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DK3223013T3 - Fluorescerende silica-baserede nanopartikler - Google Patents

Fluorescerende silica-baserede nanopartikler Download PDF

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Publication number
DK3223013T3
DK3223013T3 DK17165118.5T DK17165118T DK3223013T3 DK 3223013 T3 DK3223013 T3 DK 3223013T3 DK 17165118 T DK17165118 T DK 17165118T DK 3223013 T3 DK3223013 T3 DK 3223013T3
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Prior art keywords
nanoparticle
nanoparticles
tumor
peg
silica
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DK17165118.5T
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English (en)
Inventor
Michelle S Bradbury
Ulrich Wiesner
Medina Oula Penate
Hooisweng Ow
Andrew Burns
Jason Lewis
Steven Larson
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Sloan Kettering Inst Cancer Res
Univ Cornell
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Publication of DK3223013T3 publication Critical patent/DK3223013T3/da

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
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    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
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    • A61K9/513—Organic macromolecular compounds; Dendrimers
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Claims (15)

1. Fluorescerende silica-baseret nanopartikel omfattende: - en silica-baseret kerne omfattende en fluorescerende forbindelse positioneret i den silica-baserede kerne; - en silica-skal, der omgiver mindst en del af kernen; - en organisk polymer forbundet til nanopartiklen; og - et ligandmolekyle forbundet til nanopartiklen; hvor fra 1 til 20 ligandmolekyler er forbundet til nanopartiklen, og hvor ligandmolekylet er et lineært, cyklisk eller forgrenet peptid indeholdende Arg-Gly-Asp (RGD).
2. Nanopartikel ifølge krav 1, hvor nanopartiklen har en diameter fra ca. 0,05 nm til ca. 100 nm.
3. Nanopartikel ifølge krav 1, hvor nanopartiklen har en diameter fra ca. 0,5 nm til ca. 25 nm.
4. Nanopartikel ifølge krav 1, hvor nanopartiklen har en diameter fra ca. 0,8 nm til ca. 15 nm.
5. Nanopartikel ifølge krav 1, hvor nanopartiklen har en diameter fra ca. 1 nm til ca. 8 nm.
6. Nanopartikel ifølge et hvilket som helst af kravene 1-5, hvor den organiske polymer er valgt fra gruppen bestående af poly(ethylenglycol) (PEG), polylactat, polymælkesyrer, sukre, lipider, polyglutaminsyre (PGA), polyglycolsyre, poly(mælke-co-glycolsyre) (PLGA), polyvinylacetat (PVA), og kombinationerne deraf.
7. Nanopartikel ifølge krav 6, hvor nanopartiklen er kovalent konjugeret med PEG.
8. Nanopartikel ifølge krav 1, hvor den organiske polymer forbundet til nanopartiklen er en PEG modificeret til at inkorporere mindst en funktionel gruppe valgt fra maleimid og N-hydoxysuccinimid- (NHS) ester.
9. Nanopartikel ifølge krav 1, hvor 1 til 10 ligandmolekyler er forbundet til nanopartiklen.
10. Nanopartikel ifølge krav 1, hvor et kontraststof er forbundet til nanopartiklen.
11. Nanopartikel ifølge krav 10, hvor konstraststoffet er et radionuklid.
12. Nanopartikel ifølge krav 1, hvor et terapeutisk middel er forbundet til nanopartiklen.
13. Nanopartikel ifølge krav 1, hvor den fluorescerende forbindelse er Cy5.
14. Nanopartikel ifølge krav 1, hvor den fluorescerende forbindelse er Cy5.5.
15. Nanopartikel ifølge krav 1, hvor liganden er valgt fra gruppen bestående af RGD, cyklisk Arg-Gly-Asp (cRGD) og cRGDY.
DK17165118.5T 2009-07-02 2010-07-02 Fluorescerende silica-baserede nanopartikler DK3223013T3 (da)

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US22285109P 2009-07-02 2009-07-02
US31282710P 2010-03-11 2010-03-11
EP10794842.4A EP2449379B1 (en) 2009-07-02 2010-07-02 Fluorescent silica-based nanoparticles

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EP (3) EP2449379B1 (da)
CN (3) CN102713612B (da)
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ES (2) ES2639310T3 (da)
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PL3223013T3 (pl) 2019-07-31
US20170239378A1 (en) 2017-08-24
PL2449379T3 (pl) 2017-12-29
US10548997B2 (en) 2020-02-04
CN106421817A (zh) 2017-02-22
EP2449379A4 (en) 2014-02-19
CN102713612B (zh) 2016-10-05
EP3499233A2 (en) 2019-06-19
WO2011003109A8 (en) 2012-02-23
ES2718084T3 (es) 2019-06-27
CN102713612A (zh) 2012-10-03
US9625456B2 (en) 2017-04-18
CN115990277A (zh) 2023-04-21
EP3223013A1 (en) 2017-09-27
ES2639310T3 (es) 2017-10-26
US20130039848A1 (en) 2013-02-14
EP3499233A3 (en) 2019-09-18
WO2011003109A1 (en) 2011-01-06
EP2449379B1 (en) 2017-05-17

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