 2022-01-20
EP3390364B1 (en) 2020-07-15
BR112018012306A2 (pt) 2018-12-04
EP3390364A1 (en) 2018-10-24
CN108699000A (zh) 2018-10-23
CA3008107A1 (en) 2017-06-22
WO2017103932A1 (en) 2017-06-22
CA3008107C (en) 2023-06-27
MX2018007361A (es) 2019-05-16
US20250161291A1 (en) 2025-05-22
RU2018125293A (ru) 2020-01-17
KR102828755B1 (ko) 2025-07-03
AU2016371466A1 (en) 2018-07-19
AU2020204524A1 (en) 2020-07-30
IL260081B (en) 2021-09-30
AU2020204524B9 (en) 2022-02-03
WO2017103932A9 (en) 2017-08-24
ES2818531T3 (es) 2021-04-13
EP3390364A4 (en) 2018-10-24
JP6941611B2 (ja) 2021-09-29
IL260081A (en) 2018-07-31
JP2019502699A (ja) 2019-01-31
US20220008407A1 (en) 2022-01-13
ES2951385T3 (es) 2023-10-20
US20190336492A1 (en) 2019-11-07
EP3741432B1 (en) 2023-05-10
MX382300B (es) 2025-03-13
US12233057B2 (en) 2025-02-25
CN108699000B (zh) 2021-09-21
MX2020011500A (es) 2020-12-07
RU2018125293A3 (da) 2020-04-06
KR20180100135A (ko) 2018-09-07

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